Reviewed, UniProtKB/Swiss-Prot Q5T215 (TPC3L_HUMAN)

Names and origin

Protein names

Recommended name:
    Trafficking protein particle complex subunit 3-like protein
      Short name=TRAPPC3-like protein
Alternative name(s):
    BET3-like protein

Gene names

Name:

BET3L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in vesicular transport from endoplasmic reticulum to Golgi By similarity.
Subunit structure	Homodimer. Part of the multisubunit TRAPP (transport protein particle) complex By similarity.
Subcellular location	Golgi apparatus › cis-Golgi network By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the TRAPP small subunits family. BET3 subfamily.

Ontologies

Keywords
Biological process	ER-Golgi transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Coding sequence diversity	Alternative splicing
PTM	Lipoprotein Palmitate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T215-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T215-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Trafficking protein particle complex subunit 3-like protein		PRO_0000305083
Amino acid modifications
	Lipidation	68	1	S-palmitoyl cysteine By similarity
Natural variations
	Alternative sequence	1 – 84	84	Missing in isoform 2.		VSP_028222

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 3C2604CDF74B9CAE	FASTA	181	20,566
	10 20 30 40 50 60 MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG IGTRLVEDFL 70 80 90 100 110 120 ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK NEFSLILEKN PLVEFVEELP 130 140 150 160 170 180 AGRSSLCYCN LLCGIIRGAL EMVHLAADVT FLQDRLKGDS VTEIGITFLK KRDEKKYRGK K
	Isoform 2. Checksum: 478547732C94E687	FASTA	97	10,870
	10 20 30 40 50 60 MYLGITPSVT CNNSSKNEFS LILEKNPLVE FVEELPAGRS SLCYCNLLCG IIRGALEMVH 70 80 90 LAADVTFLQD RLKGDSVTEI GITFLKKRDE KKYRGKK

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL445224 Genomic DNA. Translation: CAI12935.1. AL445224, AL121953 Genomic DNA. Translation: CAI12936.1. AL445224, AL121953 Genomic DNA. Translation: CAI12937.1. AL121953, AL445224 Genomic DNA. Translation: CAI21550.1. AL121953, AL445224 Genomic DNA. Translation: CAI21551.1. CH471051 Genomic DNA. Translation: EAW48227.1. BC127757 mRNA. Translation: AAI27758.1. BC127758 mRNA. Translation: AAI27759.1.
IPI	IPI00642951. IPI00643474.
RefSeq	NP_001132916.1.
UniGene	Hs.134795
3D structure databases
HSSP	HSSP built from PDB template 1WC8 based on UniProtKB O55013.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5T215.
Genome annotation databases
Ensembl	ENST00000368602; ENSP00000357591; ENSG00000173626; Homo sapiens. [Genome view]
GeneID	100128327.
KEGG	hsa:100128327.
UCSC	uc003pww.1. human.
Organism-specific databases
CTD	100128327.
GeneCards	GC06M116922.
HGNC	HGNC:21090. BET3L.
PharmGKB	PA134866254.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q5T215.
HOVERGEN	Q5T215.
OMA	FSLILDK
OrthoDB	EOG980MGT
Gene expression databases
ArrayExpress	Q5T215.
Bgee	Q5T215.
CleanEx	HS_BET3L.
Genevestigator	Q5T215.
Family and domain databases
InterPro	IPR007194. TRAPP_component. IPR016721. TRAPP_I_complex_Bet3. [Graphical view]
Pfam	PF04051. TRAPP. 1 hit. [Graphical view]
PIRSF	PIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPC3L_HUMAN

Accession

Primary (citable) accession number: Q5T215
Secondary accession number(s): Q5T213, Q5T214

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 21, 2004
Last modified:	November 24, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.