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Protein

Ubiquitinyl hydrolase 1

Gene

USP49

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 85UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation
Biological processUbl conjugation pathwaySAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitinyl hydrolase 1SAAS annotation (EC:3.4.19.12SAAS annotation)
Gene namesi
Name:USP49Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164663.13
HGNCiHGNC:20078 USP49

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000164663

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5T3E1
PRIDEiQ5T3E1

Expressioni

Gene expression databases

BgeeiENSG00000164663
ExpressionAtlasiQ5T3E1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T3E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 85UBP-typeInterPro annotationAdd BLAST62
Domaini253 – 585USPInterPro annotationAdd BLAST333

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili164 – 202Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 85UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiKOG1867 Eukaryota
ENOG410XQQ0 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000015084
HOVERGENiHBG018027

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 2 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T3E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI
60 70 80 90 100
EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL
110 120 130 140 150
AVRGQKQDTP VRRGRTLRSM ASGEDVVLPQ RAPQGQPQML TALWYRRQRL
160 170 180 190 200
LARTLRLWFE KSSRGQAKLE QRRQEEALER KKEEARRRRR EVKRRLLEEL
210 220 230 240 250
ASTPPRKSAR LLLHTPRDAG PAASRPAALP TSRRVPAATL KLRRQPAMAP
260 270 280 290 300
GVTGLRNLGN TCYMNSILQV LSHLQKFREC FLNLDPSKTE HLFPKATNGK
310 320 330 340 350
TQLSGKPTNS SATELSLRND RAEACEREGF CWNGRASISR SLELIQNKEP
360 370 380 390 400
SSKHISLCRE LHTLFRVMWS GKWALVSPFA MLHSVWSLIP AFRGYDQQDA
410 420 430 440 450
QEFLCELLHK VQQELESEGT TRRILIPFSQ RKLTKQVLKV VNTIFHGQLL
460 470 480 490 500
SQVTCISCNY KSNTIEPFWD LSLEFPERYH CIEKGFVPLN QTECLLTEML
510 520 530 540 550
AKFTETEALE GRIYACDQCN SKRRKSNPKP LVLSEARKQL MIYRLPQVLR
560 570 580
LHLKRFRWSG RNHREKIGVH VVFDQVFGST AMTQS
Length:585
Mass (Da):67,479
Last modified:December 21, 2004 - v1
Checksum:i9086CAFA8DC94743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160163 Genomic DNA No translation available.
AL365205 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000373010; ENSP00000362101; ENSG00000164663
UCSCiuc063oly.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5T3E1_HUMAN
AccessioniPrimary (citable) accession number: Q5T3E1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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