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Protein

ATPase family AAA domain-containing protein 3C

Gene

ATAD3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1848ATPSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 3C
Gene namesi
Name:ATAD3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32151. ATAD3C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903201.

Polymorphism and mutation databases

BioMutaiATAD3C.
DMDMi162416279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411ATPase family AAA domain-containing protein 3CPRO_0000311979Add
BLAST

Proteomic databases

EPDiQ5T2N8.
PaxDbiQ5T2N8.
PeptideAtlasiQ5T2N8.
PRIDEiQ5T2N8.

PTM databases

iPTMnetiQ5T2N8.
PhosphoSiteiQ5T2N8.
SwissPalmiQ5T2N8.

Expressioni

Gene expression databases

BgeeiQ5T2N8.
ExpressionAtlasiQ5T2N8. baseline and differential.
GenevisibleiQ5T2N8. HS.

Interactioni

Protein-protein interaction databases

BioGridi128521. 6 interactions.
IntActiQ5T2N8. 2 interactions.
STRINGi9606.ENSP00000368062.

Structurei

3D structure databases

ProteinModelPortaliQ5T2N8.
SMRiQ5T2N8. Positions 113-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0742. Eukaryota.
COG1223. LUCA.
GeneTreeiENSGT00730000111059.
HOGENOMiHOG000231291.
HOVERGENiHBG058506.
InParanoidiQ5T2N8.
OMAiDWAINAC.
OrthoDBiEOG7J9VP8.
PhylomeDBiQ5T2N8.
TreeFamiTF313922.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR021911. DUF3523.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF12037. DUF3523. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T2N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDALNLAQ MQEQTLQLEQ QSKLKQLVNE DLRKQEESVQ KHHQTFLESI
60 70 80 90 100
RAAGTLFGEG FRAFVTDRDK VTATVAGLTL LAVGVYSAKN ATAVTGRYIE
110 120 130 140 150
ARLGKPSLVR ETSRITVLEA LRHPIQQVSR RLLSRPQDVL EGVVLSPSLE
160 170 180 190 200
ARVRDIAIMT RNIKKNRGLY RHILLYGPPG TGKTLFAKKL ALHSGMDYAI
210 220 230 240 250
MTGGDVAPMG REGVTAMHKL FDWANTSRRG LLLFVDEADA FLRKRATEKI
260 270 280 290 300
SEDLRATLNA FLYRTGQHSN KFMLILASCH PEQFDWAINA CIDVMVHFDL
310 320 330 340 350
PGQEERARLV RMYLNEYVLK PATEGKRRLK LAQFDYGRKC LEIARLTEGM
360 370 380 390 400
SCRKIAQLAV SWQATAYASK DGVLTEAMMD ACVQDFVQQH QQMMRWLKGE
410
RPGPEDEQPS S
Length:411
Mass (Da):46,380
Last modified:December 4, 2007 - v2
Checksum:iD97236C78380C4C2
GO

Sequence cautioni

The sequence AAI01212.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAI01213.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC04369.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAI22067.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI22656.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091918 mRNA. No translation available.
AK094502 mRNA. Translation: BAC04369.1. Sequence problems.
AL157945, AL391244 Genomic DNA. Translation: CAI22067.1. Sequence problems.
AL391244, AL157945 Genomic DNA. Translation: CAI22656.1. Sequence problems.
BC101211 mRNA. Translation: AAI01212.1. Sequence problems.
BC101212 mRNA. Translation: AAI01213.1. Sequence problems.
CCDSiCCDS44039.1.
RefSeqiNP_001034300.2. NM_001039211.2.
XP_011539311.1. XM_011541009.1.
UniGeneiHs.724767.

Genome annotation databases

EnsembliENST00000378785; ENSP00000368062; ENSG00000215915.
GeneIDi219293.
KEGGihsa:219293.
UCSCiuc001aft.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091918 mRNA. No translation available.
AK094502 mRNA. Translation: BAC04369.1. Sequence problems.
AL157945, AL391244 Genomic DNA. Translation: CAI22067.1. Sequence problems.
AL391244, AL157945 Genomic DNA. Translation: CAI22656.1. Sequence problems.
BC101211 mRNA. Translation: AAI01212.1. Sequence problems.
BC101212 mRNA. Translation: AAI01213.1. Sequence problems.
CCDSiCCDS44039.1.
RefSeqiNP_001034300.2. NM_001039211.2.
XP_011539311.1. XM_011541009.1.
UniGeneiHs.724767.

3D structure databases

ProteinModelPortaliQ5T2N8.
SMRiQ5T2N8. Positions 113-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128521. 6 interactions.
IntActiQ5T2N8. 2 interactions.
STRINGi9606.ENSP00000368062.

PTM databases

iPTMnetiQ5T2N8.
PhosphoSiteiQ5T2N8.
SwissPalmiQ5T2N8.

Polymorphism and mutation databases

BioMutaiATAD3C.
DMDMi162416279.

Proteomic databases

EPDiQ5T2N8.
PaxDbiQ5T2N8.
PeptideAtlasiQ5T2N8.
PRIDEiQ5T2N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378785; ENSP00000368062; ENSG00000215915.
GeneIDi219293.
KEGGihsa:219293.
UCSCiuc001aft.2. human.

Organism-specific databases

CTDi219293.
GeneCardsiATAD3C.
H-InvDBHIX0023514.
HGNCiHGNC:32151. ATAD3C.
neXtProtiNX_Q5T2N8.
PharmGKBiPA134903201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0742. Eukaryota.
COG1223. LUCA.
GeneTreeiENSGT00730000111059.
HOGENOMiHOG000231291.
HOVERGENiHBG058506.
InParanoidiQ5T2N8.
OMAiDWAINAC.
OrthoDBiEOG7J9VP8.
PhylomeDBiQ5T2N8.
TreeFamiTF313922.

Miscellaneous databases

GenomeRNAii219293.
PROiQ5T2N8.

Gene expression databases

BgeeiQ5T2N8.
ExpressionAtlasiQ5T2N8. baseline and differential.
GenevisibleiQ5T2N8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR021911. DUF3523.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF12037. DUF3523. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex and Kidney.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 350-411.

Entry informationi

Entry nameiATD3C_HUMAN
AccessioniPrimary (citable) accession number: Q5T2N8
Secondary accession number(s): Q8N1Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.