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Q5T4F7

- SFRP5_HUMAN

UniProt

Q5T4F7 - SFRP5_HUMAN

Protein

Secreted frizzled-related protein 5

Gene

SFRP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

    GO - Molecular functioni

    1. PDZ domain binding Source: RefGenome
    2. Wnt-activated receptor activity Source: RefGenome
    3. Wnt-protein binding Source: RefGenome

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. apoptotic process Source: ProtInc
    3. brain development Source: RefGenome
    4. cell differentiation Source: UniProtKB-KW
    5. convergent extension involved in axis elongation Source: Ensembl
    6. digestive tract morphogenesis Source: Ensembl
    7. establishment or maintenance of cell polarity Source: ProtInc
    8. gonad development Source: RefGenome
    9. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    10. negative regulation of catenin import into nucleus Source: BHF-UCL
    11. negative regulation of cell proliferation Source: BHF-UCL
    12. negative regulation of JUN kinase activity Source: Ensembl
    13. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
    14. negative regulation of protein kinase B signaling Source: BHF-UCL
    15. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    16. negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: BHF-UCL
    17. planar cell polarity pathway involved in neural tube closure Source: Ensembl
    18. post-anal tail morphogenesis Source: Ensembl
    19. signal transduction Source: ProtInc
    20. vasculature development Source: RefGenome
    21. visual perception Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Protein family/group databases

    MEROPSiI93.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Secreted frizzled-related protein 5
    Short name:
    sFRP-5
    Alternative name(s):
    Frizzled-related protein 1b
    Short name:
    FRP-1b
    Secreted apoptosis-related protein 3
    Short name:
    SARP-3
    Gene namesi
    Name:SFRP5
    Synonyms:FRP1B, SARP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:10779. SFRP5.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: ProtInc
    3. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35695.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 317288Secreted frizzled-related protein 5PRO_0000032555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 116By similarity
    Disulfide bondi63 ↔ 109By similarity
    Disulfide bondi100 ↔ 135By similarity
    Disulfide bondi124 ↔ 162By similarity
    Disulfide bondi128 ↔ 152By similarity
    Disulfide bondi181 ↔ 253By similarity
    Disulfide bondi184 ↔ 255By similarity
    Disulfide bondi198 ↔ 303By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ5T4F7.
    PRIDEiQ5T4F7.

    PTM databases

    PhosphoSiteiQ5T4F7.

    Expressioni

    Tissue specificityi

    Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.3 Publications

    Gene expression databases

    BgeeiQ5T4F7.
    CleanExiHS_SFRP5.
    GenevestigatoriQ5T4F7.

    Organism-specific databases

    HPAiHPA019840.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000266066.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T4F7.
    SMRiQ5T4F7. Positions 60-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 165118FZPROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 303123NTRPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The FZ domain is involved in binding with Wnt ligands.By similarity

    Sequence similaritiesi

    Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240950.
    HOGENOMiHOG000231058.
    HOVERGENiHBG052928.
    InParanoidiQ5T4F7.
    KOiK02222.
    OMAiLMEAYGF.
    OrthoDBiEOG789CBZ.
    PhylomeDBiQ5T4F7.
    TreeFamiTF350133.

    Family and domain databases

    Gene3Di1.10.2000.10. 1 hit.
    InterProiIPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PANTHERiPTHR11309. PTHR11309. 1 hit.
    PfamiPF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEiPS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5T4F7-1 [UniParc]FASTAAdd to Basket

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    MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP    50
    PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC 100
    HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML 150
    HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS 200
    DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG 250
    AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS 300
    YPCSLYYPFF YGAAEPH 317
    Length:317
    Mass (Da):35,563
    Last modified:June 26, 2007 - v3
    Checksum:i4BF060F1161751F9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331D → H(PubMed:9642118)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71G → A.4 Publications
    Corresponds to variant rs11815012 [ dbSNP | Ensembl ].
    VAR_021412

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017988 mRNA. Translation: AAB70794.1.
    AF117758 mRNA. Translation: AAD25052.1.
    CR596705 mRNA. No translation available.
    AL358938 Genomic DNA. Translation: CAI14274.1.
    BC050435 mRNA. Translation: AAH50435.2.
    CCDSiCCDS7472.1.
    PIRiJE0175.
    RefSeqiNP_003006.2. NM_003015.3.
    UniGeneiHs.279565.

    Genome annotation databases

    EnsembliENST00000266066; ENSP00000266066; ENSG00000120057.
    GeneIDi6425.
    KEGGihsa:6425.
    UCSCiuc001kor.4. human.

    Polymorphism databases

    DMDMi150421670.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF017988 mRNA. Translation: AAB70794.1 .
    AF117758 mRNA. Translation: AAD25052.1 .
    CR596705 mRNA. No translation available.
    AL358938 Genomic DNA. Translation: CAI14274.1 .
    BC050435 mRNA. Translation: AAH50435.2 .
    CCDSi CCDS7472.1.
    PIRi JE0175.
    RefSeqi NP_003006.2. NM_003015.3.
    UniGenei Hs.279565.

    3D structure databases

    ProteinModelPortali Q5T4F7.
    SMRi Q5T4F7. Positions 60-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000266066.

    Protein family/group databases

    MEROPSi I93.001.

    PTM databases

    PhosphoSitei Q5T4F7.

    Polymorphism databases

    DMDMi 150421670.

    Proteomic databases

    PaxDbi Q5T4F7.
    PRIDEi Q5T4F7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266066 ; ENSP00000266066 ; ENSG00000120057 .
    GeneIDi 6425.
    KEGGi hsa:6425.
    UCSCi uc001kor.4. human.

    Organism-specific databases

    CTDi 6425.
    GeneCardsi GC10M099516.
    H-InvDB HIX0035310.
    HGNCi HGNC:10779. SFRP5.
    HPAi HPA019840.
    MIMi 604158. gene.
    neXtProti NX_Q5T4F7.
    PharmGKBi PA35695.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240950.
    HOGENOMi HOG000231058.
    HOVERGENi HBG052928.
    InParanoidi Q5T4F7.
    KOi K02222.
    OMAi LMEAYGF.
    OrthoDBi EOG789CBZ.
    PhylomeDBi Q5T4F7.
    TreeFami TF350133.

    Miscellaneous databases

    GeneWikii SFRP5.
    GenomeRNAii 6425.
    NextBioi 24951.
    PROi Q5T4F7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T4F7.
    CleanExi HS_SFRP5.
    Genevestigatori Q5T4F7.

    Family and domain databases

    Gene3Di 1.10.2000.10. 1 hit.
    InterProi IPR015526. Frizzled/SFRP.
    IPR020067. Frizzled_dom.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    PANTHERi PTHR11309. PTHR11309. 1 hit.
    Pfami PF01392. Fz. 1 hit.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00063. FRI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    SSF63501. SSF63501. 1 hit.
    PROSITEi PS50038. FZ. 1 hit.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
      Tissue: Pancreas.
    2. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
      Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
      Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
    3. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
      Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
      Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
      Tissue: Retina.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-7.
      Tissue: PNS.

    Entry informationi

    Entry nameiSFRP5_HUMAN
    AccessioniPrimary (citable) accession number: Q5T4F7
    Secondary accession number(s): O14780, Q86TH7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3