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Protein

MAGUK p55 subfamily member 7

Gene

MPP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL
  • signaling adaptor activity Source: BHF-UCL

GO - Biological processi

  • bicellular tight junction assembly Source: BHF-UCL
  • establishment of cell polarity Source: BHF-UCL
  • positive regulation of protein complex assembly Source: BHF-UCL
  • protein localization to adherens junction Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 7
Gene namesi
Name:MPP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:26542. MPP7.

Subcellular locationi

GO - Cellular componenti

  • adherens junction Source: BHF-UCL
  • bicellular tight junction Source: BHF-UCL
  • cell-cell adherens junction Source: BHF-UCL
  • MPP7-DLG1-LIN7 complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane, Tight junction

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38L → S: Abolishes interaction with DLG1. 1 Publication1
Mutagenesisi95L → S: Does not affect the interaction with DLG1. 1 Publication1

Organism-specific databases

DisGeNETi143098.
OpenTargetsiENSG00000150054.
PharmGKBiPA134985345.

Polymorphism and mutation databases

BioMutaiMPP7.
DMDMi74762233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003200271 – 576MAGUK p55 subfamily member 7Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T2T1.
MaxQBiQ5T2T1.
PaxDbiQ5T2T1.
PeptideAtlasiQ5T2T1.
PRIDEiQ5T2T1.

PTM databases

iPTMnetiQ5T2T1.
PhosphoSitePlusiQ5T2T1.

Expressioni

Inductioni

Down-regulated in patients suffering of passive Heymann nephritis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000150054.
CleanExiHS_MPP7.
ExpressionAtlasiQ5T2T1. baseline and differential.
GenevisibleiQ5T2T1. HS.

Organism-specific databases

HPAiHPA037598.

Interactioni

Subunit structurei

Heterodimer; able to heterodimerize via its C-terminal L27 domain with LIN7A, LIN7B and LIN7C. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with DLG1 via its N-terminal L27 domain. Interacts with MPP5 and PATJ.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
LIN7AO149105EBI-2514004,EBI-2513988

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • protein complex scaffold Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi126785. 12 interactors.
IntActiQ5T2T1. 9 interactors.
STRINGi9606.ENSP00000337907.

Structurei

Secondary structure

1576
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Helixi14 – 19Combined sources6
Helixi21 – 25Combined sources5
Turni26 – 28Combined sources3
Helixi34 – 41Combined sources8
Helixi47 – 61Combined sources15
Helixi72 – 84Combined sources13
Helixi90 – 98Combined sources9
Helixi102 – 115Combined sources14
Beta strandi138 – 147Combined sources10
Beta strandi151 – 155Combined sources5
Turni157 – 159Combined sources3
Beta strandi162 – 167Combined sources6
Helixi172 – 176Combined sources5
Beta strandi184 – 188Combined sources5
Beta strandi191 – 193Combined sources3
Helixi198 – 207Combined sources10
Beta strandi210 – 217Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LRAX-ray2.95A9-120[»]
3O46X-ray1.30A135-225[»]
ProteinModelPortaliQ5T2T1.
SMRiQ5T2T1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T2T1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27 1PROSITE-ProRule annotationAdd BLAST56
Domaini67 – 122L27 2PROSITE-ProRule annotationAdd BLAST56
Domaini139 – 220PDZPROSITE-ProRule annotationAdd BLAST82
Domaini228 – 298SH3PROSITE-ProRule annotationAdd BLAST71
Domaini368 – 560Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST193

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ5T2T1.
OMAiQYDTADI.
OrthoDBiEOG091G065I.
PhylomeDBiQ5T2T1.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T2T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPALSTGSGS DTGLYELLAA LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL
60 70 80 90 100
VKIHEKLHYY EKQSPVPILH GAAALADDLA EELQNKPLNS EIRELLKLLS
110 120 130 140 150
KPNVKALLSV HDTVAQKNYD PVLPPMPEDI DDEEDSVKII RLVKNREPLG
160 170 180 190 200
ATIKKDEQTG AIIVARIMRG GAADRSGLIH VGDELREVNG IPVEDKRPEE
210 220 230 240 250
IIQILAQSQG AITFKIIPGS KEETPSKEGK MFIKALFDYN PNEDKAIPCK
260 270 280 290 300
EAGLSFKKGD ILQIMSQDDA TWWQAKHEAD ANPRAGLIPS KHFQERRLAL
310 320 330 340 350
RRPEILVQPL KVSNRKSSGF RKSFRLSRKD KKTNKSMYEC KKSDQYDTAD
360 370 380 390 400
VPTYEEVTPY RRQTNEKYRL VVLVGPVGVG LNELKRKLLI SDTQHYGVTV
410 420 430 440 450
PHTTRARRSQ ESDGVEYIFI SKHLFETDVQ NNKFIEYGEY KNNYYGTSID
460 470 480 490 500
SVRSVLAKNK VCLLDVQPHT VKHLRTLEFK PYVIFIKPPS IERLRETRKN
510 520 530 540 550
AKIISSRDDQ GAAKPFTEED FQEMIKSAQI MESQYGHLFD KIIINDDLTV
560 570
AFNELKTTFD KLETETHWVP VSWLHS
Length:576
Mass (Da):65,524
Last modified:December 21, 2004 - v1
Checksum:i86366E460A08C6A7
GO
Isoform 2 (identifier: Q5T2T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.
     470-499: TVKHLRTLEFKPYVIFIKPPSIERLRETRK → GPWFLLPLMAVPWGAKPPNARMTCGSPLDL
     500-576: Missing.

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):42,395
Checksum:iB38B15B10A3A1D54
GO

Sequence cautioni

The sequence CAI12709 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13640 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI17344 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039110322K → R.3 PublicationsCorresponds to variant rs2997211dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560651 – 125Missing in isoform 2. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_056066470 – 499TVKHL…RETRK → GPWFLLPLMAVPWGAKPPNA RMTCGSPLDL in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_056067500 – 576Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301592 mRNA. Translation: BAG63081.1.
AK315046 mRNA. Translation: BAG37526.1.
AL390866, AL355501, AL391423 Genomic DNA. Translation: CAI12708.1.
AL390866, AL355501, AL391423 Genomic DNA. Translation: CAI12709.1. Sequence problems.
AL355501, AL390866, AL391423 Genomic DNA. Translation: CAI13640.1. Sequence problems.
AL355501, AL390866, AL391423 Genomic DNA. Translation: CAI13641.1.
AL391423, AL355501, AL390866 Genomic DNA. Translation: CAI17344.1. Sequence problems.
AL391423, AL355501, AL390866 Genomic DNA. Translation: CAI17345.1.
CH471072 Genomic DNA. Translation: EAW86045.1.
CH471072 Genomic DNA. Translation: EAW86047.1.
BC038105 mRNA. Translation: AAH38105.1.
CCDSiCCDS7158.1. [Q5T2T1-1]
RefSeqiNP_001305099.1. NM_001318170.1. [Q5T2T1-1]
NP_775767.2. NM_173496.4. [Q5T2T1-1]
XP_011517639.1. XM_011519337.2. [Q5T2T1-1]
UniGeneiHs.499159.

Genome annotation databases

EnsembliENST00000337532; ENSP00000337907; ENSG00000150054. [Q5T2T1-1]
ENST00000375719; ENSP00000364871; ENSG00000150054. [Q5T2T1-1]
ENST00000375732; ENSP00000364884; ENSG00000150054. [Q5T2T1-1]
GeneIDi143098.
KEGGihsa:143098.
UCSCiuc001iua.2. human. [Q5T2T1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301592 mRNA. Translation: BAG63081.1.
AK315046 mRNA. Translation: BAG37526.1.
AL390866, AL355501, AL391423 Genomic DNA. Translation: CAI12708.1.
AL390866, AL355501, AL391423 Genomic DNA. Translation: CAI12709.1. Sequence problems.
AL355501, AL390866, AL391423 Genomic DNA. Translation: CAI13640.1. Sequence problems.
AL355501, AL390866, AL391423 Genomic DNA. Translation: CAI13641.1.
AL391423, AL355501, AL390866 Genomic DNA. Translation: CAI17344.1. Sequence problems.
AL391423, AL355501, AL390866 Genomic DNA. Translation: CAI17345.1.
CH471072 Genomic DNA. Translation: EAW86045.1.
CH471072 Genomic DNA. Translation: EAW86047.1.
BC038105 mRNA. Translation: AAH38105.1.
CCDSiCCDS7158.1. [Q5T2T1-1]
RefSeqiNP_001305099.1. NM_001318170.1. [Q5T2T1-1]
NP_775767.2. NM_173496.4. [Q5T2T1-1]
XP_011517639.1. XM_011519337.2. [Q5T2T1-1]
UniGeneiHs.499159.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LRAX-ray2.95A9-120[»]
3O46X-ray1.30A135-225[»]
ProteinModelPortaliQ5T2T1.
SMRiQ5T2T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126785. 12 interactors.
IntActiQ5T2T1. 9 interactors.
STRINGi9606.ENSP00000337907.

PTM databases

iPTMnetiQ5T2T1.
PhosphoSitePlusiQ5T2T1.

Polymorphism and mutation databases

BioMutaiMPP7.
DMDMi74762233.

Proteomic databases

EPDiQ5T2T1.
MaxQBiQ5T2T1.
PaxDbiQ5T2T1.
PeptideAtlasiQ5T2T1.
PRIDEiQ5T2T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337532; ENSP00000337907; ENSG00000150054. [Q5T2T1-1]
ENST00000375719; ENSP00000364871; ENSG00000150054. [Q5T2T1-1]
ENST00000375732; ENSP00000364884; ENSG00000150054. [Q5T2T1-1]
GeneIDi143098.
KEGGihsa:143098.
UCSCiuc001iua.2. human. [Q5T2T1-1]

Organism-specific databases

CTDi143098.
DisGeNETi143098.
GeneCardsiMPP7.
H-InvDBHIX0008732.
HGNCiHGNC:26542. MPP7.
HPAiHPA037598.
MIMi610973. gene.
neXtProtiNX_Q5T2T1.
OpenTargetsiENSG00000150054.
PharmGKBiPA134985345.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ5T2T1.
OMAiQYDTADI.
OrthoDBiEOG091G065I.
PhylomeDBiQ5T2T1.
TreeFamiTF314263.

Miscellaneous databases

ChiTaRSiMPP7. human.
EvolutionaryTraceiQ5T2T1.
GenomeRNAii143098.
PROiQ5T2T1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150054.
CleanExiHS_MPP7.
ExpressionAtlasiQ5T2T1. baseline and differential.
GenevisibleiQ5T2T1. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPP7_HUMAN
AccessioniPrimary (citable) accession number: Q5T2T1
Secondary accession number(s): B2RCC9
, B4DWL9, B5MDZ3, D3DRW3, Q5T2T0, Q8IY28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.