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Q5T2E6

- CJ076_HUMAN

UniProt

Q5T2E6 - CJ076_HUMAN

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Protein
UPF0668 protein C10orf76
Gene
C10orf76
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0668 protein C10orf76
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:25788. C10orf76.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei520 – 53819Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134903060.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 689689UPF0668 protein C10orf76
PRO_0000284515Add
BLAST

Proteomic databases

MaxQBiQ5T2E6.
PaxDbiQ5T2E6.
PRIDEiQ5T2E6.

PTM databases

PhosphoSiteiQ5T2E6.

Expressioni

Gene expression databases

ArrayExpressiQ5T2E6.
BgeeiQ5T2E6.
CleanExiHS_C10orf76.
GenevestigatoriQ5T2E6.

Organism-specific databases

HPAiHPA050913.
HPA053580.

Interactioni

Protein-protein interaction databases

BioGridi122733. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5T2E6.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0668 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275204.
HOGENOMiHOG000006637.
HOVERGENiHBG058251.
InParanoidiQ5T2E6.
OMAiTYDFTHA.
OrthoDBiEOG76X5ZQ.
PhylomeDBiQ5T2E6.
TreeFamiTF300220.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view]
PfamiPF08427. DUF1741. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T2E6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF    50
LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA 100
LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA 150
EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP 200
SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVIAQ 250
ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL 300
ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV 350
ISSVELPLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC 400
IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL 450
MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC YQKKCRVRLH YTWRELWSAL 500
INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE 550
LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF 600
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH 650
KEAAFFKELV RSISTNVRRN LAFHTLSQEV LLKEFSTIS 689
Length:689
Mass (Da):78,710
Last modified:December 21, 2004 - v1
Checksum:i5C21E860F3E2BD68
GO
Isoform 2 (identifier: Q5T2E6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:265
Mass (Da):31,142
Checksum:i20CE6A14367BD03C
GO
Isoform 3 (identifier: Q5T2E6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.
     569-584: VLRLSTNAGQWKEAAS → EPSSTTLTPKLSPTLL
     585-689: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:160
Mass (Da):18,957
Checksum:i0E5722922841E7A7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 424424Missing in isoform 2 and isoform 3.
VSP_024552Add
BLAST
Alternative sequencei569 – 58416VLRLS…KEAAS → EPSSTTLTPKLSPTLL in isoform 3.
VSP_024553Add
BLAST
Alternative sequencei585 – 689105Missing in isoform 3.
VSP_024554Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti672 – 6721A → V in BAB14447. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023176 mRNA. Translation: BAB14447.1.
AL391827, AC010789 Genomic DNA. Translation: CAI16232.1.
BC110511 mRNA. No translation available.
CCDSiCCDS41563.1. [Q5T2E6-1]
RefSeqiNP_078817.2. NM_024541.2. [Q5T2E6-1]
UniGeneiHs.16004.

Genome annotation databases

EnsembliENST00000370033; ENSP00000359050; ENSG00000120029. [Q5T2E6-1]
GeneIDi79591.
KEGGihsa:79591.
UCSCiuc009xwy.1. human. [Q5T2E6-1]

Polymorphism databases

DMDMi74744614.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK023176 mRNA. Translation: BAB14447.1 .
AL391827 , AC010789 Genomic DNA. Translation: CAI16232.1 .
BC110511 mRNA. No translation available.
CCDSi CCDS41563.1. [Q5T2E6-1 ]
RefSeqi NP_078817.2. NM_024541.2. [Q5T2E6-1 ]
UniGenei Hs.16004.

3D structure databases

ProteinModelPortali Q5T2E6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122733. 1 interaction.

PTM databases

PhosphoSitei Q5T2E6.

Polymorphism databases

DMDMi 74744614.

Proteomic databases

MaxQBi Q5T2E6.
PaxDbi Q5T2E6.
PRIDEi Q5T2E6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370033 ; ENSP00000359050 ; ENSG00000120029 . [Q5T2E6-1 ]
GeneIDi 79591.
KEGGi hsa:79591.
UCSCi uc009xwy.1. human. [Q5T2E6-1 ]

Organism-specific databases

CTDi 79591.
GeneCardsi GC10M103595.
HGNCi HGNC:25788. C10orf76.
HPAi HPA050913.
HPA053580.
neXtProti NX_Q5T2E6.
PharmGKBi PA134903060.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275204.
HOGENOMi HOG000006637.
HOVERGENi HBG058251.
InParanoidi Q5T2E6.
OMAi TYDFTHA.
OrthoDBi EOG76X5ZQ.
PhylomeDBi Q5T2E6.
TreeFami TF300220.

Miscellaneous databases

GenomeRNAii 79591.
NextBioi 68606.

Gene expression databases

ArrayExpressi Q5T2E6.
Bgeei Q5T2E6.
CleanExi HS_C10orf76.
Genevestigatori Q5T2E6.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR013636. DUF1741.
[Graphical view ]
Pfami PF08427. DUF1741. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

Entry informationi

Entry nameiCJ076_HUMAN
AccessioniPrimary (citable) accession number: Q5T2E6
Secondary accession number(s): Q2TB87, Q9H8Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi