Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug resistance-associated protein 7

Gene

ABCC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.2 Publications

Kineticsi

  1. KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication
  1. Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi633 – 640ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1280 – 1287ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-382556. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.31. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
Gene namesi
Name:ABCC10
Synonyms:MRP7, SIMRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:52. ABCC10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei133 – 153HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei391 – 411HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei414 – 434HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei507 – 527HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei538 – 558HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei875 – 895HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei933 – 953HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei974 – 994HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1051 – 1071HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1153 – 1173HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1182 – 1202HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89845.
OpenTargetsiENSG00000124574.
PharmGKBiPA24392.

Chemistry databases

ChEMBLiCHEMBL2073687.
DrugBankiDB00091. Cyclosporine.
DB00987. Cytarabine.
DB00694. Daunorubicin.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00783. Estradiol.
DB00773. Etoposide.
DB00441. Gemcitabine.
DB00563. Methotrexate.
DB01229. Paclitaxel.
DB00203. Sildenafil.
DB00300. Tenofovir.
DB00661. Verapamil.
DB00541. Vincristine.

Polymorphism and mutation databases

BioMutaiABCC10.
DMDMi74756298.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535761 – 1492Multidrug resistance-associated protein 7Add BLAST1492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei463PhosphothreonineCombined sources1
Modified residuei467PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T3U5.
PaxDbiQ5T3U5.
PeptideAtlasiQ5T3U5.
PRIDEiQ5T3U5.

PTM databases

iPTMnetiQ5T3U5.
PhosphoSitePlusiQ5T3U5.

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000124574.
CleanExiHS_ABCC10.
ExpressionAtlasiQ5T3U5. baseline and differential.
GenevisibleiQ5T3U5. HS.

Organism-specific databases

HPAiHPA041607.
HPA045464.

Interactioni

Protein-protein interaction databases

BioGridi124617. 9 interactors.
STRINGi9606.ENSP00000361608.

Structurei

3D structure databases

ProteinModelPortaliQ5T3U5.
SMRiQ5T3U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 563ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini598 – 824ABC transporter 1PROSITE-ProRule annotationAdd BLAST227
Domaini885 – 1210ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST326
Domaini1246 – 1479ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG107141.
InParanoidiQ5T3U5.
KOiK05674.
OMAiHVAKHII.
OrthoDBiEOG091G00IN.
PhylomeDBiQ5T3U5.
TreeFamiTF105203.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030249. ABCC10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF235. PTHR24223:SF235. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T3U5-1) [UniParc]FASTAAdd to basket
Also known as: Mrp7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL
60 70 80 90 100
GTPRSPDYIL PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL
110 120 130 140 150
EVLAGCVAAV AWISHSLALW VLAHSPHGHS RGPLALALVA LLPAPALVLT
160 170 180 190 200
VLWHCQRGTL LPPLLPGPMA RLCLLILQLA ALLAYALGWA APGGPREPWA
210 220 230 240 250
QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE LRQPQDICRL
260 270 280 290 300
PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF
310 320 330 340 350
SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK
360 370 380 390 400
VTLQARGAVL NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE
410 420 430 440 450
AWGLPLQLAI TLYLLYQQVG VAFVGGLILA LLLVPVNKVI ATRIMASNQE
460 470 480 490 500
MLQHKDARVK LVTELLSGIR VIKFCGWEQA LGARVEACRA RELGRLRVIK
510 520 530 540 550
YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA LALVRMLILP
560 570 580 590 600
LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL
610 620 630 640 650
HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL
660 670 680 690 700
HRLRGHVAVR GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE
710 720 730 740 750
ACALNDDLSI LPAGDQTEVG EKGVTLSGGQ RARIALARAV YQEKELYLLD
760 770 780 790 800
DPLAAVDADV ANHLLHRCIL GMLSYTTRLL CTHRTEYLER ADAVLLMEAG
810 820 830 840 850
RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP EKTKEGLEEE
860 870 880 890 900
QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN
910 920 930 940 950
AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV
960 970 980 990 1000
FPLPKAAPNG SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL
1010 1020 1030 1040 1050
HRRLLHRVLM APVTFFNATP TGRILNRFSS DVACADDSLP FILNILLANA
1060 1070 1080 1090 1100
AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH VQRHYRASSR ELRRLGSLTL
1110 1120 1130 1140 1150
SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC QFATSATMQW
1160 1170 1180 1190 1200
LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG
1210 1220 1230 1240 1250
LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD
1260 1270 1280 1290 1300
VVLAYRPGLP NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS
1310 1320 1330 1340 1350
SGRVLLDGVD TSQLELAQLR SQLAIIPQEP FLFSGTVREN LDPQGLHKDR
1360 1370 1380 1390 1400
ALWQALKQCH LSEVITSMGG LDGELGEGGR SLSLGQRQLL CLARALLTDA
1410 1420 1430 1440 1450
KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL NTILNSDRVL
1460 1470 1480 1490
VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP
Length:1,492
Mass (Da):161,629
Last modified:December 21, 2004 - v1
Checksum:i6FBC260DEFB3DF30
GO
Isoform 2 (identifier: Q5T3U5-2) [UniParc]FASTAAdd to basket
Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     44-52: VLSACYLGT → MCLLVFPLV
     588-588: P → PDCGRLGAQIKWLLCS

Show »
Length:1,464
Mass (Da):158,781
Checksum:i31644BE052337EB3
GO

Sequence cautioni

The sequence BAA92227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15736 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208D → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti220Missing in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti631I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti764L → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti809S → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti888I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1030S → F in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1134L → F in BAB15736 (PubMed:11214971).Curated1
Sequence conflicti1276L → V in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1455G → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1481S → C in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1490G → R in AAK39642 (PubMed:12566991).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028391948I → T.Corresponds to variant rs2125739dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210781 – 43Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_02107944 – 52VLSACYLGT → MCLLVFPLV in isoform 2. 1 Publication9
Alternative sequenceiVSP_021080588P → PDCGRLGAQIKWLLCS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032599 mRNA. Translation: AAK39642.1.
AK000002 mRNA. Translation: BAA92227.1. Different initiation.
AK024446 mRNA. Translation: BAB15736.1. Sequence problems.
AL359813 Genomic DNA. Translation: CAI23217.1.
AL133613 mRNA. Translation: CAB63742.1.
CCDSiCCDS4896.1. [Q5T3U5-2]
CCDS56430.1. [Q5T3U5-1]
PIRiT43469.
RefSeqiNP_001185863.1. NM_001198934.1. [Q5T3U5-1]
NP_258261.2. NM_033450.2. [Q5T3U5-2]
UniGeneiHs.55879.

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
GeneIDi89845.
KEGGihsa:89845.
UCSCiuc003ouy.2. human. [Q5T3U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032599 mRNA. Translation: AAK39642.1.
AK000002 mRNA. Translation: BAA92227.1. Different initiation.
AK024446 mRNA. Translation: BAB15736.1. Sequence problems.
AL359813 Genomic DNA. Translation: CAI23217.1.
AL133613 mRNA. Translation: CAB63742.1.
CCDSiCCDS4896.1. [Q5T3U5-2]
CCDS56430.1. [Q5T3U5-1]
PIRiT43469.
RefSeqiNP_001185863.1. NM_001198934.1. [Q5T3U5-1]
NP_258261.2. NM_033450.2. [Q5T3U5-2]
UniGeneiHs.55879.

3D structure databases

ProteinModelPortaliQ5T3U5.
SMRiQ5T3U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124617. 9 interactors.
STRINGi9606.ENSP00000361608.

Chemistry databases

ChEMBLiCHEMBL2073687.
DrugBankiDB00091. Cyclosporine.
DB00987. Cytarabine.
DB00694. Daunorubicin.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00783. Estradiol.
DB00773. Etoposide.
DB00441. Gemcitabine.
DB00563. Methotrexate.
DB01229. Paclitaxel.
DB00203. Sildenafil.
DB00300. Tenofovir.
DB00661. Verapamil.
DB00541. Vincristine.

Protein family/group databases

TCDBi3.A.1.208.31. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ5T3U5.
PhosphoSitePlusiQ5T3U5.

Polymorphism and mutation databases

BioMutaiABCC10.
DMDMi74756298.

Proteomic databases

MaxQBiQ5T3U5.
PaxDbiQ5T3U5.
PeptideAtlasiQ5T3U5.
PRIDEiQ5T3U5.

Protocols and materials databases

DNASUi89845.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
GeneIDi89845.
KEGGihsa:89845.
UCSCiuc003ouy.2. human. [Q5T3U5-1]

Organism-specific databases

CTDi89845.
DisGeNETi89845.
GeneCardsiABCC10.
HGNCiHGNC:52. ABCC10.
HPAiHPA041607.
HPA045464.
MIMi612509. gene.
neXtProtiNX_Q5T3U5.
OpenTargetsiENSG00000124574.
PharmGKBiPA24392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00860000133687.
HOVERGENiHBG107141.
InParanoidiQ5T3U5.
KOiK05674.
OMAiHVAKHII.
OrthoDBiEOG091G00IN.
PhylomeDBiQ5T3U5.
TreeFamiTF105203.

Enzyme and pathway databases

ReactomeiR-HSA-382556. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSiABCC10. human.
GeneWikiiABCC10.
GenomeRNAii89845.
PROiQ5T3U5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124574.
CleanExiHS_ABCC10.
ExpressionAtlasiQ5T3U5. baseline and differential.
GenevisibleiQ5T3U5. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030249. ABCC10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF235. PTHR24223:SF235. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP7_HUMAN
AccessioniPrimary (citable) accession number: Q5T3U5
Secondary accession number(s): Q8NHX7
, Q9H7N2, Q9NXY3, Q9UF48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.