Q5T215 (TPC3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trafficking protein particle complex subunit 3-like protein
Short name=TRAPPC3-like protein

Alternative name(s):
BET3-like protein

Gene names

Name:

BET3L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicular transport from endoplasmic reticulum to Golgi By similarity.
Subunit structure	Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, C4orf41/TRAPPC11 and TTC15/TRAPPC12.
Subcellular location	Golgi apparatus › cis-Golgi network By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the TRAPP small subunits family. BET3 subfamily.

Ontologies

Keywords
Biological process	ER-Golgi transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Coding sequence diversity	Alternative splicing
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T215-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T215-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Trafficking protein particle complex subunit 3-like protein		PRO_0000305083
Amino acid modifications
	Lipidation	68	1	S-palmitoyl cysteine By similarity
Natural variations
	Alternative sequence	1 – 84	84	Missing in isoform 2.		VSP_028222

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 3C2604CDF74B9CAE	FASTA	181	20,566
	10 20 30 40 50 60 MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG IGTRLVEDFL 70 80 90 100 110 120 ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK NEFSLILEKN PLVEFVEELP 130 140 150 160 170 180 AGRSSLCYCN LLCGIIRGAL EMVHLAADVT FLQDRLKGDS VTEIGITFLK KRDEKKYRGK K
	Isoform 2 [UniParc]. Checksum: 478547732C94E687	FASTA	97	10,870
	10 20 30 40 50 60 MYLGITPSVT CNNSSKNEFS LILEKNPLVE FVEELPAGRS SLCYCNLLCG IIRGALEMVH 70 80 90 LAADVTFLQD RLKGDSVTEI GITFLKKRDE KKYRGKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking." Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M. Mol. Biol. Cell 22:2083-2093(2011) [PubMed: 21525244] [Abstract] Cited for: IDENTIFICATION IN TRAPP COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL445224 Genomic DNA. Translation: CAI12935.1. AL445224, AL121953 Genomic DNA. Translation: CAI12936.1. AL445224, AL121953 Genomic DNA. Translation: CAI12937.1. AL121953, AL445224 Genomic DNA. Translation: CAI21550.1. AL121953, AL445224 Genomic DNA. Translation: CAI21551.1. CH471051 Genomic DNA. Translation: EAW48227.1. BC127757 mRNA. Translation: AAI27758.1. BC127758 mRNA. Translation: AAI27759.1.
IPI	IPI00642951. IPI00643474.
RefSeq	NP_001132916.1. NM_001139444.2.
UniGene	Hs.134795.
3D structure databases
HSSP	HSSP built from PDB template 1WC8 based on UniProtKB O55013.
ProteinModelPortal	Q5T215.
SMR	Q5T215. Positions 13-171.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5T215.
Polymorphism databases
DMDM	74744542.
Proteomic databases
PRIDE	Q5T215.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000368602; ENSP00000357591; ENSG00000173626.
GeneID	100128327.
KEGG	hsa:100128327.
UCSC	uc003pww.1. human.
Organism-specific databases
CTD	100128327.
GeneCards	GC06M116816.
HGNC	HGNC:21090. BET3L.
MIM	614137. gene.
neXtProt	NX_Q5T215.
PharmGKB	PA134866254.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12079.
GeneTree	ENSGT00390000003880.
HOGENOM	HBG381378.
HOVERGEN	HBG055045.
InParanoid	Q5T215.
OMA	FSLILDK.
PhylomeDB	Q5T215.
Gene expression databases
ArrayExpress	Q5T215.
Bgee	Q5T215.
CleanEx	HS_BET3L.
Genevestigator	Q5T215.
Family and domain databases
InterPro	IPR024096. NO_sig/Golgi_transp_ligand-bd. IPR007194. TRAPP_component. IPR016721. TRAPP_I_complex_Bet3. [Graphical view]
PANTHER	PTHR13048. PTHR13048. 1 hit.
Pfam	PF04051. TRAPP. 1 hit. [Graphical view]
PIRSF	PIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAM	SSF111126. Haem_NO-bd. 1 hit.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

TPC3L_HUMAN

Accession

Primary (citable) accession number: Q5T215
Secondary accession number(s): Q5T213, Q5T214

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.