Q5T1R4 (ZEP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor HIVEP3

Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 3
Kappa-B and V(D)J recombination signal sequences-binding protein
Kappa-binding protein 1
Short name=KBP-1
Zinc finger protein ZAS3

Gene names

Name:	HIVEP3
Synonyms:	KBP1, KIAA1555, KRC, ZAS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Ref.1
Subunit structure	Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Induction	By 12-O-tetradecanoylphorbol-13 acetate (TPA).
Domain	The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures By similarity. Ref.1
Post-translational modification	Phosphorylated on threonine and serine residues By similarity.
Sequence similarities	Contains 5 C2H2-type zinc fingers.
Sequence caution	The sequence BAB13381.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 15790681. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop.

Isoform 1 (identifier: Q5T1R4-1)

Also known as: HIVEP3S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T1R4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2136-2136: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2406	2406	Transcription factor HIVEP3		PRO_0000331627
Regions
	Repeat	1964 – 1967	4	1
	Repeat	1970 – 1973	4	2
	Repeat	1993 – 1996	4	3
	Repeat	1998 – 2001	4	4
	Repeat	2067 – 2070	4	5
	Repeat	2079 – 2082	4	6
	Zinc finger	192 – 214	23	C2H2-type 1
	Zinc finger	220 – 242	23	C2H2-type 2
	Zinc finger	643 – 665	23	C2H2-type 3; degenerate
	Zinc finger	1754 – 1776	23	C2H2-type 4
	Zinc finger	1782 – 1806	25	C2H2-type 5
	Region	192 – 242	51	ZAS1
	Region	211 – 1074	864	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN By similarity
	Region	264 – 287	24	Acidic 1
	Region	862 – 883	22	Acidic 2
	Region	1754 – 1806	53	ZAS2
	Region	1817 – 1872	56	Acidic 3
	Region	2053 – 2148	96	6 X 4 AA tandem repeats of S-P-X-[RK]
	Coiled coil	1442 – 1466	25	Potential
	Motif	903 – 909	7	Nuclear localization signal Potential
	Compositional bias	308 – 334	27	Ser-rich
	Compositional bias	378 – 414	37	Ser-rich
	Compositional bias	797 – 819	23	Ser-rich
	Compositional bias	844 – 880	37	Glu/Pro-rich
	Compositional bias	916 – 948	33	Ser-rich
	Compositional bias	1907 – 1936	30	Ser-rich
Natural variations
	Alternative sequence	2136	1	Missing in isoform 2.		VSP_033279
	Natural variant	35	1	V → I. Corresponds to variant rs2146315 [ dbSNP | Ensembl ].		VAR_042910
	Natural variant	484	1	V → M in a colorectal cancer sample; somatic mutation. Ref.6		VAR_042911
	Natural variant	575	1	H → R. Ref.1 Ref.2 Ref.5 Corresponds to variant rs2810566 [ dbSNP | Ensembl ].		VAR_042912
	Natural variant	1087	1	Q → H. Corresponds to variant rs17363472 [ dbSNP | Ensembl ].		VAR_042913
	Natural variant	2023	1	A → P. Ref.1 Ref.2 Ref.5 Corresponds to variant rs2483689 [ dbSNP | Ensembl ].		VAR_042914
	Natural variant	2109	1	D → A. Ref.1 Ref.2 Ref.5 Corresponds to variant rs2991344 [ dbSNP | Ensembl ].		VAR_042915
	Natural variant	2272	1	G → R. Ref.1 Corresponds to variant rs11809423 [ dbSNP | Ensembl ].		VAR_042916
	Natural variant	2339	1	T → A. Ref.1 Ref.2 Ref.5 Corresponds to variant rs9439043 [ dbSNP | Ensembl ].		VAR_042917
Experimental info
	Sequence conflict	44	1	A → P in AAK01082. Ref.1
	Sequence conflict	94 – 95	2	QL → HV in AAK01082. Ref.1
	Sequence conflict	123	1	D → S in AAK01082. Ref.1
	Sequence conflict	127	1	P → L in AAK01082. Ref.1
	Sequence conflict	133 – 134	2	FV → LL in AAK01082. Ref.1
	Sequence conflict	589	1	R → P in AAK01082. Ref.1
	Sequence conflict	901	1	L → A in AAK01082. Ref.1
	Sequence conflict	961	1	S → D in AAK01082. Ref.1
	Sequence conflict	1034 – 1035	2	RV → GE in AAK01082. Ref.1
	Sequence conflict	1048 – 1049	2	QA → SP in AAK01082. Ref.1
	Sequence conflict	1110	1	P → A in AAK01082. Ref.1
	Sequence conflict	1180	1	P → L in BAB13381. Ref.2
	Sequence conflict	1180	1	P → L in AAI52564. Ref.5
	Sequence conflict	1279	1	T → Q in AAK01082. Ref.1
	Sequence conflict	1524	1	T → Q in AAK01082. Ref.1
	Sequence conflict	2376	1	P → S in AAK01082. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HIVEP3S) [UniParc]. Last modified December 21, 2004. Version 1. Checksum: AFCCFDAF87014A7D	FASTA	2,406	259,465
	10 20 30 40 50 60 MDPEQSVKGT KKAEGSPRKR LTKGEAIQTS VSSSVPYPGS GTAATQESPA QELLAPQPFP 70 80 90 100 110 120 GPSSVLREGS QEKTGQQQKP PKRPPIEASV HISQLPQHPL TPAFMSPGKP EHLLEGSTWQ 130 140 150 160 170 180 LVDPMRPGPS GSFVAPGLHP QSQLLPSHAS IIPPEDLPGV PKVFVPRPSQ VSLKPTEEAH 190 200 210 220 230 240 KKERKPQKPG KYICQYCSRP CAKPSVLQKH IRSHTGERPY PCGPCGFSFK TKSNLYKHRK 250 260 270 280 290 300 SHAHRIKAGL ASGMGGEMYP HGLEMERIPG EEFEEPTEGE STDSEEETSA TSGHPAELSP 310 320 330 340 350 360 RPKQPLLSSG LYSSGSHSSS HERCSLSQSS TAQSLEDPPP FVEPSSEHPL SHKPEDTHTI 370 380 390 400 410 420 KQKLALRLSE RKKVIDEQAF LSPGSKGSTE SGYFSRSESA EQQVSPPNTN AKSYAEIIFG 430 440 450 460 470 480 KCGRIGQRTA MLTATSTQPL LPLSTEDKPS LVPLSVPRTQ VIEHITKLIT INEAVVDTSE 490 500 510 520 530 540 IDSVKPRRSS LSRRSSMESP KSSLYREPLS SHSEKTKPEQ SLLSLQHPPS TAPPVPLLRS 550 560 570 580 590 600 HSMPSAACTI STPHHPFRGS YSFDDHITDS EALSHSSHVF TSHPRMLKRQ PAIELPLGGE 610 620 630 640 650 660 YSSEEPGPSS KDTASKPSDE VEPKESELTK KTKKGLKTKG VIYECNICGA RYKKRDNYEA 670 680 690 700 710 720 HKKYYCSELQ IAKPISAGTH TSPEAEKSQI EHEPWSQMMH YKLGTTLELT PLRKRRKEKS 730 740 750 760 770 780 LGDEEEPPAF ESTKSQFGSP GPSDAARNLP LESTKSPAEP SKSVPSLEGP TGFQPRTPKP 790 800 810 820 830 840 GSGSESGKER RTTSKEISVI QHTSSFEKSD SLEQPSGLEG EDKPLAQFPS PPPAPHGRSA 850 860 870 880 890 900 HSLQPKLVRQ PNIQVPEILV TEEPDRPDTE PEPPPKEPEK TEEFQWPQRS QTLAQLPAEK 910 920 930 940 950 960 LPPKKKRLRL AEMAQSSGES SFESSVPLSR SPSQESNVSL SGSSRSASFE RDDHGKAEAP 970 980 990 1000 1010 1020 SPSSDMRPKP LGTHMLTVPS HHPHAREMRR SASEQSPNVS HSAHMTETRS KSFDYGSLSL 1030 1040 1050 1060 1070 1080 TGPSAPAPVA PPARVAPPER RKCFLVRQAS LSRPPESELE VAPKGRQESE EPQPSSSKPS 1090 1100 1110 1120 1130 1140 AKSSLSQISS AATSHGGPPG GKGPGQDRPP LGPTVPYTEA LQVFHHPVAQ TPLHEKPYLP 1150 1160 1170 1180 1190 1200 PPVSLFSFQH LVQHEPGQSP EFFSTQAMSS LLSSPYSMPP LPPSLFQAPP LPLQPTVLHP 1210 1220 1230 1240 1250 1260 GQLHLPQLMP HPANIPFRQP PSFLPMPYPT SSALSSGFFL PLQSQFALQL PGDVESHLPQ 1270 1280 1290 1300 1310 1320 IKTSLAPLAT GSAGLSPSTE YSSDIRLPPV APPASSSAPT SAPPLALPAC PDTMVSLVVP 1330 1340 1350 1360 1370 1380 VRVQTNMPSY GSAMYTTLSQ ILVTQSQGSS ATVALPKFEE PPSKGTTVCG ADVHEVGPGP 1390 1400 1410 1420 1430 1440 SGLSEEQSRA FPTPYLRVPV TLPERKGTSL SSESILSLEG SSSTAGGSKR VLSPAGSLEL 1450 1460 1470 1480 1490 1500 TMETQQQKRV KEEEASKADE KLELVKPCSV VLTSTEDGKR PEKSHLGNQG QGRRELEMLS 1510 1520 1530 1540 1550 1560 SLSSDPSDTK EIPPLPHPAL SHGTAPGSEA LKEYPQPSGK PHRRGLTPLS VKKEDSKEQP 1570 1580 1590 1600 1610 1620 DLPSLAPPSS LPLSETSSRP AKSQEGTDSK KVLQFPSLHT TTNVSWCYLN YIKPNHIQHA 1630 1640 1650 1660 1670 1680 DRRSSVYAGW CISLYNPNLP GVSTKAALSL LRSKQKVSKE TYTMATAPHP EAGRLVPSSS 1690 1700 1710 1720 1730 1740 RKPRMTEVHL PSLVSPEGQK DLARVEKEEE RRGEPEEDAP ASQRGEPARI KIFEGGYKSN 1750 1760 1770 1780 1790 1800 EEYVYVRGRG RGKYVCEECG IRCKKPSMLK KHIRTHTDVR PYVCKHCHFA FKTKGNLTKH 1810 1820 1830 1840 1850 1860 MKSKAHSKKC QETGVLEELE AEEGTSDDLF QDSEGREGSE AVEEHQFSDL EDSDSDSDLD 1870 1880 1890 1900 1910 1920 EDEDEDEEES QDELSRPSSE APPPGPPHAL RADSSPILGP QPPDAPASGT EATRGSSVSE 1930 1940 1950 1960 1970 1980 AERLTASSCS MSSQSMPGLP WLGPAPLGSV EKDTGSALSY KPVSPRRPWS PSKEAGSRPP 1990 2000 2010 2020 2030 2040 LARKHSLTKN DSSPQRCSPA REPQASAPSP PGLHVDPGRG MGALPCGSPR LQLSPLTLCP 2050 2060 2070 2080 2090 2100 LGRELAPRAH VLSKLEGTTD PGLPRYSPTR RWSPGQAESP PRSAPPGKWA LAGPGSPSAG 2110 2120 2130 2140 2150 2160 EHGPGLGLDP RVLFPPAPLP HKLLSRSPET CASPWQKAES RSPSCSPGPA HPLSSRPFSA 2170 2180 2190 2200 2210 2220 LHDFHGHILA RTEENIFSHL PLHSQHLTRA PCPLIPIGGI QMVQARPGAH PTLLPGPTAA 2230 2240 2250 2260 2270 2280 WVSGFSGGGS DLTGAREAQE RGRWSPTESS SASVSPVAKV SKFTLSSELE GGDYPKERER 2290 2300 2310 2320 2330 2340 TGGGPGRPPD WTPHGTGAPA EPTPTHSPCT PPDTLPRPPQ GRRAAQSWSP RLESPRAPTN 2350 2360 2370 2380 2390 2400 PEPSATPPLD RSSSVGCLAE ASARFPARTR NLSGEPRTRQ DSPKPSGSGE PRAHPHQPED RVPPNA
	Isoform 2 [UniParc]. Checksum: 2FC59B5BAB2DE97D	FASTA	2,405	259,336
	10 20 30 40 50 60 MDPEQSVKGT KKAEGSPRKR LTKGEAIQTS VSSSVPYPGS GTAATQESPA QELLAPQPFP 70 80 90 100 110 120 GPSSVLREGS QEKTGQQQKP PKRPPIEASV HISQLPQHPL TPAFMSPGKP EHLLEGSTWQ 130 140 150 160 170 180 LVDPMRPGPS GSFVAPGLHP QSQLLPSHAS IIPPEDLPGV PKVFVPRPSQ VSLKPTEEAH 190 200 210 220 230 240 KKERKPQKPG KYICQYCSRP CAKPSVLQKH IRSHTGERPY PCGPCGFSFK TKSNLYKHRK 250 260 270 280 290 300 SHAHRIKAGL ASGMGGEMYP HGLEMERIPG EEFEEPTEGE STDSEEETSA TSGHPAELSP 310 320 330 340 350 360 RPKQPLLSSG LYSSGSHSSS HERCSLSQSS TAQSLEDPPP FVEPSSEHPL SHKPEDTHTI 370 380 390 400 410 420 KQKLALRLSE RKKVIDEQAF LSPGSKGSTE SGYFSRSESA EQQVSPPNTN AKSYAEIIFG 430 440 450 460 470 480 KCGRIGQRTA MLTATSTQPL LPLSTEDKPS LVPLSVPRTQ VIEHITKLIT INEAVVDTSE 490 500 510 520 530 540 IDSVKPRRSS LSRRSSMESP KSSLYREPLS SHSEKTKPEQ SLLSLQHPPS TAPPVPLLRS 550 560 570 580 590 600 HSMPSAACTI STPHHPFRGS YSFDDHITDS EALSHSSHVF TSHPRMLKRQ PAIELPLGGE 610 620 630 640 650 660 YSSEEPGPSS KDTASKPSDE VEPKESELTK KTKKGLKTKG VIYECNICGA RYKKRDNYEA 670 680 690 700 710 720 HKKYYCSELQ IAKPISAGTH TSPEAEKSQI EHEPWSQMMH YKLGTTLELT PLRKRRKEKS 730 740 750 760 770 780 LGDEEEPPAF ESTKSQFGSP GPSDAARNLP LESTKSPAEP SKSVPSLEGP TGFQPRTPKP 790 800 810 820 830 840 GSGSESGKER RTTSKEISVI QHTSSFEKSD SLEQPSGLEG EDKPLAQFPS PPPAPHGRSA 850 860 870 880 890 900 HSLQPKLVRQ PNIQVPEILV TEEPDRPDTE PEPPPKEPEK TEEFQWPQRS QTLAQLPAEK 910 920 930 940 950 960 LPPKKKRLRL AEMAQSSGES SFESSVPLSR SPSQESNVSL SGSSRSASFE RDDHGKAEAP 970 980 990 1000 1010 1020 SPSSDMRPKP LGTHMLTVPS HHPHAREMRR SASEQSPNVS HSAHMTETRS KSFDYGSLSL 1030 1040 1050 1060 1070 1080 TGPSAPAPVA PPARVAPPER RKCFLVRQAS LSRPPESELE VAPKGRQESE EPQPSSSKPS 1090 1100 1110 1120 1130 1140 AKSSLSQISS AATSHGGPPG GKGPGQDRPP LGPTVPYTEA LQVFHHPVAQ TPLHEKPYLP 1150 1160 1170 1180 1190 1200 PPVSLFSFQH LVQHEPGQSP EFFSTQAMSS LLSSPYSMPP LPPSLFQAPP LPLQPTVLHP 1210 1220 1230 1240 1250 1260 GQLHLPQLMP HPANIPFRQP PSFLPMPYPT SSALSSGFFL PLQSQFALQL PGDVESHLPQ 1270 1280 1290 1300 1310 1320 IKTSLAPLAT GSAGLSPSTE YSSDIRLPPV APPASSSAPT SAPPLALPAC PDTMVSLVVP 1330 1340 1350 1360 1370 1380 VRVQTNMPSY GSAMYTTLSQ ILVTQSQGSS ATVALPKFEE PPSKGTTVCG ADVHEVGPGP 1390 1400 1410 1420 1430 1440 SGLSEEQSRA FPTPYLRVPV TLPERKGTSL SSESILSLEG SSSTAGGSKR VLSPAGSLEL 1450 1460 1470 1480 1490 1500 TMETQQQKRV KEEEASKADE KLELVKPCSV VLTSTEDGKR PEKSHLGNQG QGRRELEMLS 1510 1520 1530 1540 1550 1560 SLSSDPSDTK EIPPLPHPAL SHGTAPGSEA LKEYPQPSGK PHRRGLTPLS VKKEDSKEQP 1570 1580 1590 1600 1610 1620 DLPSLAPPSS LPLSETSSRP AKSQEGTDSK KVLQFPSLHT TTNVSWCYLN YIKPNHIQHA 1630 1640 1650 1660 1670 1680 DRRSSVYAGW CISLYNPNLP GVSTKAALSL LRSKQKVSKE TYTMATAPHP EAGRLVPSSS 1690 1700 1710 1720 1730 1740 RKPRMTEVHL PSLVSPEGQK DLARVEKEEE RRGEPEEDAP ASQRGEPARI KIFEGGYKSN 1750 1760 1770 1780 1790 1800 EEYVYVRGRG RGKYVCEECG IRCKKPSMLK KHIRTHTDVR PYVCKHCHFA FKTKGNLTKH 1810 1820 1830 1840 1850 1860 MKSKAHSKKC QETGVLEELE AEEGTSDDLF QDSEGREGSE AVEEHQFSDL EDSDSDSDLD 1870 1880 1890 1900 1910 1920 EDEDEDEEES QDELSRPSSE APPPGPPHAL RADSSPILGP QPPDAPASGT EATRGSSVSE 1930 1940 1950 1960 1970 1980 AERLTASSCS MSSQSMPGLP WLGPAPLGSV EKDTGSALSY KPVSPRRPWS PSKEAGSRPP 1990 2000 2010 2020 2030 2040 LARKHSLTKN DSSPQRCSPA REPQASAPSP PGLHVDPGRG MGALPCGSPR LQLSPLTLCP 2050 2060 2070 2080 2090 2100 LGRELAPRAH VLSKLEGTTD PGLPRYSPTR RWSPGQAESP PRSAPPGKWA LAGPGSPSAG 2110 2120 2130 2140 2150 2160 EHGPGLGLDP RVLFPPAPLP HKLLSRSPET CASPWKAESR SPSCSPGPAH PLSSRPFSAL 2170 2180 2190 2200 2210 2220 HDFHGHILAR TEENIFSHLP LHSQHLTRAP CPLIPIGGIQ MVQARPGAHP TLLPGPTAAW 2230 2240 2250 2260 2270 2280 VSGFSGGGSD LTGAREAQER GRWSPTESSS ASVSPVAKVS KFTLSSELEG GDYPKERERT 2290 2300 2310 2320 2330 2340 GGGPGRPPDW TPHGTGAPAE PTPTHSPCTP PDTLPRPPQG RRAAQSWSPR LESPRAPTNP 2350 2360 2370 2380 2390 2400 EPSATPPLDR SSSVGCLAEA SARFPARTRN LSGEPRTRQD SPKPSGSGEP RAHPHQPEDR VPPNA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2." Hicar M.D., Liu Y., Allen C.E., Wu L.-C. Genomics 71:89-100(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, DOMAIN, VARIANTS ARG-575; PRO-2023; ALA-2109; ARG-2272 AND ALA-2339. Tissue: Brain.
[2]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339. Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-484.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF278765 mRNA. Translation: AAK01082.1. AB046775 mRNA. Translation: BAB13381.2. Different initiation. AL445933 Genomic DNA. Translation: CAI14537.1. AL445933 Genomic DNA. Translation: CAI14538.1. BC152563 mRNA. Translation: AAI52564.1.
IPI	IPI00328089. IPI00641105.
RefSeq	NP_001121186.1. NM_001127714.2. NP_078779.2. NM_024503.4.
UniGene	Hs.403972. Hs.648369.
3D structure databases
HSSP	HSSP built from PDB template 1BBO based on UniProtKB P15822.
ProteinModelPortal	Q5T1R4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000247584.
PTM databases
PhosphoSite	Q5T1R4.
Polymorphism databases
DMDM	74756245.
Proteomic databases
PaxDb	Q5T1R4.
PRIDE	Q5T1R4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247584; ENSP00000247584; ENSG00000127124. ENST00000372583; ENSP00000361664; ENSG00000127124. ENST00000372584; ENSP00000361665; ENSG00000127124. ENST00000429157; ENSP00000410828; ENSG00000127124.
GeneID	59269.
KEGG	hsa:59269.
UCSC	uc001cgz.4. human. uc001cha.4. human.
Organism-specific databases
CTD	59269.
GeneCards	GC01M041974.
HGNC	HGNC:13561. HIVEP3.
HPA	HPA005728.
MIM	606649. gene.
neXtProt	NX_Q5T1R4.
PharmGKB	PA29299.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG296349.
HOGENOM	HOG000155774.
HOVERGEN	HBG095595.
InParanoid	Q5T1R4.
KO	K09239.
OMA	MERIPGE.
PhylomeDB	Q5T1R4.
Gene expression databases
Bgee	Q5T1R4.
CleanEx	HS_HIVEP3.
Genevestigator	Q5T1R4.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HIVEP3. human.
GenomeRNAi	59269.
NextBio	65146.
SOURCE	Search...

Entry information

Entry name

ZEP3_HUMAN

Accession

Primary (citable) accession number: Q5T1R4
Secondary accession number(s): A7YY91 , Q5T1R5, Q9BZS0, Q9HCL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.