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Q5T1Q4 (S35F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member F1
Gene names
Name:SLC35F1
Synonyms:C6orf169
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative solute transporter Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the SLC35F solute transporter family.

Sequence caution

The sequence AAH36493.1 differs from that shown. Reason: Frameshift at positions 53 and 242.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Solute carrier family 35 member F1
PRO_0000307307

Regions

Transmembrane60 – 8021Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane129 – 14719Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane221 – 24121Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane335 – 35521Helical; Potential

Experimental info

Sequence conflict11 – 133LQP → AER in AAH36493. Ref.3
Sequence conflict531R → G in AAH36493. Ref.3
Sequence conflict1541T → N in AAH28615. Ref.3
Sequence conflict3011P → Q in AAH28615. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5T1Q4 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 2E459610FC84ECD8

FASTA40845,346
        10         20         30         40         50         60 
MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ RIRKVLNREM 

        70         80         90        100        110        120 
LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN YILLFLVYTT TLAVRQGEEN 

       130        140        150        160        170        180 
LLAILRRRWW KYMILGLIDL EANYLVVKAY QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR 

       190        200        210        220        230        240 
YKAVHFIGIV VCILGMGCMV GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI 

       250        260        270        280        290        300 
IRTLSRVEFL GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM 

       310        320        330        340        350        360 
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL VLYSSTSTYI 

       370        380        390        400 
AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE EEPHVRVA 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408.
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL449196 expand/collapse EMBL AC list , AL133379, AL136478, Z95326 Genomic DNA. Translation: CAI16177.2.
AL133379 expand/collapse EMBL AC list , AL136478, AL449196, Z95326 Genomic DNA. Translation: CAI19872.2.
Z95326 expand/collapse EMBL AC list , AL133379, AL136478, AL449196 Genomic DNA. Translation: CAI20271.2.
AL136478 expand/collapse EMBL AC list , AL133379, AL449196, Z95326 Genomic DNA. Translation: CAM28261.1.
CH471051 Genomic DNA. Translation: EAW48199.1.
CH471051 Genomic DNA. Translation: EAW48200.1.
BC028615 mRNA. Translation: AAH28615.1.
BC036493 mRNA. Translation: AAH36493.1. Frameshift.
BC114925 mRNA. Translation: AAI14926.1.
BX640761 mRNA. Translation: CAE45867.1.
CCDSCCDS34524.1.
RefSeqNP_001025029.2. NM_001029858.3.
XP_005266922.1. XM_005266865.2.
UniGeneHs.654841.

3D structure databases

ProteinModelPortalQ5T1Q4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000353557.

Protein family/group databases

TCDB2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ5T1Q4.

Polymorphism databases

DMDM160177559.

Proteomic databases

PaxDbQ5T1Q4.
PRIDEQ5T1Q4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000360388; ENSP00000353557; ENSG00000196376.
GeneID222553.
KEGGhsa:222553.
UCSCuc003pxx.4. human.

Organism-specific databases

CTD222553.
GeneCardsGC06P118274.
HGNCHGNC:21483. SLC35F1.
HPAHPA019576.
neXtProtNX_Q5T1Q4.
PharmGKBPA134985447.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0697.
HOGENOMHOG000241333.
HOVERGENHBG058983.
InParanoidQ5T1Q4.
KOK15287.
OMAQQGAGEN.
OrthoDBEOG7PCJJB.
PhylomeDBQ5T1Q4.
TreeFamTF313645.

Gene expression databases

ArrayExpressQ5T1Q4.
BgeeQ5T1Q4.
CleanExHS_SLC35F1.
GenevestigatorQ5T1Q4.

Family and domain databases

InterProIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamPF06027. DUF914. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi222553.
NextBio91627.
PROQ5T1Q4.

Entry information

Entry nameS35F1_HUMAN
AccessionPrimary (citable) accession number: Q5T1Q4
Secondary accession number(s): E1P564 expand/collapse secondary AC list , Q1RMG1, Q4G0U9, Q4G167, Q6N007
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM