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Q5T3U5

- MRP7_HUMAN

UniProt

Q5T3U5 - MRP7_HUMAN

Protein

Multidrug resistance-associated protein 7

Gene

ABCC10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.2 Publications

    Kineticsi

    1. KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

    Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi633 – 6408ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1280 – 12878ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15480. ABC-family proteins mediated transport.

    Protein family/group databases

    TCDBi3.A.1.208.31. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance-associated protein 7
    Alternative name(s):
    ATP-binding cassette sub-family C member 10
    Gene namesi
    Name:ABCC10
    Synonyms:MRP7, SIMRP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:52. ABCC10.

    Subcellular locationi

    Cell membrane 2 Publications; Multi-pass membrane protein 2 PublicationsPROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14921492Multidrug resistance-associated protein 7PRO_0000253576Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei463 – 4631Phosphothreonine1 Publication
    Modified residuei467 – 4671Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5T3U5.
    PaxDbiQ5T3U5.
    PRIDEiQ5T3U5.

    PTM databases

    PhosphoSiteiQ5T3U5.

    Expressioni

    Tissue specificityi

    Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ5T3U5.
    BgeeiQ5T3U5.
    CleanExiHS_ABCC10.
    GenevestigatoriQ5T3U5.

    Organism-specific databases

    HPAiHPA041607.
    HPA045464.

    Interactioni

    Protein-protein interaction databases

    BioGridi124617. 2 interactions.
    STRINGi9606.ENSP00000244533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T3U5.
    SMRiQ5T3U5. Positions 374-829, 870-1486.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei70 – 9021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei102 – 12221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei133 – 15321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei172 – 19221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei293 – 31321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei320 – 34021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei391 – 41121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei414 – 43421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei507 – 52721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei538 – 55821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei875 – 89521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei933 – 95321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei974 – 99421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1051 – 107121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1153 – 117321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1182 – 120221HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini285 – 563279ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini598 – 824227ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini885 – 1210326ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1246 – 1479234ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG107141.
    InParanoidiQ5T3U5.
    KOiK05674.
    OMAiHWQEGAR.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiQ5T3U5.
    TreeFamiTF105203.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T3U5-1) [UniParc]FASTAAdd to Basket

    Also known as: Mrp7

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL     50
    GTPRSPDYIL PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL 100
    EVLAGCVAAV AWISHSLALW VLAHSPHGHS RGPLALALVA LLPAPALVLT 150
    VLWHCQRGTL LPPLLPGPMA RLCLLILQLA ALLAYALGWA APGGPREPWA 200
    QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE LRQPQDICRL 250
    PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF 300
    SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK 350
    VTLQARGAVL NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE 400
    AWGLPLQLAI TLYLLYQQVG VAFVGGLILA LLLVPVNKVI ATRIMASNQE 450
    MLQHKDARVK LVTELLSGIR VIKFCGWEQA LGARVEACRA RELGRLRVIK 500
    YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA LALVRMLILP 550
    LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL 600
    HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL 650
    HRLRGHVAVR GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE 700
    ACALNDDLSI LPAGDQTEVG EKGVTLSGGQ RARIALARAV YQEKELYLLD 750
    DPLAAVDADV ANHLLHRCIL GMLSYTTRLL CTHRTEYLER ADAVLLMEAG 800
    RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP EKTKEGLEEE 850
    QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN 900
    AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV 950
    FPLPKAAPNG SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL 1000
    HRRLLHRVLM APVTFFNATP TGRILNRFSS DVACADDSLP FILNILLANA 1050
    AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH VQRHYRASSR ELRRLGSLTL 1100
    SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC QFATSATMQW 1150
    LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG 1200
    LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD 1250
    VVLAYRPGLP NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS 1300
    SGRVLLDGVD TSQLELAQLR SQLAIIPQEP FLFSGTVREN LDPQGLHKDR 1350
    ALWQALKQCH LSEVITSMGG LDGELGEGGR SLSLGQRQLL CLARALLTDA 1400
    KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL NTILNSDRVL 1450
    VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP 1492
    Length:1,492
    Mass (Da):161,629
    Last modified:December 21, 2004 - v1
    Checksum:i6FBC260DEFB3DF30
    GO
    Isoform 2 (identifier: Q5T3U5-2) [UniParc]FASTAAdd to Basket

    Also known as: Mrp7A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.
         44-52: VLSACYLGT → MCLLVFPLV
         588-588: P → PDCGRLGAQIKWLLCS

    Show »
    Length:1,464
    Mass (Da):158,781
    Checksum:i31644BE052337EB3
    GO

    Sequence cautioni

    The sequence BAB15736.1 differs from that shown. Reason: Intron retention.
    The sequence BAA92227.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081D → E in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti220 – 2201Missing in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti631 – 6311I → T in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti764 – 7641L → P in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti809 – 8091S → P in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti888 – 8881I → T in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti1030 – 10301S → F in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti1134 – 11341L → F in BAB15736. (PubMed:11214971)Curated
    Sequence conflicti1276 – 12761L → V in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti1455 – 14551G → E in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti1481 – 14811S → C in AAK39642. (PubMed:12566991)Curated
    Sequence conflicti1490 – 14901G → R in AAK39642. (PubMed:12566991)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti948 – 9481I → T.
    Corresponds to variant rs2125739 [ dbSNP | Ensembl ].
    VAR_028391

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_021078Add
    BLAST
    Alternative sequencei44 – 529VLSACYLGT → MCLLVFPLV in isoform 2. 1 PublicationVSP_021079
    Alternative sequencei588 – 5881P → PDCGRLGAQIKWLLCS in isoform 2. 1 PublicationVSP_021080

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032599 mRNA. Translation: AAK39642.1.
    AK000002 mRNA. Translation: BAA92227.1. Different initiation.
    AK024446 mRNA. Translation: BAB15736.1. Sequence problems.
    AL359813 Genomic DNA. Translation: CAI23217.1.
    AL133613 mRNA. Translation: CAB63742.1.
    CCDSiCCDS4896.1. [Q5T3U5-2]
    CCDS56430.1. [Q5T3U5-1]
    PIRiT43469.
    RefSeqiNP_001185863.1. NM_001198934.1. [Q5T3U5-1]
    NP_258261.2. NM_033450.2. [Q5T3U5-2]
    UniGeneiHs.55879.

    Genome annotation databases

    EnsembliENST00000244533; ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
    ENST00000372530; ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
    GeneIDi89845.
    KEGGihsa:89845.
    UCSCiuc003ouy.1. human. [Q5T3U5-1]
    uc003ouz.1. human. [Q5T3U5-2]

    Polymorphism databases

    DMDMi74756298.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY032599 mRNA. Translation: AAK39642.1 .
    AK000002 mRNA. Translation: BAA92227.1 . Different initiation.
    AK024446 mRNA. Translation: BAB15736.1 . Sequence problems.
    AL359813 Genomic DNA. Translation: CAI23217.1 .
    AL133613 mRNA. Translation: CAB63742.1 .
    CCDSi CCDS4896.1. [Q5T3U5-2 ]
    CCDS56430.1. [Q5T3U5-1 ]
    PIRi T43469.
    RefSeqi NP_001185863.1. NM_001198934.1. [Q5T3U5-1 ]
    NP_258261.2. NM_033450.2. [Q5T3U5-2 ]
    UniGenei Hs.55879.

    3D structure databases

    ProteinModelPortali Q5T3U5.
    SMRi Q5T3U5. Positions 374-829, 870-1486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124617. 2 interactions.
    STRINGi 9606.ENSP00000244533.

    Chemistry

    ChEMBLi CHEMBL2073687.
    DrugBanki DB00091. Cyclosporine.
    DB00987. Cytarabine.
    DB00694. Daunorubicin.
    DB01248. Docetaxel.
    DB00997. Doxorubicin.
    DB00783. Estradiol.
    DB00773. Etoposide.
    DB00441. Gemcitabine.
    DB00563. Methotrexate.
    DB01229. Paclitaxel.
    DB00203. Sildenafil.
    DB00300. Tenofovir.
    DB00661. Verapamil.
    DB00541. Vincristine.

    Protein family/group databases

    TCDBi 3.A.1.208.31. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q5T3U5.

    Polymorphism databases

    DMDMi 74756298.

    Proteomic databases

    MaxQBi Q5T3U5.
    PaxDbi Q5T3U5.
    PRIDEi Q5T3U5.

    Protocols and materials databases

    DNASUi 89845.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244533 ; ENSP00000244533 ; ENSG00000124574 . [Q5T3U5-2 ]
    ENST00000372530 ; ENSP00000361608 ; ENSG00000124574 . [Q5T3U5-1 ]
    GeneIDi 89845.
    KEGGi hsa:89845.
    UCSCi uc003ouy.1. human. [Q5T3U5-1 ]
    uc003ouz.1. human. [Q5T3U5-2 ]

    Organism-specific databases

    CTDi 89845.
    GeneCardsi GC06P043442.
    HGNCi HGNC:52. ABCC10.
    HPAi HPA041607.
    HPA045464.
    MIMi 612509. gene.
    neXtProti NX_Q5T3U5.
    PharmGKBi PA24392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG107141.
    InParanoidi Q5T3U5.
    KOi K05674.
    OMAi HWQEGAR.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi Q5T3U5.
    TreeFami TF105203.

    Enzyme and pathway databases

    Reactomei REACT_15480. ABC-family proteins mediated transport.

    Miscellaneous databases

    ChiTaRSi ABCC10. human.
    GeneWikii ABCC10.
    GenomeRNAii 89845.
    NextBioi 76328.
    PROi Q5T3U5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5T3U5.
    Bgeei Q5T3U5.
    CleanExi HS_ABCC10.
    Genevestigatori Q5T3U5.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7."
      Kao H.-H., Chang M.-S., Cheng J.-F., Huang J.-D.
      J. Biomed. Sci. 10:98-110(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Small intestine.
    2. "Characterization of long cDNA clones from human adult spleen."
      Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
      DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 793-1492 (ISOFORMS 1/2).
      Tissue: Testis.
    5. "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)."
      Chen Z.-S., Hopper-Borge E., Belinsky M.G., Shchaveleva I., Kotova E., Kruh G.D.
      Mol. Pharmacol. 63:351-358(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    6. "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel."
      Hopper-Borge E., Chen Z.-S., Shchaveleva I., Belinsky M.G., Kruh G.D.
      Cancer Res. 64:4927-4930(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463 AND SER-467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiMRP7_HUMAN
    AccessioniPrimary (citable) accession number: Q5T3U5
    Secondary accession number(s): Q8NHX7
    , Q9H7N2, Q9NXY3, Q9UF48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3