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Q5T4T1 (T170B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 170B
Gene names
Name:TMEM170B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM170 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 132132Transmembrane protein 170B
PRO_0000342267

Regions

Topological domain1 – 3737Extracellular Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 6810Cytoplasmic Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 10415Extracellular Potential
Transmembrane105 – 12521Helical; Potential
Topological domain126 – 1327Cytoplasmic Potential

Amino acid modifications

Glycosylation121N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q5T4T1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: DA9D091B59214A52

FASTA13214,360
        10         20         30         40         50         60 
MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH GAAGVLMFVM 

        70         80         90        100        110        120 
LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA GKNMAPLEAL VWGVGQTVLT 

       130 
LIISFSRILA TL 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL357518 Genomic DNA. Translation: CAI16364.1.
RefSeqNP_001094299.1. NM_001100829.2.
UniGeneHs.146317.

3D structure databases

ProteinModelPortalQ5T4T1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid755893. 1 interaction.
STRING9606.ENSP00000368737.

PTM databases

PhosphoSiteQ5T4T1.

Polymorphism databases

DMDM74744982.

Proteomic databases

PRIDEQ5T4T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379426; ENSP00000368737; ENSG00000205269.
ENST00000543875; ENSP00000442131; ENSG00000205269.
GeneID100113407.
KEGGhsa:100113407.
UCSCuc010jpa.4. human.

Organism-specific databases

CTD100113407.
GeneCardsGC06P011537.
HGNCHGNC:34244. TMEM170B.
HPAHPA055134.
neXtProtNX_Q5T4T1.
PharmGKBPA162405923.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245599.
HOGENOMHOG000290672.
HOVERGENHBG108536.
InParanoidQ5T4T1.
OMAEAGDNSM.
OrthoDBEOG7HXCSS.
TreeFamTF314615.

Gene expression databases

BgeeQ5T4T1.
CleanExHS_TMEM170B.
GenevestigatorQ5T4T1.

Family and domain databases

InterProIPR019334. Transmembrane_pr_170.
[Graphical view]
PfamPF10190. Tmemb_170. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio136330.
PROQ5T4T1.

Entry information

Entry nameT170B_HUMAN
AccessionPrimary (citable) accession number: Q5T4T1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 21, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM