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Q5T4T1

- T170B_HUMAN

UniProt

Q5T4T1 - T170B_HUMAN

Protein

Transmembrane protein 170B

Gene

TMEM170B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 170B
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:34244. TMEM170B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405923.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Transmembrane protein 170BPRO_0000342267Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ5T4T1.

    PTM databases

    PhosphoSiteiQ5T4T1.

    Expressioni

    Gene expression databases

    BgeeiQ5T4T1.
    CleanExiHS_TMEM170B.
    GenevestigatoriQ5T4T1.

    Organism-specific databases

    HPAiHPA055134.

    Interactioni

    Protein-protein interaction databases

    BioGridi755893. 1 interaction.
    STRINGi9606.ENSP00000368737.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T4T1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini59 – 6810CytoplasmicSequence Analysis
    Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini126 – 1327CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM170 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245599.
    HOGENOMiHOG000290672.
    HOVERGENiHBG108536.
    InParanoidiQ5T4T1.
    OMAiSMAPLEA.
    OrthoDBiEOG7HXCSS.
    PhylomeDBiQ5T4T1.
    TreeFamiTF314615.

    Family and domain databases

    InterProiIPR019334. Transmembrane_pr_170.
    [Graphical view]
    PfamiPF10190. Tmemb_170. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T4T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH    50
    GAAGVLMFVM LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA 100
    GKNMAPLEAL VWGVGQTVLT LIISFSRILA TL 132
    Length:132
    Mass (Da):14,360
    Last modified:December 21, 2004 - v1
    Checksum:iDA9D091B59214A52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL357518 Genomic DNA. Translation: CAI16364.1.
    CCDSiCCDS43425.1.
    RefSeqiNP_001094299.1. NM_001100829.2.
    UniGeneiHs.146317.

    Genome annotation databases

    EnsembliENST00000379426; ENSP00000368737; ENSG00000205269.
    GeneIDi100113407.
    KEGGihsa:100113407.
    UCSCiuc010jpa.4. human.

    Polymorphism databases

    DMDMi74744982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL357518 Genomic DNA. Translation: CAI16364.1 .
    CCDSi CCDS43425.1.
    RefSeqi NP_001094299.1. NM_001100829.2.
    UniGenei Hs.146317.

    3D structure databases

    ProteinModelPortali Q5T4T1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 755893. 1 interaction.
    STRINGi 9606.ENSP00000368737.

    PTM databases

    PhosphoSitei Q5T4T1.

    Polymorphism databases

    DMDMi 74744982.

    Proteomic databases

    PRIDEi Q5T4T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379426 ; ENSP00000368737 ; ENSG00000205269 .
    GeneIDi 100113407.
    KEGGi hsa:100113407.
    UCSCi uc010jpa.4. human.

    Organism-specific databases

    CTDi 100113407.
    GeneCardsi GC06P011537.
    HGNCi HGNC:34244. TMEM170B.
    HPAi HPA055134.
    neXtProti NX_Q5T4T1.
    PharmGKBi PA162405923.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245599.
    HOGENOMi HOG000290672.
    HOVERGENi HBG108536.
    InParanoidi Q5T4T1.
    OMAi SMAPLEA.
    OrthoDBi EOG7HXCSS.
    PhylomeDBi Q5T4T1.
    TreeFami TF314615.

    Miscellaneous databases

    NextBioi 136330.
    PROi Q5T4T1.

    Gene expression databases

    Bgeei Q5T4T1.
    CleanExi HS_TMEM170B.
    Genevestigatori Q5T4T1.

    Family and domain databases

    InterProi IPR019334. Transmembrane_pr_170.
    [Graphical view ]
    Pfami PF10190. Tmemb_170. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiT170B_HUMAN
    AccessioniPrimary (citable) accession number: Q5T4T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3