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Q5T4E8

- Q5T4E8_HUMAN

UniProt

Q5T4E8 - Q5T4E8_HUMAN

Protein
Submitted name:

PR domain containing 1, with ZNF domain

Gene

PRDM1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metal ion binding Source: InterPro
    2. sequence-specific DNA binding Source: Ensembl

    GO - Biological processi

    1. cell fate commitment Source: Ensembl
    2. eye photoreceptor cell development Source: Ensembl
    3. germ cell development Source: Ensembl
    4. maternal placenta development Source: Ensembl
    5. negative regulation of B cell proliferation Source: Ensembl
    6. negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
    7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. positive regulation of B cell differentiation Source: Ensembl
    9. positive regulation of gene expression Source: Ensembl
    10. trophoblast giant cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PR domain containing 1, with ZNF domainImported
    Submitted name:
    PR domain containing 1, with ZNF domain, isoform CRA_bImported
    Gene namesi
    Name:PRDM1Imported
    ORF Names:hCG_33515Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Structurei

    3D structure databases

    SMRiQ5T4E8. Positions 8-187, 496-694.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.UniRule annotation
    Contains SET domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG053670.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR016608. Znf_PRDM1.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF013212. PRDM1. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T4E8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMDMEDADM TLWTEAEFEE KCTYIVNDHP WDSGADGGTS VQAEASLPRN    50
    LLFKYATNSE EVIGVMSKEY IPKGTRFGPL IGEIYTNDTV PKNANRKYFW 100
    RIYSRGELHH FIDGFNEEKS NWMRYVNPAH SPREQNLAAC QNGMNIYFYT 150
    IKPIPANQEL LVWYCRDFAE RLHYPYPGEL TMMNLTQTQS SLKQPSTEKN 200
    ELCPKNVPKR EYSVKEILKL DSNPSKGKDL YRSNISPLTS EKDLDDFRRR 250
    GSPEMPFYPR VVYPIRAPLP EDFLKASLAY GIERPTYITR SPIPSSTTPS 300
    PSARSSPDQS LKSSSPHSSP GNTVSPVGPG SQEHRDSYAY LNASYGTEGL 350
    GSYPGYAPLP HLPPAFIPSY NAHYPKFLLP PYGMNCNGLS AVSSMNGINN 400
    FGLFPRLCPV YSNLLGGGSL PHPMLNPTSL PSSLPSDGAR RLLQPEHPRE 450
    VLVPAPHSAF SFTGAAASMK DKACSPTSGS PTAGTAATAE HVVQPKATSA 500
    AMAAPSSDEA MNLIKNKRNM TGYKTLPYPL KKQNGKIKYE CNVCAKTFGQ 550
    LSNLKVHLRV HSGERPFKCQ TCNKGFTQLA HLQKHYLVHT GEKPHECQVC 600
    HKRFSSTSNL KTHLRLHSGE KPYQCKVCPA KFTQFVHLKL HKRLHTRERP 650
    HKCSQCHKNY IHLCSLKVHL KGNCAAAPAP GLPLEDLTRI NEEIEKFDIS 700
    DNADRLEDVE DDISVISVVE KEILAVVRKE KEETGLKVSL QRNMGNGLLS 750
    SGCSLYESSD LPLMKLPPSN PLPLVPVKVK QETVEPMDP 789
    Length:789
    Mass (Da):87,991
    Last modified:May 10, 2005 - v1
    Checksum:i6A1FEBEAD309BC7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF064715 Genomic DNA. Translation: ABK41898.1.
    CH471051 Genomic DNA. Translation: EAW48420.1.
    UniGeneiHs.436023.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF064715 Genomic DNA. Translation: ABK41898.1 .
    CH471051 Genomic DNA. Translation: EAW48420.1 .
    UniGenei Hs.436023.

    3D structure databases

    SMRi Q5T4E8. Positions 8-187, 496-694.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG053670.

    Miscellaneous databases

    ChiTaRSi PRDM1. human.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR016608. Znf_PRDM1.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF013212. PRDM1. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of the human genome."
      Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
      , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
      Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ5T4E8_HUMAN
    AccessioniPrimary (citable) accession number: Q5T4E8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.