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Q5T4E8

- Q5T4E8_HUMAN

UniProt

Q5T4E8 - Q5T4E8_HUMAN

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Protein
Submitted name:

PR domain containing 1, with ZNF domain

Gene

PRDM1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. eye photoreceptor cell development Source: Ensembl
  3. germ cell development Source: Ensembl
  4. intestinal epithelial cell development Source: Ensembl
  5. maternal placenta development Source: Ensembl
  6. negative regulation of B cell proliferation Source: Ensembl
  7. negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. positive regulation of B cell differentiation Source: Ensembl
  10. positive regulation of gene expression Source: Ensembl
  11. post-embryonic development Source: Ensembl
  12. trophoblast giant cell differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PR domain containing 1, with ZNF domainImported
Submitted name:
PR domain containing 1, with ZNF domain, isoform CRA_bImported
Gene namesi
Name:PRDM1Imported
ORF Names:hCG_33515Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ5T4E8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5T4E8.
SMRiQ5T4E8. Positions 8-187, 496-694.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00740000115517.
HOVERGENiHBG053670.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR016608. Znf_PRDM1.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF013212. PRDM1. 1 hit.
SMARTiSM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T4E8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKMDMEDADM TLWTEAEFEE KCTYIVNDHP WDSGADGGTS VQAEASLPRN
60 70 80 90 100
LLFKYATNSE EVIGVMSKEY IPKGTRFGPL IGEIYTNDTV PKNANRKYFW
110 120 130 140 150
RIYSRGELHH FIDGFNEEKS NWMRYVNPAH SPREQNLAAC QNGMNIYFYT
160 170 180 190 200
IKPIPANQEL LVWYCRDFAE RLHYPYPGEL TMMNLTQTQS SLKQPSTEKN
210 220 230 240 250
ELCPKNVPKR EYSVKEILKL DSNPSKGKDL YRSNISPLTS EKDLDDFRRR
260 270 280 290 300
GSPEMPFYPR VVYPIRAPLP EDFLKASLAY GIERPTYITR SPIPSSTTPS
310 320 330 340 350
PSARSSPDQS LKSSSPHSSP GNTVSPVGPG SQEHRDSYAY LNASYGTEGL
360 370 380 390 400
GSYPGYAPLP HLPPAFIPSY NAHYPKFLLP PYGMNCNGLS AVSSMNGINN
410 420 430 440 450
FGLFPRLCPV YSNLLGGGSL PHPMLNPTSL PSSLPSDGAR RLLQPEHPRE
460 470 480 490 500
VLVPAPHSAF SFTGAAASMK DKACSPTSGS PTAGTAATAE HVVQPKATSA
510 520 530 540 550
AMAAPSSDEA MNLIKNKRNM TGYKTLPYPL KKQNGKIKYE CNVCAKTFGQ
560 570 580 590 600
LSNLKVHLRV HSGERPFKCQ TCNKGFTQLA HLQKHYLVHT GEKPHECQVC
610 620 630 640 650
HKRFSSTSNL KTHLRLHSGE KPYQCKVCPA KFTQFVHLKL HKRLHTRERP
660 670 680 690 700
HKCSQCHKNY IHLCSLKVHL KGNCAAAPAP GLPLEDLTRI NEEIEKFDIS
710 720 730 740 750
DNADRLEDVE DDISVISVVE KEILAVVRKE KEETGLKVSL QRNMGNGLLS
760 770 780
SGCSLYESSD LPLMKLPPSN PLPLVPVKVK QETVEPMDP
Length:789
Mass (Da):87,991
Last modified:May 10, 2005 - v1
Checksum:i6A1FEBEAD309BC7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF064715 Genomic DNA. Translation: ABK41898.1.
CH471051 Genomic DNA. Translation: EAW48420.1.
UniGeneiHs.436023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF064715 Genomic DNA. Translation: ABK41898.1 .
CH471051 Genomic DNA. Translation: EAW48420.1 .
UniGenei Hs.436023.

3D structure databases

ProteinModelPortali Q5T4E8.
SMRi Q5T4E8. Positions 8-187, 496-694.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

GeneTreei ENSGT00740000115517.
HOVERGENi HBG053670.

Miscellaneous databases

ChiTaRSi PRDM1. human.

Gene expression databases

ExpressionAtlasi Q5T4E8. baseline and differential.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR016608. Znf_PRDM1.
[Graphical view ]
Pfami PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF013212. PRDM1. 1 hit.
SMARTi SM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5T4E8_HUMAN
AccessioniPrimary (citable) accession number: Q5T4E8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.