Q5T2E6 (CJ076_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0668 protein C10orf76

Gene names

Name:

C10orf76

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	689 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0668 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T2E6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T2E6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Isoform 3 (identifier: Q5T2E6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.
     569-584: VLRLSTNAGQWKEAAS → EPSSTTLTPKLSPTLL
     585-689: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 689	689	UPF0668 protein C10orf76		PRO_0000284515
Regions
	Transmembrane	520 – 538	19	Helical; Potential
Natural variations
	Alternative sequence	1 – 424	424	Missing in isoform 2 and isoform 3.		VSP_024552
	Alternative sequence	569 – 584	16	VLRLS…KEAAS → EPSSTTLTPKLSPTLL in isoform 3.		VSP_024553
	Alternative sequence	585 – 689	105	Missing in isoform 3.		VSP_024554
Experimental info
	Sequence conflict	672	1	A → V in BAB14447. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 5C21E860F3E2BD68	FASTA	689	78,710
	10 20 30 40 50 60 MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF LMKVNLEYLE 70 80 90 100 110 120 GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA LQTLCALIRG VHQKNKSTSG 130 140 150 160 170 180 FDIINMLMGF DKAELCMKNL MESLDSLLCA EGSESLKSLC LKLLLCLVTV TDNISQNTIL 190 200 210 220 230 240 EYVMINSIFE AILQILSHPP SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT 250 260 270 280 290 300 LNGMGLVIAQ ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL 310 320 330 340 350 360 ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV ISSVELPLDA 370 380 390 400 410 420 DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC IAEDQYANAF LHDDNMNFRV 430 440 450 460 470 480 NLHRMPMRHR KKAADKNLPC RPLVCAVLDL MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC 490 500 510 520 530 540 YQKKCRVRLH YTWRELWSAL INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT 550 560 570 580 590 600 FLPTPSSYDE LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF 610 620 630 640 650 660 NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH KEAAFFKELV 670 680 RSISTNVRRN LAFHTLSQEV LLKEFSTIS
	Isoform 2 [UniParc]. Checksum: 20CE6A14367BD03C	FASTA	265	31,142
	10 20 30 40 50 60 MPMRHRKKAA DKNLPCRPLV CAVLDLMVEF IVTHMMKEFP MDLYIRCIQV VHKLLCYQKK 70 80 90 100 110 120 CRVRLHYTWR ELWSALINLL KFLMSNETVL LAKHNIFTLA LMIVNLFNMF ITYGDTFLPT 130 140 150 160 170 180 PSSYDELYYE IIRMHQSFDN LYSMVLRLST NAGQWKEAAS KVTHALVNIR AIINHFNPKI 190 200 210 220 230 240 ESYAAVNHIS QLSEEQVLEV VRANYDTLTL KLQDGLDQYE RYSEQHKEAA FFKELVRSIS 250 260 TNVRRNLAFH TLSQEVLLKE FSTIS
	Isoform 3 [UniParc]. Checksum: 0E5722922841E7A7	FASTA	160	18,957
	10 20 30 40 50 60 MPMRHRKKAA DKNLPCRPLV CAVLDLMVEF IVTHMMKEFP MDLYIRCIQV VHKLLCYQKK 70 80 90 100 110 120 CRVRLHYTWR ELWSALINLL KFLMSNETVL LAKHNIFTLA LMIVNLFNMF ITYGDTFLPT 130 140 150 160 PSSYDELYYE IIRMHQSFDN LYSMEPSSTT LTPKLSPTLL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK023176 mRNA. Translation: BAB14447.1. AL391827, AC010789 Genomic DNA. Translation: CAI16232.1. BC110511 mRNA. No translation available.
IPI	IPI00646323. IPI00843920. IPI00844372.
RefSeq	NP_078817.2. NM_024541.2.
UniGene	Hs.16004.
3D structure databases
ProteinModelPortal	Q5T2E6.
ModBase	Search...
PTM databases
PhosphoSite	Q5T2E6.
Polymorphism databases
DMDM	74744614.
Proteomic databases
PaxDb	Q5T2E6.
PRIDE	Q5T2E6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370033; ENSP00000359050; ENSG00000120029.
GeneID	79591.
KEGG	hsa:79591.
UCSC	uc009xwy.1. human.
Organism-specific databases
CTD	79591.
GeneCards	GC10M103595.
HGNC	HGNC:25788. C10orf76.
HPA	HPA050913. HPA053580.
neXtProt	NX_Q5T2E6.
PharmGKB	PA134903060.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG275204.
HOGENOM	HOG000006637.
HOVERGEN	HBG058251.
InParanoid	Q5T2E6.
OMA	ERYSEQP.
OrthoDB	EOG4P5K8N.
Gene expression databases
ArrayExpress	Q5T2E6.
Bgee	Q5T2E6.
CleanEx	HS_C10orf76.
Genevestigator	Q5T2E6.
Family and domain databases
InterPro	IPR013636. DUF1741. [Graphical view]
Pfam	PF08427. DUF1741. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79591.
NextBio	68606.

Entry information

Entry name

CJ076_HUMAN

Accession

Primary (citable) accession number: Q5T2E6
Secondary accession number(s): Q2TB87, Q9H8Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.