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Protein

Putative aldo-keto reductase family 1 member C8

Gene

AKR1C8P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Important for substrate specificityBy similarity1
Active sitei58Proton donorBy similarity1
Sitei87Lowers pKa of active site TyrBy similarity1
Binding sitei120SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 25NADPBy similarity10

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aldo-keto reductase family 1 member C8
Alternative name(s):
Aldo-keto reductase family 1 member C-like protein 1 (EC:1.1.1.-)
Gene namesi
Name:AKR1C8PImported
Synonyms:AKR1CL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23469. AKR1C8P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002878791 – 129Putative aldo-keto reductase family 1 member C8Add BLAST129

Proteomic databases

PaxDbiQ5T2L2.
PRIDEiQ5T2L2.

Expressioni

Gene expression databases

BgeeiENSG00000196326.
CleanExiHS_AKR1CL1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000417935.

Structurei

3D structure databases

ProteinModelPortaliQ5T2L2.
SMRiQ5T2L2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiQ5T2L2.
PhylomeDBiQ5T2L2.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T2L2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTDLKQSHS VRLNDGPFMP VLGFGTYAPD HTPKSQAAEA TKVAIDVGFR
60 70 80 90 100
HIDSAYLYQN EEEVGQAIWE KIADGTVKRE EIFYTIKLWA TFFRAELVHP
110 120
ALERSLKKLG PDYVDLFIIH VPFAMKGSS
Length:129
Mass (Da):14,588
Last modified:September 22, 2009 - v2
Checksum:iEE42253565182210
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03235550R → H.Corresponds to variant rs7097295dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131335 mRNA. Translation: BAD18494.1.
AL355303 Genomic DNA. No translation available.
AL391427 Genomic DNA. No translation available.
BC101204 mRNA. Translation: AAI01205.1.
BC101205 mRNA. Translation: AAI01206.1.
UniGeneiHs.282513.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131335 mRNA. Translation: BAD18494.1.
AL355303 Genomic DNA. No translation available.
AL391427 Genomic DNA. No translation available.
BC101204 mRNA. Translation: AAI01205.1.
BC101205 mRNA. Translation: AAI01206.1.
UniGeneiHs.282513.

3D structure databases

ProteinModelPortaliQ5T2L2.
SMRiQ5T2L2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000417935.

Proteomic databases

PaxDbiQ5T2L2.
PRIDEiQ5T2L2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

HGNCiHGNC:23469. AKR1C8P.
neXtProtiNX_Q5T2L2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
HOVERGENiHBG000020.
InParanoidiQ5T2L2.
PhylomeDBiQ5T2L2.

Miscellaneous databases

PROiQ5T2L2.

Gene expression databases

BgeeiENSG00000196326.
CleanExiHS_AKR1CL1.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAKCL1_HUMAN
AccessioniPrimary (citable) accession number: Q5T2L2
Secondary accession number(s): A6NF66, Q6ZN81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Much shorter than related proteins.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.