Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5T280 (CI114_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C9orf114
Gene names
Name:C9orf114
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Uncharacterized protein C9orf114
PRO_0000238468

Natural variations

Natural variant631A → V.
Corresponds to variant rs34500948 [ dbSNP | Ensembl ].
VAR_050844
Natural variant1301T → R. Ref.2
Corresponds to variant rs6478854 [ dbSNP | Ensembl ].
VAR_026552
Natural variant3691I → T. Ref.2
Corresponds to variant rs2280843 [ dbSNP | Ensembl ].
VAR_026553

Experimental info

Sequence conflict3431C → Y in AAH33677. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q5T280 [UniParc].

Last modified February 20, 2007. Version 3.
Checksum: 30A5AA406834DC27

FASTA37642,009
        10         20         30         40         50         60 
MAERGRKRPC GPGEHGQRIE WRKWKQQKKE EKKKWKDLKL MKKLERQRAQ EEQAKRLEEE 

        70         80         90        100        110        120 
EAAAEKEDRG RPYTLSVALP GSILDNAQSP ELRTYLAGQI ARACAIFCVD EIVVFDEEGQ 

       130        140        150        160        170        180 
DAKTVEGEFT GVGKKGQACV QLARILQYLE CPQYLRKAFF PKHQDLQFAG LLNPLDSPHH 

       190        200        210        220        230        240 
MRQDEESEFR EGIVVDRPTR PGHGSFVNCG MKKEVKIDKN LEPGLRVTVR LNQQQHPDCK 

       250        260        270        280        290        300 
TYHGKVVSSQ DPRTKAGLYW GYTVRLASCL SAVFAEAPFQ DGYDLTIGTS ERGSDVASAQ 

       310        320        330        340        350        360 
LPNFRHALVV FGGLQGLEAG ADADPNLEVA EPSVLFDLYV NTCPGQGSRT IRTEEAILIS 

       370 
LAALQPGLIQ AGARHT 

« Hide

References

[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-130 AND THR-369.
Tissue: Brain, Eye, Leukocyte, Ovary and Testis.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL441992 Genomic DNA. Translation: CAI15413.1.
BC010579 mRNA. Translation: AAH10579.1.
BC033677 mRNA. Translation: AAH33677.1.
BC039590 mRNA. Translation: AAH39590.1.
BC046133 mRNA. Translation: AAH46133.1.
BC063644 mRNA. Translation: AAH63644.1.
BC021273 mRNA. Translation: AAH21273.1.
CCDSCCDS6913.1.
RefSeqNP_057474.2. NM_016390.3.
UniGeneHs.224137.

3D structure databases

ProteinModelPortalQ5T280.
SMRQ5T280. Positions 75-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119567. 5 interactions.
IntActQ5T280. 3 interactions.
MINTMINT-4826834.
STRING9606.ENSP00000354812.

PTM databases

PhosphoSiteQ5T280.

Polymorphism databases

DMDM126302532.

Proteomic databases

MaxQBQ5T280.
PaxDbQ5T280.
PRIDEQ5T280.

Protocols and materials databases

DNASU51490.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361256; ENSP00000354812; ENSG00000198917.
GeneID51490.
KEGGhsa:51490.
UCSCuc004bwd.3. human.

Organism-specific databases

CTD51490.
GeneCardsGC09M131581.
HGNCHGNC:26933. C9orf114.
HPAHPA022990.
neXtProtNX_Q5T280.
PharmGKBPA134958095.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2106.
HOGENOMHOG000230622.
HOVERGENHBG058241.
KOK09142.
OMAYLNTCPS.
OrthoDBEOG773XGP.
PhylomeDBQ5T280.
TreeFamTF105821.

Gene expression databases

BgeeQ5T280.
CleanExHS_C9orf114.
GenevestigatorQ5T280.

Family and domain databases

Gene3D3.40.1280.10. 2 hits.
InterProIPR029028. Alpha/beta_knot_MTases.
IPR012340. NA-bd_OB-fold.
IPR003750. Put_MeTrfase.
IPR029026. tRNA_m1G_MTases_N.
[Graphical view]
PANTHERPTHR12150. PTHR12150. 1 hit.
PfamPF02598. Methyltrn_RNA_3. 1 hit.
[Graphical view]
SUPFAMSSF50249. SSF50249. 1 hit.
SSF75217. SSF75217. 2 hits.
ProtoNetSearch...

Other

GenomeRNAi51490.
NextBio55150.

Entry information

Entry nameCI114_HUMAN
AccessionPrimary (citable) accession number: Q5T280
Secondary accession number(s): Q0D2P6 expand/collapse secondary AC list , Q6P469, Q6PGP9, Q6PIJ1, Q6PJV9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM