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Protein

Integrin beta

Gene

ITGB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. peptide binding Source: Ensembl
  2. receptor activity Source: InterPro

GO - Biological processi

  1. axon extension Source: Ensembl
  2. cardiac muscle cell differentiation Source: Ensembl
  3. cell fate specification Source: Ensembl
  4. cell-matrix adhesion Source: Ensembl
  5. cell migration involved in sprouting angiogenesis Source: Ensembl
  6. cellular calcium ion homeostasis Source: Ensembl
  7. cellular response to ionizing radiation Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. cellular response to vitamin D Source: Ensembl
  10. dendrite morphogenesis Source: Ensembl
  11. formation of radial glial scaffolds Source: Ensembl
  12. G1/S transition of mitotic cell cycle Source: Ensembl
  13. germ cell migration Source: Ensembl
  14. integrin-mediated signaling pathway Source: UniProtKB-KW
  15. in utero embryonic development Source: Ensembl
  16. maternal process involved in female pregnancy Source: Ensembl
  17. negative regulation of cell projection organization Source: Ensembl
  18. negative regulation of cell proliferation Source: Ensembl
  19. negative regulation of neuron differentiation Source: Ensembl
  20. negative regulation of Rho protein signal transduction Source: Ensembl
  21. positive regulation of cell migration Source: Ensembl
  22. positive regulation of cell proliferation Source: Ensembl
  23. positive regulation of cell-substrate adhesion Source: Ensembl
  24. positive regulation of endocytosis Source: Ensembl
  25. positive regulation of MAPK cascade Source: Ensembl
  26. positive regulation of neuron projection development Source: Ensembl
  27. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  28. protein transport within lipid bilayer Source: Ensembl
  29. regulation of cell cycle Source: Ensembl
  30. regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  31. response to activity Source: Ensembl
  32. response to drug Source: Ensembl
  33. response to gonadotropin Source: Ensembl
  34. response to transforming growth factor beta Source: Ensembl
  35. sarcomere organization Source: Ensembl
  36. tight junction assembly Source: Ensembl
  37. tissue homeostasis Source: Ensembl
  38. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotation

Keywords - Biological processi

Cell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiQ5T3E6.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:6153. ITGB1.

Subcellular locationi

Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. basement membrane Source: Ensembl
  3. dendritic spine Source: Ensembl
  4. external side of plasma membrane Source: Ensembl
  5. focal adhesion Source: Ensembl
  6. hemidesmosome Source: Ensembl
  7. integrin alpha3-beta1 complex Source: Ensembl
  8. integrin alpha7-beta1 complex Source: Ensembl
  9. integrin alpha9-beta1 complex Source: Ensembl
  10. intercalated disc Source: Ensembl
  11. membrane raft Source: Ensembl
  12. myelin sheath abaxonal region Source: Ensembl
  13. neuromuscular junction Source: Ensembl
  14. sarcolemma Source: Ensembl
  15. synaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ5T3E6.

Expressioni

Gene expression databases

ExpressionAtlasiQ5T3E6. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ5T3E6.
SMRiQ5T3E6. Positions 25-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.

Family and domain databases

InterProiIPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR002369. Integrin_bsu_N.
IPR016201. Plexin-like_fold.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
PfamiPF00362. Integrin_beta. 1 hit.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5T3E6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN
60 70 80 90 100
STFLQEGMPT SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK
110 120 130
GTAEKLKPED ITQIQPQQLV LRLRSGEPQT FTLKFK
Length:136
Mass (Da):15,105
Last modified:December 21, 2004 - v1
Checksum:i780C560B9A9CE3AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei136 – 1361Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365203 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000437302; ENSP00000398029; ENSG00000150093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL365203 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5T3E6.
SMRiQ5T3E6. Positions 25-136.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ5T3E6.

Proteomic databases

PRIDEiQ5T3E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437302; ENSP00000398029; ENSG00000150093.

Organism-specific databases

HGNCiHGNC:6153. ITGB1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.

Enzyme and pathway databases

SignaLinkiQ5T3E6.

Miscellaneous databases

ChiTaRSiITGB1. human.

Gene expression databases

ExpressionAtlasiQ5T3E6. baseline and differential.

Family and domain databases

InterProiIPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR002369. Integrin_bsu_N.
IPR016201. Plexin-like_fold.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
PfamiPF00362. Integrin_beta. 1 hit.
[Graphical view]
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5T3E6_HUMAN
AccessioniPrimary (citable) accession number: Q5T3E6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.