Q5T1Q4 (S35F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member F1

Gene names

Name:	SLC35F1
Synonyms:	C6orf169

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative solute transporter Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the SLC35F solute transporter family.
Sequence caution	The sequence AAH36493.1 differs from that shown. Reason: Frameshift at positions 53 and 242.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Solute carrier family 35 member F1		PRO_0000307307
Regions
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Transmembrane	129 – 147	19	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	221 – 241	21	Helical; Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Transmembrane	284 – 304	21	Helical; Potential
	Transmembrane	311 – 331	21	Helical; Potential
	Transmembrane	335 – 355	21	Helical; Potential
Experimental info
	Sequence conflict	11 – 13	3	LQP → AER in AAH36493. Ref.3
	Sequence conflict	53	1	R → G in AAH36493. Ref.3
	Sequence conflict	154	1	T → N in AAH28615. Ref.3
	Sequence conflict	301	1	P → Q in AAH28615. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5T1Q4 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 2E459610FC84ECD8	FASTA	408	45,346
	10 20 30 40 50 60 MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ RIRKVLNREM 70 80 90 100 110 120 LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN YILLFLVYTT TLAVRQGEEN 130 140 150 160 170 180 LLAILRRRWW KYMILGLIDL EANYLVVKAY QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR 190 200 210 220 230 240 YKAVHFIGIV VCILGMGCMV GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI 250 260 270 280 290 300 IRTLSRVEFL GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM 310 320 330 340 350 360 PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL VLYSSTSTYI 370 380 390 400 AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE EEPHVRVA

References

[1]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL449196 , AL133379, AL136478, Z95326 Genomic DNA. Translation: CAI16177.2. AL133379 , AL136478, AL449196, Z95326 Genomic DNA. Translation: CAI19872.2. Z95326 , AL133379, AL136478, AL449196 Genomic DNA. Translation: CAI20271.2. AL136478 , AL133379, AL449196, Z95326 Genomic DNA. Translation: CAM28261.1. CH471051 Genomic DNA. Translation: EAW48199.1. CH471051 Genomic DNA. Translation: EAW48200.1. BC028615 mRNA. Translation: AAH28615.1. BC036493 mRNA. Translation: AAH36493.1. Frameshift. BC114925 mRNA. Translation: AAI14926.1. BX640761 mRNA. Translation: CAE45867.1.
IPI	IPI00299619.
RefSeq	NP_001025029.2. NM_001029858.3.
UniGene	Hs.654841.
3D structure databases
ProteinModelPortal	Q5T1Q4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000353557.
PTM databases
PhosphoSite	Q5T1Q4.
Polymorphism databases
DMDM	160177559.
Proteomic databases
PaxDb	Q5T1Q4.
PRIDE	Q5T1Q4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360388; ENSP00000353557; ENSG00000196376.
GeneID	222553.
KEGG	hsa:222553.
UCSC	uc003pxx.4. human.
Organism-specific databases
CTD	222553.
GeneCards	GC06P118274.
HGNC	HGNC:21483. SLC35F1.
HPA	HPA019576.
neXtProt	NX_Q5T1Q4.
PharmGKB	PA134985447.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0697.
HOGENOM	HOG000241333.
HOVERGEN	HBG058983.
InParanoid	Q5T1Q4.
KO	K15287.
OMA	QQGAGEN.
OrthoDB	EOG43BMPS.
Gene expression databases
ArrayExpress	Q5T1Q4.
Bgee	Q5T1Q4.
CleanEx	HS_SLC35F1.
Genevestigator	Q5T1Q4.
Family and domain databases
InterPro	IPR009262. DUF914_euk. [Graphical view]
PANTHER	PTHR14233. PTHR14233. 1 hit.
Pfam	PF06027. DUF914. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	222553.
NextBio	91627.

Entry information

Entry name

S35F1_HUMAN

Accession

Primary (citable) accession number: Q5T1Q4
Secondary accession number(s): E1P564 , Q1RMG1, Q4G0U9, Q4G167, Q6N007

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 20, 2007
Last modified:	April 3, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.