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Protein

Trafficking protein particle complex subunit 3-like protein

Gene

TRAPPC3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3-like protein
Short name:
TRAPPC3-like protein
Alternative name(s):
BET3-like protein
Gene namesi
Name:TRAPPC3L
Synonyms:BET3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21090. TRAPPC3L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi100128327.
OpenTargetsiENSG00000173626.
PharmGKBiPA134866254.

Polymorphism and mutation databases

BioMutaiTRAPPC3L.
DMDMi74744542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050831 – 181Trafficking protein particle complex subunit 3-like proteinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ5T215.
PRIDEiQ5T215.

PTM databases

iPTMnetiQ5T215.
PhosphoSitePlusiQ5T215.

Expressioni

Gene expression databases

BgeeiENSG00000173626.
CleanExiHS_BET3L.
ExpressionAtlasiQ5T215. baseline and differential.
GenevisibleiQ5T215. HS.

Organism-specific databases

HPAiCAB006839.

Interactioni

Subunit structurei

Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.1 Publication

Protein-protein interaction databases

BioGridi128706. 12 interactors.
STRINGi9606.ENSP00000357591.

Structurei

3D structure databases

ProteinModelPortaliQ5T215.
SMRiQ5T215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiQ5T215.
KOiK20302.
OMAiCRSYSET.
OrthoDBiEOG091G0N4X.
PhylomeDBiQ5T215.
TreeFamiTF300091.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T215-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG
60 70 80 90 100
IGTRLVEDFL ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK
110 120 130 140 150
NEFSLILEKN PLVEFVEELP AGRSSLCYCN LLCGIIRGAL EMVHLAADVT
160 170 180
FLQDRLKGDS VTEIGITFLK KRDEKKYRGK K
Length:181
Mass (Da):20,566
Last modified:December 21, 2004 - v1
Checksum:i3C2604CDF74B9CAE
GO
Isoform 2 (identifier: Q5T215-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:97
Mass (Da):10,870
Checksum:i478547732C94E687
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0282221 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445224 Genomic DNA. Translation: CAI12935.1.
AL445224, AL121953 Genomic DNA. Translation: CAI12936.1.
AL445224, AL121953 Genomic DNA. Translation: CAI12937.1.
AL121953, AL445224 Genomic DNA. Translation: CAI21550.1.
AL121953, AL445224 Genomic DNA. Translation: CAI21551.1.
CH471051 Genomic DNA. Translation: EAW48227.1.
BC127757 mRNA. Translation: AAI27758.1.
BC127758 mRNA. Translation: AAI27759.1.
CCDSiCCDS47468.1. [Q5T215-1]
RefSeqiNP_001132916.1. NM_001139444.2. [Q5T215-1]
UniGeneiHs.134795.

Genome annotation databases

EnsembliENST00000356128; ENSP00000348445; ENSG00000173626. [Q5T215-2]
ENST00000368602; ENSP00000357591; ENSG00000173626. [Q5T215-1]
GeneIDi100128327.
KEGGihsa:100128327.
UCSCiuc003pwx.4. human. [Q5T215-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445224 Genomic DNA. Translation: CAI12935.1.
AL445224, AL121953 Genomic DNA. Translation: CAI12936.1.
AL445224, AL121953 Genomic DNA. Translation: CAI12937.1.
AL121953, AL445224 Genomic DNA. Translation: CAI21550.1.
AL121953, AL445224 Genomic DNA. Translation: CAI21551.1.
CH471051 Genomic DNA. Translation: EAW48227.1.
BC127757 mRNA. Translation: AAI27758.1.
BC127758 mRNA. Translation: AAI27759.1.
CCDSiCCDS47468.1. [Q5T215-1]
RefSeqiNP_001132916.1. NM_001139444.2. [Q5T215-1]
UniGeneiHs.134795.

3D structure databases

ProteinModelPortaliQ5T215.
SMRiQ5T215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128706. 12 interactors.
STRINGi9606.ENSP00000357591.

PTM databases

iPTMnetiQ5T215.
PhosphoSitePlusiQ5T215.

Polymorphism and mutation databases

BioMutaiTRAPPC3L.
DMDMi74744542.

Proteomic databases

PaxDbiQ5T215.
PRIDEiQ5T215.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356128; ENSP00000348445; ENSG00000173626. [Q5T215-2]
ENST00000368602; ENSP00000357591; ENSG00000173626. [Q5T215-1]
GeneIDi100128327.
KEGGihsa:100128327.
UCSCiuc003pwx.4. human. [Q5T215-1]

Organism-specific databases

CTDi100128327.
DisGeNETi100128327.
GeneCardsiTRAPPC3L.
HGNCiHGNC:21090. TRAPPC3L.
HPAiCAB006839.
MIMi614137. gene.
neXtProtiNX_Q5T215.
OpenTargetsiENSG00000173626.
PharmGKBiPA134866254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiQ5T215.
KOiK20302.
OMAiCRSYSET.
OrthoDBiEOG091G0N4X.
PhylomeDBiQ5T215.
TreeFamiTF300091.

Miscellaneous databases

GenomeRNAii100128327.
PROiQ5T215.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173626.
CleanExiHS_BET3L.
ExpressionAtlasiQ5T215. baseline and differential.
GenevisibleiQ5T215. HS.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPC3L_HUMAN
AccessioniPrimary (citable) accession number: Q5T215
Secondary accession number(s): Q5T213, Q5T214
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.