ID   Q5T3E4_HUMAN            Unreviewed;        49 AA.
AC   Q5T3E4;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 123.
DE   SubName: Full=Integrin subunit beta 1 {ECO:0000313|Ensembl:ENSP00000400544.1};
DE   Flags: Fragment;
GN   Name=ITGB1 {ECO:0000313|Ensembl:ENSP00000400544.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400544.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400544.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000400544.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL365203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5T3E4; -.
DR   MassIVE; Q5T3E4; -.
DR   PeptideAtlas; Q5T3E4; -.
DR   ProteomicsDB; 64385; -.
DR   Antibodypedia; 3126; 3334 antibodies from 52 providers.
DR   Ensembl; ENST00000414670.2; ENSP00000400544.1; ENSG00000150093.20.
DR   UCSC; uc057squ.1; human.
DR   HGNC; HGNC:6153; ITGB1.
DR   VEuPathDB; HostDB:ENSG00000150093; -.
DR   GeneTree; ENSGT01090000259987; -.
DR   HOGENOM; CLU_3146921_0_0_1; -.
DR   OMA; NCVCGAC; -.
DR   ChiTaRS; ITGB1; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000150093; Expressed in visceral pleura and 212 other cell types or tissues.
DR   ExpressionAtlas; Q5T3E4; baseline and differential.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   InterPro; IPR033760; Integrin_beta_N.
DR   Pfam; PF17205; PSI_integrin; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00022692};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q5T3E4,
KW   ECO:0007829|ProteomicsDB:Q5T3E4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..49
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004262987"
FT   DOMAIN          25..49
FT                   /note="Integrin beta N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17205"
FT   NON_TER         49
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000400544.1"
SQ   SEQUENCE   49 AA;  5325 MW;  75C953A947A48D37 CRC64;
     MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCT
//