Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5T4F4

- ZFY27_HUMAN

UniProt

Q5T4F4 - ZFY27_HUMAN

Protein

Protrudin

Gene

ZFYVE27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri344 – 41067FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. neuron projection development Source: UniProtKB
    3. neurotrophin TRK receptor signaling pathway Source: UniProtKB
    4. protein localization to plasma membrane Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protrudin
    Alternative name(s):
    Zinc finger FYVE domain-containing protein 27
    Gene namesi
    Name:ZFYVE27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:26559. ZFYVE27.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    5. growth cone membrane Source: UniProtKB
    6. integral component of membrane Source: UniProtKB-KW
    7. recycling endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Endoplasmic reticulum, Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Spastic paraplegia 33, autosomal dominant (SPG33) [MIM:610244]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti191 – 1911G → V in SPG33; aberrant subcellular localization and altered interaction with SPAST. 1 Publication
    Corresponds to variant rs35077384 [ dbSNP | Ensembl ].
    VAR_027269

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi13 – 131L → A: Alters interaction with RAB11A; when associated with A-49. 1 Publication
    Mutagenesisi49 – 491I → A: Alters interaction with RAB11A; when associated with A-13. 1 Publication
    Mutagenesisi289 – 2891D → A: Loss of interaction with VAPA and loss of function in cell projections formation. 1 Publication

    Keywords - Diseasei

    Disease mutation, Hereditary spastic paraplegia, Neurodegeneration

    Organism-specific databases

    MIMi610244. phenotype.
    PharmGKBiPA134863310.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411ProtrudinPRO_0000245601Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated. Phosphorylation is induced by NGF through the MAPK/ERK pathway and modulates interaction with RAB11A.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ5T4F4.
    PaxDbiQ5T4F4.
    PRIDEiQ5T4F4.

    PTM databases

    PhosphoSiteiQ5T4F4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T4F4.
    BgeeiQ5T4F4.
    GenevestigatoriQ5T4F4.

    Organism-specific databases

    HPAiHPA037523.

    Interactioni

    Subunit structurei

    Interacts with SPAST. Interacts with RAB11A (GDP-bound form); regulates RAB11A. Interacts with FKBP8; may negatively regulate ZFYVE27 phosphorylation. Interacts with VAPA (via MSP domain); may regulate ZFYVE27 retention in the endoplasmic reticulum and its function in cell projections formation. Interacts with VAPB (via MSP domain).4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FKBP8Q143184EBI-3892947,EBI-724839
    RAB11AP624914EBI-3892947,EBI-745098
    VAPAQ9P0L05EBI-3892947,EBI-1059156
    VAPBO952922EBI-3892947,EBI-1188298

    Protein-protein interaction databases

    BioGridi125623. 2 interactions.
    IntActiQ5T4F4. 7 interactions.

    Structurei

    Secondary structure

    1
    411
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi351 – 3533
    Beta strandi359 – 3613
    Beta strandi367 – 3693
    Turni375 – 3773
    Beta strandi380 – 3823
    Turni385 – 3873
    Beta strandi399 – 4013
    Helixi403 – 4108

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X4UNMR-A341-411[»]
    ProteinModelPortaliQ5T4F4.
    SMRiQ5T4F4. Positions 341-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5T4F4.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6666CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini88 – 881ExtracellularSequence Analysis
    Topological domaini110 – 18778CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini209 – 411203ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni51 – 6414Necessary for interaction with RAB11A and function in neurite outgrowthAdd
    BLAST
    Regioni286 – 2927Necessary for interaction with VAPA and function in cell projections formation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi246 – 2494Poly-Pro

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri344 – 41067FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG28771.
    HOVERGENiHBG054907.
    OMAiSYKRLEI.
    OrthoDBiEOG7VTDNG.
    PhylomeDBiQ5T4F4.
    TreeFamiTF331044.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T4F4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQTSEREGSG PELSPSVMPE APLESPPFPT KSPAFDLFNL VLSYKRLEIY    50
    LEPLKDAGDG VRYLLRWQMP LCSLLTCLGL NVLFLTLNEG AWYSVGALMI 100
    SVPALLGYLQ EVCRARLPDS ELMRRKYHSV RQEDLQRGRL SRPEAVAEVK 150
    SFLIQLEAFL SRLCCTCEAA YRVLHWENPV VSSQFYGALL GTVCMLYLLP 200
    LCWVLTLLNS TLFLGNVEFF RVVSEYRASL QQRMNPKQEE HAFESPPPPD 250
    VGGKDGLMDS TPALTPTEDL TPGSVEEAEE AEPDEEFKDA IEETHLVVLE 300
    DDEGAPCPAE DELALQDNGF LSKNEVLRSK VSRLTERLRK RYPTNNFGNC 350
    TGCSATFSVL KKRRSCSNCG NSFCSRCCSF KVPKSSMGAT APEAQRETVF 400
    VCASCNQTLS K 411
    Length:411
    Mass (Da):45,843
    Last modified:December 21, 2004 - v1
    Checksum:i5B86C64A398033D2
    GO
    Isoform 2 (identifier: Q5T4F4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         294-300: Missing.

    Show »
    Length:404
    Mass (Da):45,052
    Checksum:i0FA0436DAE7716D7
    GO
    Isoform 3 (identifier: Q5T4F4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         268-268: E → ESLSSQ

    Show »
    Length:416
    Mass (Da):46,346
    Checksum:iBF488D2456C6B924
    GO
    Isoform 4 (identifier: Q5T4F4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-68: Missing.
         268-268: E → ESLSSQ
         294-300: Missing.
         349-356: NCTGCSAT → VTGAGSS
         357-411: Missing.

    Show »
    Length:285
    Mass (Da):31,744
    Checksum:i977E99E1E5857BDD
    GO
    Isoform 5 (identifier: Q5T4F4-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-152: RWQMPLCSLL...PEAVAEVKSF → S
         294-300: Missing.

    Show »
    Length:318
    Mass (Da):35,205
    Checksum:i1E3E1DF487779DEB
    GO
    Isoform 6 (identifier: Q5T4F4-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         67-184: Missing.
         294-300: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):31,612
    Checksum:iC4F817D0A286151B
    GO
    Isoform 7 (identifier: Q5T4F4-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-98: Missing.
         268-268: E → ESLSSQ
         294-300: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:311
    Mass (Da):34,681
    Checksum:i3035EAF2EF4EEA53
    GO
    Isoform 8 (identifier: Q5T4F4-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         58-89: Missing.
         294-300: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:372
    Mass (Da):41,417
    Checksum:i0D235A6E1A98B2E2
    GO

    Sequence cautioni

    The sequence CAD38913.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501Y → N in AAH30621. (PubMed:15489334)Curated
    Sequence conflicti218 – 2181E → G in BAC11260. (PubMed:14702039)Curated
    Sequence conflicti222 – 2221V → F in BAH13112. (PubMed:14702039)Curated
    Sequence conflicti340 – 3401K → R in BAH13112. (PubMed:14702039)Curated
    Sequence conflicti387 – 3871M → A in BAH13112. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821V → I.
    Corresponds to variant rs17108378 [ dbSNP | Ensembl ].
    VAR_027002
    Natural varianti138 – 1381G → V.3 Publications
    Corresponds to variant rs10882993 [ dbSNP | Ensembl ].
    VAR_027003
    Natural varianti191 – 1911G → V in SPG33; aberrant subcellular localization and altered interaction with SPAST. 1 Publication
    Corresponds to variant rs35077384 [ dbSNP | Ensembl ].
    VAR_027269

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9898Missing in isoform 7. 1 PublicationVSP_045265Add
    BLAST
    Alternative sequencei1 – 6868Missing in isoform 4. 1 PublicationVSP_019751Add
    BLAST
    Alternative sequencei58 – 8932Missing in isoform 8. 1 PublicationVSP_046051Add
    BLAST
    Alternative sequencei66 – 15287RWQMP…EVKSF → S in isoform 5. 1 PublicationVSP_019752Add
    BLAST
    Alternative sequencei67 – 184118Missing in isoform 6. 1 PublicationVSP_045266Add
    BLAST
    Alternative sequencei268 – 2681E → ESLSSQ in isoform 3, isoform 4 and isoform 7. 2 PublicationsVSP_019753
    Alternative sequencei294 – 3007Missing in isoform 2, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationVSP_019754
    Alternative sequencei349 – 3568NCTGCSAT → VTGAGSS in isoform 4. 1 PublicationVSP_019755
    Alternative sequencei357 – 41155Missing in isoform 4. 1 PublicationVSP_019756Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057481 mRNA. Translation: BAB71506.1.
    AK097945 mRNA. Translation: BAC05200.1.
    AK074876 mRNA. Translation: BAC11260.1.
    AK296295 mRNA. Translation: BAH12306.1.
    AK296588 mRNA. Translation: BAH12390.1.
    AK299735 mRNA. Translation: BAH13112.1.
    AL358938 Genomic DNA. Translation: CAI14270.1.
    AL358938 Genomic DNA. Translation: CAI14271.1.
    AL358938 Genomic DNA. Translation: CAI14272.1.
    BC030621 mRNA. Translation: AAH30621.2.
    AL834235 mRNA. Translation: CAD38913.2. Different initiation.
    CCDSiCCDS31262.1. [Q5T4F4-3]
    CCDS31263.1. [Q5T4F4-1]
    CCDS31264.1. [Q5T4F4-2]
    CCDS53562.1. [Q5T4F4-8]
    CCDS53563.1. [Q5T4F4-5]
    CCDS53564.1. [Q5T4F4-6]
    CCDS53565.1. [Q5T4F4-7]
    RefSeqiNP_001002261.1. NM_001002261.3. [Q5T4F4-3]
    NP_001002262.1. NM_001002262.3. [Q5T4F4-2]
    NP_001167590.1. NM_001174119.1. [Q5T4F4-8]
    NP_001167591.1. NM_001174120.1. [Q5T4F4-5]
    NP_001167592.1. NM_001174121.1. [Q5T4F4-7]
    NP_001167593.1. NM_001174122.1. [Q5T4F4-6]
    NP_653189.3. NM_144588.6. [Q5T4F4-1]
    XP_005269559.1. XM_005269502.1. [Q5T4F4-3]
    XP_005269560.1. XM_005269503.1. [Q5T4F4-3]
    XP_005269561.1. XM_005269504.1. [Q5T4F4-1]
    XP_005269563.1. XM_005269506.1. [Q5T4F4-2]
    UniGeneiHs.744075.

    Genome annotation databases

    EnsembliENST00000337540; ENSP00000337993; ENSG00000155256. [Q5T4F4-8]
    ENST00000357540; ENSP00000350148; ENSG00000155256. [Q5T4F4-5]
    ENST00000359980; ENSP00000353069; ENSG00000155256. [Q5T4F4-2]
    ENST00000370610; ENSP00000359642; ENSG00000155256. [Q5T4F4-7]
    ENST00000370613; ENSP00000359646; ENSG00000155256. [Q5T4F4-6]
    ENST00000393677; ENSP00000377282; ENSG00000155256. [Q5T4F4-1]
    GeneIDi118813.
    KEGGihsa:118813.
    UCSCiuc001kol.2. human. [Q5T4F4-1]
    uc001kom.2. human. [Q5T4F4-2]
    uc001koq.3. human. [Q5T4F4-5]
    uc021pwq.1. human. [Q5T4F4-3]

    Polymorphism databases

    DMDMi74744927.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057481 mRNA. Translation: BAB71506.1 .
    AK097945 mRNA. Translation: BAC05200.1 .
    AK074876 mRNA. Translation: BAC11260.1 .
    AK296295 mRNA. Translation: BAH12306.1 .
    AK296588 mRNA. Translation: BAH12390.1 .
    AK299735 mRNA. Translation: BAH13112.1 .
    AL358938 Genomic DNA. Translation: CAI14270.1 .
    AL358938 Genomic DNA. Translation: CAI14271.1 .
    AL358938 Genomic DNA. Translation: CAI14272.1 .
    BC030621 mRNA. Translation: AAH30621.2 .
    AL834235 mRNA. Translation: CAD38913.2 . Different initiation.
    CCDSi CCDS31262.1. [Q5T4F4-3 ]
    CCDS31263.1. [Q5T4F4-1 ]
    CCDS31264.1. [Q5T4F4-2 ]
    CCDS53562.1. [Q5T4F4-8 ]
    CCDS53563.1. [Q5T4F4-5 ]
    CCDS53564.1. [Q5T4F4-6 ]
    CCDS53565.1. [Q5T4F4-7 ]
    RefSeqi NP_001002261.1. NM_001002261.3. [Q5T4F4-3 ]
    NP_001002262.1. NM_001002262.3. [Q5T4F4-2 ]
    NP_001167590.1. NM_001174119.1. [Q5T4F4-8 ]
    NP_001167591.1. NM_001174120.1. [Q5T4F4-5 ]
    NP_001167592.1. NM_001174121.1. [Q5T4F4-7 ]
    NP_001167593.1. NM_001174122.1. [Q5T4F4-6 ]
    NP_653189.3. NM_144588.6. [Q5T4F4-1 ]
    XP_005269559.1. XM_005269502.1. [Q5T4F4-3 ]
    XP_005269560.1. XM_005269503.1. [Q5T4F4-3 ]
    XP_005269561.1. XM_005269504.1. [Q5T4F4-1 ]
    XP_005269563.1. XM_005269506.1. [Q5T4F4-2 ]
    UniGenei Hs.744075.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X4U NMR - A 341-411 [» ]
    ProteinModelPortali Q5T4F4.
    SMRi Q5T4F4. Positions 341-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125623. 2 interactions.
    IntActi Q5T4F4. 7 interactions.

    PTM databases

    PhosphoSitei Q5T4F4.

    Polymorphism databases

    DMDMi 74744927.

    Proteomic databases

    MaxQBi Q5T4F4.
    PaxDbi Q5T4F4.
    PRIDEi Q5T4F4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337540 ; ENSP00000337993 ; ENSG00000155256 . [Q5T4F4-8 ]
    ENST00000357540 ; ENSP00000350148 ; ENSG00000155256 . [Q5T4F4-5 ]
    ENST00000359980 ; ENSP00000353069 ; ENSG00000155256 . [Q5T4F4-2 ]
    ENST00000370610 ; ENSP00000359642 ; ENSG00000155256 . [Q5T4F4-7 ]
    ENST00000370613 ; ENSP00000359646 ; ENSG00000155256 . [Q5T4F4-6 ]
    ENST00000393677 ; ENSP00000377282 ; ENSG00000155256 . [Q5T4F4-1 ]
    GeneIDi 118813.
    KEGGi hsa:118813.
    UCSCi uc001kol.2. human. [Q5T4F4-1 ]
    uc001kom.2. human. [Q5T4F4-2 ]
    uc001koq.3. human. [Q5T4F4-5 ]
    uc021pwq.1. human. [Q5T4F4-3 ]

    Organism-specific databases

    CTDi 118813.
    GeneCardsi GC10P099486.
    HGNCi HGNC:26559. ZFYVE27.
    HPAi HPA037523.
    MIMi 610243. gene.
    610244. phenotype.
    neXtProti NX_Q5T4F4.
    PharmGKBi PA134863310.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28771.
    HOVERGENi HBG054907.
    OMAi SYKRLEI.
    OrthoDBi EOG7VTDNG.
    PhylomeDBi Q5T4F4.
    TreeFami TF331044.

    Miscellaneous databases

    ChiTaRSi ZFYVE27. human.
    EvolutionaryTracei Q5T4F4.
    GenomeRNAii 118813.
    NextBioi 35535086.
    PROi Q5T4F4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T4F4.
    Bgeei Q5T4F4.
    Genevestigatori Q5T4F4.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4; 5; 6; 7 AND 8), VARIANT VAL-138.
      Tissue: Brain, Testis, Thalamus and Thymus.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-138.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-411 (ISOFORM 3), VARIANT VAL-138.
      Tissue: Brain.
    5. "Protrudin induces neurite formation by directional membrane trafficking."
      Shirane M., Nakayama K.I.
      Science 314:818-821(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH FKBP8 AND RAB11A, PHOSPHORYLATION, MUTAGENESIS OF LEU-13 AND ILE-49.
    6. "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."
      Shirane M., Ogawa M., Motoyama J., Nakayama K.I.
      Genes Cells 13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FKBP8.
    7. "Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein."
      Saita S., Shirane M., Natume T., Iemura S., Nakayama K.I.
      J. Biol. Chem. 284:13766-13777(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VAPA AND VAPB, MUTAGENESIS OF ASP-289, SUBCELLULAR LOCATION.
    8. "Solution structure of the FYVE domain from human FYVE domain containing 27 isoform B protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 341-411.
    9. "ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia."
      Mannan A.U., Krawen P., Sauter S.M., Boehm J., Chronowska A., Paulus W., Neesen J., Engel W.
      Am. J. Hum. Genet. 79:351-357(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SPG33 VAL-191, CHARACTERIZATION OF VARIANT SPG33 VAL-191, SUBCELLULAR LOCATION, INTERACTION WITH SPAST.
    10. "The role of ZFYVE27/protrudin in hereditary spastic paraplegia."
      Martignoni M., Riano E., Rugarli E.I.
      Am. J. Hum. Genet. 83:127-130(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT SPG33 VAL-191.

    Entry informationi

    Entry nameiZFY27_HUMAN
    AccessioniPrimary (citable) accession number: Q5T4F4
    Secondary accession number(s): B7Z3S0
    , B7Z404, B7Z626, G8JLC3, G8JLF0, J3KP98, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3