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Q5T3U5 (MRP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
Gene names
Name:ABCC10
Synonyms:MRP7, SIMRP7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1492 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Ref.5 Ref.6

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1 Ref.6.

Tissue specificity

Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed. Ref.1

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Biophysicochemical properties

Kinetic parameters:

KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) Ref.5

Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)

Sequence caution

The sequence BAA92227.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB15736.1 differs from that shown. Reason: Intron retention.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T3U5-1)

Also known as: Mrp7;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T3U5-2)

Also known as: Mrp7A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     44-52: VLSACYLGT → MCLLVFPLV
     588-588: P → PDCGRLGAQIKWLLCS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14921492Multidrug resistance-associated protein 7
PRO_0000253576

Regions

Transmembrane32 – 5221Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane172 – 19221Helical; Potential
Transmembrane293 – 31321Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane507 – 52721Helical; Potential
Transmembrane538 – 55821Helical; Potential
Transmembrane875 – 89521Helical; Potential
Transmembrane933 – 95321Helical; Potential
Transmembrane974 – 99421Helical; Potential
Transmembrane1051 – 107121Helical; Potential
Transmembrane1153 – 117321Helical; Potential
Transmembrane1182 – 120221Helical; Potential
Domain285 – 563279ABC transmembrane type-1 1
Domain598 – 824227ABC transporter 1
Domain885 – 1210326ABC transmembrane type-1 2
Domain1246 – 1479234ABC transporter 2
Nucleotide binding633 – 6408ATP 1 Potential
Nucleotide binding1280 – 12878ATP 2 Potential

Amino acid modifications

Modified residue4631Phosphothreonine Ref.7
Modified residue4671Phosphoserine Ref.7

Natural variations

Alternative sequence1 – 4343Missing in isoform 2.
VSP_021078
Alternative sequence44 – 529VLSACYLGT → MCLLVFPLV in isoform 2.
VSP_021079
Alternative sequence5881P → PDCGRLGAQIKWLLCS in isoform 2.
VSP_021080
Natural variant9481I → T.
Corresponds to variant rs2125739 [ dbSNP | Ensembl ].
VAR_028391

Experimental info

Sequence conflict2081D → E in AAK39642. Ref.1
Sequence conflict2201Missing in AAK39642. Ref.1
Sequence conflict6311I → T in AAK39642. Ref.1
Sequence conflict7641L → P in AAK39642. Ref.1
Sequence conflict8091S → P in AAK39642. Ref.1
Sequence conflict8881I → T in AAK39642. Ref.1
Sequence conflict10301S → F in AAK39642. Ref.1
Sequence conflict11341L → F in BAB15736. Ref.2
Sequence conflict12761L → V in AAK39642. Ref.1
Sequence conflict14551G → E in AAK39642. Ref.1
Sequence conflict14811S → C in AAK39642. Ref.1
Sequence conflict14901G → R in AAK39642. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Mrp7) [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: 6FBC260DEFB3DF30

FASTA1,492161,629
        10         20         30         40         50         60 
MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL GTPRSPDYIL 

        70         80         90        100        110        120 
PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL EVLAGCVAAV AWISHSLALW 

       130        140        150        160        170        180 
VLAHSPHGHS RGPLALALVA LLPAPALVLT VLWHCQRGTL LPPLLPGPMA RLCLLILQLA 

       190        200        210        220        230        240 
ALLAYALGWA APGGPREPWA QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE 

       250        260        270        280        290        300 
LRQPQDICRL PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF 

       310        320        330        340        350        360 
SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK VTLQARGAVL 

       370        380        390        400        410        420 
NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE AWGLPLQLAI TLYLLYQQVG 

       430        440        450        460        470        480 
VAFVGGLILA LLLVPVNKVI ATRIMASNQE MLQHKDARVK LVTELLSGIR VIKFCGWEQA 

       490        500        510        520        530        540 
LGARVEACRA RELGRLRVIK YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA 

       550        560        570        580        590        600 
LALVRMLILP LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL 

       610        620        630        640        650        660 
HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL HRLRGHVAVR 

       670        680        690        700        710        720 
GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE ACALNDDLSI LPAGDQTEVG 

       730        740        750        760        770        780 
EKGVTLSGGQ RARIALARAV YQEKELYLLD DPLAAVDADV ANHLLHRCIL GMLSYTTRLL 

       790        800        810        820        830        840 
CTHRTEYLER ADAVLLMEAG RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP 

       850        860        870        880        890        900 
EKTKEGLEEE QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN 

       910        920        930        940        950        960 
AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV FPLPKAAPNG 

       970        980        990       1000       1010       1020 
SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL HRRLLHRVLM APVTFFNATP 

      1030       1040       1050       1060       1070       1080 
TGRILNRFSS DVACADDSLP FILNILLANA AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH 

      1090       1100       1110       1120       1130       1140 
VQRHYRASSR ELRRLGSLTL SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC 

      1150       1160       1170       1180       1190       1200 
QFATSATMQW LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG 

      1210       1220       1230       1240       1250       1260 
LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD VVLAYRPGLP 

      1270       1280       1290       1300       1310       1320 
NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS SGRVLLDGVD TSQLELAQLR 

      1330       1340       1350       1360       1370       1380 
SQLAIIPQEP FLFSGTVREN LDPQGLHKDR ALWQALKQCH LSEVITSMGG LDGELGEGGR 

      1390       1400       1410       1420       1430       1440 
SLSLGQRQLL CLARALLTDA KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL 

      1450       1460       1470       1480       1490 
NTILNSDRVL VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP 

« Hide

Isoform 2 (Mrp7A) [UniParc].

Checksum: 31644BE052337EB3
Show »

FASTA1,464158,781

References

« Hide 'large scale' references
[1]"Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7."
Kao H.-H., Chang M.-S., Cheng J.-F., Huang J.-D.
J. Biomed. Sci. 10:98-110(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
Tissue: Small intestine.
[2]"Characterization of long cDNA clones from human adult spleen."
Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 793-1492 (ISOFORMS 1/2).
Tissue: Testis.
[5]"Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)."
Chen Z.-S., Hopper-Borge E., Belinsky M.G., Shchaveleva I., Kotova E., Kruh G.D.
Mol. Pharmacol. 63:351-358(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[6]"Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel."
Hopper-Borge E., Chen Z.-S., Shchaveleva I., Belinsky M.G., Kruh G.D.
Cancer Res. 64:4927-4930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463 AND SER-467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Web resources

ABCMdb

Database for mutations in ABC proteins

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY032599 mRNA. Translation: AAK39642.1.
AK000002 mRNA. Translation: BAA92227.1. Different initiation.
AK024446 mRNA. Translation: BAB15736.1. Sequence problems.
AL359813 Genomic DNA. Translation: CAI23217.1.
AL133613 mRNA. Translation: CAB63742.1.
PIRT43469.
RefSeqNP_001185863.1. NM_001198934.1.
NP_258261.2. NM_033450.2.
UniGeneHs.55879.

3D structure databases

ProteinModelPortalQ5T3U5.
SMRQ5T3U5. Positions 374-825, 867-1485.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124617. 2 interactions.
STRING9606.ENSP00000244533.

Chemistry

ChEMBLCHEMBL2073687.

PTM databases

PhosphoSiteQ5T3U5.

Polymorphism databases

DMDM74756298.

Proteomic databases

PaxDbQ5T3U5.
PRIDEQ5T3U5.

Protocols and materials databases

DNASU89845.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244533; ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
GeneID89845.
KEGGhsa:89845.
UCSCuc003ouy.1. human. [Q5T3U5-1]
uc003ouz.1. human. [Q5T3U5-2]

Organism-specific databases

CTD89845.
GeneCardsGC06P043442.
HGNCHGNC:52. ABCC10.
HPAHPA041607.
HPA045464.
MIM612509. gene.
neXtProtNX_Q5T3U5.
PharmGKBPA24392.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1132.
HOVERGENHBG107141.
InParanoidQ5T3U5.
KOK05674.
OMAHWQEGAR.
OrthoDBEOG7MWGW0.
PhylomeDBQ5T3U5.
TreeFamTF105203.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ5T3U5.
BgeeQ5T3U5.
CleanExHS_ABCC10.
GenevestigatorQ5T3U5.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABCC10. human.
GeneWikiABCC10.
GenomeRNAi89845.
NextBio76328.
PROQ5T3U5.
SOURCESearch...

Entry information

Entry nameMRP7_HUMAN
AccessionPrimary (citable) accession number: Q5T3U5
Secondary accession number(s): Q8NHX7 expand/collapse secondary AC list , Q9H7N2, Q9NXY3, Q9UF48
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM