Q5T2P9 (AGA10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 10
Short name=AGAP-10

Alternative name(s):
Centaurin-gamma-like family member 7

Gene names

Name:	AGAP10
Synonyms:	CTGLF7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	658 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative GTPase-activating protein Potential.
Miscellaneous	Encoded by one of the numerous copies of centaurin gamma-like genes clustered in the q11 region of chromosome 10.
Sequence similarities	Belongs to the centaurin gamma-like family. Contains 1 ANK repeat. Contains 1 Arf-GAP domain. Contains 1 PH domain.
Sequence caution	The sequence CAI12206.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	ANK repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of ARF GTPase activity Inferred from electronic annotation. Source: InterPro
Molecular function	ARF GTPase activator activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 658	658	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 10		PRO_0000331540
Regions
	Repeat	75 – 97	23	1
	Repeat	98 – 120	23	2
	Domain	282 – 443	162	PH
	Domain	464 – 584	121	Arf-GAP
	Repeat	527 – 596	70	ANK
	Zinc finger	479 – 502	24	C4-type
	Region	75 – 120	46	2 X 23 AA tandem repeats of A-L-E-F-N-[LS]-S-A-N-P-E-A-S-T-I-F-Q-R-N-S-Q-T-D

Sequences

	Sequence		Length	Mass (Da)
	Q5T2P9 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 82D971C0D33A383C	FASTA	658	72,707
	10 20 30 40 50 60 MGNILTCRVH PSVSLEFDQQ QGSVCPSESE IYEAGAEDRM AGAPMAAAVQ PAEVTVEVGE 70 80 90 100 110 120 DLHMHQVRDR EMPEALEFNL SANPEASTIF QRNSQTDALE FNSSANPEAS TIFQRNSQTD 130 140 150 160 170 180 VVEIRRSNCT NHVSTERFSQ QYSSCSTIFL DDSTAIQHYL TMTIISVTLE IPHHITQRDA 190 200 210 220 230 240 DRSLSIPDEQ LHSFAVSTVH IMKKRNGGGS LNNYSSSIPP TPSTSQEDPQ FSVPPTANTP 250 260 270 280 290 300 TPVCKLSMRW SNLFTSEKGS DPDKERKAPE NHADTIGSGR AIPIKQGMLL KRSGKWLKTW 310 320 330 340 350 360 KKKYVTLCSN GVLTYYSSLG DYMKNIHKKE IDLRTSTIKV PGKWPSLATS ACAPISSSKS 370 380 390 400 410 420 NGLSKDMDTG LGDSICFSPG ISSTTSPKLN PPPSPHANKK KHLKKKSTNN FMIVSATGQT 430 440 450 460 470 480 WHFEATTYEE RDAWVQAIQS QILASLQSCK SSKSKSQLTS QSEAMALQSI QNMRGNAHCV 490 500 510 520 530 540 DCETQNPKWA SLNLGVLMCI ECSGIHRSFG TRLSRVRSLE LDDWPVELRK VMSSIGNELA 550 560 570 580 590 600 NSIWEGSSQG QTKPSIKSTR EEKEWWIRSK YEEKLFLAPL PCTELSLGQQ LLRATTDEDL 610 620 630 640 650 QTAILLLAHG SREEVNETCG EGDGCTALHL ACRKGNVVLE QLLTGWTSWP EMPTGTQR

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL391137 Genomic DNA. Translation: CAI12206.1. Sequence problems.
IPI	IPI00939972.
UniGene	Hs.712688.
3D structure databases
ProteinModelPortal	Q5T2P9.
SMR	Q5T2P9. Positions 280-447, 465-657.
ModBase	Search...
Polymorphism databases
DMDM	215274171.
Proteomic databases
PRIDE	Q5T2P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000452145; ENSP00000392206; ENSG00000204172.
Organism-specific databases
GeneCards	GC10M047191.
HGNC	HGNC:23462. AGAP10.
neXtProt	NX_Q5T2P9.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG0705.
GeneTree	ENSGT00600000084361.
HOVERGEN	HBG054045.
InParanoid	Q5T2P9.
PhylomeDB	Q5T2P9.
Gene expression databases
ArrayExpress	Q5T2P9.
CleanEx	HS_AGAP10.
Genevestigator	Q5T2P9.
Family and domain databases
InterPro	IPR020683. Ankyrin_rpt-contain_dom. IPR001164. ArfGAP. IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit. G3DSA:2.30.29.30. PH_type. 2 hits.
Pfam	PF01412. ArfGap. 1 hit. PF00169. PH. 1 hit. [Graphical view]
PRINTS	PR00405. REVINTRACTNG.
SMART	SM00105. ArfGap. 1 hit. SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF57863. ArfGAP. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. False negative. PS50115. ARFGAP. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AGA10_HUMAN

Accession

Primary (citable) accession number: Q5T2P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	November 25, 2008
Last modified:	December 14, 2011
This is version 55 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.