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Protein

Trem-like transcript 2 protein

Gene

TREML2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.2 Publications

GO - Molecular functioni

  • receptor activity Source: UniProtKB

GO - Biological processi

  • regulation of immune response Source: Reactome
  • T cell activation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Trem-like transcript 2 protein
Short name:
TLT-2
Alternative name(s):
Triggering receptor expressed on myeloid cells-like protein 2
Gene namesi
Name:TREML2
Synonyms:C6orf76, TLT2
ORF Names:UNQ6268/PRO20473
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21092. TREML2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 268ExtracellularSequence analysisAdd BLAST250
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 321CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79865.
OpenTargetsiENSG00000112195.
PharmGKBiPA134921444.

Polymorphism and mutation databases

BioMutaiTREML2.
DMDMi116256100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000025385719 – 321Trem-like transcript 2 proteinAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 105PROSITE-ProRule annotation
Disulfide bondi56 ↔ 63PROSITE-ProRule annotation
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5T2D2.
PeptideAtlasiQ5T2D2.
PRIDEiQ5T2D2.

PTM databases

iPTMnetiQ5T2D2.
PhosphoSitePlusiQ5T2D2.

Expressioni

Tissue specificityi

Detected in cultured B-cells, T-cell leukemia and monocyte leukemia. Expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation.2 Publications

Inductioni

Induced in CD4 T-cells by concanavalin-A.1 Publication

Gene expression databases

BgeeiENSG00000112195.
CleanExiHS_TREML2.
GenevisibleiQ5T2D2. HS.

Interactioni

Subunit structurei

Interacts with CD276 and this interaction enhances T-cell activation.1 Publication

Protein-protein interaction databases

BioGridi122953. 14 interactors.
IntActiQ5T2D2. 1 interactor.
STRINGi9606.ENSP00000418767.

Structurei

3D structure databases

ProteinModelPortaliQ5T2D2.
SMRiQ5T2D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 121Ig-like V-typeAdd BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGCV. Eukaryota.
ENOG411199V. LUCA.
GeneTreeiENSGT00390000016358.
HOGENOMiHOG000000686.
HOVERGENiHBG082421.
InParanoidiQ5T2D2.
KOiK14364.
OMAiVWCKIRR.
OrthoDBiEOG091G0LQ1.
PhylomeDBiQ5T2D2.
TreeFamiTF337556.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T2D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAFLLLLL LWPQGCVSGP SADSVYTKVR LLEGETLSVQ CSYKGYKNRV
60 70 80 90 100
EGKVWCKIRK KKCEPGFARV WVKGPRYLLQ DDAQAKVVNI TMVALKLQDS
110 120 130 140 150
GRYWCMRNTS GILYPLMGFQ LDVSPAPQTE RNIPFTHLDN ILKSGTVTTG
160 170 180 190 200
QAPTSGPDAP FTTGVMVFTP GLITLPRLLA STRPASKTGY SFTATSTTSQ
210 220 230 240 250
GPRRTMGSQT VTASPSNARD SSAGPESIST KSGDLSTRSP TTGLCLTSRS
260 270 280 290 300
LLNRLPSMPS IRHQDVYSTV LGVVLTLLVL MLIMVYGFWK KRHMASYSMC
310 320
SDPSTRDPPG RPEPYVEVYL I
Length:321
Mass (Da):35,127
Last modified:October 17, 2006 - v2
Checksum:iC273DABCED03F3E7
GO

Sequence cautioni

The sequence AAI25079 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI25080 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14668 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI19858 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI19909 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → G in AAI25080 (PubMed:15489334).Curated1
Sequence conflicti25V → A in AAI25080 (PubMed:15489334).Curated1
Sequence conflicti59R → K in BAB14668 (PubMed:14702039).Curated1
Sequence conflicti129T → S in AAI25079 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05941219G → C.Corresponds to variant rs4418164dbSNPEnsembl.1
Natural variantiVAR_05541850V → M.Corresponds to variant rs35512890dbSNPEnsembl.1
Natural variantiVAR_055419144S → G.1 PublicationCorresponds to variant rs3747742dbSNPEnsembl.1
Natural variantiVAR_055420285V → I.Corresponds to variant rs35521209dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF534824 mRNA. Translation: AAO15022.1.
AY358171 mRNA. Translation: AAQ88538.1.
AK023755 mRNA. Translation: BAB14668.1. Different initiation.
AL391903, AL133404 Genomic DNA. Translation: CAI19858.1. Different initiation.
AL133404, AL391903 Genomic DNA. Translation: CAI19909.1. Different initiation.
BC125078 mRNA. Translation: AAI25079.1. Different initiation.
BC125079 mRNA. Translation: AAI25080.1. Different initiation.
CCDSiCCDS4853.2.
RefSeqiNP_079083.2. NM_024807.3.
UniGeneiHs.164797.

Genome annotation databases

EnsembliENST00000483722; ENSP00000418767; ENSG00000112195.
GeneIDi79865.
KEGGihsa:79865.
UCSCiuc010jxm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF534824 mRNA. Translation: AAO15022.1.
AY358171 mRNA. Translation: AAQ88538.1.
AK023755 mRNA. Translation: BAB14668.1. Different initiation.
AL391903, AL133404 Genomic DNA. Translation: CAI19858.1. Different initiation.
AL133404, AL391903 Genomic DNA. Translation: CAI19909.1. Different initiation.
BC125078 mRNA. Translation: AAI25079.1. Different initiation.
BC125079 mRNA. Translation: AAI25080.1. Different initiation.
CCDSiCCDS4853.2.
RefSeqiNP_079083.2. NM_024807.3.
UniGeneiHs.164797.

3D structure databases

ProteinModelPortaliQ5T2D2.
SMRiQ5T2D2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122953. 14 interactors.
IntActiQ5T2D2. 1 interactor.
STRINGi9606.ENSP00000418767.

PTM databases

iPTMnetiQ5T2D2.
PhosphoSitePlusiQ5T2D2.

Polymorphism and mutation databases

BioMutaiTREML2.
DMDMi116256100.

Proteomic databases

PaxDbiQ5T2D2.
PeptideAtlasiQ5T2D2.
PRIDEiQ5T2D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000483722; ENSP00000418767; ENSG00000112195.
GeneIDi79865.
KEGGihsa:79865.
UCSCiuc010jxm.3. human.

Organism-specific databases

CTDi79865.
DisGeNETi79865.
GeneCardsiTREML2.
H-InvDBHIX0200912.
HGNCiHGNC:21092. TREML2.
MIMi609715. gene.
neXtProtiNX_Q5T2D2.
OpenTargetsiENSG00000112195.
PharmGKBiPA134921444.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCV. Eukaryota.
ENOG411199V. LUCA.
GeneTreeiENSGT00390000016358.
HOGENOMiHOG000000686.
HOVERGENiHBG082421.
InParanoidiQ5T2D2.
KOiK14364.
OMAiVWCKIRR.
OrthoDBiEOG091G0LQ1.
PhylomeDBiQ5T2D2.
TreeFamiTF337556.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAii79865.
PROiQ5T2D2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112195.
CleanExiHS_TREML2.
GenevisibleiQ5T2D2. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRML2_HUMAN
AccessioniPrimary (citable) accession number: Q5T2D2
Secondary accession number(s): Q08AP8
, Q08AP9, Q8IWY0, Q9H8E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.