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Protein

Transmembrane protein 170B

Gene

TMEM170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600).1 Publication

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 170B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000205269.5
HGNCiHGNC:34244 TMEM170B
neXtProtiNX_Q5T4T1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 104ExtracellularSequence analysisAdd BLAST15
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Topological domaini126 – 132CytoplasmicSequence analysis7

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205269
PharmGKBiPA162405923

Polymorphism and mutation databases

DMDMi74744982

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422671 – 132Transmembrane protein 170BAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T4T1
PRIDEiQ5T4T1

PTM databases

iPTMnetiQ5T4T1
PhosphoSitePlusiQ5T4T1

Expressioni

Tissue specificityi

Expressed in normal breast tissues. Down-regulated in breast cancer cells (at protein level) (PubMed:29367600).1 Publication

Gene expression databases

BgeeiENSG00000205269
CleanExiHS_TMEM170B
GenevisibleiQ5T4T1 HS

Organism-specific databases

HPAiHPA055134

Interactioni

Subunit structurei

Interacts with CTNNB1(PubMed:29367600).1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5T4T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM170 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4349 Eukaryota
ENOG4111MVH LUCA
GeneTreeiENSGT00390000002101
HOGENOMiHOG000290672
HOVERGENiHBG108536
InParanoidiQ5T4T1
OMAiLWCLFSS
OrthoDBiEOG091G0V4L
PhylomeDBiQ5T4T1
TreeFamiTF314615

Family and domain databases

InterProiView protein in InterPro
IPR019334 Transmembrane_pr_170
PANTHERiPTHR22779 PTHR22779, 1 hit
PfamiView protein in Pfam
PF10190 Tmemb_170, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T4T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAEGGDHSM INLSVQQVLS LWAHGTVLRN LTEMWYWIFL WALFSSLFVH
60 70 80 90 100
GAAGVLMFVM LQRHRQGRVI SVIAVSIGFL ASVTGAMITS AAVAGIYRVA
110 120 130
GKNMAPLEAL VWGVGQTVLT LIISFSRILA TL
Length:132
Mass (Da):14,360
Last modified:December 21, 2004 - v1
Checksum:iDA9D091B59214A52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL357518 Genomic DNA No translation available.
CCDSiCCDS43425.1
RefSeqiNP_001094299.1, NM_001100829.2
UniGeneiHs.146317

Genome annotation databases

EnsembliENST00000379426; ENSP00000368737; ENSG00000205269
GeneIDi100113407
KEGGihsa:100113407
UCSCiuc010jpa.5 human

Similar proteinsi

Entry informationi

Entry nameiT170B_HUMAN
AccessioniPrimary (citable) accession number: Q5T4T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health