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Protein

Transmembrane protein 170B

Gene

TMEM170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 170B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:34244. TMEM170B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104ExtracellularSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 132CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100113407.
OpenTargetsiENSG00000205269.
PharmGKBiPA162405923.

Polymorphism and mutation databases

DMDMi74744982.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422671 – 132Transmembrane protein 170BAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T4T1.
PRIDEiQ5T4T1.

PTM databases

iPTMnetiQ5T4T1.
PhosphoSitePlusiQ5T4T1.

Expressioni

Gene expression databases

BgeeiENSG00000205269.
CleanExiHS_TMEM170B.
GenevisibleiQ5T4T1. HS.

Organism-specific databases

HPAiHPA055134.

Structurei

3D structure databases

ProteinModelPortaliQ5T4T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM170 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4349. Eukaryota.
ENOG4111MVH. LUCA.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ5T4T1.
OMAiADHSMIN.
OrthoDBiEOG091G0V4L.
PhylomeDBiQ5T4T1.
TreeFamiTF314615.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T4T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH
60 70 80 90 100
GAAGVLMFVM LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA
110 120 130
GKNMAPLEAL VWGVGQTVLT LIISFSRILA TL
Length:132
Mass (Da):14,360
Last modified:December 21, 2004 - v1
Checksum:iDA9D091B59214A52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357518 Genomic DNA. Translation: CAI16364.1.
CCDSiCCDS43425.1.
RefSeqiNP_001094299.1. NM_001100829.2.
UniGeneiHs.146317.

Genome annotation databases

EnsembliENST00000379426; ENSP00000368737; ENSG00000205269.
GeneIDi100113407.
KEGGihsa:100113407.
UCSCiuc010jpa.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357518 Genomic DNA. Translation: CAI16364.1.
CCDSiCCDS43425.1.
RefSeqiNP_001094299.1. NM_001100829.2.
UniGeneiHs.146317.

3D structure databases

ProteinModelPortaliQ5T4T1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5T4T1.
PhosphoSitePlusiQ5T4T1.

Polymorphism and mutation databases

DMDMi74744982.

Proteomic databases

PaxDbiQ5T4T1.
PRIDEiQ5T4T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379426; ENSP00000368737; ENSG00000205269.
GeneIDi100113407.
KEGGihsa:100113407.
UCSCiuc010jpa.5. human.

Organism-specific databases

CTDi100113407.
DisGeNETi100113407.
GeneCardsiTMEM170B.
HGNCiHGNC:34244. TMEM170B.
HPAiHPA055134.
neXtProtiNX_Q5T4T1.
OpenTargetsiENSG00000205269.
PharmGKBiPA162405923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4349. Eukaryota.
ENOG4111MVH. LUCA.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ5T4T1.
OMAiADHSMIN.
OrthoDBiEOG091G0V4L.
PhylomeDBiQ5T4T1.
TreeFamiTF314615.

Enzyme and pathway databases

BioCyciZFISH:G66-32370-MONOMER.

Miscellaneous databases

PROiQ5T4T1.

Gene expression databases

BgeeiENSG00000205269.
CleanExiHS_TMEM170B.
GenevisibleiQ5T4T1. HS.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT170B_HUMAN
AccessioniPrimary (citable) accession number: Q5T4T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.