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Protein

E3 ubiquitin-protein ligase UBR4

Gene

UBR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1656 – 172974UBR-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • ligase activity Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Host-virus interaction, Ubl conjugation pathway

Keywords - Ligandi

Calmodulin-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR4 (EC:6.3.2.-)
Alternative name(s):
600 kDa retinoblastoma protein-associated factor
N-recognin-4
Retinoblastoma-associated factor of 600 kDa
Short name:
RBAF600
Short name:
p600
Zinc finger UBR1-type protein 1
Gene namesi
Name:UBR4
Synonyms:KIAA0462, KIAA1307, RBAF600, ZUBR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30313. UBR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei850 – 87021HelicalSequence analysisAdd
BLAST
Transmembranei993 – 101321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • centrosome Source: HPA
  • cytoplasm Source: HPA
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407958.

Polymorphism and mutation databases

BioMutaiUBR4.
DMDMi74744979.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 51835183E3 ubiquitin-protein ligase UBR4PRO_0000286861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781PhosphoserineCombined sources
Modified residuei181 – 1811PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineBy similarity
Modified residuei370 – 3701PhosphotyrosineBy similarity
Modified residuei1084 – 10841N6-acetyllysineCombined sources
Modified residuei1402 – 14021PhosphoserineBy similarity
Modified residuei1647 – 16471PhosphoserineCombined sources
Modified residuei1652 – 16521PhosphoserineCombined sources
Modified residuei1754 – 17541PhosphoserineBy similarity
Modified residuei1763 – 17631PhosphoserineCombined sources
Modified residuei2715 – 27151PhosphothreonineCombined sources
Modified residuei2719 – 27191PhosphoserineCombined sources1 Publication
Modified residuei2722 – 27221PhosphoserineBy similarity
Modified residuei2724 – 27241PhosphothreonineBy similarity
Modified residuei2944 – 29441PhosphothreonineCombined sources
Modified residuei2952 – 29521PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5T4S7.
MaxQBiQ5T4S7.
PaxDbiQ5T4S7.
PRIDEiQ5T4S7.

PTM databases

iPTMnetiQ5T4S7.
PhosphoSiteiQ5T4S7.
SwissPalmiQ5T4S7.

Expressioni

Gene expression databases

BgeeiQ5T4S7.
ExpressionAtlasiQ5T4S7. baseline and differential.
GenevisibleiQ5T4S7. HS.

Organism-specific databases

HPAiHPA013394.
HPA021046.

Interactioni

Subunit structurei

Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
E7P031294EBI-1995940,EBI-866453From a different organism.

Protein-protein interaction databases

BioGridi116934. 106 interactions.
IntActiQ5T4S7. 36 interactions.
MINTiMINT-4715511.
STRINGi9606.ENSP00000364403.

Structurei

3D structure databases

ProteinModelPortaliQ5T4S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 157Poly-Ala
Compositional biasi608 – 63124Pro-richAdd
BLAST
Compositional biasi2728 – 273811Poly-AspAdd
BLAST
Compositional biasi3339 – 337032Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the UBR4 family.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1656 – 172974UBR-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
GeneTreeiENSGT00600000084471.
HOVERGENiHBG058328.
InParanoidiQ5T4S7.
KOiK10691.
OMAiEGDVHTS.
OrthoDBiEOG7288QF.
PhylomeDBiQ5T4S7.
TreeFamiTF314406.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 9 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T4S7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSGGEEAA AAAPAPGTPA TGADTTPGWE VAVRPLLSAS YSAFEMKELP
60 70 80 90 100
QLVASVIESE SEILHHEKQY EPFYSSFVAL STHYITTVCS LIPRNQLQSV
110 120 130 140 150
AAACKVLIEF SLLRLENPDE ACAVSQKHLI LLIKGLCTGC SRLDRTEIIT
160 170 180 190 200
FTAMMKSAKL PQTVKTLSDV EDQKELASPV SPELRQKEVQ MNFLNQLTSV
210 220 230 240 250
FNPRTVASQP ISTQTLVEGE NDEQSSTDQA SAIKTKNVFI AQNVASLQEL
260 270 280 290 300
GGSEKLLRVC LNLPYFLRYI NRFQDAVLAN SFFIMPATVA DATAVRNGFH
310 320 330 340 350
SLVIDVTMAL DTLSLPVLEP LNPSRLQDVT VLSLSCLYAG VSVATCMAIL
360 370 380 390 400
HVGSAQQVRT GSTSSKEDDY ESDAATIVQK CLEIYDMIGQ AISSSRRAGG
410 420 430 440 450
EHYQNFQLLG AWCLLNSLFL ILNLSPTALA DKGKEKDPLA ALRVRDILSR
460 470 480 490 500
TKEGVGSPKL GPGKGHQGFG VLSVILANHA IKLLTSLFQD LQVEALHKGW
510 520 530 540 550
ETDGPPAALS IMAQSTSIQR IQRLIDSVPL MNLLLTLLST SYRKACVLQR
560 570 580 590 600
QRKGSMSSDA SASTDSNTYY EDDFSSTEED SSQDDDSEPI LGQWFEETIS
610 620 630 640 650
PSKEKAAPPP PPPPPPLESS PRVKSPSKQA PGEKGNILAS RKDPELFLGL
660 670 680 690 700
ASNILNFITS SMLNSRNNFI RNYLSVSLSE HHMATLASII KEVDKDGLKG
710 720 730 740 750
SSDEEFAAAL YHFNHSLVTS DLQSPNLQNT LLQQLGVAPF SEGPWPLYIH
760 770 780 790 800
PQSLSVLSRL LLIWQHKASA QGDPDVPECL KVWDRFLSTM KQNALQGVVP
810 820 830 840 850
SETEDLNVEH LQMLLLIFHN FTETGRRAIL SLFVQIIQEL SVNMDAQMRF
860 870 880 890 900
VPLILARLLL IFDYLLHQYS KAPVYLFEQV QHNLLSPPFG WASGSQDSNS
910 920 930 940 950
RRATTPLYHG FKEVEENWSK HFSSDAVPHP RFYCVLSPEA SEDDLNRLDS
960 970 980 990 1000
VACDVLFSKL VKYDELYAAL TALLAAGSQL DTVRRKENKN VTALEACALQ
1010 1020 1030 1040 1050
YYFLILWRIL GILPPSKTYI NQLSMNSPEM SECDILHTLR WSSRLRISSY
1060 1070 1080 1090 1100
VNWIKDHLIK QGMKAEHASS LLELASTTKC SSVKYDVEIV EEYFARQISS
1110 1120 1130 1140 1150
FCSIDCTTIL QLHEIPSLQS IYTLDAAISK VQVSLDEHFS KMAAETDPHK
1160 1170 1180 1190 1200
SSEITKNLLP ATLQLIDTYA SFTRAYLLQN FNEEGTTEKP SKEKLQGFAA
1210 1220 1230 1240 1250
VLAIGSSRCK ANTLGPTLVQ NLPSSVQTVC ESWNNINTNE FPNIGSWRNA
1260 1270 1280 1290 1300
FANDTIPSES YISAVQAAHL GTLCSQSLPL AASLKHTLLS LVRLTGDLIV
1310 1320 1330 1340 1350
WSDEMNPPQV IRTLLPLLLE SSTESVAEIS SNSLERILGP AESDEFLARV
1360 1370 1380 1390 1400
YEKLITGCYN ILANHADPNS GLDESILEEC LQYLEKQLES SQARKAMEEF
1410 1420 1430 1440 1450
FSDSGELVQI MMATANENLS AKFCNRVLKF FTKLFQLTEK SPNPSLLHLC
1460 1470 1480 1490 1500
GSLAQLACVE PVRLQAWLTR MTTSPPKDSD QLDVIQENRQ LLQLLTTYIV
1510 1520 1530 1540 1550
RENSQVGEGV CAVLLGTLTP MATEMLANGD GTGFPELMVV MATLASAGQG
1560 1570 1580 1590 1600
AGHLQLHNAA VDWLSRCKKY LSQKNVVEKL NANVMHGKHV MILECTCHIM
1610 1620 1630 1640 1650
SYLADVTNAL SQSNGQGPSH LSVDGEERAI EVDSDWVEEL AVEEEDSQAE
1660 1670 1680 1690 1700
DSDEDSLCNK LCTFTITQKE FMNQHWYHCH TCKMVDGVGV CTVCAKVCHK
1710 1720 1730 1740 1750
DHEISYAKYG SFFCDCGAKE DGSCLALVKR TPSSGMSSTM KESAFQSEPR
1760 1770 1780 1790 1800
ISESLVRHAS TSSPADKAKV TISDGKVADE EKPKKSSLCR TVEGCREELQ
1810 1820 1830 1840 1850
NQANFSFAPL VLDMLNFLMD AIQTNFQQAS AVGSSSRAQQ ALSELHTVEK
1860 1870 1880 1890 1900
AVEMTDQLMV PTLGSQEGAF ENVRMNYSGD QGQTIRQLIS AHVLRRVAMC
1910 1920 1930 1940 1950
VLSSPHGRRQ HLAVSHEKGK ITVLQLSALL KQADSSKRKL TLTRLASAPV
1960 1970 1980 1990 2000
PFTVLSLTGN PCKEDYLAVC GLKDCHVLTF SSSGSVSDHL VLHPQLATGN
2010 2020 2030 2040 2050
FIIKAVWLPG SQTELAIVTA DFVKIYDLCV DALSPTFYFL LPSSKIRDVT
2060 2070 2080 2090 2100
FLFNEEGKNI IVIMSSAGYI YTQLMEEASS AQQGPFYVTN VLEINHEDLK
2110 2120 2130 2140 2150
DSNSQVAGGG VSVYYSHVLQ MLFFSYCQGK SFAATISRTT LEVLQLFPIN
2160 2170 2180 2190 2200
IKSSNGGSKT SPALCQWSEV MNHPGLVCCV QQTTGVPLVV MVKPDTFLIQ
2210 2220 2230 2240 2250
EIKTLPAKAK IQDMVAIRHT ACNEQQRTTM ILLCEDGSLR IYMANVENTS
2260 2270 2280 2290 2300
YWLQPSLQPS SVISIMKPVR KRKTATITTR TSSQVTFPID FFEHNQQLTD
2310 2320 2330 2340 2350
VEFGGNDLLQ VYNAQQIKHR LNSTGMYVAN TKPGGFTIEI SNNNSTMVMT
2360 2370 2380 2390 2400
GMRIQIGTQA IERAPSYIEI FGRTMQLNLS RSRWFDFPFT REEALQADKK
2410 2420 2430 2440 2450
LNLFIGASVD PAGVTMIDAV KIYGKTKEQF GWPDEPPEEF PSASVSNICP
2460 2470 2480 2490 2500
SNLNQSNGTG DSDSAAPTTT SGTVLERLVV SSLEALESCF AVGPIIEKER
2510 2520 2530 2540 2550
NKNAAQELAT LLLSLPAPAS VQQQSKSLLA SLHTSRSAYH SHKDQALLSK
2560 2570 2580 2590 2600
AVQCLNTSSK EGKDLDPEVF QRLVITARSI AIMRPNNLVH FTESKLPQME
2610 2620 2630 2640 2650
TEGMDEGKEP QKQLEGDCCS FITQLVNHFW KLHASKPKNA FLAPACLPGL
2660 2670 2680 2690 2700
THIEATVNAL VDIIHGYCTC ELDCINTASK IYMQMLLCPD PAVSFSCKQA
2710 2720 2730 2740 2750
LIRVLRPRNK RRHVTLPSSP RSNTPMGDKD DDDDDDADEK MQSSGIPNGG
2760 2770 2780 2790 2800
HIRQESQEQS EVDHGDFEMV SESMVLETAE NVNNGNPSPL EALLAGAEGF
2810 2820 2830 2840 2850
PPMLDIPPDA DDETMVELAI ALSLQQDQQG SSSSALGLQS LGLSGQAPSS
2860 2870 2880 2890 2900
SSLDAGTLSD TTASAPASDD EGSTAATDGS TLRTSPADHG GSVGSESGGS
2910 2920 2930 2940 2950
AVDSVAGEHS VSGRSSAYGD ATAEGHPAGP GSVSSSTGAI STTTGHQEGD
2960 2970 2980 2990 3000
GSEGEGEGET EGDVHTSNRL HMVRLMLLER LLQTLPQLRN VGGVRAIPYM
3010 3020 3030 3040 3050
QVILMLTTDL DGEDEKDKGA LDNLLSQLIA ELGMDKKDVS KKNERSALNE
3060 3070 3080 3090 3100
VHLVVMRLLS VFMSRTKSGS KSSICESSSL ISSATAAALL SSGAVDYCLH
3110 3120 3130 3140 3150
VLKSLLEYWK SQQNDEEPVA TSQLLKPHTT SSPPDMSPFF LRQYVKGHAA
3160 3170 3180 3190 3200
DVFEAYTQLL TEMVLRLPYQ IKKITDTNSR IPPPVFDHSW FYFLSEYLMI
3210 3220 3230 3240 3250
QQTPFVRRQV RKLLLFICGS KEKYRQLRDL HTLDSHVRGI KKLLEEQGIF
3260 3270 3280 3290 3300
LRASVVTASS GSALQYDTLI SLMEHLKACA EIAAQRTINW QKFCIKDDSV
3310 3320 3330 3340 3350
LYFLLQVSFL VDEGVSPVLL QLLSCALCGS KVLAALAASS GSSSASSSSA
3360 3370 3380 3390 3400
PVAASSGQAT TQSKSSTKKS KKEEKEKEKD GETSGSQEDQ LCTALVNQLN
3410 3420 3430 3440 3450
KFADKETLIQ FLRCFLLESN SSSVRWQAHC LTLHIYRNSS KSQQELLLDL
3460 3470 3480 3490 3500
MWSIWPELPA YGRKAAQFVD LLGYFSLKTP QTEKKLKEYS QKAVEILRTQ
3510 3520 3530 3540 3550
NHILTNHPNS NIYNTLSGLV EFDGYYLESD PCLVCNNPEV PFCYIKLSSI
3560 3570 3580 3590 3600
KVDTRYTTTQ QVVKLIGSHT ISKVTVKIGD LKRTKMVRTI NLYYNNRTVQ
3610 3620 3630 3640 3650
AIVELKNKPA RWHKAKKVQL TPGQTEVKID LPLPIVASNL MIEFADFYEN
3660 3670 3680 3690 3700
YQASTETLQC PRCSASVPAN PGVCGNCGEN VYQCHKCRSI NYDEKDPFLC
3710 3720 3730 3740 3750
NACGFCKYAR FDFMLYAKPC CAVDPIENEE DRKKAVSNIN TLLDKADRVY
3760 3770 3780 3790 3800
HQLMGHRPQL ENLLCKVNEA APEKPQDDSG TAGGISSTSA SVNRYILQLA
3810 3820 3830 3840 3850
QEYCGDCKNS FDELSKIIQK VFASRKELLE YDLQQREAAT KSSRTSVQPT
3860 3870 3880 3890 3900
FTASQYRALS VLGCGHTSST KCYGCASAVT EHCITLLRAL ATNPALRHIL
3910 3920 3930 3940 3950
VSQGLIRELF DYNLRRGAAA MREEVRQLMC LLTRDNPEAT QQMNDLIIGK
3960 3970 3980 3990 4000
VSTALKGHWA NPDLASSLQY EMLLLTDSIS KEDSCWELRL RCALSLFLMA
4010 4020 4030 4040 4050
VNIKTPVVVE NITLMCLRIL QKLIKPPAPT SKKNKDVPVE ALTTVKPYCN
4060 4070 4080 4090 4100
EIHAQAQLWL KRDPKASYDA WKKCLPIRGI DGNGKAPSKS ELRHLYLTEK
4110 4120 4130 4140 4150
YVWRWKQFLS RRGKRTSPLD LKLGHNNWLR QVLFTPATQA ARQAACTIVE
4160 4170 4180 4190 4200
ALATIPSRKQ QVLDLLTSYL DELSIAGECA AEYLALYQKL ITSAHWKVYL
4210 4220 4230 4240 4250
AARGVLPYVG NLITKEIARL LALEEATLST DLQQGYALKS LTGLLSSFVE
4260 4270 4280 4290 4300
VESIKRHFKS RLVGTVLNGY LCLRKLVVQR TKLIDETQDM LLEMLEDMTT
4310 4320 4330 4340 4350
GTESETKAFM AVCIETAKRY NLDDYRTPVF IFERLCSIIY PEENEVTEFF
4360 4370 4380 4390 4400
VTLEKDPQQE DFLQGRMPGN PYSSNEPGIG PLMRDIKNKI CQDCDLVALL
4410 4420 4430 4440 4450
EDDSGMELLV NNKIISLDLP VAEVYKKVWC TTNEGEPMRI VYRMRGLLGD
4460 4470 4480 4490 4500
ATEEFIESLD STTDEEEDEE EVYKMAGVMA QCGGLECMLN RLAGIRDFKQ
4510 4520 4530 4540 4550
GRHLLTVLLK LFSYCVKVKV NRQQLVKLEM NTLNVMLGTL NLALVAEQES
4560 4570 4580 4590 4600
KDSGGAAVAE QVLSIMEIIL DESNAEPLSE DKGNLLLTGD KDQLVMLLDQ
4610 4620 4630 4640 4650
INSTFVRSNP SVLQGLLRII PYLSFGEVEK MQILVERFKP YCNFDKYDED
4660 4670 4680 4690 4700
HSGDDKVFLD CFCKIAAGIK NNSNGHQLKD LILQKGITQN ALDYMKKHIP
4710 4720 4730 4740 4750
SAKNLDADIW KKFLSRPALP FILRLLRGLA IQHPGTQVLI GTDSIPNLHK
4760 4770 4780 4790 4800
LEQVSSDEGI GTLAENLLEA LREHPDVNKK IDAARRETRA EKKRMAMAMR
4810 4820 4830 4840 4850
QKALGTLGMT TNEKGQVVTK TALLKQMEEL IEEPGLTCCI CREGYKFQPT
4860 4870 4880 4890 4900
KVLGIYTFTK RVALEEMENK PRKQQGYSTV SHFNIVHYDC HLAAVRLARG
4910 4920 4930 4940 4950
REEWESAALQ NANTKCNGLL PVWGPHVPES AFATCLARHN TYLQECTGQR
4960 4970 4980 4990 5000
EPTYQLNIHD IKLLFLRFAM EQSFSADTGG GGRESNIHLI PYIIHTVLYV
5010 5020 5030 5040 5050
LNTTRATSRE EKNLQGFLEQ PKEKWVESAF EVDGPYYFTV LALHILPPEQ
5060 5070 5080 5090 5100
WRATRVEILR RLLVTSQARA VAPGGATRLT DKAVKDYSAY RSSLLFWALV
5110 5120 5130 5140 5150
DLIYNMFKKV PTSNTEGGWS CSLAEYIRHN DMPIYEAADK ALKTFQEEFM
5160 5170 5180
PVETFSEFLD VAGLLSEITD PESFLKDLLN SVP
Length:5,183
Mass (Da):573,841
Last modified:December 21, 2004 - v1
Checksum:i5F6DD7B565E27609
GO
Isoform 2 (identifier: Q5T4S7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5108-5108: K → KKQTTPTVGGIDTGSLEPCVCE

Note: No experimental confirmation available.
Show »
Length:5,204
Mass (Da):575,958
Checksum:iC580B55ED321E0B5
GO
Isoform 3 (identifier: Q5T4S7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2476-2476: E → ESSETESLTKLD
     2830-2864: Missing.

Show »
Length:5,159
Mass (Da):571,852
Checksum:i105A95F4082DE465
GO
Isoform 4 (identifier: Q5T4S7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2601-2601: T → TDCFFPRCACWSLGIVGILIGAPLETPSP
     2830-2864: Missing.

Show »
Length:5,176
Mass (Da):573,606
Checksum:i281A2009C12F24D0
GO
Isoform 5 (identifier: Q5T4S7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2100-2100: K → KQ
     2405-2486: IGASVDPAGV...RLVVSSLEAL → SESPTPGADS...SGNFELHLMY
     2487-5183: Missing.

Show »
Length:2,456
Mass (Da):270,740
Checksum:i90C55A7CA76CD6C1
GO
Isoform 6 (identifier: Q5T4S7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3585: Missing.
     3777-3797: DDSGTAGGISSTSASVNRYIL → VVPRCKGHLDKGLGLDQKTAS
     3798-5183: Missing.

Show »
Length:212
Mass (Da):23,957
Checksum:i3B21A4D0316669AB
GO

Sequence cautioni

The sequence CAD43719.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI19271.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2016 – 20161A → S in AAL83880 (PubMed:16214886).Curated
Sequence conflicti2410 – 24101D → E in AAL83880 (PubMed:16214886).Curated
Sequence conflicti3957 – 39571G → S in AAL83880 (PubMed:16214886).Curated
Sequence conflicti4589 – 45891G → V in AAH18694 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1107 – 11071T → A.
Corresponds to variant rs16862578 [ dbSNP | Ensembl ].
VAR_032193
Natural varianti1394 – 13941R → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035540
Natural varianti4867 – 48671M → L.3 Publications
Corresponds to variant rs12584 [ dbSNP | Ensembl ].
VAR_032194
Natural varianti4924 – 49241G → R in a melanoma patient. 1 Publication
VAR_032195
Natural varianti5084 – 50841V → M.
Corresponds to variant rs2274010 [ dbSNP | Ensembl ].
VAR_032196

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 35853585Missing in isoform 6. 1 PublicationVSP_025200Add
BLAST
Alternative sequencei2100 – 21001K → KQ in isoform 5. 1 PublicationVSP_025201
Alternative sequencei2405 – 248682IGASV…SLEAL → SESPTPGADSVLIVTAKLGA TGLWLSNILGSLHSADFSVL SSGNFELHLMY in isoform 5. 1 PublicationVSP_025202Add
BLAST
Alternative sequencei2476 – 24761E → ESSETESLTKLD in isoform 3. CuratedVSP_025203
Alternative sequencei2487 – 51832697Missing in isoform 5. 1 PublicationVSP_025204Add
BLAST
Alternative sequencei2601 – 26011T → TDCFFPRCACWSLGIVGILI GAPLETPSP in isoform 4. CuratedVSP_025205
Alternative sequencei2830 – 286435Missing in isoform 3 and isoform 4. CuratedVSP_025206Add
BLAST
Alternative sequencei3777 – 379721DDSGT…NRYIL → VVPRCKGHLDKGLGLDQKTA S in isoform 6. 1 PublicationVSP_025207Add
BLAST
Alternative sequencei3798 – 51831386Missing in isoform 6. 1 PublicationVSP_025208Add
BLAST
Alternative sequencei5108 – 51081K → KKQTTPTVGGIDTGSLEPCV CE in isoform 2. 1 PublicationVSP_025209

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348492 mRNA. Translation: AAL83880.1.
AK022322 mRNA. Translation: BAB14011.1.
AL137127, AL357564 Genomic DNA. Translation: CAI19268.1.
AL137127, AL357564 Genomic DNA. Translation: CAI19269.1.
AL137127 Genomic DNA. Translation: CAI19271.1. Sequence problems.
AL137127, AL357564 Genomic DNA. Translation: CAI19272.1.
AL137127 Genomic DNA. Translation: CAI19273.1.
AL137127 Genomic DNA. Translation: CAI19274.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20972.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20973.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20974.1.
AB037728 mRNA. Translation: BAA92545.1.
AB007931 mRNA. Translation: BAA32307.1.
BC018694 mRNA. Translation: AAH18694.2.
BC063573 mRNA. Translation: AAH63573.1.
BC073905 mRNA. Translation: AAH73905.1.
BC096758 mRNA. Translation: AAH96758.1.
AJ505016 mRNA. Translation: CAD43719.1. Different initiation.
AL049972 mRNA. Translation: CAB43227.1.
AF055010 mRNA. Translation: AAC09360.1.
CCDSiCCDS189.1. [Q5T4S7-1]
PIRiT00076.
RefSeqiNP_065816.2. NM_020765.2. [Q5T4S7-1]
UniGeneiHs.148078.
Hs.649405.

Genome annotation databases

EnsembliENST00000375218; ENSP00000364366; ENSG00000127481. [Q5T4S7-6]
ENST00000375254; ENSP00000364403; ENSG00000127481. [Q5T4S7-1]
GeneIDi23352.
KEGGihsa:23352.
UCSCiuc001bbi.4. human. [Q5T4S7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348492 mRNA. Translation: AAL83880.1.
AK022322 mRNA. Translation: BAB14011.1.
AL137127, AL357564 Genomic DNA. Translation: CAI19268.1.
AL137127, AL357564 Genomic DNA. Translation: CAI19269.1.
AL137127 Genomic DNA. Translation: CAI19271.1. Sequence problems.
AL137127, AL357564 Genomic DNA. Translation: CAI19272.1.
AL137127 Genomic DNA. Translation: CAI19273.1.
AL137127 Genomic DNA. Translation: CAI19274.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20972.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20973.1.
AL357564, AL137127 Genomic DNA. Translation: CAI20974.1.
AB037728 mRNA. Translation: BAA92545.1.
AB007931 mRNA. Translation: BAA32307.1.
BC018694 mRNA. Translation: AAH18694.2.
BC063573 mRNA. Translation: AAH63573.1.
BC073905 mRNA. Translation: AAH73905.1.
BC096758 mRNA. Translation: AAH96758.1.
AJ505016 mRNA. Translation: CAD43719.1. Different initiation.
AL049972 mRNA. Translation: CAB43227.1.
AF055010 mRNA. Translation: AAC09360.1.
CCDSiCCDS189.1. [Q5T4S7-1]
PIRiT00076.
RefSeqiNP_065816.2. NM_020765.2. [Q5T4S7-1]
UniGeneiHs.148078.
Hs.649405.

3D structure databases

ProteinModelPortaliQ5T4S7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116934. 106 interactions.
IntActiQ5T4S7. 36 interactions.
MINTiMINT-4715511.
STRINGi9606.ENSP00000364403.

PTM databases

iPTMnetiQ5T4S7.
PhosphoSiteiQ5T4S7.
SwissPalmiQ5T4S7.

Polymorphism and mutation databases

BioMutaiUBR4.
DMDMi74744979.

Proteomic databases

EPDiQ5T4S7.
MaxQBiQ5T4S7.
PaxDbiQ5T4S7.
PRIDEiQ5T4S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375218; ENSP00000364366; ENSG00000127481. [Q5T4S7-6]
ENST00000375254; ENSP00000364403; ENSG00000127481. [Q5T4S7-1]
GeneIDi23352.
KEGGihsa:23352.
UCSCiuc001bbi.4. human. [Q5T4S7-1]

Organism-specific databases

CTDi23352.
GeneCardsiUBR4.
H-InvDBHIX0000191.
HGNCiHGNC:30313. UBR4.
HPAiHPA013394.
HPA021046.
MIMi609890. gene.
neXtProtiNX_Q5T4S7.
PharmGKBiPA162407958.
HUGEiSearch...
Search...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1776. Eukaryota.
ENOG410XPP8. LUCA.
GeneTreeiENSGT00600000084471.
HOVERGENiHBG058328.
InParanoidiQ5T4S7.
KOiK10691.
OMAiEGDVHTS.
OrthoDBiEOG7288QF.
PhylomeDBiQ5T4S7.
TreeFamiTF314406.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiUBR4. human.
GeneWikiiUBR4.
GenomeRNAii23352.
PROiQ5T4S7.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T4S7.
ExpressionAtlasiQ5T4S7. baseline and differential.
GenevisibleiQ5T4S7. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR025704. E3_Ub_ligase_UBR4.
IPR017986. WD40_repeat_dom.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF13764. E3_UbLigase_R4. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 9 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH RB1 AND CALM, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, FUNCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
    Tissue: Mammary gland.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Bienvenut W.V., Boldt K., von Kriegsheim A.F., Kolch W.
    Submitted (JUL-2007) to UniProtKB
    Tissue: Hepatoma.
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 779-5183 (ISOFORM 5).
    Tissue: Brain.
  6. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2908-5183 (ISOFORM 1).
    Tissue: Brain.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4385-5183 (ISOFORMS 1 AND 2), VARIANT LEU-4867.
    Tissue: Kidney, Liver, Lung and Spleen.
  8. "The response of autologous T cells to a human melanoma is dominated by mutated neoantigens."
    Lennerz V., Fatho M., Gentilini C., Frye R.A., Lifke A., Ferel D., Woelfel C., Huber C., Woelfel T.
    Proc. Natl. Acad. Sci. U.S.A. 102:16013-16018(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4583-5183 (ISOFORM 1), VARIANTS LEU-4867 AND ARG-4924.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4686-5183 (ISOFORM 1).
    Tissue: Brain.
  10. Yu W., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4709-5183 (ISOFORM 1), VARIANT LEU-4867.
    Tissue: Brain.
  11. "Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600."
    Huh K.-W., DeMasi J., Ogawa H., Nakatani Y., Howley P.M., Muenger K.
    Proc. Natl. Acad. Sci. U.S.A. 102:11492-11497(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HPV-16 E7; HPV-6B E7 AND HPV-11 E7, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181 AND THR-2715, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1084, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-181 AND SER-1763, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2719, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth."
    Lin R., Tao R., Gao X., Li T., Zhou X., Guan K.L., Xiong Y., Lei Q.Y.
    Mol. Cell 51:506-518(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1647; SER-1652; THR-2944 AND SER-2952, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  22. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-1394.

Entry informationi

Entry nameiUBR4_HUMAN
AccessioniPrimary (citable) accession number: Q5T4S7
Secondary accession number(s): A8MPT2
, A8MQ33, A8MQB1, O60646, O75050, Q4QRK5, Q5T4S8, Q5T4S9, Q5TBN8, Q5TBP2, Q6DKH8, Q6P4A4, Q7L8P7, Q8IXJ4, Q8TDN5, Q8WV67, Q9HA46, Q9P2N9, Q9UG82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.