Q5T3E6 (Q5T3E6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Integrin beta-1 Ensembl ENSP00000398029

Gene names

Name:

ITGB1 Ensembl ENSP00000398029

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000398029

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	136 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000398029

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G1/S transition of mitotic cell cycle Inferred from electronic annotation. Source: Compara cardiac muscle cell differentiation Inferred from electronic annotation. Source: Compara cell fate specification Inferred from electronic annotation. Source: Compara cell migration involved in sprouting angiogenesis Inferred from electronic annotation. Source: Compara cell-matrix adhesion Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular response to ionizing radiation Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara cellular response to vitamin D Inferred from electronic annotation. Source: Compara germ cell migration Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara integrin-mediated signaling pathway Inferred from electronic annotation. Source: Compara maternal process involved in female pregnancy Inferred from electronic annotation. Source: Compara negative regulation of cell projection organization Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cell-substrate adhesion Inferred from electronic annotation. Source: Compara positive regulation of endocytosis Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara protein transport within lipid bilayer Inferred from electronic annotation. Source: Compara regulation of G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara response to activity Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to gonadotropin stimulus Inferred from electronic annotation. Source: Compara response to transforming growth factor beta stimulus Inferred from electronic annotation. Source: Compara sarcomere organization Inferred from electronic annotation. Source: Compara tight junction assembly Inferred from electronic annotation. Source: Compara tissue homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	acrosomal vesicle Inferred from electronic annotation. Source: Compara alpha3-beta1 integrin complex Inferred from electronic annotation. Source: Compara alpha9-beta1 integrin complex Inferred from electronic annotation. Source: Compara basement membrane Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from electronic annotation. Source: Compara focal adhesion Inferred from electronic annotation. Source: Compara hemidesmosome Inferred from electronic annotation. Source: Compara intercalated disc Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara myelin sheath abaxonal region Inferred from electronic annotation. Source: Compara neuromuscular junction Inferred from electronic annotation. Source: Compara sarcolemma Inferred from electronic annotation. Source: Compara
Molecular_function	peptide binding Inferred from electronic annotation. Source: Compara receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	136	1	Ensembl ENSP00000398029

Sequences

	Sequence		Length	Mass (Da)
	Q5T3E6 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 780C560B9A9CE3AF	FASTA	136	15,105
	10 20 30 40 50 60 MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 70 80 90 100 110 120 SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV 130 LRLRSGEPQT FTLKFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL365203 Genomic DNA. No translation available.
IPI	IPI00979111.
3D structure databases
SMR	Q5T3E6. Positions 25-136.
ModBase	Search...
Proteomic databases
PRIDE	Q5T3E6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000437302; ENSP00000398029; ENSG00000150093.
Organism-specific databases
HGNC	HGNC:6153. ITGB1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000252936.
Enzyme and pathway databases
SignaLink	Q5T3E6.
Gene expression databases
ArrayExpress	Q5T3E6.
Family and domain databases
InterPro	IPR027071. Integrin_beta-1. IPR015812. Integrin_bsu. IPR002369. Integrin_bsu_N. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. [Graphical view]
PANTHER	PTHR10082. PTHR10082. 1 hit. PTHR10082:SF28. PTHR10082:SF28. 1 hit.
Pfam	PF00362. Integrin_beta. 1 hit. [Graphical view]
PRINTS	PR01186. INTEGRINB.
SMART	SM00187. INB. 1 hit. SM00423. PSI. 1 hit. [Graphical view]
SUPFAM	SSF103575. Plexin-like_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	ITGB1. human.

Entry information

Entry name

Q5T3E6_HUMAN

Accession

Primary (citable) accession number: Q5T3E6

Entry history

Integrated into UniProtKB/TrEMBL:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	May 29, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.