ID   Q5T2H3_HUMAN            Unreviewed;       123 AA.
AC   Q5T2H3;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   27-MAR-2024, entry version 117.
DE   SubName: Full=Androgen induced 1 {ECO:0000313|Ensembl:ENSP00000405048.1};
DE   Flags: Fragment;
GN   Name=AIG1 {ECO:0000313|Ensembl:ENSP00000405048.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000405048.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000405048.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000405048.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         hexadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52072,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372,
CC         ChEBI:CHEBI:84201, ChEBI:CHEBI:136312;
CC         Evidence={ECO:0000256|ARBA:ARBA00000255};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52073;
CC         Evidence={ECO:0000256|ARBA:ARBA00000255};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=12-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         octadecenoate + 12-hydroxyoctadecanoate + H(+); Xref=Rhea:RHEA:52060,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823,
CC         ChEBI:CHEBI:84201, ChEBI:CHEBI:136302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000674};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52061;
CC         Evidence={ECO:0000256|ARBA:ARBA00000674};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=12-hexadecanoyloxy-octadecanoate + H2O = 12-
CC         hydroxyoctadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52056,
CC         ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:83677, ChEBI:CHEBI:84201;
CC         Evidence={ECO:0000256|ARBA:ARBA00000293};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52057;
CC         Evidence={ECO:0000256|ARBA:ARBA00000293};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=12-octadecanoyloxy-octadecanoate + H2O = 12-
CC         hydroxyoctadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52080,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629,
CC         ChEBI:CHEBI:84201, ChEBI:CHEBI:136330;
CC         Evidence={ECO:0000256|ARBA:ARBA00000748};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52081;
CC         Evidence={ECO:0000256|ARBA:ARBA00000748};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         hexadecenoate + 13-hydroxy-octadecanoate + H(+);
CC         Xref=Rhea:RHEA:52076, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:32372, ChEBI:CHEBI:136304, ChEBI:CHEBI:136315;
CC         Evidence={ECO:0000256|ARBA:ARBA00001217};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52077;
CC         Evidence={ECO:0000256|ARBA:ARBA00001217};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         octadecenoate + 13-hydroxy-octadecanoate + H(+);
CC         Xref=Rhea:RHEA:52064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30823, ChEBI:CHEBI:136303, ChEBI:CHEBI:136304;
CC         Evidence={ECO:0000256|ARBA:ARBA00001489};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52065;
CC         Evidence={ECO:0000256|ARBA:ARBA00001489};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-
CC         octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52084,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629,
CC         ChEBI:CHEBI:136304, ChEBI:CHEBI:136335;
CC         Evidence={ECO:0000256|ARBA:ARBA00000277};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52085;
CC         Evidence={ECO:0000256|ARBA:ARBA00000277};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         hexadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52068,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372,
CC         ChEBI:CHEBI:136286, ChEBI:CHEBI:136309;
CC         Evidence={ECO:0000256|ARBA:ARBA00000923};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52069;
CC         Evidence={ECO:0000256|ARBA:ARBA00000923};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9-(9Z-octadecenoyloxy)-octadecanoate + H2O = (9Z)-
CC         octadecenoate + 9-hydroxy-octadecanoate + H(+); Xref=Rhea:RHEA:52048,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823,
CC         ChEBI:CHEBI:136282, ChEBI:CHEBI:136286;
CC         Evidence={ECO:0000256|ARBA:ARBA00001664};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52049;
CC         Evidence={ECO:0000256|ARBA:ARBA00001664};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-
CC         octadecanoate + H(+) + hexadecanoate; Xref=Rhea:RHEA:52052,
CC         ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:83670, ChEBI:CHEBI:136286;
CC         Evidence={ECO:0000256|ARBA:ARBA00001873};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52053;
CC         Evidence={ECO:0000256|ARBA:ARBA00001873};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-
CC         octadecanoate + H(+) + octadecanoate; Xref=Rhea:RHEA:52096,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629,
CC         ChEBI:CHEBI:136286, ChEBI:CHEBI:136373;
CC         Evidence={ECO:0000256|ARBA:ARBA00001078};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52097;
CC         Evidence={ECO:0000256|ARBA:ARBA00001078};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the AIG1 family.
CC       {ECO:0000256|ARBA:ARBA00009300}.
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DR   EMBL; AL023581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL136116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL450335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF458306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5T2H3; -.
DR   MassIVE; Q5T2H3; -.
DR   PeptideAtlas; Q5T2H3; -.
DR   ProteomicsDB; 64340; -.
DR   Antibodypedia; 53852; 168 antibodies from 30 providers.
DR   Ensembl; ENST00000447498.5; ENSP00000405048.1; ENSG00000146416.19.
DR   UCSC; uc063rys.1; human.
DR   HGNC; HGNC:21607; AIG1.
DR   VEuPathDB; HostDB:ENSG00000146416; -.
DR   GeneTree; ENSGT00940000158696; -.
DR   HOGENOM; CLU_073346_3_0_1; -.
DR   ChiTaRS; AIG1; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   Bgee; ENSG00000146416; Expressed in buccal mucosa cell and 188 other cell types or tissues.
DR   ExpressionAtlas; Q5T2H3; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006838; ADTRP_AIG1.
DR   PANTHER; PTHR10989:SF11; ANDROGEN-INDUCED GENE 1 PROTEIN; 1.
DR   PANTHER; PTHR10989; ANDROGEN-INDUCED PROTEIN 1-RELATED; 1.
DR   Pfam; PF04750; Far-17a_AIG1; 2.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:Q5T2H3,
KW   ECO:0007829|MaxQB:Q5T2H3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   NON_TER         123
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000405048.1"
SQ   SEQUENCE   123 AA;  14320 MW;  E3E0F3A23349C966 CRC64;
     MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLFVV AVFWIIYAYD
     REMIYPKLLD NFIPGWLNHG MHTTVLPFIL IEMRTSHHQY PSRSSGLTAI CTFSVGYILW
     VCW
//