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Q5T2E6

- CJ076_HUMAN

UniProt

Q5T2E6 - CJ076_HUMAN

Protein

UPF0668 protein C10orf76

Gene

C10orf76

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0668 protein C10orf76
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25788. C10orf76.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134903060.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 689689UPF0668 protein C10orf76PRO_0000284515Add
    BLAST

    Proteomic databases

    MaxQBiQ5T2E6.
    PaxDbiQ5T2E6.
    PRIDEiQ5T2E6.

    PTM databases

    PhosphoSiteiQ5T2E6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T2E6.
    BgeeiQ5T2E6.
    CleanExiHS_C10orf76.
    GenevestigatoriQ5T2E6.

    Organism-specific databases

    HPAiHPA050913.
    HPA053580.

    Interactioni

    Protein-protein interaction databases

    BioGridi122733. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T2E6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei520 – 53819HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0668 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275204.
    HOGENOMiHOG000006637.
    HOVERGENiHBG058251.
    InParanoidiQ5T2E6.
    OMAiTYDFTHA.
    OrthoDBiEOG76X5ZQ.
    PhylomeDBiQ5T2E6.
    TreeFamiTF300220.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR013636. DUF1741.
    [Graphical view]
    PfamiPF08427. DUF1741. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T2E6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF    50
    LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA 100
    LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA 150
    EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP 200
    SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVIAQ 250
    ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL 300
    ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV 350
    ISSVELPLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC 400
    IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL 450
    MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC YQKKCRVRLH YTWRELWSAL 500
    INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE 550
    LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF 600
    NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH 650
    KEAAFFKELV RSISTNVRRN LAFHTLSQEV LLKEFSTIS 689
    Length:689
    Mass (Da):78,710
    Last modified:December 21, 2004 - v1
    Checksum:i5C21E860F3E2BD68
    GO
    Isoform 2 (identifier: Q5T2E6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-424: Missing.

    Show »
    Length:265
    Mass (Da):31,142
    Checksum:i20CE6A14367BD03C
    GO
    Isoform 3 (identifier: Q5T2E6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-424: Missing.
         569-584: VLRLSTNAGQWKEAAS → EPSSTTLTPKLSPTLL
         585-689: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:160
    Mass (Da):18,957
    Checksum:i0E5722922841E7A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti672 – 6721A → V in BAB14447. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 424424Missing in isoform 2 and isoform 3. 2 PublicationsVSP_024552Add
    BLAST
    Alternative sequencei569 – 58416VLRLS…KEAAS → EPSSTTLTPKLSPTLL in isoform 3. 1 PublicationVSP_024553Add
    BLAST
    Alternative sequencei585 – 689105Missing in isoform 3. 1 PublicationVSP_024554Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023176 mRNA. Translation: BAB14447.1.
    AL391827, AC010789 Genomic DNA. Translation: CAI16232.1.
    BC110511 mRNA. No translation available.
    CCDSiCCDS41563.1. [Q5T2E6-1]
    RefSeqiNP_078817.2. NM_024541.2. [Q5T2E6-1]
    UniGeneiHs.16004.

    Genome annotation databases

    EnsembliENST00000370033; ENSP00000359050; ENSG00000120029. [Q5T2E6-1]
    GeneIDi79591.
    KEGGihsa:79591.
    UCSCiuc009xwy.1. human. [Q5T2E6-1]

    Polymorphism databases

    DMDMi74744614.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK023176 mRNA. Translation: BAB14447.1 .
    AL391827 , AC010789 Genomic DNA. Translation: CAI16232.1 .
    BC110511 mRNA. No translation available.
    CCDSi CCDS41563.1. [Q5T2E6-1 ]
    RefSeqi NP_078817.2. NM_024541.2. [Q5T2E6-1 ]
    UniGenei Hs.16004.

    3D structure databases

    ProteinModelPortali Q5T2E6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122733. 1 interaction.

    PTM databases

    PhosphoSitei Q5T2E6.

    Polymorphism databases

    DMDMi 74744614.

    Proteomic databases

    MaxQBi Q5T2E6.
    PaxDbi Q5T2E6.
    PRIDEi Q5T2E6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370033 ; ENSP00000359050 ; ENSG00000120029 . [Q5T2E6-1 ]
    GeneIDi 79591.
    KEGGi hsa:79591.
    UCSCi uc009xwy.1. human. [Q5T2E6-1 ]

    Organism-specific databases

    CTDi 79591.
    GeneCardsi GC10M103595.
    HGNCi HGNC:25788. C10orf76.
    HPAi HPA050913.
    HPA053580.
    neXtProti NX_Q5T2E6.
    PharmGKBi PA134903060.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275204.
    HOGENOMi HOG000006637.
    HOVERGENi HBG058251.
    InParanoidi Q5T2E6.
    OMAi TYDFTHA.
    OrthoDBi EOG76X5ZQ.
    PhylomeDBi Q5T2E6.
    TreeFami TF300220.

    Miscellaneous databases

    GenomeRNAii 79591.
    NextBioi 68606.

    Gene expression databases

    ArrayExpressi Q5T2E6.
    Bgeei Q5T2E6.
    CleanExi HS_C10orf76.
    Genevestigatori Q5T2E6.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR013636. DUF1741.
    [Graphical view ]
    Pfami PF08427. DUF1741. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

    Entry informationi

    Entry nameiCJ076_HUMAN
    AccessioniPrimary (citable) accession number: Q5T2E6
    Secondary accession number(s): Q2TB87, Q9H8Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3