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Q5T4F7

- SFRP5_HUMAN

UniProt

Q5T4F7 - SFRP5_HUMAN

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Protein
Secreted frizzled-related protein 5
Gene
SFRP5, FRP1B, SARP3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

GO - Molecular functioni

  1. PDZ domain binding Source: RefGenome
  2. Wnt-activated receptor activity Source: RefGenome
  3. Wnt-protein binding Source: RefGenome
Complete GO annotation...

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. apoptotic process Source: ProtInc
  3. brain development Source: RefGenome
  4. cell differentiation Source: UniProtKB-KW
  5. convergent extension involved in axis elongation Source: Ensembl
  6. digestive tract morphogenesis Source: Ensembl
  7. establishment or maintenance of cell polarity Source: ProtInc
  8. gonad development Source: RefGenome
  9. negative regulation of JUN kinase activity Source: Ensembl
  10. negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: BHF-UCL
  11. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  12. negative regulation of catenin import into nucleus Source: BHF-UCL
  13. negative regulation of cell proliferation Source: BHF-UCL
  14. negative regulation of planar cell polarity pathway involved in axis elongation Source: Ensembl
  15. negative regulation of protein kinase B signaling Source: BHF-UCL
  16. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  17. planar cell polarity pathway involved in neural tube closure Source: Ensembl
  18. post-anal tail morphogenesis Source: Ensembl
  19. signal transduction Source: ProtInc
  20. vasculature development Source: RefGenome
  21. visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 5
Short name:
sFRP-5
Alternative name(s):
Frizzled-related protein 1b
Short name:
FRP-1b
Secreted apoptosis-related protein 3
Short name:
SARP-3
Gene namesi
Name:SFRP5
Synonyms:FRP1B, SARP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10779. SFRP5.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: ProtInc
  3. plasma membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35695.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 317288Secreted frizzled-related protein 5
PRO_0000032555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 116 By similarity
Disulfide bondi63 ↔ 109 By similarity
Disulfide bondi100 ↔ 135 By similarity
Disulfide bondi124 ↔ 162 By similarity
Disulfide bondi128 ↔ 152 By similarity
Disulfide bondi181 ↔ 253 By similarity
Disulfide bondi184 ↔ 255 By similarity
Disulfide bondi198 ↔ 303 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5T4F7.
PRIDEiQ5T4F7.

PTM databases

PhosphoSiteiQ5T4F7.

Expressioni

Tissue specificityi

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.3 Publications

Gene expression databases

BgeeiQ5T4F7.
CleanExiHS_SFRP5.
GenevestigatoriQ5T4F7.

Organism-specific databases

HPAiHPA019840.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266066.

Structurei

3D structure databases

ProteinModelPortaliQ5T4F7.
SMRiQ5T4F7. Positions 60-156.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 165118FZ
Add
BLAST
Domaini181 – 303123NTR
Add
BLAST

Domaini

The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG240950.
HOGENOMiHOG000231058.
HOVERGENiHBG052928.
InParanoidiQ5T4F7.
KOiK02222.
OMAiLMEAYGF.
OrthoDBiEOG789CBZ.
PhylomeDBiQ5T4F7.
TreeFamiTF350133.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PfamiPF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T4F7-1 [UniParc]FASTAAdd to Basket

« Hide

MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP    50
PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC 100
HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML 150
HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS 200
DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG 250
AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS 300
YPCSLYYPFF YGAAEPH 317
Length:317
Mass (Da):35,563
Last modified:June 26, 2007 - v3
Checksum:i4BF060F1161751F9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71G → A.4 Publications
Corresponds to variant rs11815012 [ dbSNP | Ensembl ].
VAR_021412

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331D → H1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017988 mRNA. Translation: AAB70794.1.
AF117758 mRNA. Translation: AAD25052.1.
CR596705 mRNA. No translation available.
AL358938 Genomic DNA. Translation: CAI14274.1.
BC050435 mRNA. Translation: AAH50435.2.
CCDSiCCDS7472.1.
PIRiJE0175.
RefSeqiNP_003006.2. NM_003015.3.
UniGeneiHs.279565.

Genome annotation databases

EnsembliENST00000266066; ENSP00000266066; ENSG00000120057.
GeneIDi6425.
KEGGihsa:6425.
UCSCiuc001kor.4. human.

Polymorphism databases

DMDMi150421670.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF017988 mRNA. Translation: AAB70794.1 .
AF117758 mRNA. Translation: AAD25052.1 .
CR596705 mRNA. No translation available.
AL358938 Genomic DNA. Translation: CAI14274.1 .
BC050435 mRNA. Translation: AAH50435.2 .
CCDSi CCDS7472.1.
PIRi JE0175.
RefSeqi NP_003006.2. NM_003015.3.
UniGenei Hs.279565.

3D structure databases

ProteinModelPortali Q5T4F7.
SMRi Q5T4F7. Positions 60-156.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000266066.

Protein family/group databases

MEROPSi I93.001.

PTM databases

PhosphoSitei Q5T4F7.

Polymorphism databases

DMDMi 150421670.

Proteomic databases

PaxDbi Q5T4F7.
PRIDEi Q5T4F7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266066 ; ENSP00000266066 ; ENSG00000120057 .
GeneIDi 6425.
KEGGi hsa:6425.
UCSCi uc001kor.4. human.

Organism-specific databases

CTDi 6425.
GeneCardsi GC10M099516.
H-InvDB HIX0035310.
HGNCi HGNC:10779. SFRP5.
HPAi HPA019840.
MIMi 604158. gene.
neXtProti NX_Q5T4F7.
PharmGKBi PA35695.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240950.
HOGENOMi HOG000231058.
HOVERGENi HBG052928.
InParanoidi Q5T4F7.
KOi K02222.
OMAi LMEAYGF.
OrthoDBi EOG789CBZ.
PhylomeDBi Q5T4F7.
TreeFami TF350133.

Miscellaneous databases

GeneWikii SFRP5.
GenomeRNAii 6425.
NextBioi 24951.
PROi Q5T4F7.
SOURCEi Search...

Gene expression databases

Bgeei Q5T4F7.
CleanExi HS_SFRP5.
Genevestigatori Q5T4F7.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
Pfami PF01392. Fz. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
    Tissue: Pancreas.
  2. "Tissue restricted expression of two human Frzbs in preadipocytes and pancreas."
    Hu E., Zhu Y., Fredrickson T., Barnes M., Kelsell D., Beeley L., Brooks D.
    Biochem. Biophys. Res. Commun. 247:287-293(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
  3. "Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium."
    Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B., Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.
    Hum. Mol. Genet. 8:575-583(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT ALA-7, TISSUE SPECIFICITY.
    Tissue: Retina.
  4. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-7.
    Tissue: PNS.

Entry informationi

Entry nameiSFRP5_HUMAN
AccessioniPrimary (citable) accession number: Q5T4F7
Secondary accession number(s): O14780, Q86TH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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