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Q5T4B2

- GT253_HUMAN

UniProt

Q5T4B2 - GT253_HUMAN

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Protein
Probable inactive glycosyltransferase 25 family member 3
Gene
CERCAM, CEECAM1, GLT25D3, KIAA1502
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity.2 Publications

GO - Biological processi

  1. cell adhesion Source: MGI
  2. cellular component movement Source: ProtInc
  3. leukocyte cell-cell adhesion Source: ProtInc
  4. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3, KIAA1502
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:23723. CERCAM.

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 595573Probable inactive glycosyltransferase 25 family member 3
PRO_0000309544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5T4B2.
PaxDbiQ5T4B2.
PRIDEiQ5T4B2.

PTM databases

PhosphoSiteiQ5T4B2.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in secretory and nervous tissues.2 Publications

Gene expression databases

ArrayExpressiQ5T4B2.
BgeeiQ5T4B2.
CleanExiHS_CERCAM.
GenevestigatoriQ5T4B2.

Organism-specific databases

HPAiHPA021657.
HPA051595.

Interactioni

Protein-protein interaction databases

BioGridi119332. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5T4B2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi592 – 5954Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOVERGENiHBG058097.
InParanoidiQ5T4B2.
OMAiEHRYGYM.
OrthoDBiEOG7060RC.
PhylomeDBiQ5T4B2.
TreeFamiTF313826.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T4B2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRAARAAPLL QLLLLLGPWL EAAGVAESPL PAVVLAILAR NAEHSLPHYL    50
GALERLDYPR ARMALWCATD HNVDNTTEML QEWLAAVGDD YAAVVWRPEG 100
EPRFYPDEEG PKHWTKERHQ FLMELKQEAL TFARNWGADY ILFADTDNIL 150
TNNQTLRLLM GQGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTAEYFPTK 200
NRQRRGCFRV PMVHSTFLAS LRAEGADQLA FYPPHPNYTW PFDDIIVFAY 250
ACQAAGVSVH VCNEHRYGYM NVPVKSHQGL EDERVNFIHL ILEALVDGPR 300
MQASAHVTRP SKRPSKIGFD EVFVISLARR PDRRERMLAS LWEMEISGRV 350
VDAVDGWMLN SSAIRNLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE 400
EVVARGLARV LVFEDDVRFE SNFRGRLERL MEDVEAEKLS WDLIYLGRKQ 450
VNPEKETAVE GLPGLVVAGY SYWTLAYALR LAGARKLLAS QPLRRMLPVD 500
EFLPIMFDQH PNEQYKAHFW PRDLVAFSAQ PLLAAPTHYA GDAEWLSDTE 550
TSSPWDDDSG RLISWSGSQK TLRSPRLDLT GSSGHSLQPQ PRDEL 595
Length:595
Mass (Da):67,592
Last modified:December 21, 2004 - v1
Checksum:iFC2157AD8C7AC558
GO
Isoform 2 (identifier: Q5T4B2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:517
Mass (Da):59,100
Checksum:i8E8C443064488AE7
GO

Sequence cautioni

The sequence AAH98432.2 differs from that shown. Reason: Erroneous initiation.
The sequence AAI19699.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI19700.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA96026.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC11040.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI13495.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878Missing in isoform 2.
VSP_029234Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091R → H in AAI19700. 1 Publication
Sequence conflicti356 – 3583GWM → AGW in AAD51367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177203 mRNA. Translation: AAD51367.1.
AK074519 mRNA. Translation: BAC11036.1.
AK074523 mRNA. Translation: BAC11040.1. Different initiation.
AL359091 Genomic DNA. Translation: CAI13494.1.
AL359091 Genomic DNA. Translation: CAI13495.1. Sequence problems.
AL359091 Genomic DNA. Translation: CAI13496.1.
CH471090 Genomic DNA. Translation: EAW87787.1.
CH471090 Genomic DNA. Translation: EAW87789.1.
BC011811 mRNA. Translation: AAH11811.2.
BC098432 mRNA. Translation: AAH98432.2. Different initiation.
BC108698 mRNA. Translation: AAI08699.1.
BC119698 mRNA. Translation: AAI19699.1. Different initiation.
BC119699 mRNA. Translation: AAI19700.1. Different initiation.
AB040935 mRNA. Translation: BAA96026.1. Different initiation.
CCDSiCCDS6901.2. [Q5T4B2-1]
CCDS69675.1. [Q5T4B2-2]
RefSeqiNP_001273689.1. NM_001286760.1. [Q5T4B2-2]
NP_057258.3. NM_016174.4. [Q5T4B2-1]
XP_005252092.1. XM_005252035.1. [Q5T4B2-1]
XP_005252094.1. XM_005252037.1. [Q5T4B2-2]
XP_006717200.1. XM_006717137.1. [Q5T4B2-2]
UniGeneiHs.495230.

Genome annotation databases

EnsembliENST00000372838; ENSP00000361929; ENSG00000167123. [Q5T4B2-1]
ENST00000372842; ENSP00000361933; ENSG00000167123. [Q5T4B2-2]
GeneIDi51148.
KEGGihsa:51148.
UCSCiuc004buy.1. human. [Q5T4B2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF177203 mRNA. Translation: AAD51367.1 .
AK074519 mRNA. Translation: BAC11036.1 .
AK074523 mRNA. Translation: BAC11040.1 . Different initiation.
AL359091 Genomic DNA. Translation: CAI13494.1 .
AL359091 Genomic DNA. Translation: CAI13495.1 . Sequence problems.
AL359091 Genomic DNA. Translation: CAI13496.1 .
CH471090 Genomic DNA. Translation: EAW87787.1 .
CH471090 Genomic DNA. Translation: EAW87789.1 .
BC011811 mRNA. Translation: AAH11811.2 .
BC098432 mRNA. Translation: AAH98432.2 . Different initiation.
BC108698 mRNA. Translation: AAI08699.1 .
BC119698 mRNA. Translation: AAI19699.1 . Different initiation.
BC119699 mRNA. Translation: AAI19700.1 . Different initiation.
AB040935 mRNA. Translation: BAA96026.1 . Different initiation.
CCDSi CCDS6901.2. [Q5T4B2-1 ]
CCDS69675.1. [Q5T4B2-2 ]
RefSeqi NP_001273689.1. NM_001286760.1. [Q5T4B2-2 ]
NP_057258.3. NM_016174.4. [Q5T4B2-1 ]
XP_005252092.1. XM_005252035.1. [Q5T4B2-1 ]
XP_005252094.1. XM_005252037.1. [Q5T4B2-2 ]
XP_006717200.1. XM_006717137.1. [Q5T4B2-2 ]
UniGenei Hs.495230.

3D structure databases

ProteinModelPortali Q5T4B2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119332. 3 interactions.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

PTM databases

PhosphoSitei Q5T4B2.

Proteomic databases

MaxQBi Q5T4B2.
PaxDbi Q5T4B2.
PRIDEi Q5T4B2.

Protocols and materials databases

DNASUi 51148.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372838 ; ENSP00000361929 ; ENSG00000167123 . [Q5T4B2-1 ]
ENST00000372842 ; ENSP00000361933 ; ENSG00000167123 . [Q5T4B2-2 ]
GeneIDi 51148.
KEGGi hsa:51148.
UCSCi uc004buy.1. human. [Q5T4B2-1 ]

Organism-specific databases

CTDi 51148.
GeneCardsi GC09P131174.
H-InvDB HIX0008429.
HGNCi HGNC:23723. CERCAM.
HPAi HPA021657.
HPA051595.
neXtProti NX_Q5T4B2.
PharmGKBi PA162382177.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3306.
HOVERGENi HBG058097.
InParanoidi Q5T4B2.
OMAi EHRYGYM.
OrthoDBi EOG7060RC.
PhylomeDBi Q5T4B2.
TreeFami TF313826.

Miscellaneous databases

ChiTaRSi CERCAM. human.
GenomeRNAii 51148.
NextBioi 54025.
PROi Q5T4B2.

Gene expression databases

ArrayExpressi Q5T4B2.
Bgeei Q5T4B2.
CleanExi HS_CERCAM.
Genevestigatori Q5T4B2.

Family and domain databases

InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium."
    Starzyk R.M., Rosenow C., Frye J., Leismann M., Rodzinski E., Putney S., Tuomanen E.I.
    J. Infect. Dis. 181:181-187(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain capillary.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-595 (ISOFORM 1).
    Tissue: Embryo.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-595 (ISOFORMS 1/2).
    Tissue: Muscle, Ovary and PNS.
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-561 (ISOFORM 2).
    Tissue: Brain.
  7. "Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases."
    Schegg B., Huelsmeier A.J., Rutschmann C., Maag C., Hennet T.
    Mol. Cell. Biol. 29:943-952(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, LACK OF GALACTOSYLTRANSFERASE ACTIVITY, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGT253_HUMAN
AccessioniPrimary (citable) accession number: Q5T4B2
Secondary accession number(s): A7MD00
, C4AMA2, Q0VDF3, Q2VPJ4, Q4KMP2, Q5T4B1, Q8N107, Q96EZ5, Q9P226, Q9UMW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has no glucosyltransferase activity. Concerning beta-galactosyltransferase activity, the level of CERCAM could be too low to detect any activity when tested in transfected insect cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi