Q5T292 (CJ128_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative uncharacterized protein C10orf128

Gene names

Name:

C10orf128

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane protein.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T292-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T292-2)

The sequence of this isoform differs from the canonical sequence as follows:
     91-105: RNHNFSKRDAQVIEL → AHVLRDGPAL...KVKSFPKYAY

Note: No experimental confirmation available.

Isoform 3 (identifier: Q5T292-3)

The sequence of this isoform differs from the canonical sequence as follows:
     91-105: RNHNFSKRDAQVIEL → AHVLRDGPAL...KVSCKSDHLS

Isoform 4 (identifier: Q5T292-4)

The sequence of this isoform differs from the canonical sequence as follows:
     91-105: RNHNFSKRDAQVIEL → KLQASTLFSFKSLLQCHHCIMEGLFKAKPQFLQKRCTGD

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 105	86	Putative uncharacterized protein C10orf128		PRO_0000307322
Regions
	Topological domain	20 – 38	19	Extracellular Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 105	46	Cytoplasmic Potential
Natural variations
	Alternative sequence	91 – 105	15	RNHNF…QVIEL → AHVLRDGPALGPLHLLFSVI GMLFARKLQASTLFSFKSLL QCHHCIMEGLFKAKPQFLQK HLARSVQIHQLQKVKSFPKY AY in isoform 2.		VSP_028715
	Alternative sequence	91 – 105	15	RNHNF…QVIEL → AHVLRDGPALGPLHLLFSVI GMLFARKLQASTLFSFKSLL QCHHCIMEGLFKAKPQFLQK VSCKSDHLS in isoform 3.		VSP_028716
	Alternative sequence	91 – 105	15	RNHNF…QVIEL → KLQASTLFSFKSLLQCHHCI MEGLFKAKPQFLQKRCTGD in isoform 4.		VSP_028717
	Natural variant	83	1	P → L. Corresponds to variant rs12257132 [ dbSNP | Ensembl ].		VAR_035409
Experimental info
	Sequence conflict	16	1	V → A in BI544323. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 31E0A590BAB765A7	FASTA	105	11,325
	10 20 30 40 50 60 MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR 70 80 90 100 RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR RNHNFSKRDA QVIEL
	Isoform 2 [UniParc]. Checksum: F209505109808CE4	FASTA	172	18,857
	10 20 30 40 50 60 MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR 70 80 90 100 110 120 RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR AHVLRDGPAL GPLHLLFSVI GMLFARKLQA 130 140 150 160 170 STLFSFKSLL QCHHCIMEGL FKAKPQFLQK HLARSVQIHQ LQKVKSFPKY AY
	Isoform 3 [UniParc]. Checksum: B479ECDDB58BE17D	FASTA	159	17,190
	10 20 30 40 50 60 MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR 70 80 90 100 110 120 RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR AHVLRDGPAL GPLHLLFSVI GMLFARKLQA 130 140 150 STLFSFKSLL QCHHCIMEGL FKAKPQFLQK VSCKSDHLS
	Isoform 4 [UniParc]. Checksum: 10690E2878F71A77	FASTA	129	13,983
	10 20 30 40 50 60 MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR 70 80 90 100 110 120 RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR KLQASTLFSF KSLLQCHHCI MEGLFKAKPQ FLQKRCTGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A computer system platform used to predict novel genes." Yu Z., Zheng Z., Tang T., Fu Y. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Neuroblastoma.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Hippocampus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ884399 mRNA. Translation: ABI63366.1. AL524299 mRNA. No translation available. AL441885, AC084727 Genomic DNA. Translation: CAI12987.1. AL441885, AC084727 Genomic DNA. Translation: CAI12988.1. AL441885, AC084727 Genomic DNA. Translation: CAI12990.1. CH471187 Genomic DNA. Translation: EAW93107.1. CH471187 Genomic DNA. Translation: EAW93108.1. CH471187 Genomic DNA. Translation: EAW93110.1. BC104438 mRNA. No translation available. BC104439 mRNA. No translation available. BI544323 mRNA. No translation available.
IPI	IPI00456030. IPI00513963. IPI00514406. IPI00869108.
RefSeq	NP_001010863.1. NM_001010863.1.
UniGene	Hs.385493.
3D structure databases
ProteinModelPortal	Q5T292.
ModBase	Search...
Polymorphism databases
DMDM	74744592.
Proteomic databases
PRIDE	Q5T292.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000474718; ENSP00000417246; ENSG00000204161.
GeneID	170371.
KEGG	hsa:170371.
UCSC	uc001jhm.2. human. uc001jhn.2. human. uc001jho.2. human. uc009xoc.1. human.
Organism-specific databases
CTD	170371.
GeneCards	GC10M050362.
HGNC	HGNC:27274. C10orf128.
HPA	HPA036719.
neXtProt	NX_Q5T292.
PharmGKB	PA134962893.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000000409.
Gene expression databases
ArrayExpress	Q5T292.
Bgee	Q5T292.
CleanEx	HS_C10orf128.
Genevestigator	Q5T292.
Family and domain databases
ProtoNet	Search...
Other
NextBio	88891.

Entry information

Entry name

CJ128_HUMAN

Accession

Primary (citable) accession number: Q5T292
Secondary accession number(s): A6XND2, Q5T289, Q5T291

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.