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Q5T1R4

- ZEP3_HUMAN

UniProt

Q5T1R4 - ZEP3_HUMAN

Protein

Transcription factor HIVEP3

Gene

HIVEP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri192 – 21423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1754 – 177623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1782 – 180625C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: MGI
    2. skeletal muscle cell differentiation Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor HIVEP3
    Alternative name(s):
    Human immunodeficiency virus type I enhancer-binding protein 3
    Kappa-B and V(D)J recombination signal sequences-binding protein
    Kappa-binding protein 1
    Short name:
    KBP-1
    Zinc finger protein ZAS3
    Gene namesi
    Name:HIVEP3
    Synonyms:KBP1, KIAA1555, KRC, ZAS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13561. HIVEP3.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29299.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24062406Transcription factor HIVEP3PRO_0000331627Add
    BLAST

    Post-translational modificationi

    Phosphorylated on threonine and serine residues.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5T1R4.
    PRIDEiQ5T1R4.

    PTM databases

    PhosphoSiteiQ5T1R4.

    Expressioni

    Inductioni

    By 12-O-tetradecanoylphorbol-13 acetate (TPA).

    Gene expression databases

    BgeeiQ5T1R4.
    CleanExiHS_HIVEP3.
    GenevestigatoriQ5T1R4.

    Organism-specific databases

    HPAiHPA005728.

    Interactioni

    Subunit structurei

    Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi121861. 6 interactions.
    STRINGi9606.ENSP00000247584.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T1R4.
    SMRiQ5T1R4. Positions 191-247, 1753-1809.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati1964 – 196741
    Repeati1970 – 197342
    Repeati1993 – 199643
    Repeati1998 – 200144
    Repeati2067 – 207045
    Repeati2079 – 208246

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni192 – 24251ZAS1Add
    BLAST
    Regioni211 – 1074864No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUNBy similarityAdd
    BLAST
    Regioni264 – 28724Acidic 1Add
    BLAST
    Regioni862 – 88322Acidic 2Add
    BLAST
    Regioni1754 – 180653ZAS2Add
    BLAST
    Regioni1817 – 187256Acidic 3Add
    BLAST
    Regioni2053 – 2148966 X 4 AA tandem repeats of S-P-X-[RK]Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1442 – 146625Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi903 – 9097Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi308 – 33427Ser-richAdd
    BLAST
    Compositional biasi378 – 41437Ser-richAdd
    BLAST
    Compositional biasi797 – 81923Ser-richAdd
    BLAST
    Compositional biasi844 – 88037Glu/Pro-richAdd
    BLAST
    Compositional biasi916 – 94833Ser-richAdd
    BLAST
    Compositional biasi1907 – 193630Ser-richAdd
    BLAST

    Domaini

    The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.By similarity

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri192 – 21423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri220 – 24223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri643 – 66523C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1754 – 177623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1782 – 180625C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG296349.
    HOGENOMiHOG000155774.
    HOVERGENiHBG095595.
    InParanoidiQ5T1R4.
    KOiK09239.
    OMAiMERIPGE.
    OrthoDBiEOG7V1FPQ.
    PhylomeDBiQ5T1R4.
    TreeFamiTF331837.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop.1 Publication

    Isoform 1 (identifier: Q5T1R4-1) [UniParc]FASTAAdd to Basket

    Also known as: HIVEP3S

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDPEQSVKGT KKAEGSPRKR LTKGEAIQTS VSSSVPYPGS GTAATQESPA     50
    QELLAPQPFP GPSSVLREGS QEKTGQQQKP PKRPPIEASV HISQLPQHPL 100
    TPAFMSPGKP EHLLEGSTWQ LVDPMRPGPS GSFVAPGLHP QSQLLPSHAS 150
    IIPPEDLPGV PKVFVPRPSQ VSLKPTEEAH KKERKPQKPG KYICQYCSRP 200
    CAKPSVLQKH IRSHTGERPY PCGPCGFSFK TKSNLYKHRK SHAHRIKAGL 250
    ASGMGGEMYP HGLEMERIPG EEFEEPTEGE STDSEEETSA TSGHPAELSP 300
    RPKQPLLSSG LYSSGSHSSS HERCSLSQSS TAQSLEDPPP FVEPSSEHPL 350
    SHKPEDTHTI KQKLALRLSE RKKVIDEQAF LSPGSKGSTE SGYFSRSESA 400
    EQQVSPPNTN AKSYAEIIFG KCGRIGQRTA MLTATSTQPL LPLSTEDKPS 450
    LVPLSVPRTQ VIEHITKLIT INEAVVDTSE IDSVKPRRSS LSRRSSMESP 500
    KSSLYREPLS SHSEKTKPEQ SLLSLQHPPS TAPPVPLLRS HSMPSAACTI 550
    STPHHPFRGS YSFDDHITDS EALSHSSHVF TSHPRMLKRQ PAIELPLGGE 600
    YSSEEPGPSS KDTASKPSDE VEPKESELTK KTKKGLKTKG VIYECNICGA 650
    RYKKRDNYEA HKKYYCSELQ IAKPISAGTH TSPEAEKSQI EHEPWSQMMH 700
    YKLGTTLELT PLRKRRKEKS LGDEEEPPAF ESTKSQFGSP GPSDAARNLP 750
    LESTKSPAEP SKSVPSLEGP TGFQPRTPKP GSGSESGKER RTTSKEISVI 800
    QHTSSFEKSD SLEQPSGLEG EDKPLAQFPS PPPAPHGRSA HSLQPKLVRQ 850
    PNIQVPEILV TEEPDRPDTE PEPPPKEPEK TEEFQWPQRS QTLAQLPAEK 900
    LPPKKKRLRL AEMAQSSGES SFESSVPLSR SPSQESNVSL SGSSRSASFE 950
    RDDHGKAEAP SPSSDMRPKP LGTHMLTVPS HHPHAREMRR SASEQSPNVS 1000
    HSAHMTETRS KSFDYGSLSL TGPSAPAPVA PPARVAPPER RKCFLVRQAS 1050
    LSRPPESELE VAPKGRQESE EPQPSSSKPS AKSSLSQISS AATSHGGPPG 1100
    GKGPGQDRPP LGPTVPYTEA LQVFHHPVAQ TPLHEKPYLP PPVSLFSFQH 1150
    LVQHEPGQSP EFFSTQAMSS LLSSPYSMPP LPPSLFQAPP LPLQPTVLHP 1200
    GQLHLPQLMP HPANIPFRQP PSFLPMPYPT SSALSSGFFL PLQSQFALQL 1250
    PGDVESHLPQ IKTSLAPLAT GSAGLSPSTE YSSDIRLPPV APPASSSAPT 1300
    SAPPLALPAC PDTMVSLVVP VRVQTNMPSY GSAMYTTLSQ ILVTQSQGSS 1350
    ATVALPKFEE PPSKGTTVCG ADVHEVGPGP SGLSEEQSRA FPTPYLRVPV 1400
    TLPERKGTSL SSESILSLEG SSSTAGGSKR VLSPAGSLEL TMETQQQKRV 1450
    KEEEASKADE KLELVKPCSV VLTSTEDGKR PEKSHLGNQG QGRRELEMLS 1500
    SLSSDPSDTK EIPPLPHPAL SHGTAPGSEA LKEYPQPSGK PHRRGLTPLS 1550
    VKKEDSKEQP DLPSLAPPSS LPLSETSSRP AKSQEGTDSK KVLQFPSLHT 1600
    TTNVSWCYLN YIKPNHIQHA DRRSSVYAGW CISLYNPNLP GVSTKAALSL 1650
    LRSKQKVSKE TYTMATAPHP EAGRLVPSSS RKPRMTEVHL PSLVSPEGQK 1700
    DLARVEKEEE RRGEPEEDAP ASQRGEPARI KIFEGGYKSN EEYVYVRGRG 1750
    RGKYVCEECG IRCKKPSMLK KHIRTHTDVR PYVCKHCHFA FKTKGNLTKH 1800
    MKSKAHSKKC QETGVLEELE AEEGTSDDLF QDSEGREGSE AVEEHQFSDL 1850
    EDSDSDSDLD EDEDEDEEES QDELSRPSSE APPPGPPHAL RADSSPILGP 1900
    QPPDAPASGT EATRGSSVSE AERLTASSCS MSSQSMPGLP WLGPAPLGSV 1950
    EKDTGSALSY KPVSPRRPWS PSKEAGSRPP LARKHSLTKN DSSPQRCSPA 2000
    REPQASAPSP PGLHVDPGRG MGALPCGSPR LQLSPLTLCP LGRELAPRAH 2050
    VLSKLEGTTD PGLPRYSPTR RWSPGQAESP PRSAPPGKWA LAGPGSPSAG 2100
    EHGPGLGLDP RVLFPPAPLP HKLLSRSPET CASPWQKAES RSPSCSPGPA 2150
    HPLSSRPFSA LHDFHGHILA RTEENIFSHL PLHSQHLTRA PCPLIPIGGI 2200
    QMVQARPGAH PTLLPGPTAA WVSGFSGGGS DLTGAREAQE RGRWSPTESS 2250
    SASVSPVAKV SKFTLSSELE GGDYPKERER TGGGPGRPPD WTPHGTGAPA 2300
    EPTPTHSPCT PPDTLPRPPQ GRRAAQSWSP RLESPRAPTN PEPSATPPLD 2350
    RSSSVGCLAE ASARFPARTR NLSGEPRTRQ DSPKPSGSGE PRAHPHQPED 2400
    RVPPNA 2406
    Length:2,406
    Mass (Da):259,465
    Last modified:December 21, 2004 - v1
    Checksum:iAFCCFDAF87014A7D
    GO
    Isoform 2 (identifier: Q5T1R4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2136-2136: Missing.

    Show »
    Length:2,405
    Mass (Da):259,336
    Checksum:i2FC59B5BAB2DE97D
    GO

    Sequence cautioni

    The sequence BAB13381.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441A → P in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti94 – 952QL → HV in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti123 – 1231D → S in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti127 – 1271P → L in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti133 – 1342FV → LL in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti589 – 5891R → P in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti901 – 9011L → A in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti961 – 9611S → D in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti1034 – 10352RV → GE in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti1048 – 10492QA → SP in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti1110 – 11101P → A in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti1180 – 11801P → L in BAB13381. (PubMed:10997877)Curated
    Sequence conflicti1180 – 11801P → L in AAI52564. (PubMed:15489334)Curated
    Sequence conflicti1279 – 12791T → Q in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti1524 – 15241T → Q in AAK01082. (PubMed:11161801)Curated
    Sequence conflicti2376 – 23761P → S in AAK01082. (PubMed:11161801)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti35 – 351V → I.
    Corresponds to variant rs2146315 [ dbSNP | Ensembl ].
    VAR_042910
    Natural varianti484 – 4841V → M in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_042911
    Natural varianti575 – 5751H → R.3 Publications
    Corresponds to variant rs2810566 [ dbSNP | Ensembl ].
    VAR_042912
    Natural varianti1087 – 10871Q → H.
    Corresponds to variant rs17363472 [ dbSNP | Ensembl ].
    VAR_042913
    Natural varianti2023 – 20231A → P.3 Publications
    Corresponds to variant rs2483689 [ dbSNP | Ensembl ].
    VAR_042914
    Natural varianti2109 – 21091D → A.3 Publications
    Corresponds to variant rs2991344 [ dbSNP | Ensembl ].
    VAR_042915
    Natural varianti2272 – 22721G → R.1 Publication
    Corresponds to variant rs11809423 [ dbSNP | Ensembl ].
    VAR_042916
    Natural varianti2339 – 23391T → A.3 Publications
    Corresponds to variant rs9439043 [ dbSNP | Ensembl ].
    VAR_042917

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2136 – 21361Missing in isoform 2. 2 PublicationsVSP_033279

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF278765 mRNA. Translation: AAK01082.1.
    AB046775 mRNA. Translation: BAB13381.2. Different initiation.
    AL445933 Genomic DNA. Translation: CAI14537.1.
    AL445933 Genomic DNA. Translation: CAI14538.1.
    BC152563 mRNA. Translation: AAI52564.1.
    CCDSiCCDS44124.1. [Q5T1R4-2]
    CCDS463.1. [Q5T1R4-1]
    RefSeqiNP_001121186.1. NM_001127714.2. [Q5T1R4-2]
    NP_078779.2. NM_024503.4. [Q5T1R4-1]
    XP_006710871.1. XM_006710808.1. [Q5T1R4-1]
    UniGeneiHs.403972.
    Hs.648369.

    Genome annotation databases

    EnsembliENST00000247584; ENSP00000247584; ENSG00000127124. [Q5T1R4-1]
    ENST00000372583; ENSP00000361664; ENSG00000127124. [Q5T1R4-1]
    ENST00000372584; ENSP00000361665; ENSG00000127124. [Q5T1R4-2]
    GeneIDi59269.
    KEGGihsa:59269.
    UCSCiuc001cgz.4. human. [Q5T1R4-1]
    uc001cha.4. human. [Q5T1R4-2]

    Polymorphism databases

    DMDMi74756245.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF278765 mRNA. Translation: AAK01082.1 .
    AB046775 mRNA. Translation: BAB13381.2 . Different initiation.
    AL445933 Genomic DNA. Translation: CAI14537.1 .
    AL445933 Genomic DNA. Translation: CAI14538.1 .
    BC152563 mRNA. Translation: AAI52564.1 .
    CCDSi CCDS44124.1. [Q5T1R4-2 ]
    CCDS463.1. [Q5T1R4-1 ]
    RefSeqi NP_001121186.1. NM_001127714.2. [Q5T1R4-2 ]
    NP_078779.2. NM_024503.4. [Q5T1R4-1 ]
    XP_006710871.1. XM_006710808.1. [Q5T1R4-1 ]
    UniGenei Hs.403972.
    Hs.648369.

    3D structure databases

    ProteinModelPortali Q5T1R4.
    SMRi Q5T1R4. Positions 191-247, 1753-1809.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121861. 6 interactions.
    STRINGi 9606.ENSP00000247584.

    PTM databases

    PhosphoSitei Q5T1R4.

    Polymorphism databases

    DMDMi 74756245.

    Proteomic databases

    PaxDbi Q5T1R4.
    PRIDEi Q5T1R4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247584 ; ENSP00000247584 ; ENSG00000127124 . [Q5T1R4-1 ]
    ENST00000372583 ; ENSP00000361664 ; ENSG00000127124 . [Q5T1R4-1 ]
    ENST00000372584 ; ENSP00000361665 ; ENSG00000127124 . [Q5T1R4-2 ]
    GeneIDi 59269.
    KEGGi hsa:59269.
    UCSCi uc001cgz.4. human. [Q5T1R4-1 ]
    uc001cha.4. human. [Q5T1R4-2 ]

    Organism-specific databases

    CTDi 59269.
    GeneCardsi GC01M041974.
    HGNCi HGNC:13561. HIVEP3.
    HPAi HPA005728.
    MIMi 606649. gene.
    neXtProti NX_Q5T1R4.
    PharmGKBi PA29299.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296349.
    HOGENOMi HOG000155774.
    HOVERGENi HBG095595.
    InParanoidi Q5T1R4.
    KOi K09239.
    OMAi MERIPGE.
    OrthoDBi EOG7V1FPQ.
    PhylomeDBi Q5T1R4.
    TreeFami TF331837.

    Miscellaneous databases

    ChiTaRSi HIVEP3. human.
    GeneWikii HIVEP3.
    GenomeRNAii 59269.
    NextBioi 65146.
    PROi Q5T1R4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5T1R4.
    CleanExi HS_HIVEP3.
    Genevestigatori Q5T1R4.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2."
      Hicar M.D., Liu Y., Allen C.E., Wu L.-C.
      Genomics 71:89-100(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, ALTERNATIVE SPLICING, DOMAIN, VARIANTS ARG-575; PRO-2023; ALA-2109; ARG-2272 AND ALA-2339.
      Tissue: Brain.
    2. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339.
      Tissue: Brain.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-575; PRO-2023; ALA-2109 AND ALA-2339.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-484.

    Entry informationi

    Entry nameiZEP3_HUMAN
    AccessioniPrimary (citable) accession number: Q5T1R4
    Secondary accession number(s): A7YY91
    , Q5T1R5, Q9BZS0, Q9HCL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3