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Q5T2W1

- NHRF3_HUMAN

UniProt

Q5T2W1 - NHRF3_HUMAN

Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Gene

PDZK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function By similarity.By similarity

    GO - Molecular functioni

    1. PDZ domain binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. transporter activity Source: UniProtKB

    GO - Biological processi

    1. carnitine transport Source: BHF-UCL
    2. cell proliferation Source: UniProtKB
    3. drug transport Source: UniProtKB
    4. establishment of protein localization to plasma membrane Source: Ensembl
    5. positive regulation of ion transmembrane transport Source: BHF-UCL
    6. positive regulation of protein targeting to membrane Source: UniProtKB
    7. regulation of anion transport Source: UniProtKB
    8. transport Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Na(+)/H(+) exchange regulatory cofactor NHE-RF3
    Short name:
    NHERF-3
    Alternative name(s):
    CFTR-associated protein of 70 kDa
    Na(+)/H(+) exchanger regulatory factor 3
    Na/Pi cotransporter C-terminal-associated protein 1
    Short name:
    NaPi-Cap1
    PDZ domain-containing protein 1
    Sodium-hydrogen exchanger regulatory factor 3
    Gene namesi
    Name:PDZK1
    Synonyms:CAP70, NHERF3, PDZD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8821. PDZK1.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity
    Note: Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. brush border membrane Source: UniProtKB
    3. cytoplasm Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. membrane raft Source: Ensembl
    6. microvillus membrane Source: Ensembl
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33165.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Na(+)/H(+) exchange regulatory cofactor NHE-RF3PRO_0000058287Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei492 – 4921PhosphoserineBy similarity
    Modified residuei514 – 5141PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5T2W1.
    PaxDbiQ5T2W1.
    PRIDEiQ5T2W1.

    PTM databases

    PhosphoSiteiQ5T2W1.

    Expressioni

    Tissue specificityi

    Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.3 Publications

    Gene expression databases

    BgeeiQ5T2W1.
    CleanExiHS_PDZK1.
    GenevestigatoriQ5T2W1.

    Organism-specific databases

    HPAiCAB008971.
    HPA005755.
    HPA006155.

    Interactioni

    Subunit structurei

    Interacts with PDZK1IP1 and ABCC2. Interacts (via PDZ domains 1 and 3) with SCARB1 (C-terminal domain). Forms a heterodimeric complex with SLC9A3R1. Interacts with AKAP2, BCR, CFTR, SLC22A12, SLC22A4, SLC22A5, SLC9A3R2 and SLC17A1. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts (via the first PDZ domain) with PTGIR (via non-isoprenylated C-terminus) By similarity. Interacts (via C-terminal PDZ domain) with SLC26A6 (via C-terminal domain) By similarity. Interacts (via C-terminal PDZ domain) with SLC9A3 (via C-terminal domain).By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CFTRP135692EBI-349819,EBI-349854

    Protein-protein interaction databases

    BioGridi111200. 25 interactions.
    IntActiQ5T2W1. 10 interactions.
    MINTiMINT-4999193.
    STRINGi9606.ENSP00000342143.

    Structurei

    Secondary structure

    1
    519
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi132 – 1398
    Beta strandi142 – 1443
    Helixi168 – 1725
    Beta strandi176 – 1838
    Helixi193 – 20311
    Beta strandi205 – 2117
    Turni214 – 2163
    Beta strandi376 – 3827
    Beta strandi385 – 3873
    Beta strandi389 – 3924
    Beta strandi398 – 4058
    Helixi411 – 4144
    Beta strandi422 – 4265
    Beta strandi432 – 4343
    Helixi436 – 4438
    Beta strandi448 – 4558

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EEINMR-A132-224[»]
    2EEJNMR-A376-458[»]
    2VSPX-ray2.60A/B/C/D375-459[»]
    3TMHX-ray3.80A/E/I375-459[»]
    ProteinModelPortaliQ5T2W1.
    SMRiQ5T2W1. Positions 1-107, 132-357, 375-517.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5T2W1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 9082PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 21582PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini243 – 32381PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini378 – 45881PDZ 4PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.By similarity
    Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.By similarity
    The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.By similarity
    The PDZ 1 domain interacts with BCR.
    The PDZ 2 and 4 domains do not interact with the C-terminal region of SCARB1.By similarity

    Sequence similaritiesi

    Belongs to the NHER family.Curated
    Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG315208.
    HOGENOMiHOG000113782.
    HOVERGENiHBG082115.
    InParanoidiQ5T2W1.
    OMAiFNPRECK.
    OrthoDBiEOG73V6K7.
    PhylomeDBiQ5T2W1.
    TreeFamiTF350449.

    Family and domain databases

    Gene3Di2.30.42.10. 4 hits.
    InterProiIPR001478. PDZ.
    [Graphical view]
    PfamiPF00595. PDZ. 4 hits.
    [Graphical view]
    SMARTiSM00228. PDZ. 4 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 4 hits.
    PROSITEiPS50106. PDZ. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T2W1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ    50
    DGDRVLRING VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAVKTRV 100
    DLKELGQSQK EQGLSDNILS PVMNGGVQTW TQPRLCYLVK EGGSYGFSLK 150
    TVQGKKGVYM TDITPQGVAM RAGVLADDHL IEVNGENVED ASHEEVVEKV 200
    KKSGSRVMFL LVDKETDKRH VEQKIQFKRE TASLKLLPHQ PRIVEMKKGS 250
    NGYGFYLRAG SEQKGQIIKD IDSGSPAEEA GLKNNDLVVA VNGESVETLD 300
    HDSVVEMIRK GGDQTSLLVV DKETDNMYRL AHFSPFLYYQ SQELPNGSVK 350
    EAPAPTPTSL EVSSPPDTTE EVDHKPKLCR LAKGENGYGF HLNAIRGLPG 400
    SFIKEVQKGG PADLAGLEDE DVIIEVNGVN VLDEPYEKVV DRIQSSGKNV 450
    TLLVCGKKAY DYFQAKKIPI VSSLADPLDT PPDSKEGIVV ESNHDSHMAK 500
    ERAHSTASHS SSNSEDTEM 519
    Length:519
    Mass (Da):57,129
    Last modified:August 16, 2005 - v2
    Checksum:i98BF707F87CD77A6
    GO
    Isoform 2 (identifier: Q5T2W1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-264: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:408
    Mass (Da):44,665
    Checksum:i6AF5DA3B9EF406E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti195 – 1951E → K in AAC12264. (PubMed:9461128)Curated
    Sequence conflicti270 – 2701D → G in BAG60531. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei154 – 264111Missing in isoform 2. 1 PublicationVSP_044637Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012281 mRNA. Translation: AAC12264.1.
    AK298269 mRNA. Translation: BAG60531.1.
    AL390725 Genomic DNA. Translation: CAI13715.1.
    AL390725 Genomic DNA. Translation: CAI13716.1.
    BC006496 mRNA. Translation: AAH06496.1.
    BC006518 mRNA. Translation: AAH06518.1.
    CCDSiCCDS55629.1. [Q5T2W1-2]
    CCDS924.1. [Q5T2W1-1]
    RefSeqiNP_001188254.1. NM_001201325.1. [Q5T2W1-1]
    NP_001188255.1. NM_001201326.1. [Q5T2W1-2]
    NP_002605.2. NM_002614.4. [Q5T2W1-1]
    UniGeneiHs.444751.
    Hs.732345.

    Genome annotation databases

    EnsembliENST00000344770; ENSP00000342143; ENSG00000174827. [Q5T2W1-1]
    ENST00000417171; ENSP00000394485; ENSG00000174827. [Q5T2W1-1]
    ENST00000443667; ENSP00000409291; ENSG00000174827.
    ENST00000451928; ENSP00000403422; ENSG00000174827. [Q5T2W1-2]
    GeneIDi5174.
    KEGGihsa:5174.
    UCSCiuc001eon.2. human. [Q5T2W1-1]

    Polymorphism databases

    DMDMi73621372.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012281 mRNA. Translation: AAC12264.1 .
    AK298269 mRNA. Translation: BAG60531.1 .
    AL390725 Genomic DNA. Translation: CAI13715.1 .
    AL390725 Genomic DNA. Translation: CAI13716.1 .
    BC006496 mRNA. Translation: AAH06496.1 .
    BC006518 mRNA. Translation: AAH06518.1 .
    CCDSi CCDS55629.1. [Q5T2W1-2 ]
    CCDS924.1. [Q5T2W1-1 ]
    RefSeqi NP_001188254.1. NM_001201325.1. [Q5T2W1-1 ]
    NP_001188255.1. NM_001201326.1. [Q5T2W1-2 ]
    NP_002605.2. NM_002614.4. [Q5T2W1-1 ]
    UniGenei Hs.444751.
    Hs.732345.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EEI NMR - A 132-224 [» ]
    2EEJ NMR - A 376-458 [» ]
    2VSP X-ray 2.60 A/B/C/D 375-459 [» ]
    3TMH X-ray 3.80 A/E/I 375-459 [» ]
    ProteinModelPortali Q5T2W1.
    SMRi Q5T2W1. Positions 1-107, 132-357, 375-517.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111200. 25 interactions.
    IntActi Q5T2W1. 10 interactions.
    MINTi MINT-4999193.
    STRINGi 9606.ENSP00000342143.

    PTM databases

    PhosphoSitei Q5T2W1.

    Polymorphism databases

    DMDMi 73621372.

    Proteomic databases

    MaxQBi Q5T2W1.
    PaxDbi Q5T2W1.
    PRIDEi Q5T2W1.

    Protocols and materials databases

    DNASUi 5174.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344770 ; ENSP00000342143 ; ENSG00000174827 . [Q5T2W1-1 ]
    ENST00000417171 ; ENSP00000394485 ; ENSG00000174827 . [Q5T2W1-1 ]
    ENST00000443667 ; ENSP00000409291 ; ENSG00000174827 .
    ENST00000451928 ; ENSP00000403422 ; ENSG00000174827 . [Q5T2W1-2 ]
    GeneIDi 5174.
    KEGGi hsa:5174.
    UCSCi uc001eon.2. human. [Q5T2W1-1 ]

    Organism-specific databases

    CTDi 5174.
    GeneCardsi GC01P145726.
    H-InvDB HIX0056850.
    HIX0178034.
    HGNCi HGNC:8821. PDZK1.
    HPAi CAB008971.
    HPA005755.
    HPA006155.
    MIMi 603831. gene.
    neXtProti NX_Q5T2W1.
    PharmGKBi PA33165.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315208.
    HOGENOMi HOG000113782.
    HOVERGENi HBG082115.
    InParanoidi Q5T2W1.
    OMAi FNPRECK.
    OrthoDBi EOG73V6K7.
    PhylomeDBi Q5T2W1.
    TreeFami TF350449.

    Miscellaneous databases

    ChiTaRSi PDZK1. human.
    EvolutionaryTracei Q5T2W1.
    GeneWikii PDZK1.
    GenomeRNAii 5174.
    NextBioi 20022.
    PROi Q5T2W1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T2W1.
    CleanExi HS_PDZK1.
    Genevestigatori Q5T2W1.

    Family and domain databases

    Gene3Di 2.30.42.10. 4 hits.
    InterProi IPR001478. PDZ.
    [Graphical view ]
    Pfami PF00595. PDZ. 4 hits.
    [Graphical view ]
    SMARTi SM00228. PDZ. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 4 hits.
    PROSITEi PS50106. PDZ. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains."
      Kocher O., Comella N., Tognazzi K., Brown L.F.
      Lab. Invest. 78:117-125(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH PDZK1IP1.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    5. "PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein."
      Kocher O., Comella N., Gilchrist A., Pal R., Tognazzi K., Brown L.F., Knoll J.H.
      Lab. Invest. 79:1161-1170(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH ABCC2.
    6. "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity."
      Wang S., Yue H., Derin R.B., Guggino W.B., Li M.
      Cell 103:169-179(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3."
      Malmberg E.K., Andersson C.X., Gentzsch M., Chen J.H., Mengos A., Cui L., Hansson G.C., Riordan J.R.
      J. Cell Sci. 117:5535-5541(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCR.
    8. "The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3-exchanger DRA in rabbit small intestinal mucosa."
      Rossmann H., Jacob P., Baisch S., Hassoun R., Meier J., Natour D., Yahya K., Yun C., Biber J., Lackner K.J., Fiehn W., Gregor M., Seidler U., Lamprecht G.
      Biochemistry 44:4477-4487(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SLC26A3.
    9. Cited for: INTERACTION WITH SLC9A3.
    10. "Solution structure of PDZ domains of PDZ domain containing protein 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (FEB-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 132-224 AND 376-458.

    Entry informationi

    Entry nameiNHRF3_HUMAN
    AccessioniPrimary (citable) accession number: Q5T2W1
    Secondary accession number(s): B4DPB9
    , E7EU02, O60450, Q5T5P6, Q9BQ41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3