Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin

Gene

ANXA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:ANXA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000135046.13
HGNCiHGNC:533 ANXA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135046

PTM / Processingi

Proteomic databases

MaxQBiQ5T3N0
PeptideAtlasiQ5T3N0
PRIDEiQ5T3N0

Expressioni

Gene expression databases

BgeeiENSG00000135046
ExpressionAtlasiQ5T3N0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T3N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815

Family and domain databases

Gene3Di1.10.220.10, 1 hit
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002388 ANX1
PANTHERiPTHR10502:SF17 PTHR10502:SF17, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 1 hit
PRINTSiPR00196 ANNEXIN
PR00197 ANNEXINI
SMARTiView protein in SMART
SM00335 ANX, 1 hit
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 1 hit

Sequencei

Sequence statusi: Fragment.

Q5T3N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110
TGHLEEVVLA LLKTP
Length:115
Mass (Da):12,643
Last modified:December 21, 2004 - v1
Checksum:iEF00F9FFBD3C7875
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei115Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359997 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000415424; ENSP00000414013; ENSG00000135046
UCSCiuc064tth.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5T3N0_HUMAN
AccessioniPrimary (citable) accession number: Q5T3N0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health