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Q5T3U5

- MRP7_HUMAN

UniProt

Q5T3U5 - MRP7_HUMAN

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Protein

Multidrug resistance-associated protein 7

Gene

ABCC10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.2 Publications

Kineticsi

  1. KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi633 – 6408ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1280 – 12878ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_15480. ABC-family proteins mediated transport.

Protein family/group databases

TCDBi3.A.1.208.31. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
Gene namesi
Name:ABCC10
Synonyms:MRP7, SIMRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:52. ABCC10.

Subcellular locationi

Cell membrane 2 Publications; Multi-pass membrane protein 2 PublicationsPROSITE-ProRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24392.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14921492Multidrug resistance-associated protein 7PRO_0000253576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei463 – 4631Phosphothreonine1 Publication
Modified residuei467 – 4671Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T3U5.
PaxDbiQ5T3U5.
PRIDEiQ5T3U5.

PTM databases

PhosphoSiteiQ5T3U5.

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.1 Publication

Gene expression databases

BgeeiQ5T3U5.
CleanExiHS_ABCC10.
ExpressionAtlasiQ5T3U5. baseline and differential.
GenevestigatoriQ5T3U5.

Organism-specific databases

HPAiHPA041607.
HPA045464.

Interactioni

Protein-protein interaction databases

BioGridi124617. 4 interactions.
STRINGi9606.ENSP00000244533.

Structurei

3D structure databases

ProteinModelPortaliQ5T3U5.
SMRiQ5T3U5. Positions 374-837, 984-1479.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei70 – 9021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei102 – 12221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei133 – 15321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei172 – 19221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei293 – 31321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei320 – 34021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei391 – 41121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei414 – 43421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei507 – 52721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei538 – 55821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei875 – 89521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei933 – 95321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei974 – 99421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1051 – 107121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1153 – 117321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1182 – 120221HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini285 – 563279ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini598 – 824227ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini885 – 1210326ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1246 – 1479234ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00760000119433.
HOVERGENiHBG107141.
InParanoidiQ5T3U5.
KOiK05674.
OMAiHWQEGAR.
OrthoDBiEOG7MWGW0.
PhylomeDBiQ5T3U5.
TreeFamiTF105203.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T3U5-1) [UniParc]FASTAAdd to Basket

Also known as: Mrp7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL
60 70 80 90 100
GTPRSPDYIL PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL
110 120 130 140 150
EVLAGCVAAV AWISHSLALW VLAHSPHGHS RGPLALALVA LLPAPALVLT
160 170 180 190 200
VLWHCQRGTL LPPLLPGPMA RLCLLILQLA ALLAYALGWA APGGPREPWA
210 220 230 240 250
QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE LRQPQDICRL
260 270 280 290 300
PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF
310 320 330 340 350
SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK
360 370 380 390 400
VTLQARGAVL NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE
410 420 430 440 450
AWGLPLQLAI TLYLLYQQVG VAFVGGLILA LLLVPVNKVI ATRIMASNQE
460 470 480 490 500
MLQHKDARVK LVTELLSGIR VIKFCGWEQA LGARVEACRA RELGRLRVIK
510 520 530 540 550
YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA LALVRMLILP
560 570 580 590 600
LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL
610 620 630 640 650
HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL
660 670 680 690 700
HRLRGHVAVR GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE
710 720 730 740 750
ACALNDDLSI LPAGDQTEVG EKGVTLSGGQ RARIALARAV YQEKELYLLD
760 770 780 790 800
DPLAAVDADV ANHLLHRCIL GMLSYTTRLL CTHRTEYLER ADAVLLMEAG
810 820 830 840 850
RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP EKTKEGLEEE
860 870 880 890 900
QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN
910 920 930 940 950
AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV
960 970 980 990 1000
FPLPKAAPNG SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL
1010 1020 1030 1040 1050
HRRLLHRVLM APVTFFNATP TGRILNRFSS DVACADDSLP FILNILLANA
1060 1070 1080 1090 1100
AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH VQRHYRASSR ELRRLGSLTL
1110 1120 1130 1140 1150
SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC QFATSATMQW
1160 1170 1180 1190 1200
LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG
1210 1220 1230 1240 1250
LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD
1260 1270 1280 1290 1300
VVLAYRPGLP NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS
1310 1320 1330 1340 1350
SGRVLLDGVD TSQLELAQLR SQLAIIPQEP FLFSGTVREN LDPQGLHKDR
1360 1370 1380 1390 1400
ALWQALKQCH LSEVITSMGG LDGELGEGGR SLSLGQRQLL CLARALLTDA
1410 1420 1430 1440 1450
KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL NTILNSDRVL
1460 1470 1480 1490
VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP
Length:1,492
Mass (Da):161,629
Last modified:December 21, 2004 - v1
Checksum:i6FBC260DEFB3DF30
GO
Isoform 2 (identifier: Q5T3U5-2) [UniParc]FASTAAdd to Basket

Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     44-52: VLSACYLGT → MCLLVFPLV
     588-588: P → PDCGRLGAQIKWLLCS

Show »
Length:1,464
Mass (Da):158,781
Checksum:i31644BE052337EB3
GO

Sequence cautioni

The sequence BAB15736.1 differs from that shown. Reason: Intron retention.
The sequence BAA92227.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081D → E in AAK39642. (PubMed:12566991)Curated
Sequence conflicti220 – 2201Missing in AAK39642. (PubMed:12566991)Curated
Sequence conflicti631 – 6311I → T in AAK39642. (PubMed:12566991)Curated
Sequence conflicti764 – 7641L → P in AAK39642. (PubMed:12566991)Curated
Sequence conflicti809 – 8091S → P in AAK39642. (PubMed:12566991)Curated
Sequence conflicti888 – 8881I → T in AAK39642. (PubMed:12566991)Curated
Sequence conflicti1030 – 10301S → F in AAK39642. (PubMed:12566991)Curated
Sequence conflicti1134 – 11341L → F in BAB15736. (PubMed:11214971)Curated
Sequence conflicti1276 – 12761L → V in AAK39642. (PubMed:12566991)Curated
Sequence conflicti1455 – 14551G → E in AAK39642. (PubMed:12566991)Curated
Sequence conflicti1481 – 14811S → C in AAK39642. (PubMed:12566991)Curated
Sequence conflicti1490 – 14901G → R in AAK39642. (PubMed:12566991)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti948 – 9481I → T.
Corresponds to variant rs2125739 [ dbSNP | Ensembl ].
VAR_028391

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4343Missing in isoform 2. 1 PublicationVSP_021078Add
BLAST
Alternative sequencei44 – 529VLSACYLGT → MCLLVFPLV in isoform 2. 1 PublicationVSP_021079
Alternative sequencei588 – 5881P → PDCGRLGAQIKWLLCS in isoform 2. 1 PublicationVSP_021080

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032599 mRNA. Translation: AAK39642.1.
AK000002 mRNA. Translation: BAA92227.1. Different initiation.
AK024446 mRNA. Translation: BAB15736.1. Sequence problems.
AL359813 Genomic DNA. Translation: CAI23217.1.
AL133613 mRNA. Translation: CAB63742.1.
CCDSiCCDS4896.1. [Q5T3U5-2]
CCDS56430.1. [Q5T3U5-1]
PIRiT43469.
RefSeqiNP_001185863.1. NM_001198934.1. [Q5T3U5-1]
NP_258261.2. NM_033450.2. [Q5T3U5-2]
UniGeneiHs.55879.

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574. [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574. [Q5T3U5-1]
GeneIDi89845.
KEGGihsa:89845.
UCSCiuc003ouy.1. human. [Q5T3U5-1]
uc003ouz.1. human. [Q5T3U5-2]

Polymorphism databases

DMDMi74756298.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY032599 mRNA. Translation: AAK39642.1 .
AK000002 mRNA. Translation: BAA92227.1 . Different initiation.
AK024446 mRNA. Translation: BAB15736.1 . Sequence problems.
AL359813 Genomic DNA. Translation: CAI23217.1 .
AL133613 mRNA. Translation: CAB63742.1 .
CCDSi CCDS4896.1. [Q5T3U5-2 ]
CCDS56430.1. [Q5T3U5-1 ]
PIRi T43469.
RefSeqi NP_001185863.1. NM_001198934.1. [Q5T3U5-1 ]
NP_258261.2. NM_033450.2. [Q5T3U5-2 ]
UniGenei Hs.55879.

3D structure databases

ProteinModelPortali Q5T3U5.
SMRi Q5T3U5. Positions 374-837, 984-1479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124617. 4 interactions.
STRINGi 9606.ENSP00000244533.

Chemistry

ChEMBLi CHEMBL2073687.
DrugBanki DB00091. Cyclosporine.
DB00987. Cytarabine.
DB00694. Daunorubicin.
DB01248. Docetaxel.
DB00997. Doxorubicin.
DB00783. Estradiol.
DB00773. Etoposide.
DB00441. Gemcitabine.
DB00563. Methotrexate.
DB01229. Paclitaxel.
DB00203. Sildenafil.
DB00300. Tenofovir.
DB00661. Verapamil.
DB00541. Vincristine.

Protein family/group databases

TCDBi 3.A.1.208.31. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q5T3U5.

Polymorphism databases

DMDMi 74756298.

Proteomic databases

MaxQBi Q5T3U5.
PaxDbi Q5T3U5.
PRIDEi Q5T3U5.

Protocols and materials databases

DNASUi 89845.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244533 ; ENSP00000244533 ; ENSG00000124574 . [Q5T3U5-2 ]
ENST00000372530 ; ENSP00000361608 ; ENSG00000124574 . [Q5T3U5-1 ]
GeneIDi 89845.
KEGGi hsa:89845.
UCSCi uc003ouy.1. human. [Q5T3U5-1 ]
uc003ouz.1. human. [Q5T3U5-2 ]

Organism-specific databases

CTDi 89845.
GeneCardsi GC06P043396.
HGNCi HGNC:52. ABCC10.
HPAi HPA041607.
HPA045464.
MIMi 612509. gene.
neXtProti NX_Q5T3U5.
PharmGKBi PA24392.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00760000119433.
HOVERGENi HBG107141.
InParanoidi Q5T3U5.
KOi K05674.
OMAi HWQEGAR.
OrthoDBi EOG7MWGW0.
PhylomeDBi Q5T3U5.
TreeFami TF105203.

Enzyme and pathway databases

Reactomei REACT_15480. ABC-family proteins mediated transport.

Miscellaneous databases

ChiTaRSi ABCC10. human.
GeneWikii ABCC10.
GenomeRNAii 89845.
NextBioi 76328.
PROi Q5T3U5.
SOURCEi Search...

Gene expression databases

Bgeei Q5T3U5.
CleanExi HS_ABCC10.
ExpressionAtlasi Q5T3U5. baseline and differential.
Genevestigatori Q5T3U5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7."
    Kao H.-H., Chang M.-S., Cheng J.-F., Huang J.-D.
    J. Biomed. Sci. 10:98-110(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Small intestine.
  2. "Characterization of long cDNA clones from human adult spleen."
    Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
    DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 793-1492 (ISOFORMS 1/2).
    Tissue: Testis.
  5. "Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)."
    Chen Z.-S., Hopper-Borge E., Belinsky M.G., Shchaveleva I., Kotova E., Kruh G.D.
    Mol. Pharmacol. 63:351-358(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  6. "Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel."
    Hopper-Borge E., Chen Z.-S., Shchaveleva I., Belinsky M.G., Kruh G.D.
    Cancer Res. 64:4927-4930(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463 AND SER-467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiMRP7_HUMAN
AccessioniPrimary (citable) accession number: Q5T3U5
Secondary accession number(s): Q8NHX7
, Q9H7N2, Q9NXY3, Q9UF48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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