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Q5T1R4 (ZEP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor HIVEP3
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 3
Kappa-B and V(D)J recombination signal sequences-binding protein
Kappa-binding protein 1
Short name=KBP-1
Zinc finger protein ZAS3
Gene names
Name:HIVEP3
Synonyms:KBP1, KIAA1555, KRC, ZAS3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2406 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. Ref.1

Subunit structure

Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Induction

By 12-O-tetradecanoylphorbol-13 acetate (TPA).

Domain

The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures By similarity. Ref.1

Post-translational modification

Phosphorylated on threonine and serine residues By similarity.

Sequence similarities

Contains 5 C2H2-type zinc fingers.

Sequence caution

The sequence BAB13381.2 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop.
Isoform 1 (identifier: Q5T1R4-1)

Also known as: HIVEP3S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T1R4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2136-2136: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24062406Transcription factor HIVEP3
PRO_0000331627

Regions

Repeat1964 – 196741
Repeat1970 – 197342
Repeat1993 – 199643
Repeat1998 – 200144
Repeat2067 – 207045
Repeat2079 – 208246
Zinc finger192 – 21423C2H2-type 1
Zinc finger220 – 24223C2H2-type 2
Zinc finger643 – 66523C2H2-type 3; degenerate
Zinc finger1754 – 177623C2H2-type 4
Zinc finger1782 – 180625C2H2-type 5
Region192 – 24251ZAS1
Region211 – 1074864No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN By similarity
Region264 – 28724Acidic 1
Region862 – 88322Acidic 2
Region1754 – 180653ZAS2
Region1817 – 187256Acidic 3
Region2053 – 2148966 X 4 AA tandem repeats of S-P-X-[RK]
Coiled coil1442 – 146625 Potential
Motif903 – 9097Nuclear localization signal Potential
Compositional bias308 – 33427Ser-rich
Compositional bias378 – 41437Ser-rich
Compositional bias797 – 81923Ser-rich
Compositional bias844 – 88037Glu/Pro-rich
Compositional bias916 – 94833Ser-rich
Compositional bias1907 – 193630Ser-rich

Natural variations

Alternative sequence21361Missing in isoform 2.
VSP_033279
Natural variant351V → I.
Corresponds to variant rs2146315 [ dbSNP | Ensembl ].
VAR_042910
Natural variant4841V → M in a colorectal cancer sample; somatic mutation. Ref.6
VAR_042911
Natural variant5751H → R. Ref.1 Ref.2 Ref.5
Corresponds to variant rs2810566 [ dbSNP | Ensembl ].
VAR_042912
Natural variant10871Q → H.
Corresponds to variant rs17363472 [ dbSNP | Ensembl ].
VAR_042913
Natural variant20231A → P. Ref.1 Ref.2 Ref.5
Corresponds to variant rs2483689 [ dbSNP | Ensembl ].
VAR_042914
Natural variant21091D → A. Ref.1 Ref.2 Ref.5
Corresponds to variant rs2991344 [ dbSNP | Ensembl ].
VAR_042915
Natural variant22721G → R. Ref.1
Corresponds to variant rs11809423 [ dbSNP | Ensembl ].
VAR_042916
Natural variant23391T → A. Ref.1 Ref.2 Ref.5
Corresponds to variant rs9439043 [ dbSNP | Ensembl ].
VAR_042917

Experimental info

Sequence conflict441A → P in AAK01082. Ref.1
Sequence conflict94 – 952QL → HV in AAK01082. Ref.1
Sequence conflict1231D → S in AAK01082. Ref.1
Sequence conflict1271P → L in AAK01082. Ref.1
Sequence conflict133 – 1342FV → LL in AAK01082. Ref.1
Sequence conflict5891R → P in AAK01082. Ref.1
Sequence conflict9011L → A in AAK01082. Ref.1
Sequence conflict9611S → D in AAK01082. Ref.1
Sequence conflict1034 – 10352RV → GE in AAK01082. Ref.1
Sequence conflict1048 – 10492QA → SP in AAK01082. Ref.1
Sequence conflict11101P → A in AAK01082. Ref.1
Sequence conflict11801P → L in BAB13381. Ref.2
Sequence conflict11801P → L in AAI52564. Ref.5
Sequence conflict12791T → Q in AAK01082. Ref.1
Sequence conflict15241T → Q in AAK01082. Ref.1
Sequence conflict23761P → S in AAK01082. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (HIVEP3S) [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: AFCCFDAF87014A7D

FASTA2,406259,465
        10         20         30         40         50         60 
MDPEQSVKGT KKAEGSPRKR LTKGEAIQTS VSSSVPYPGS GTAATQESPA QELLAPQPFP 

        70         80         90        100        110        120 
GPSSVLREGS QEKTGQQQKP PKRPPIEASV HISQLPQHPL TPAFMSPGKP EHLLEGSTWQ 

       130        140        150        160        170        180 
LVDPMRPGPS GSFVAPGLHP QSQLLPSHAS IIPPEDLPGV PKVFVPRPSQ VSLKPTEEAH 

       190        200        210        220        230        240 
KKERKPQKPG KYICQYCSRP CAKPSVLQKH IRSHTGERPY PCGPCGFSFK TKSNLYKHRK 

       250        260        270        280        290        300 
SHAHRIKAGL ASGMGGEMYP HGLEMERIPG EEFEEPTEGE STDSEEETSA TSGHPAELSP 

       310        320        330        340        350        360 
RPKQPLLSSG LYSSGSHSSS HERCSLSQSS TAQSLEDPPP FVEPSSEHPL SHKPEDTHTI 

       370        380        390        400        410        420 
KQKLALRLSE RKKVIDEQAF LSPGSKGSTE SGYFSRSESA EQQVSPPNTN AKSYAEIIFG 

       430        440        450        460        470        480 
KCGRIGQRTA MLTATSTQPL LPLSTEDKPS LVPLSVPRTQ VIEHITKLIT INEAVVDTSE 

       490        500        510        520        530        540 
IDSVKPRRSS LSRRSSMESP KSSLYREPLS SHSEKTKPEQ SLLSLQHPPS TAPPVPLLRS 

       550        560        570        580        590        600 
HSMPSAACTI STPHHPFRGS YSFDDHITDS EALSHSSHVF TSHPRMLKRQ PAIELPLGGE 

       610        620        630        640        650        660 
YSSEEPGPSS KDTASKPSDE VEPKESELTK KTKKGLKTKG VIYECNICGA RYKKRDNYEA 

       670        680        690        700        710        720 
HKKYYCSELQ IAKPISAGTH TSPEAEKSQI EHEPWSQMMH YKLGTTLELT PLRKRRKEKS 

       730        740        750        760        770        780 
LGDEEEPPAF ESTKSQFGSP GPSDAARNLP LESTKSPAEP SKSVPSLEGP TGFQPRTPKP 

       790        800        810        820        830        840 
GSGSESGKER RTTSKEISVI QHTSSFEKSD SLEQPSGLEG EDKPLAQFPS PPPAPHGRSA 

       850        860        870        880        890        900 
HSLQPKLVRQ PNIQVPEILV TEEPDRPDTE PEPPPKEPEK TEEFQWPQRS QTLAQLPAEK 

       910        920        930        940        950        960 
LPPKKKRLRL AEMAQSSGES SFESSVPLSR SPSQESNVSL SGSSRSASFE RDDHGKAEAP 

       970        980        990       1000       1010       1020 
SPSSDMRPKP LGTHMLTVPS HHPHAREMRR SASEQSPNVS HSAHMTETRS KSFDYGSLSL 

      1030       1040       1050       1060       1070       1080 
TGPSAPAPVA PPARVAPPER RKCFLVRQAS LSRPPESELE VAPKGRQESE EPQPSSSKPS 

      1090       1100       1110       1120       1130       1140 
AKSSLSQISS AATSHGGPPG GKGPGQDRPP LGPTVPYTEA LQVFHHPVAQ TPLHEKPYLP 

      1150       1160       1170       1180       1190       1200 
PPVSLFSFQH LVQHEPGQSP EFFSTQAMSS LLSSPYSMPP LPPSLFQAPP LPLQPTVLHP 

      1210       1220       1230       1240       1250       1260 
GQLHLPQLMP HPANIPFRQP PSFLPMPYPT SSALSSGFFL PLQSQFALQL PGDVESHLPQ 

      1270       1280       1290       1300       1310       1320 
IKTSLAPLAT GSAGLSPSTE YSSDIRLPPV APPASSSAPT SAPPLALPAC PDTMVSLVVP 

      1330       1340       1350       1360       1370       1380 
VRVQTNMPSY GSAMYTTLSQ ILVTQSQGSS ATVALPKFEE PPSKGTTVCG ADVHEVGPGP 

      1390       1400       1410       1420       1430       1440 
SGLSEEQSRA FPTPYLRVPV TLPERKGTSL SSESILSLEG SSSTAGGSKR VLSPAGSLEL 

      1450       1460       1470       1480       1490       1500 
TMETQQQKRV KEEEASKADE KLELVKPCSV VLTSTEDGKR PEKSHLGNQG QGRRELEMLS 

      1510       1520       1530       1540       1550       1560 
SLSSDPSDTK EIPPLPHPAL SHGTAPGSEA LKEYPQPSGK PHRRGLTPLS VKKEDSKEQP 

      1570       1580       1590       1600       1610       1620 
DLPSLAPPSS LPLSETSSRP AKSQEGTDSK KVLQFPSLHT TTNVSWCYLN YIKPNHIQHA 

      1630       1640       1650       1660       1670       1680 
DRRSSVYAGW CISLYNPNLP GVSTKAALSL LRSKQKVSKE TYTMATAPHP EAGRLVPSSS 

      1690       1700       1710       1720       1730       1740 
RKPRMTEVHL PSLVSPEGQK DLARVEKEEE RRGEPEEDAP ASQRGEPARI KIFEGGYKSN 

      1750       1760       1770       1780       1790       1800 
EEYVYVRGRG RGKYVCEECG IRCKKPSMLK KHIRTHTDVR PYVCKHCHFA FKTKGNLTKH 

      1810       1820       1830       1840       1850       1860 
MKSKAHSKKC QETGVLEELE AEEGTSDDLF QDSEGREGSE AVEEHQFSDL EDSDSDSDLD 

      1870       1880       1890       1900       1910       1920 
EDEDEDEEES QDELSRPSSE APPPGPPHAL RADSSPILGP QPPDAPASGT EATRGSSVSE 

      1930       1940       1950       1960       1970       1980 
AERLTASSCS MSSQSMPGLP WLGPAPLGSV EKDTGSALSY KPVSPRRPWS PSKEAGSRPP 

      1990       2000       2010       2020       2030       2040 
LARKHSLTKN DSSPQRCSPA REPQASAPSP PGLHVDPGRG MGALPCGSPR LQLSPLTLCP 

      2050       2060       2070       2080       2090       2100 
LGRELAPRAH VLSKLEGTTD PGLPRYSPTR RWSPGQAESP PRSAPPGKWA LAGPGSPSAG 

      2110       2120       2130       2140       2150       2160 
EHGPGLGLDP RVLFPPAPLP HKLLSRSPET CASPWQKAES RSPSCSPGPA HPLSSRPFSA 

      2170       2180       2190       2200       2210       2220 
LHDFHGHILA RTEENIFSHL PLHSQHLTRA PCPLIPIGGI QMVQARPGAH PTLLPGPTAA 

      2230       2240       2250       2260       2270       2280 
WVSGFSGGGS DLTGAREAQE RGRWSPTESS SASVSPVAKV SKFTLSSELE GGDYPKERER 

      2290       2300       2310       2320       2330       2340 
TGGGPGRPPD WTPHGTGAPA EPTPTHSPCT PPDTLPRPPQ GRRAAQSWSP RLESPRAPTN 

      2350       2360       2370       2380       2390       2400 
PEPSATPPLD RSSSVGCLAE ASARFPARTR NLSGEPRTRQ DSPKPSGSGE PRAHPHQPED 


RVPPNA 

« Hide

Isoform 2 [UniParc].

Checksum: 2FC59B5BAB2DE97D
Show »

FASTA2,405259,336

References

« Hide 'large scale' references
[1]"Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2."
Hicar M.D., Liu Y., Allen C.E., Wu L.-C.
Genomics 71:89-100(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, DOMAIN, VARIANTS ARG-575; PRO-2023; ALA-2109; ARG-2272 AND ALA-2339.
Tissue: Brain.
[2]"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339.
Tissue: Brain.
[3]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339.
[6]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-484.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF278765 mRNA. Translation: AAK01082.1.
AB046775 mRNA. Translation: BAB13381.2. Different initiation.
AL445933 Genomic DNA. Translation: CAI14537.1.
AL445933 Genomic DNA. Translation: CAI14538.1.
BC152563 mRNA. Translation: AAI52564.1.
CCDSCCDS44124.1. [Q5T1R4-2]
CCDS463.1. [Q5T1R4-1]
RefSeqNP_001121186.1. NM_001127714.2. [Q5T1R4-2]
NP_078779.2. NM_024503.4. [Q5T1R4-1]
XP_006710871.1. XM_006710808.1. [Q5T1R4-1]
UniGeneHs.403972.
Hs.648369.

3D structure databases

ProteinModelPortalQ5T1R4.
SMRQ5T1R4. Positions 191-247, 1753-1809.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121861. 6 interactions.
STRING9606.ENSP00000247584.

PTM databases

PhosphoSiteQ5T1R4.

Polymorphism databases

DMDM74756245.

Proteomic databases

PaxDbQ5T1R4.
PRIDEQ5T1R4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000247584; ENSP00000247584; ENSG00000127124. [Q5T1R4-1]
ENST00000372583; ENSP00000361664; ENSG00000127124. [Q5T1R4-1]
ENST00000372584; ENSP00000361665; ENSG00000127124. [Q5T1R4-2]
ENST00000429157; ENSP00000410828; ENSG00000127124. [Q5T1R4-2]
GeneID59269.
KEGGhsa:59269.
UCSCuc001cgz.4. human. [Q5T1R4-1]
uc001cha.4. human. [Q5T1R4-2]

Organism-specific databases

CTD59269.
GeneCardsGC01M041974.
HGNCHGNC:13561. HIVEP3.
HPAHPA005728.
MIM606649. gene.
neXtProtNX_Q5T1R4.
PharmGKBPA29299.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296349.
HOGENOMHOG000155774.
HOVERGENHBG095595.
InParanoidQ5T1R4.
KOK09239.
OMAMERIPGE.
OrthoDBEOG7V1FPQ.
PhylomeDBQ5T1R4.
TreeFamTF331837.

Gene expression databases

BgeeQ5T1R4.
CleanExHS_HIVEP3.
GenevestigatorQ5T1R4.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHIVEP3. human.
GeneWikiHIVEP3.
GenomeRNAi59269.
NextBio65146.
PROQ5T1R4.
SOURCESearch...

Entry information

Entry nameZEP3_HUMAN
AccessionPrimary (citable) accession number: Q5T1R4
Secondary accession number(s): A7YY91 expand/collapse secondary AC list , Q5T1R5, Q9BZS0, Q9HCL7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM