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Q5T1Q4

- S35F1_HUMAN

UniProt

Q5T1Q4 - S35F1_HUMAN

Protein

Solute carrier family 35 member F1

Gene

SLC35F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Putative solute transporter.Curated

    GO - Biological processi

    1. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member F1
    Gene namesi
    Name:SLC35F1
    Synonyms:C6orf169
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21483. SLC35F1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134985447.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Solute carrier family 35 member F1PRO_0000307307Add
    BLAST

    Proteomic databases

    PaxDbiQ5T1Q4.
    PRIDEiQ5T1Q4.

    PTM databases

    PhosphoSiteiQ5T1Q4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T1Q4.
    BgeeiQ5T1Q4.
    CleanExiHS_SLC35F1.
    GenevestigatoriQ5T1Q4.

    Organism-specific databases

    HPAiHPA019576.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000353557.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T1Q4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14719HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei311 – 33121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei335 – 35521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC35F solute transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    HOGENOMiHOG000241333.
    HOVERGENiHBG058983.
    InParanoidiQ5T1Q4.
    KOiK15287.
    OMAiQQGAGEN.
    OrthoDBiEOG7PCJJB.
    PhylomeDBiQ5T1Q4.
    TreeFamiTF313645.

    Family and domain databases

    InterProiIPR009262. SLC35_F1/F2/F6.
    [Graphical view]
    PfamiPF06027. DUF914. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5T1Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ    50
    RIRKVLNREM LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN 100
    YILLFLVYTT TLAVRQGEEN LLAILRRRWW KYMILGLIDL EANYLVVKAY 150
    QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR YKAVHFIGIV VCILGMGCMV 200
    GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI IRTLSRVEFL 250
    GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM 300
    PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL 350
    VLYSSTSTYI AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE 400
    EEPHVRVA 408
    Length:408
    Mass (Da):45,346
    Last modified:February 20, 2007 - v2
    Checksum:i2E459610FC84ECD8
    GO

    Sequence cautioni

    The sequence AAH36493.1 differs from that shown. Reason: Frameshift at positions 53 and 242.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 133LQP → AER in AAH36493. (PubMed:15489334)Curated
    Sequence conflicti53 – 531R → G in AAH36493. (PubMed:15489334)Curated
    Sequence conflicti154 – 1541T → N in AAH28615. (PubMed:15489334)Curated
    Sequence conflicti301 – 3011P → Q in AAH28615. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL449196
    , AL133379, AL136478, Z95326 Genomic DNA. Translation: CAI16177.2.
    AL133379
    , AL136478, AL449196, Z95326 Genomic DNA. Translation: CAI19872.2.
    Z95326
    , AL133379, AL136478, AL449196 Genomic DNA. Translation: CAI20271.2.
    AL136478
    , AL133379, AL449196, Z95326 Genomic DNA. Translation: CAM28261.1.
    CH471051 Genomic DNA. Translation: EAW48199.1.
    CH471051 Genomic DNA. Translation: EAW48200.1.
    BC028615 mRNA. Translation: AAH28615.1.
    BC036493 mRNA. Translation: AAH36493.1. Frameshift.
    BC114925 mRNA. Translation: AAI14926.1.
    BX640761 mRNA. Translation: CAE45867.1.
    CCDSiCCDS34524.1.
    RefSeqiNP_001025029.2. NM_001029858.3.
    XP_005266922.1. XM_005266865.2.
    UniGeneiHs.654841.

    Genome annotation databases

    EnsembliENST00000360388; ENSP00000353557; ENSG00000196376.
    GeneIDi222553.
    KEGGihsa:222553.
    UCSCiuc003pxx.4. human.

    Polymorphism databases

    DMDMi160177559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL449196
    , AL133379 , AL136478 , Z95326 Genomic DNA. Translation: CAI16177.2 .
    AL133379
    , AL136478 , AL449196 , Z95326 Genomic DNA. Translation: CAI19872.2 .
    Z95326
    , AL133379 , AL136478 , AL449196 Genomic DNA. Translation: CAI20271.2 .
    AL136478
    , AL133379 , AL449196 , Z95326 Genomic DNA. Translation: CAM28261.1 .
    CH471051 Genomic DNA. Translation: EAW48199.1 .
    CH471051 Genomic DNA. Translation: EAW48200.1 .
    BC028615 mRNA. Translation: AAH28615.1 .
    BC036493 mRNA. Translation: AAH36493.1 . Frameshift.
    BC114925 mRNA. Translation: AAI14926.1 .
    BX640761 mRNA. Translation: CAE45867.1 .
    CCDSi CCDS34524.1.
    RefSeqi NP_001025029.2. NM_001029858.3.
    XP_005266922.1. XM_005266865.2.
    UniGenei Hs.654841.

    3D structure databases

    ProteinModelPortali Q5T1Q4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000353557.

    Protein family/group databases

    TCDBi 2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q5T1Q4.

    Polymorphism databases

    DMDMi 160177559.

    Proteomic databases

    PaxDbi Q5T1Q4.
    PRIDEi Q5T1Q4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360388 ; ENSP00000353557 ; ENSG00000196376 .
    GeneIDi 222553.
    KEGGi hsa:222553.
    UCSCi uc003pxx.4. human.

    Organism-specific databases

    CTDi 222553.
    GeneCardsi GC06P118274.
    HGNCi HGNC:21483. SLC35F1.
    HPAi HPA019576.
    neXtProti NX_Q5T1Q4.
    PharmGKBi PA134985447.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0697.
    HOGENOMi HOG000241333.
    HOVERGENi HBG058983.
    InParanoidi Q5T1Q4.
    KOi K15287.
    OMAi QQGAGEN.
    OrthoDBi EOG7PCJJB.
    PhylomeDBi Q5T1Q4.
    TreeFami TF313645.

    Miscellaneous databases

    GenomeRNAii 222553.
    NextBioi 91627.
    PROi Q5T1Q4.

    Gene expression databases

    ArrayExpressi Q5T1Q4.
    Bgeei Q5T1Q4.
    CleanExi HS_SLC35F1.
    Genevestigatori Q5T1Q4.

    Family and domain databases

    InterProi IPR009262. SLC35_F1/F2/F6.
    [Graphical view ]
    Pfami PF06027. DUF914. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408.
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiS35F1_HUMAN
    AccessioniPrimary (citable) accession number: Q5T1Q4
    Secondary accession number(s): E1P564
    , Q1RMG1, Q4G0U9, Q4G167, Q6N007
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3