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Q5T4F4

- ZFY27_HUMAN

UniProt

Q5T4F4 - ZFY27_HUMAN

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Protein
Protrudin
Gene
ZFYVE27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri344 – 41067FYVE-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. neuron projection development Source: UniProtKB
  3. neurotrophin TRK receptor signaling pathway Source: UniProtKB
  4. protein localization to plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protrudin
Alternative name(s):
Zinc finger FYVE domain-containing protein 27
Gene namesi
Name:ZFYVE27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:26559. ZFYVE27.

Subcellular locationi

Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projectiongrowth cone membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Note: Localizes at both dendrites and axons By similarity.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6666Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Topological domaini88 – 881Extracellular Reviewed prediction
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Topological domaini110 – 18778Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Topological domaini209 – 411203Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  5. growth cone membrane Source: UniProtKB
  6. integral component of membrane Source: UniProtKB-KW
  7. recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Spastic paraplegia 33, autosomal dominant (SPG33) [MIM:610244]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Note: The disease is caused by mutations affecting the gene represented in this entry. According to 1 Publication, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti191 – 1911G → V in SPG33; aberrant subcellular localization and altered interaction with SPAST. 2 Publications
Corresponds to variant rs35077384 [ dbSNP | Ensembl ].
VAR_027269

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi13 – 131L → A: Alters interaction with RAB11A; when associated with A-49. 1 Publication
Mutagenesisi49 – 491I → A: Alters interaction with RAB11A; when associated with A-13. 1 Publication
Mutagenesisi289 – 2891D → A: Loss of interaction with VAPA and loss of function in cell projections formation. 1 Publication

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

MIMi610244. phenotype.
PharmGKBiPA134863310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Protrudin
PRO_0000245601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi209 – 2091N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ5T4F4.
PaxDbiQ5T4F4.
PRIDEiQ5T4F4.

PTM databases

PhosphoSiteiQ5T4F4.

Expressioni

Gene expression databases

ArrayExpressiQ5T4F4.
BgeeiQ5T4F4.
GenevestigatoriQ5T4F4.

Organism-specific databases

HPAiHPA037523.

Interactioni

Subunit structurei

Interacts with SPAST. Interacts with RAB11A (GDP-bound form); regulates RAB11A. Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FKBP8Q143184EBI-3892947,EBI-724839
RAB11AP624914EBI-3892947,EBI-745098
VAPAQ9P0L05EBI-3892947,EBI-1059156
VAPBO952922EBI-3892947,EBI-1188298

Protein-protein interaction databases

BioGridi125623. 2 interactions.
IntActiQ5T4F4. 7 interactions.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi351 – 3533
Beta strandi359 – 3613
Beta strandi367 – 3693
Turni375 – 3773
Beta strandi380 – 3823
Turni385 – 3873
Beta strandi399 – 4013
Helixi403 – 4108

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X4UNMR-A341-411[»]
ProteinModelPortaliQ5T4F4.
SMRiQ5T4F4. Positions 341-411.

Miscellaneous databases

EvolutionaryTraceiQ5T4F4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 6414Necessary for interaction with RAB11A and function in neurite outgrowth
Add
BLAST
Regioni286 – 2927Necessary for interaction with VAPA and function in cell projections formation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi246 – 2494Poly-Pro

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG28771.
HOVERGENiHBG054907.
OMAiSYKRLEI.
OrthoDBiEOG7VTDNG.
PhylomeDBiQ5T4F4.
TreeFamiTF331044.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T4F4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQTSEREGSG PELSPSVMPE APLESPPFPT KSPAFDLFNL VLSYKRLEIY    50
LEPLKDAGDG VRYLLRWQMP LCSLLTCLGL NVLFLTLNEG AWYSVGALMI 100
SVPALLGYLQ EVCRARLPDS ELMRRKYHSV RQEDLQRGRL SRPEAVAEVK 150
SFLIQLEAFL SRLCCTCEAA YRVLHWENPV VSSQFYGALL GTVCMLYLLP 200
LCWVLTLLNS TLFLGNVEFF RVVSEYRASL QQRMNPKQEE HAFESPPPPD 250
VGGKDGLMDS TPALTPTEDL TPGSVEEAEE AEPDEEFKDA IEETHLVVLE 300
DDEGAPCPAE DELALQDNGF LSKNEVLRSK VSRLTERLRK RYPTNNFGNC 350
TGCSATFSVL KKRRSCSNCG NSFCSRCCSF KVPKSSMGAT APEAQRETVF 400
VCASCNQTLS K 411
Length:411
Mass (Da):45,843
Last modified:December 21, 2004 - v1
Checksum:i5B86C64A398033D2
GO
Isoform 2 (identifier: Q5T4F4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-300: Missing.

Show »
Length:404
Mass (Da):45,052
Checksum:i0FA0436DAE7716D7
GO
Isoform 3 (identifier: Q5T4F4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     268-268: E → ESLSSQ

Show »
Length:416
Mass (Da):46,346
Checksum:iBF488D2456C6B924
GO
Isoform 4 (identifier: Q5T4F4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     268-268: E → ESLSSQ
     294-300: Missing.
     349-356: NCTGCSAT → VTGAGSS
     357-411: Missing.

Show »
Length:285
Mass (Da):31,744
Checksum:i977E99E1E5857BDD
GO
Isoform 5 (identifier: Q5T4F4-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-152: RWQMPLCSLL...PEAVAEVKSF → S
     294-300: Missing.

Show »
Length:318
Mass (Da):35,205
Checksum:i1E3E1DF487779DEB
GO
Isoform 6 (identifier: Q5T4F4-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-184: Missing.
     294-300: Missing.

Note: No experimental confirmation available.

Show »
Length:286
Mass (Da):31,612
Checksum:iC4F817D0A286151B
GO
Isoform 7 (identifier: Q5T4F4-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     268-268: E → ESLSSQ
     294-300: Missing.

Note: No experimental confirmation available.

Show »
Length:311
Mass (Da):34,681
Checksum:i3035EAF2EF4EEA53
GO
Isoform 8 (identifier: Q5T4F4-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-89: Missing.
     294-300: Missing.

Note: No experimental confirmation available.

Show »
Length:372
Mass (Da):41,417
Checksum:i0D235A6E1A98B2E2
GO

Sequence cautioni

The sequence CAD38913.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821V → I.
Corresponds to variant rs17108378 [ dbSNP | Ensembl ].
VAR_027002
Natural varianti138 – 1381G → V.3 Publications
Corresponds to variant rs10882993 [ dbSNP | Ensembl ].
VAR_027003
Natural varianti191 – 1911G → V in SPG33; aberrant subcellular localization and altered interaction with SPAST. 2 Publications
Corresponds to variant rs35077384 [ dbSNP | Ensembl ].
VAR_027269

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9898Missing in isoform 7.
VSP_045265Add
BLAST
Alternative sequencei1 – 6868Missing in isoform 4.
VSP_019751Add
BLAST
Alternative sequencei58 – 8932Missing in isoform 8.
VSP_046051Add
BLAST
Alternative sequencei66 – 15287RWQMP…EVKSF → S in isoform 5.
VSP_019752Add
BLAST
Alternative sequencei67 – 184118Missing in isoform 6.
VSP_045266Add
BLAST
Alternative sequencei268 – 2681E → ESLSSQ in isoform 3, isoform 4 and isoform 7.
VSP_019753
Alternative sequencei294 – 3007Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
VSP_019754
Alternative sequencei349 – 3568NCTGCSAT → VTGAGSS in isoform 4.
VSP_019755
Alternative sequencei357 – 41155Missing in isoform 4.
VSP_019756Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501Y → N in AAH30621. 1 Publication
Sequence conflicti218 – 2181E → G in BAC11260. 1 Publication
Sequence conflicti222 – 2221V → F in BAH13112. 1 Publication
Sequence conflicti340 – 3401K → R in BAH13112. 1 Publication
Sequence conflicti387 – 3871M → A in BAH13112. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057481 mRNA. Translation: BAB71506.1.
AK097945 mRNA. Translation: BAC05200.1.
AK074876 mRNA. Translation: BAC11260.1.
AK296295 mRNA. Translation: BAH12306.1.
AK296588 mRNA. Translation: BAH12390.1.
AK299735 mRNA. Translation: BAH13112.1.
AL358938 Genomic DNA. Translation: CAI14270.1.
AL358938 Genomic DNA. Translation: CAI14271.1.
AL358938 Genomic DNA. Translation: CAI14272.1.
BC030621 mRNA. Translation: AAH30621.2.
AL834235 mRNA. Translation: CAD38913.2. Different initiation.
CCDSiCCDS31262.1. [Q5T4F4-3]
CCDS31263.1. [Q5T4F4-1]
CCDS31264.1. [Q5T4F4-2]
CCDS53562.1. [Q5T4F4-8]
CCDS53563.1. [Q5T4F4-5]
CCDS53564.1. [Q5T4F4-6]
CCDS53565.1. [Q5T4F4-7]
RefSeqiNP_001002261.1. NM_001002261.3. [Q5T4F4-3]
NP_001002262.1. NM_001002262.3. [Q5T4F4-2]
NP_001167590.1. NM_001174119.1. [Q5T4F4-8]
NP_001167591.1. NM_001174120.1. [Q5T4F4-5]
NP_001167592.1. NM_001174121.1. [Q5T4F4-7]
NP_001167593.1. NM_001174122.1. [Q5T4F4-6]
NP_653189.3. NM_144588.6. [Q5T4F4-1]
XP_005269559.1. XM_005269502.1. [Q5T4F4-3]
XP_005269560.1. XM_005269503.1. [Q5T4F4-3]
XP_005269561.1. XM_005269504.1. [Q5T4F4-1]
XP_005269563.1. XM_005269506.1. [Q5T4F4-2]
UniGeneiHs.744075.

Genome annotation databases

EnsembliENST00000337540; ENSP00000337993; ENSG00000155256. [Q5T4F4-8]
ENST00000356257; ENSP00000348593; ENSG00000155256. [Q5T4F4-3]
ENST00000357540; ENSP00000350148; ENSG00000155256. [Q5T4F4-5]
ENST00000359980; ENSP00000353069; ENSG00000155256. [Q5T4F4-2]
ENST00000370610; ENSP00000359642; ENSG00000155256. [Q5T4F4-7]
ENST00000370613; ENSP00000359646; ENSG00000155256. [Q5T4F4-6]
ENST00000393677; ENSP00000377282; ENSG00000155256. [Q5T4F4-1]
GeneIDi118813.
KEGGihsa:118813.
UCSCiuc001kol.2. human. [Q5T4F4-1]
uc001kom.2. human. [Q5T4F4-2]
uc001koq.3. human. [Q5T4F4-5]
uc021pwq.1. human. [Q5T4F4-3]

Polymorphism databases

DMDMi74744927.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057481 mRNA. Translation: BAB71506.1 .
AK097945 mRNA. Translation: BAC05200.1 .
AK074876 mRNA. Translation: BAC11260.1 .
AK296295 mRNA. Translation: BAH12306.1 .
AK296588 mRNA. Translation: BAH12390.1 .
AK299735 mRNA. Translation: BAH13112.1 .
AL358938 Genomic DNA. Translation: CAI14270.1 .
AL358938 Genomic DNA. Translation: CAI14271.1 .
AL358938 Genomic DNA. Translation: CAI14272.1 .
BC030621 mRNA. Translation: AAH30621.2 .
AL834235 mRNA. Translation: CAD38913.2 . Different initiation.
CCDSi CCDS31262.1. [Q5T4F4-3 ]
CCDS31263.1. [Q5T4F4-1 ]
CCDS31264.1. [Q5T4F4-2 ]
CCDS53562.1. [Q5T4F4-8 ]
CCDS53563.1. [Q5T4F4-5 ]
CCDS53564.1. [Q5T4F4-6 ]
CCDS53565.1. [Q5T4F4-7 ]
RefSeqi NP_001002261.1. NM_001002261.3. [Q5T4F4-3 ]
NP_001002262.1. NM_001002262.3. [Q5T4F4-2 ]
NP_001167590.1. NM_001174119.1. [Q5T4F4-8 ]
NP_001167591.1. NM_001174120.1. [Q5T4F4-5 ]
NP_001167592.1. NM_001174121.1. [Q5T4F4-7 ]
NP_001167593.1. NM_001174122.1. [Q5T4F4-6 ]
NP_653189.3. NM_144588.6. [Q5T4F4-1 ]
XP_005269559.1. XM_005269502.1. [Q5T4F4-3 ]
XP_005269560.1. XM_005269503.1. [Q5T4F4-3 ]
XP_005269561.1. XM_005269504.1. [Q5T4F4-1 ]
XP_005269563.1. XM_005269506.1. [Q5T4F4-2 ]
UniGenei Hs.744075.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1X4U NMR - A 341-411 [» ]
ProteinModelPortali Q5T4F4.
SMRi Q5T4F4. Positions 341-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125623. 2 interactions.
IntActi Q5T4F4. 7 interactions.

PTM databases

PhosphoSitei Q5T4F4.

Polymorphism databases

DMDMi 74744927.

Proteomic databases

MaxQBi Q5T4F4.
PaxDbi Q5T4F4.
PRIDEi Q5T4F4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337540 ; ENSP00000337993 ; ENSG00000155256 . [Q5T4F4-8 ]
ENST00000356257 ; ENSP00000348593 ; ENSG00000155256 . [Q5T4F4-3 ]
ENST00000357540 ; ENSP00000350148 ; ENSG00000155256 . [Q5T4F4-5 ]
ENST00000359980 ; ENSP00000353069 ; ENSG00000155256 . [Q5T4F4-2 ]
ENST00000370610 ; ENSP00000359642 ; ENSG00000155256 . [Q5T4F4-7 ]
ENST00000370613 ; ENSP00000359646 ; ENSG00000155256 . [Q5T4F4-6 ]
ENST00000393677 ; ENSP00000377282 ; ENSG00000155256 . [Q5T4F4-1 ]
GeneIDi 118813.
KEGGi hsa:118813.
UCSCi uc001kol.2. human. [Q5T4F4-1 ]
uc001kom.2. human. [Q5T4F4-2 ]
uc001koq.3. human. [Q5T4F4-5 ]
uc021pwq.1. human. [Q5T4F4-3 ]

Organism-specific databases

CTDi 118813.
GeneCardsi GC10P099486.
HGNCi HGNC:26559. ZFYVE27.
HPAi HPA037523.
MIMi 610243. gene.
610244. phenotype.
neXtProti NX_Q5T4F4.
PharmGKBi PA134863310.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28771.
HOVERGENi HBG054907.
OMAi SYKRLEI.
OrthoDBi EOG7VTDNG.
PhylomeDBi Q5T4F4.
TreeFami TF331044.

Miscellaneous databases

ChiTaRSi ZFYVE27. human.
EvolutionaryTracei Q5T4F4.
GenomeRNAii 118813.
NextBioi 35535086.
PROi Q5T4F4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5T4F4.
Bgeei Q5T4F4.
Genevestigatori Q5T4F4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
PROSITEi PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 5; 6; 7 AND 8), VARIANT VAL-138.
    Tissue: Brain, Testis, Thalamus and Thymus.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-138.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-411 (ISOFORM 3), VARIANT VAL-138.
    Tissue: Brain.
  5. "Protrudin induces neurite formation by directional membrane trafficking."
    Shirane M., Nakayama K.I.
    Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FKBP8 AND RAB11A, PHOSPHORYLATION, MUTAGENESIS OF LEU-13 AND ILE-49.
  6. "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."
    Shirane M., Ogawa M., Motoyama J., Nakayama K.I.
    Genes Cells 13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FKBP8.
  7. "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein."
    Saita S., Shirane M., Natume T., Iemura S., Nakayama K.I.
    J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VAPA AND VAPB, MUTAGENESIS OF ASP-289, SUBCELLULAR LOCATION.
  8. "Solution structure of the FYVE domain from human FYVE domain containing 27 isoform B protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 341-411.
  9. "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia."
    Mannan A.U., Krawen P., Sauter S.M., Boehm J., Chronowska A., Paulus W., Neesen J., Engel W.
    Am. J. Hum. Genet. 79:351-357(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SPG33 VAL-191, CHARACTERIZATION OF VARIANT SPG33 VAL-191, SUBCELLULAR LOCATION, INTERACTION WITH SPAST.
  10. "The role of ZFYVE27/protrudin in hereditary spastic paraplegia."
    Martignoni M., Riano E., Rugarli E.I.
    Am. J. Hum. Genet. 83:127-130(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANT SPG33 VAL-191.

Entry informationi

Entry nameiZFY27_HUMAN
AccessioniPrimary (citable) accession number: Q5T4F4
Secondary accession number(s): B7Z3S0
, B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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