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Protein

Transmembrane protein 170B

Gene

TMEM170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 170B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:34244. TMEM170B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Topological domaini59 – 6810CytoplasmicSequence Analysis
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Topological domaini90 – 10415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Topological domaini126 – 1327CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405923.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Transmembrane protein 170BPRO_0000342267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi12 – 121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5T4T1.

PTM databases

PhosphoSiteiQ5T4T1.

Expressioni

Gene expression databases

BgeeiQ5T4T1.
CleanExiHS_TMEM170B.
GenevestigatoriQ5T4T1.

Organism-specific databases

HPAiHPA055134.

Interactioni

Protein-protein interaction databases

BioGridi755893. 1 interaction.
STRINGi9606.ENSP00000368737.

Structurei

3D structure databases

ProteinModelPortaliQ5T4T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM170 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245599.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ5T4T1.
OMAiADHSMIN.
OrthoDBiEOG7HXCSS.
PhylomeDBiQ5T4T1.
TreeFamiTF314615.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T4T1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH
60 70 80 90 100
GAAGVLMFVM LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA
110 120 130
GKNMAPLEAL VWGVGQTVLT LIISFSRILA TL
Length:132
Mass (Da):14,360
Last modified:December 21, 2004 - v1
Checksum:iDA9D091B59214A52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357518 Genomic DNA. Translation: CAI16364.1.
CCDSiCCDS43425.1.
RefSeqiNP_001094299.1. NM_001100829.2.
UniGeneiHs.146317.

Genome annotation databases

EnsembliENST00000379426; ENSP00000368737; ENSG00000205269.
GeneIDi100113407.
KEGGihsa:100113407.
UCSCiuc010jpa.4. human.

Polymorphism databases

DMDMi74744982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357518 Genomic DNA. Translation: CAI16364.1.
CCDSiCCDS43425.1.
RefSeqiNP_001094299.1. NM_001100829.2.
UniGeneiHs.146317.

3D structure databases

ProteinModelPortaliQ5T4T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi755893. 1 interaction.
STRINGi9606.ENSP00000368737.

PTM databases

PhosphoSiteiQ5T4T1.

Polymorphism databases

DMDMi74744982.

Proteomic databases

PRIDEiQ5T4T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379426; ENSP00000368737; ENSG00000205269.
GeneIDi100113407.
KEGGihsa:100113407.
UCSCiuc010jpa.4. human.

Organism-specific databases

CTDi100113407.
GeneCardsiGC06P011537.
HGNCiHGNC:34244. TMEM170B.
HPAiHPA055134.
neXtProtiNX_Q5T4T1.
PharmGKBiPA162405923.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245599.
GeneTreeiENSGT00390000002101.
HOGENOMiHOG000290672.
HOVERGENiHBG108536.
InParanoidiQ5T4T1.
OMAiADHSMIN.
OrthoDBiEOG7HXCSS.
PhylomeDBiQ5T4T1.
TreeFamiTF314615.

Miscellaneous databases

NextBioi136330.
PROiQ5T4T1.

Gene expression databases

BgeeiQ5T4T1.
CleanExiHS_TMEM170B.
GenevestigatoriQ5T4T1.

Family and domain databases

InterProiIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamiPF10190. Tmemb_170. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiT170B_HUMAN
AccessioniPrimary (citable) accession number: Q5T4T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 21, 2004
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.