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Q5T1Q4

- S35F1_HUMAN

UniProt

Q5T1Q4 - S35F1_HUMAN

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Protein
Solute carrier family 35 member F1
Gene
SLC35F1, C6orf169
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative solute transporter Reviewed prediction.

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F1
Gene namesi
Name:SLC35F1
Synonyms:C6orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21483. SLC35F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11421Helical; Reviewed prediction
Add
BLAST
Transmembranei129 – 14719Helical; Reviewed prediction
Add
BLAST
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Transmembranei247 – 26721Helical; Reviewed prediction
Add
BLAST
Transmembranei284 – 30421Helical; Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Transmembranei335 – 35521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Solute carrier family 35 member F1
PRO_0000307307Add
BLAST

Proteomic databases

PaxDbiQ5T1Q4.
PRIDEiQ5T1Q4.

PTM databases

PhosphoSiteiQ5T1Q4.

Expressioni

Gene expression databases

ArrayExpressiQ5T1Q4.
BgeeiQ5T1Q4.
CleanExiHS_SLC35F1.
GenevestigatoriQ5T1Q4.

Organism-specific databases

HPAiHPA019576.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353557.

Structurei

3D structure databases

ProteinModelPortaliQ5T1Q4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ5T1Q4.
KOiK15287.
OMAiQQGAGEN.
OrthoDBiEOG7PCJJB.
PhylomeDBiQ5T1Q4.
TreeFamiTF313645.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. DUF914. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T1Q4-1 [UniParc]FASTAAdd to Basket

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MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ    50
RIRKVLNREM LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN 100
YILLFLVYTT TLAVRQGEEN LLAILRRRWW KYMILGLIDL EANYLVVKAY 150
QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR YKAVHFIGIV VCILGMGCMV 200
GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI IRTLSRVEFL 250
GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM 300
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL 350
VLYSSTSTYI AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE 400
EEPHVRVA 408
Length:408
Mass (Da):45,346
Last modified:February 20, 2007 - v2
Checksum:i2E459610FC84ECD8
GO

Sequence cautioni

The sequence AAH36493.1 differs from that shown. Reason: Frameshift at positions 53 and 242.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 133LQP → AER in AAH36493. 1 Publication
Sequence conflicti53 – 531R → G in AAH36493. 1 Publication
Sequence conflicti154 – 1541T → N in AAH28615. 1 Publication
Sequence conflicti301 – 3011P → Q in AAH28615. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL449196
, AL133379, AL136478, Z95326 Genomic DNA. Translation: CAI16177.2.
AL133379
, AL136478, AL449196, Z95326 Genomic DNA. Translation: CAI19872.2.
Z95326
, AL133379, AL136478, AL449196 Genomic DNA. Translation: CAI20271.2.
AL136478
, AL133379, AL449196, Z95326 Genomic DNA. Translation: CAM28261.1.
CH471051 Genomic DNA. Translation: EAW48199.1.
CH471051 Genomic DNA. Translation: EAW48200.1.
BC028615 mRNA. Translation: AAH28615.1.
BC036493 mRNA. Translation: AAH36493.1. Frameshift.
BC114925 mRNA. Translation: AAI14926.1.
BX640761 mRNA. Translation: CAE45867.1.
CCDSiCCDS34524.1.
RefSeqiNP_001025029.2. NM_001029858.3.
XP_005266922.1. XM_005266865.2.
UniGeneiHs.654841.

Genome annotation databases

EnsembliENST00000360388; ENSP00000353557; ENSG00000196376.
GeneIDi222553.
KEGGihsa:222553.
UCSCiuc003pxx.4. human.

Polymorphism databases

DMDMi160177559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL449196
, AL133379 , AL136478 , Z95326 Genomic DNA. Translation: CAI16177.2 .
AL133379
, AL136478 , AL449196 , Z95326 Genomic DNA. Translation: CAI19872.2 .
Z95326
, AL133379 , AL136478 , AL449196 Genomic DNA. Translation: CAI20271.2 .
AL136478
, AL133379 , AL449196 , Z95326 Genomic DNA. Translation: CAM28261.1 .
CH471051 Genomic DNA. Translation: EAW48199.1 .
CH471051 Genomic DNA. Translation: EAW48200.1 .
BC028615 mRNA. Translation: AAH28615.1 .
BC036493 mRNA. Translation: AAH36493.1 . Frameshift.
BC114925 mRNA. Translation: AAI14926.1 .
BX640761 mRNA. Translation: CAE45867.1 .
CCDSi CCDS34524.1.
RefSeqi NP_001025029.2. NM_001029858.3.
XP_005266922.1. XM_005266865.2.
UniGenei Hs.654841.

3D structure databases

ProteinModelPortali Q5T1Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353557.

Protein family/group databases

TCDBi 2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q5T1Q4.

Polymorphism databases

DMDMi 160177559.

Proteomic databases

PaxDbi Q5T1Q4.
PRIDEi Q5T1Q4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360388 ; ENSP00000353557 ; ENSG00000196376 .
GeneIDi 222553.
KEGGi hsa:222553.
UCSCi uc003pxx.4. human.

Organism-specific databases

CTDi 222553.
GeneCardsi GC06P118274.
HGNCi HGNC:21483. SLC35F1.
HPAi HPA019576.
neXtProti NX_Q5T1Q4.
PharmGKBi PA134985447.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
HOGENOMi HOG000241333.
HOVERGENi HBG058983.
InParanoidi Q5T1Q4.
KOi K15287.
OMAi QQGAGEN.
OrthoDBi EOG7PCJJB.
PhylomeDBi Q5T1Q4.
TreeFami TF313645.

Miscellaneous databases

GenomeRNAii 222553.
NextBioi 91627.
PROi Q5T1Q4.

Gene expression databases

ArrayExpressi Q5T1Q4.
Bgeei Q5T1Q4.
CleanExi HS_SLC35F1.
Genevestigatori Q5T1Q4.

Family and domain databases

InterProi IPR009262. SLC35_F1/F2/F6.
[Graphical view ]
Pfami PF06027. DUF914. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408.
    Tissue: Cerebellum.

Entry informationi

Entry nameiS35F1_HUMAN
AccessioniPrimary (citable) accession number: Q5T1Q4
Secondary accession number(s): E1P564
, Q1RMG1, Q4G0U9, Q4G167, Q6N007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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