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Q5T3N0

- Q5T3N0_HUMAN

UniProt

Q5T3N0 - Q5T3N0_HUMAN

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Protein

Annexin

Gene

ANXA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB-KW
  2. calcium ion binding Source: InterPro
  3. phospholipase A2 inhibitor activity Source: Ensembl

GO - Biological processi

  1. alpha-beta T cell differentiation Source: Ensembl
  2. arachidonic acid secretion Source: Ensembl
  3. cell surface receptor signaling pathway Source: Ensembl
  4. cellular response to glucocorticoid stimulus Source: Ensembl
  5. cellular response to hydrogen peroxide Source: Ensembl
  6. endocrine pancreas development Source: Ensembl
  7. estrous cycle phase Source: Ensembl
  8. gliogenesis Source: Ensembl
  9. hepatocyte differentiation Source: Ensembl
  10. insulin secretion Source: Ensembl
  11. negative regulation of acute inflammatory response Source: Ensembl
  12. negative regulation of apoptotic process Source: Ensembl
  13. negative regulation of protein secretion Source: Ensembl
  14. neutrophil homeostasis Source: Ensembl
  15. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  16. positive regulation of neutrophil apoptotic process Source: Ensembl
  17. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  18. regulation of cell proliferation Source: Ensembl
  19. response to drug Source: Ensembl
  20. response to estradiol Source: Ensembl
  21. response to interleukin-1 Source: Ensembl
  22. response to peptide hormone Source: Ensembl
  23. response to X-ray Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:533. ANXA1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. extracellular space Source: Ensembl
  3. mitochondrial membrane Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: HPA
  6. protein complex Source: Ensembl
  7. sarcolemma Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ5T3N0.

Expressioni

Gene expression databases

ExpressionAtlasiQ5T3N0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5T3N0.
SMRiQ5T3N0. Positions 2-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation
Contains 1 annexin repeat.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view]
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTiSM00335. ANX. 1 hit.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5T3N0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110
TGHLEEVVLA LLKTP
Length:115
Mass (Da):12,643
Last modified:December 21, 2004 - v1
Checksum:iEF00F9FFBD3C7875
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei115 – 1151Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL359997 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000415424; ENSP00000414013; ENSG00000135046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL359997 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5T3N0.
SMRi Q5T3N0. Positions 2-115.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5T3N0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000415424 ; ENSP00000414013 ; ENSG00000135046 .

Organism-specific databases

HGNCi HGNC:533. ANXA1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118972.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.

Miscellaneous databases

ChiTaRSi ANXA1. human.

Gene expression databases

ExpressionAtlasi Q5T3N0. baseline and differential.

Family and domain databases

Gene3Di 1.10.220.10. 1 hit.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002388. AnnexinI.
[Graphical view ]
Pfami PF00191. Annexin. 1 hit.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00197. ANNEXINI.
SMARTi SM00335. ANX. 1 hit.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5T3N0_HUMAN
AccessioniPrimary (citable) accession number: Q5T3N0
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3