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Protein

Secreted frizzled-related protein 5

Gene

SFRP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • apoptotic process Source: ProtInc
  • canonical Wnt signaling pathway Source: GO_Central
  • cell differentiation Source: UniProtKB-KW
  • establishment or maintenance of cell polarity Source: ProtInc
  • multicellular organismal development Source: UniProtKB-KW
  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • negative regulation of catenin import into nucleus Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of protein kinase B signaling Source: BHF-UCL
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: BHF-UCL
  • non-canonical Wnt signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 5
Short name:
sFRP-5
Alternative name(s):
Frizzled-related protein 1b
Short name:
FRP-1b
Secreted apoptosis-related protein 3
Short name:
SARP-3
Gene namesi
Name:SFRP5
Synonyms:FRP1B, SARP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:10779. SFRP5.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35695.

Polymorphism and mutation databases

BioMutaiSFRP5.
DMDMi150421670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 317288Secreted frizzled-related protein 5PRO_0000032555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 116By similarity
Disulfide bondi63 ↔ 109By similarity
Disulfide bondi100 ↔ 135By similarity
Disulfide bondi124 ↔ 162By similarity
Disulfide bondi128 ↔ 152By similarity
Disulfide bondi181 ↔ 253By similarity
Disulfide bondi184 ↔ 255By similarity
Disulfide bondi198 ↔ 303By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5T4F7.
PRIDEiQ5T4F7.

PTM databases

PhosphoSiteiQ5T4F7.

Expressioni

Tissue specificityi

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.3 Publications

Gene expression databases

BgeeiQ5T4F7.
CleanExiHS_SFRP5.
GenevisibleiQ5T4F7. HS.

Organism-specific databases

HPAiHPA019840.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266066.

Structurei

3D structure databases

ProteinModelPortaliQ5T4F7.
SMRiQ5T4F7. Positions 60-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 165118FZPROSITE-ProRule annotationAdd
BLAST
Domaini181 – 303123NTRPROSITE-ProRule annotationAdd
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ5T4F7.
KOiK02222.
OMAiAPLMEAY.
OrthoDBiEOG789CBZ.
PhylomeDBiQ5T4F7.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T4F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP
60 70 80 90 100
PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC
110 120 130 140 150
HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML
160 170 180 190 200
HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS
210 220 230 240 250
DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG
260 270 280 290 300
AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS
310
YPCSLYYPFF YGAAEPH
Length:317
Mass (Da):35,563
Last modified:June 26, 2007 - v3
Checksum:i4BF060F1161751F9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331D → H (PubMed:9642118).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71G → A.4 Publications
Corresponds to variant rs11815012 [ dbSNP | Ensembl ].
VAR_021412

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017988 mRNA. Translation: AAB70794.1.
AF117758 mRNA. Translation: AAD25052.1.
CR596705 mRNA. No translation available.
AL358938 Genomic DNA. Translation: CAI14274.1.
BC050435 mRNA. Translation: AAH50435.2.
CCDSiCCDS7472.1.
PIRiJE0175.
RefSeqiNP_003006.2. NM_003015.3.
UniGeneiHs.279565.

Genome annotation databases

EnsembliENST00000266066; ENSP00000266066; ENSG00000120057.
GeneIDi6425.
KEGGihsa:6425.
UCSCiuc001kor.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017988 mRNA. Translation: AAB70794.1.
AF117758 mRNA. Translation: AAD25052.1.
CR596705 mRNA. No translation available.
AL358938 Genomic DNA. Translation: CAI14274.1.
BC050435 mRNA. Translation: AAH50435.2.
CCDSiCCDS7472.1.
PIRiJE0175.
RefSeqiNP_003006.2. NM_003015.3.
UniGeneiHs.279565.

3D structure databases

ProteinModelPortaliQ5T4F7.
SMRiQ5T4F7. Positions 60-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266066.

Protein family/group databases

MEROPSiI93.002.

PTM databases

PhosphoSiteiQ5T4F7.

Polymorphism and mutation databases

BioMutaiSFRP5.
DMDMi150421670.

Proteomic databases

PaxDbiQ5T4F7.
PRIDEiQ5T4F7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266066; ENSP00000266066; ENSG00000120057.
GeneIDi6425.
KEGGihsa:6425.
UCSCiuc001kor.4. human.

Organism-specific databases

CTDi6425.
GeneCardsiGC10M099516.
H-InvDBHIX0035310.
HGNCiHGNC:10779. SFRP5.
HPAiHPA019840.
MIMi604158. gene.
neXtProtiNX_Q5T4F7.
PharmGKBiPA35695.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG240950.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ5T4F7.
KOiK02222.
OMAiAPLMEAY.
OrthoDBiEOG789CBZ.
PhylomeDBiQ5T4F7.
TreeFamiTF350133.

Miscellaneous databases

GeneWikiiSFRP5.
GenomeRNAii6425.
NextBioi24951.
PROiQ5T4F7.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T4F7.
CleanExiHS_SFRP5.
GenevisibleiQ5T4F7. HS.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
    Tissue: Pancreas.
  2. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
    Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
    Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
  3. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
    Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
    Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
    Tissue: Retina.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-7.
    Tissue: PNS.

Entry informationi

Entry nameiSFRP5_HUMAN
AccessioniPrimary (citable) accession number: Q5T4F7
Secondary accession number(s): O14780, Q86TH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 26, 2007
Last modified: July 22, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.