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Protein

ATPase family AAA domain-containing protein 3C

Gene

ATAD3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 184ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 3C
Gene namesi
Name:ATAD3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000215915.9.
HGNCiHGNC:32151. ATAD3C.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi219293.
PharmGKBiPA134903201.

Polymorphism and mutation databases

BioMutaiATAD3C.
DMDMi162416279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119791 – 411ATPase family AAA domain-containing protein 3CAdd BLAST411

Proteomic databases

EPDiQ5T2N8.
MaxQBiQ5T2N8.
PaxDbiQ5T2N8.
PeptideAtlasiQ5T2N8.
PRIDEiQ5T2N8.

PTM databases

iPTMnetiQ5T2N8.
PhosphoSitePlusiQ5T2N8.
SwissPalmiQ5T2N8.

Expressioni

Gene expression databases

BgeeiENSG00000215915.
ExpressionAtlasiQ5T2N8. baseline and differential.
GenevisibleiQ5T2N8. HS.

Organism-specific databases

HPAiHPA065305.

Interactioni

Protein-protein interaction databases

BioGridi128521. 7 interactors.
IntActiQ5T2N8. 2 interactors.
STRINGi9606.ENSP00000368062.

Structurei

3D structure databases

ProteinModelPortaliQ5T2N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0742. Eukaryota.
COG1223. LUCA.
GeneTreeiENSGT00730000111059.
HOGENOMiHOG000231291.
HOVERGENiHBG058506.
InParanoidiQ5T2N8.
OMAiDWAINAC.
OrthoDBiEOG091G04JN.
PhylomeDBiQ5T2N8.
TreeFamiTF313922.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR021911. DUF3523.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF12037. DUF3523. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5T2N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDALNLAQ MQEQTLQLEQ QSKLKQLVNE DLRKQEESVQ KHHQTFLESI
60 70 80 90 100
RAAGTLFGEG FRAFVTDRDK VTATVAGLTL LAVGVYSAKN ATAVTGRYIE
110 120 130 140 150
ARLGKPSLVR ETSRITVLEA LRHPIQQVSR RLLSRPQDVL EGVVLSPSLE
160 170 180 190 200
ARVRDIAIMT RNIKKNRGLY RHILLYGPPG TGKTLFAKKL ALHSGMDYAI
210 220 230 240 250
MTGGDVAPMG REGVTAMHKL FDWANTSRRG LLLFVDEADA FLRKRATEKI
260 270 280 290 300
SEDLRATLNA FLYRTGQHSN KFMLILASCH PEQFDWAINA CIDVMVHFDL
310 320 330 340 350
PGQEERARLV RMYLNEYVLK PATEGKRRLK LAQFDYGRKC LEIARLTEGM
360 370 380 390 400
SCRKIAQLAV SWQATAYASK DGVLTEAMMD ACVQDFVQQH QQMMRWLKGE
410
RPGPEDEQPS S
Length:411
Mass (Da):46,380
Last modified:December 4, 2007 - v2
Checksum:iD97236C78380C4C2
GO

Sequence cautioni

The sequence AAI01212 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAI01213 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC04369 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAI22067 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22656 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091918 mRNA. No translation available.
AK094502 mRNA. Translation: BAC04369.1. Sequence problems.
AL157945, AL391244 Genomic DNA. Translation: CAI22067.1. Sequence problems.
AL391244, AL157945 Genomic DNA. Translation: CAI22656.1. Sequence problems.
BC101211 mRNA. Translation: AAI01212.1. Sequence problems.
BC101212 mRNA. Translation: AAI01213.1. Sequence problems.
CCDSiCCDS44039.1.
RefSeqiNP_001034300.2. NM_001039211.2.
UniGeneiHs.724767.

Genome annotation databases

EnsembliENST00000378785; ENSP00000368062; ENSG00000215915.
GeneIDi219293.
KEGGihsa:219293.
UCSCiuc001aft.2. human.

Similar proteinsi

Entry informationi

Entry nameiATD3C_HUMAN
AccessioniPrimary (citable) accession number: Q5T2N8
Secondary accession number(s): Q8N1Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 27, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families