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Protein

UPF0668 protein C10orf76

Gene

C10orf76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0668 protein C10orf76
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:25788. C10orf76.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei520 – 53819HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689UPF0668 protein C10orf76PRO_0000284515Add
BLAST

Proteomic databases

MaxQBiQ5T2E6.
PaxDbiQ5T2E6.
PRIDEiQ5T2E6.

PTM databases

PhosphoSiteiQ5T2E6.

Expressioni

Gene expression databases

BgeeiQ5T2E6.
CleanExiHS_C10orf76.
ExpressionAtlasiQ5T2E6. baseline and differential.
GenevestigatoriQ5T2E6.

Organism-specific databases

HPAiHPA050913.
HPA053580.

Interactioni

Protein-protein interaction databases

BioGridi122733. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5T2E6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0668 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275204.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ5T2E6.
OMAiRILCYQK.
OrthoDBiEOG76X5ZQ.
PhylomeDBiQ5T2E6.
TreeFamiTF300220.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T2E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF
60 70 80 90 100
LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA
110 120 130 140 150
LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA
160 170 180 190 200
EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP
210 220 230 240 250
SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVIAQ
260 270 280 290 300
ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL
310 320 330 340 350
ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV
360 370 380 390 400
ISSVELPLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC
410 420 430 440 450
IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL
460 470 480 490 500
MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC YQKKCRVRLH YTWRELWSAL
510 520 530 540 550
INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE
560 570 580 590 600
LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
610 620 630 640 650
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH
660 670 680
KEAAFFKELV RSISTNVRRN LAFHTLSQEV LLKEFSTIS
Length:689
Mass (Da):78,710
Last modified:December 21, 2004 - v1
Checksum:i5C21E860F3E2BD68
GO
Isoform 2 (identifier: Q5T2E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:265
Mass (Da):31,142
Checksum:i20CE6A14367BD03C
GO
Isoform 3 (identifier: Q5T2E6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.
     569-584: VLRLSTNAGQWKEAAS → EPSSTTLTPKLSPTLL
     585-689: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:160
Mass (Da):18,957
Checksum:i0E5722922841E7A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti672 – 6721A → V in BAB14447 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 424424Missing in isoform 2 and isoform 3. 2 PublicationsVSP_024552Add
BLAST
Alternative sequencei569 – 58416VLRLS…KEAAS → EPSSTTLTPKLSPTLL in isoform 3. 1 PublicationVSP_024553Add
BLAST
Alternative sequencei585 – 689105Missing in isoform 3. 1 PublicationVSP_024554Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023176 mRNA. Translation: BAB14447.1.
AL391827, AC010789 Genomic DNA. Translation: CAI16232.1.
BC110511 mRNA. No translation available.
CCDSiCCDS41563.1. [Q5T2E6-1]
RefSeqiNP_078817.2. NM_024541.2. [Q5T2E6-1]
UniGeneiHs.16004.

Genome annotation databases

EnsembliENST00000370033; ENSP00000359050; ENSG00000120029. [Q5T2E6-1]
GeneIDi79591.
KEGGihsa:79591.
UCSCiuc009xwy.1. human. [Q5T2E6-1]

Polymorphism databases

DMDMi74744614.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023176 mRNA. Translation: BAB14447.1.
AL391827, AC010789 Genomic DNA. Translation: CAI16232.1.
BC110511 mRNA. No translation available.
CCDSiCCDS41563.1. [Q5T2E6-1]
RefSeqiNP_078817.2. NM_024541.2. [Q5T2E6-1]
UniGeneiHs.16004.

3D structure databases

ProteinModelPortaliQ5T2E6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122733. 4 interactions.

PTM databases

PhosphoSiteiQ5T2E6.

Polymorphism databases

DMDMi74744614.

Proteomic databases

MaxQBiQ5T2E6.
PaxDbiQ5T2E6.
PRIDEiQ5T2E6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370033; ENSP00000359050; ENSG00000120029. [Q5T2E6-1]
GeneIDi79591.
KEGGihsa:79591.
UCSCiuc009xwy.1. human. [Q5T2E6-1]

Organism-specific databases

CTDi79591.
GeneCardsiGC10M103595.
HGNCiHGNC:25788. C10orf76.
HPAiHPA050913.
HPA053580.
neXtProtiNX_Q5T2E6.
PharmGKBiPA134903060.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275204.
GeneTreeiENSGT00390000002554.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ5T2E6.
OMAiRILCYQK.
OrthoDBiEOG76X5ZQ.
PhylomeDBiQ5T2E6.
TreeFamiTF300220.

Miscellaneous databases

GenomeRNAii79591.
NextBioi68606.

Gene expression databases

BgeeiQ5T2E6.
CleanExiHS_C10orf76.
ExpressionAtlasiQ5T2E6. baseline and differential.
GenevestigatoriQ5T2E6.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

Entry informationi

Entry nameiCJ076_HUMAN
AccessioniPrimary (citable) accession number: Q5T2E6
Secondary accession number(s): Q2TB87, Q9H8Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.