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Q5T2W1

- NHRF3_HUMAN

UniProt

Q5T2W1 - NHRF3_HUMAN

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Protein

Na(+)/H(+) exchange regulatory cofactor NHE-RF3

Gene

PDZK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).By similarity

GO - Molecular functioni

  1. PDZ domain binding Source: UniProtKB
  2. transporter activity Source: UniProtKB

GO - Biological processi

  1. carnitine transport Source: BHF-UCL
  2. cell proliferation Source: UniProtKB
  3. drug transport Source: UniProtKB
  4. establishment of protein localization to plasma membrane Source: Ensembl
  5. positive regulation of ion transmembrane transport Source: BHF-UCL
  6. positive regulation of protein targeting to membrane Source: UniProtKB
  7. regulation of anion transport Source: UniProtKB
  8. transport Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Short name:
NHERF-3
Alternative name(s):
CFTR-associated protein of 70 kDa
Na(+)/H(+) exchanger regulatory factor 3
Na/Pi cotransporter C-terminal-associated protein 1
Short name:
NaPi-Cap1
PDZ domain-containing protein 1
Sodium-hydrogen exchanger regulatory factor 3
Gene namesi
Name:PDZK1
Synonyms:CAP70, NHERF3, PDZD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8821. PDZK1.

Subcellular locationi

Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity
Note: Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes (By similarity).By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. brush border membrane Source: UniProtKB
  3. cytoplasm Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProt
  5. membrane raft Source: Ensembl
  6. microvillus membrane Source: Ensembl
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33165.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Na(+)/H(+) exchange regulatory cofactor NHE-RF3PRO_0000058287Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei492 – 4921PhosphoserineBy similarity
Modified residuei514 – 5141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5T2W1.
PaxDbiQ5T2W1.
PRIDEiQ5T2W1.

PTM databases

PhosphoSiteiQ5T2W1.

Expressioni

Tissue specificityi

Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.3 Publications

Gene expression databases

BgeeiQ5T2W1.
CleanExiHS_PDZK1.
GenevestigatoriQ5T2W1.

Organism-specific databases

HPAiCAB008971.
HPA005755.
HPA006155.

Interactioni

Subunit structurei

Interacts with PDZK1IP1 and ABCC2. Interacts (via PDZ domains 1 and 3) with SCARB1 (C-terminal domain). Forms a heterodimeric complex with SLC9A3R1. Interacts with AKAP2, BCR, CFTR, SLC22A12, SLC22A4, SLC22A5, SLC9A3R2 and SLC17A1. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts (via PDZ1 domain) directly with KLHL17; the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts (via the first PDZ domain) with PTGIR (via non-isoprenylated C-terminus) (By similarity). Interacts (via C-terminal PDZ domain) with SLC26A6 (via C-terminal domain) (By similarity). Interacts (via C-terminal PDZ domain) with SLC9A3 (via C-terminal domain).By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CFTRP135692EBI-349819,EBI-349854

Protein-protein interaction databases

BioGridi111200. 27 interactions.
IntActiQ5T2W1. 10 interactions.
MINTiMINT-4999193.
STRINGi9606.ENSP00000342143.

Structurei

Secondary structure

1
519
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi134 – 1396Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi148 – 1503Combined sources
Beta strandi159 – 1613Combined sources
Helixi168 – 1725Combined sources
Beta strandi179 – 1835Combined sources
Helixi193 – 20210Combined sources
Turni203 – 2053Combined sources
Beta strandi206 – 2127Combined sources
Turni214 – 2163Combined sources
Beta strandi376 – 3827Combined sources
Beta strandi385 – 3873Combined sources
Beta strandi389 – 3924Combined sources
Beta strandi398 – 4058Combined sources
Helixi411 – 4144Combined sources
Beta strandi422 – 4265Combined sources
Beta strandi432 – 4343Combined sources
Helixi436 – 4438Combined sources
Beta strandi448 – 4558Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EEINMR-A132-224[»]
2EEJNMR-A376-458[»]
2VSPX-ray2.60A/B/C/D375-459[»]
3TMHX-ray3.80A/E/I375-459[»]
4Q2PX-ray2.05A/B/C132-215[»]
ProteinModelPortaliQ5T2W1.
SMRiQ5T2W1. Positions 1-107, 132-357, 375-517.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T2W1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9082PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini134 – 21582PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 32381PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini378 – 45881PDZ 4PROSITE-ProRule annotationAdd
BLAST

Domaini

The PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3.By similarity
Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains.By similarity
The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1.By similarity
The PDZ 1 domain interacts with BCR.
The PDZ 2 and 4 domains do not interact with the C-terminal region of SCARB1.By similarity

Sequence similaritiesi

Belongs to the NHER family.Curated
Contains 4 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG315208.
GeneTreeiENSGT00530000062999.
HOGENOMiHOG000113782.
HOVERGENiHBG082115.
InParanoidiQ5T2W1.
OMAiFNPRECK.
OrthoDBiEOG73V6K7.
PhylomeDBiQ5T2W1.
TreeFamiTF350449.

Family and domain databases

Gene3Di2.30.42.10. 4 hits.
InterProiIPR001478. PDZ.
[Graphical view]
PfamiPF00595. PDZ. 4 hits.
[Graphical view]
SMARTiSM00228. PDZ. 4 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 4 hits.
PROSITEiPS50106. PDZ. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T2W1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSTFNPREC KLSKQEGQNY GFFLRIEKDT EGHLVRVVEK CSPAEKAGLQ
60 70 80 90 100
DGDRVLRING VFVDKEEHMQ VVDLVRKSGN SVTLLVLDGD SYEKAVKTRV
110 120 130 140 150
DLKELGQSQK EQGLSDNILS PVMNGGVQTW TQPRLCYLVK EGGSYGFSLK
160 170 180 190 200
TVQGKKGVYM TDITPQGVAM RAGVLADDHL IEVNGENVED ASHEEVVEKV
210 220 230 240 250
KKSGSRVMFL LVDKETDKRH VEQKIQFKRE TASLKLLPHQ PRIVEMKKGS
260 270 280 290 300
NGYGFYLRAG SEQKGQIIKD IDSGSPAEEA GLKNNDLVVA VNGESVETLD
310 320 330 340 350
HDSVVEMIRK GGDQTSLLVV DKETDNMYRL AHFSPFLYYQ SQELPNGSVK
360 370 380 390 400
EAPAPTPTSL EVSSPPDTTE EVDHKPKLCR LAKGENGYGF HLNAIRGLPG
410 420 430 440 450
SFIKEVQKGG PADLAGLEDE DVIIEVNGVN VLDEPYEKVV DRIQSSGKNV
460 470 480 490 500
TLLVCGKKAY DYFQAKKIPI VSSLADPLDT PPDSKEGIVV ESNHDSHMAK
510
ERAHSTASHS SSNSEDTEM
Length:519
Mass (Da):57,129
Last modified:August 16, 2005 - v2
Checksum:i98BF707F87CD77A6
GO
Isoform 2 (identifier: Q5T2W1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-264: Missing.

Note: No experimental confirmation available.

Show »
Length:408
Mass (Da):44,665
Checksum:i6AF5DA3B9EF406E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951E → K in AAC12264. (PubMed:9461128)Curated
Sequence conflicti270 – 2701D → G in BAG60531. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 264111Missing in isoform 2. 1 PublicationVSP_044637Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012281 mRNA. Translation: AAC12264.1.
AK298269 mRNA. Translation: BAG60531.1.
AL390725 Genomic DNA. Translation: CAI13715.1.
AL390725 Genomic DNA. Translation: CAI13716.1.
BC006496 mRNA. Translation: AAH06496.1.
BC006518 mRNA. Translation: AAH06518.1.
CCDSiCCDS72859.1. [Q5T2W1-2]
CCDS72860.1. [Q5T2W1-1]
RefSeqiNP_001188254.1. NM_001201325.1. [Q5T2W1-1]
NP_001188255.1. NM_001201326.1. [Q5T2W1-2]
NP_002605.2. NM_002614.4. [Q5T2W1-1]
UniGeneiHs.444751.
Hs.732345.

Genome annotation databases

EnsembliENST00000344770; ENSP00000342143; ENSG00000174827. [Q5T2W1-1]
ENST00000417171; ENSP00000394485; ENSG00000174827. [Q5T2W1-1]
ENST00000443667; ENSP00000409291; ENSG00000174827.
ENST00000451928; ENSP00000403422; ENSG00000174827. [Q5T2W1-2]
GeneIDi5174.
KEGGihsa:5174.
UCSCiuc001eon.2. human. [Q5T2W1-1]

Polymorphism databases

DMDMi73621372.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012281 mRNA. Translation: AAC12264.1 .
AK298269 mRNA. Translation: BAG60531.1 .
AL390725 Genomic DNA. Translation: CAI13715.1 .
AL390725 Genomic DNA. Translation: CAI13716.1 .
BC006496 mRNA. Translation: AAH06496.1 .
BC006518 mRNA. Translation: AAH06518.1 .
CCDSi CCDS72859.1. [Q5T2W1-2 ]
CCDS72860.1. [Q5T2W1-1 ]
RefSeqi NP_001188254.1. NM_001201325.1. [Q5T2W1-1 ]
NP_001188255.1. NM_001201326.1. [Q5T2W1-2 ]
NP_002605.2. NM_002614.4. [Q5T2W1-1 ]
UniGenei Hs.444751.
Hs.732345.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EEI NMR - A 132-224 [» ]
2EEJ NMR - A 376-458 [» ]
2VSP X-ray 2.60 A/B/C/D 375-459 [» ]
3TMH X-ray 3.80 A/E/I 375-459 [» ]
4Q2P X-ray 2.05 A/B/C 132-215 [» ]
ProteinModelPortali Q5T2W1.
SMRi Q5T2W1. Positions 1-107, 132-357, 375-517.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111200. 27 interactions.
IntActi Q5T2W1. 10 interactions.
MINTi MINT-4999193.
STRINGi 9606.ENSP00000342143.

PTM databases

PhosphoSitei Q5T2W1.

Polymorphism databases

DMDMi 73621372.

Proteomic databases

MaxQBi Q5T2W1.
PaxDbi Q5T2W1.
PRIDEi Q5T2W1.

Protocols and materials databases

DNASUi 5174.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344770 ; ENSP00000342143 ; ENSG00000174827 . [Q5T2W1-1 ]
ENST00000417171 ; ENSP00000394485 ; ENSG00000174827 . [Q5T2W1-1 ]
ENST00000443667 ; ENSP00000409291 ; ENSG00000174827 .
ENST00000451928 ; ENSP00000403422 ; ENSG00000174827 . [Q5T2W1-2 ]
GeneIDi 5174.
KEGGi hsa:5174.
UCSCi uc001eon.2. human. [Q5T2W1-1 ]

Organism-specific databases

CTDi 5174.
GeneCardsi GC01P145726.
H-InvDB HIX0056850.
HIX0178034.
HGNCi HGNC:8821. PDZK1.
HPAi CAB008971.
HPA005755.
HPA006155.
MIMi 603831. gene.
neXtProti NX_Q5T2W1.
PharmGKBi PA33165.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315208.
GeneTreei ENSGT00530000062999.
HOGENOMi HOG000113782.
HOVERGENi HBG082115.
InParanoidi Q5T2W1.
OMAi FNPRECK.
OrthoDBi EOG73V6K7.
PhylomeDBi Q5T2W1.
TreeFami TF350449.

Miscellaneous databases

ChiTaRSi PDZK1. human.
EvolutionaryTracei Q5T2W1.
GeneWikii PDZK1.
GenomeRNAii 5174.
NextBioi 20022.
PROi Q5T2W1.
SOURCEi Search...

Gene expression databases

Bgeei Q5T2W1.
CleanExi HS_PDZK1.
Genevestigatori Q5T2W1.

Family and domain databases

Gene3Di 2.30.42.10. 4 hits.
InterProi IPR001478. PDZ.
[Graphical view ]
Pfami PF00595. PDZ. 4 hits.
[Graphical view ]
SMARTi SM00228. PDZ. 4 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 4 hits.
PROSITEi PS50106. PDZ. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains."
    Kocher O., Comella N., Tognazzi K., Brown L.F.
    Lab. Invest. 78:117-125(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH PDZK1IP1.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  5. "PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein."
    Kocher O., Comella N., Gilchrist A., Pal R., Tognazzi K., Brown L.F., Knoll J.H.
    Lab. Invest. 79:1161-1170(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INTERACTION WITH ABCC2.
  6. "Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity."
    Wang S., Yue H., Derin R.B., Guggino W.B., Li M.
    Cell 103:169-179(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  7. "Bcr (breakpoint cluster region) protein binds to PDZ-domains of scaffold protein PDZK1 and vesicle coat protein Mint3."
    Malmberg E.K., Andersson C.X., Gentzsch M., Chen J.H., Mengos A., Cui L., Hansson G.C., Riordan J.R.
    J. Cell Sci. 117:5535-5541(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCR.
  8. "The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3-exchanger DRA in rabbit small intestinal mucosa."
    Rossmann H., Jacob P., Baisch S., Hassoun R., Meier J., Natour D., Yahya K., Yun C., Biber J., Lackner K.J., Fiehn W., Gregor M., Seidler U., Lamprecht G.
    Biochemistry 44:4477-4487(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SLC26A3.
  9. Cited for: INTERACTION WITH SLC9A3.
  10. "Solution structure of PDZ domains of PDZ domain containing protein 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (FEB-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 132-224 AND 376-458.

Entry informationi

Entry nameiNHRF3_HUMAN
AccessioniPrimary (citable) accession number: Q5T2W1
Secondary accession number(s): B4DPB9
, E7EU02, O60450, Q5T5P6, Q9BQ41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3