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Q5T3E6

- Q5T3E6_HUMAN

UniProt

Q5T3E6 - Q5T3E6_HUMAN

Protein

Integrin beta

Gene

ITGB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. peptide binding Source: Ensembl
    2. receptor activity Source: InterPro

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: Ensembl
    2. cell fate specification Source: Ensembl
    3. cell-matrix adhesion Source: Ensembl
    4. cell migration involved in sprouting angiogenesis Source: Ensembl
    5. cellular calcium ion homeostasis Source: Ensembl
    6. cellular response to ionizing radiation Source: Ensembl
    7. cellular response to mechanical stimulus Source: Ensembl
    8. cellular response to vitamin D Source: Ensembl
    9. formation of radial glial scaffolds Source: Ensembl
    10. G1/S transition of mitotic cell cycle Source: Ensembl
    11. germ cell migration Source: Ensembl
    12. integrin-mediated signaling pathway Source: UniProtKB-KW
    13. in utero embryonic development Source: Ensembl
    14. maternal process involved in female pregnancy Source: Ensembl
    15. negative regulation of cell projection organization Source: Ensembl
    16. negative regulation of cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron projection development Source: Ensembl
    19. positive regulation of cell migration Source: Ensembl
    20. positive regulation of cell proliferation Source: Ensembl
    21. positive regulation of cell-substrate adhesion Source: Ensembl
    22. positive regulation of endocytosis Source: Ensembl
    23. positive regulation of MAPK cascade Source: Ensembl
    24. positive regulation of neuron differentiation Source: Ensembl
    25. positive regulation of neuron projection development Source: Ensembl
    26. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    27. protein transport within lipid bilayer Source: Ensembl
    28. regulation of cell cycle Source: Ensembl
    29. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    30. response to activity Source: Ensembl
    31. response to drug Source: Ensembl
    32. response to gonadotropin Source: Ensembl
    33. response to transforming growth factor beta Source: Ensembl
    34. sarcomere organization Source: Ensembl
    35. tight junction assembly Source: Ensembl
    36. tissue homeostasis Source: Ensembl

    Keywords - Molecular functioni

    IntegrinUniRule annotation

    Keywords - Biological processi

    Cell adhesionUniRule annotation

    Enzyme and pathway databases

    SignaLinkiQ5T3E6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrin betaUniRule annotation
    Gene namesi
    Name:ITGB1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:6153. ITGB1.

    Subcellular locationi

    Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. basement membrane Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. focal adhesion Source: Ensembl
    5. hemidesmosome Source: Ensembl
    6. integrin alpha3-beta1 complex Source: Ensembl
    7. integrin alpha7-beta1 complex Source: Ensembl
    8. integrin alpha9-beta1 complex Source: Ensembl
    9. intercalated disc Source: Ensembl
    10. membrane raft Source: Ensembl
    11. myelin sheath abaxonal region Source: Ensembl
    12. neuromuscular junction Source: Ensembl
    13. sarcolemma Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Proteomic databases

    PRIDEiQ5T3E6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T3E6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T3E6.
    SMRiQ5T3E6. Positions 25-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the integrin beta chain family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000252936.

    Family and domain databases

    InterProiIPR027071. Integrin_beta-1.
    IPR015812. Integrin_bsu.
    IPR002369. Integrin_bsu_N.
    IPR016201. Plexin-like_fold.
    [Graphical view]
    PANTHERiPTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF28. PTHR10082:SF28. 1 hit.
    PfamiPF00362. Integrin_beta. 1 hit.
    [Graphical view]
    PRINTSiPR01186. INTEGRINB.
    SMARTiSM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    [Graphical view]
    SUPFAMiSSF103575. SSF103575. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q5T3E6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN    50
    STFLQEGMPT SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK 100
    GTAEKLKPED ITQIQPQQLV LRLRSGEPQT FTLKFK 136
    Length:136
    Mass (Da):15,105
    Last modified:December 21, 2004 - v1
    Checksum:i780C560B9A9CE3AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei136 – 1361Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365203 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000437302; ENSP00000398029; ENSG00000150093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365203 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5T3E6.
    SMRi Q5T3E6. Positions 25-136.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q5T3E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000437302 ; ENSP00000398029 ; ENSG00000150093 .

    Organism-specific databases

    HGNCi HGNC:6153. ITGB1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000252936.

    Enzyme and pathway databases

    SignaLinki Q5T3E6.

    Miscellaneous databases

    ChiTaRSi ITGB1. human.

    Gene expression databases

    ArrayExpressi Q5T3E6.

    Family and domain databases

    InterProi IPR027071. Integrin_beta-1.
    IPR015812. Integrin_bsu.
    IPR002369. Integrin_bsu_N.
    IPR016201. Plexin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10082. PTHR10082. 1 hit.
    PTHR10082:SF28. PTHR10082:SF28. 1 hit.
    Pfami PF00362. Integrin_beta. 1 hit.
    [Graphical view ]
    PRINTSi PR01186. INTEGRINB.
    SMARTi SM00187. INB. 1 hit.
    SM00423. PSI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103575. SSF103575. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ5T3E6_HUMAN
    AccessioniPrimary (citable) accession number: Q5T3E6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3