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Q5T1Q4

- S35F1_HUMAN

UniProt

Q5T1Q4 - S35F1_HUMAN

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Protein

Solute carrier family 35 member F1

Gene

SLC35F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Putative solute transporter.Curated

GO - Biological processi

  1. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F1
Gene namesi
Name:SLC35F1
Synonyms:C6orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21483. SLC35F1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Transmembranei129 – 14719HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Transmembranei247 – 26721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence AnalysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134985447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Solute carrier family 35 member F1PRO_0000307307Add
BLAST

Proteomic databases

PaxDbiQ5T1Q4.
PRIDEiQ5T1Q4.

PTM databases

PhosphoSiteiQ5T1Q4.

Expressioni

Gene expression databases

BgeeiQ5T1Q4.
CleanExiHS_SLC35F1.
ExpressionAtlasiQ5T1Q4. baseline and differential.
GenevestigatoriQ5T1Q4.

Organism-specific databases

HPAiHPA019576.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353557.

Structurei

3D structure databases

ProteinModelPortaliQ5T1Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00390000015655.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ5T1Q4.
KOiK15287.
OMAiDHITGSN.
OrthoDBiEOG7PCJJB.
PhylomeDBiQ5T1Q4.
TreeFamiTF313645.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. DUF914. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T1Q4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ
60 70 80 90 100
RIRKVLNREM LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN
110 120 130 140 150
YILLFLVYTT TLAVRQGEEN LLAILRRRWW KYMILGLIDL EANYLVVKAY
160 170 180 190 200
QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR YKAVHFIGIV VCILGMGCMV
210 220 230 240 250
GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI IRTLSRVEFL
260 270 280 290 300
GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM
310 320 330 340 350
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL
360 370 380 390 400
VLYSSTSTYI AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE

EEPHVRVA
Length:408
Mass (Da):45,346
Last modified:February 20, 2007 - v2
Checksum:i2E459610FC84ECD8
GO
Isoform 2 (identifier: Q5T1Q4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available

Show »
Length:349
Mass (Da):39,127
Checksum:i08336293619D0C28
GO

Sequence cautioni

The sequence AAH36493.1 differs from that shown. Reason: Frameshift at positions 53 and 242. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 133LQP → AER in AAH36493. (PubMed:15489334)Curated
Sequence conflicti53 – 531R → G in AAH36493. (PubMed:15489334)Curated
Sequence conflicti154 – 1541T → N in AAH28615. (PubMed:15489334)Curated
Sequence conflicti301 – 3011P → Q in AAH28615. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5959Missing in isoform 2. 1 PublicationVSP_057263Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295860 mRNA. Translation: BAG58664.1.
AL449196
, AL133379, AL136478, Z95326 Genomic DNA. Translation: CAI16177.2.
AL133379
, AL136478, AL449196, Z95326 Genomic DNA. Translation: CAI19872.2.
Z95326
, AL133379, AL136478, AL449196 Genomic DNA. Translation: CAI20271.2.
AL136478
, AL133379, AL449196, Z95326 Genomic DNA. Translation: CAM28261.1.
AL450405 Genomic DNA. No translation available.
AL590621 Genomic DNA. No translation available.
KF458261 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48199.1.
CH471051 Genomic DNA. Translation: EAW48200.1.
BC028615 mRNA. Translation: AAH28615.1.
BC036493 mRNA. Translation: AAH36493.1. Frameshift.
BC114925 mRNA. Translation: AAI14926.1.
BX640761 mRNA. Translation: CAE45867.1.
CCDSiCCDS34524.1.
RefSeqiNP_001025029.2. NM_001029858.3.
XP_005266922.1. XM_005266865.2.
UniGeneiHs.654841.

Genome annotation databases

EnsembliENST00000360388; ENSP00000353557; ENSG00000196376.
GeneIDi222553.
KEGGihsa:222553.
UCSCiuc003pxx.4. human.

Polymorphism databases

DMDMi160177559.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295860 mRNA. Translation: BAG58664.1 .
AL449196
, AL133379 , AL136478 , Z95326 Genomic DNA. Translation: CAI16177.2 .
AL133379
, AL136478 , AL449196 , Z95326 Genomic DNA. Translation: CAI19872.2 .
Z95326
, AL133379 , AL136478 , AL449196 Genomic DNA. Translation: CAI20271.2 .
AL136478
, AL133379 , AL449196 , Z95326 Genomic DNA. Translation: CAM28261.1 .
AL450405 Genomic DNA. No translation available.
AL590621 Genomic DNA. No translation available.
KF458261 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48199.1 .
CH471051 Genomic DNA. Translation: EAW48200.1 .
BC028615 mRNA. Translation: AAH28615.1 .
BC036493 mRNA. Translation: AAH36493.1 . Frameshift.
BC114925 mRNA. Translation: AAI14926.1 .
BX640761 mRNA. Translation: CAE45867.1 .
CCDSi CCDS34524.1.
RefSeqi NP_001025029.2. NM_001029858.3.
XP_005266922.1. XM_005266865.2.
UniGenei Hs.654841.

3D structure databases

ProteinModelPortali Q5T1Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000353557.

Protein family/group databases

TCDBi 2.A.7.24.9. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q5T1Q4.

Polymorphism databases

DMDMi 160177559.

Proteomic databases

PaxDbi Q5T1Q4.
PRIDEi Q5T1Q4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360388 ; ENSP00000353557 ; ENSG00000196376 .
GeneIDi 222553.
KEGGi hsa:222553.
UCSCi uc003pxx.4. human.

Organism-specific databases

CTDi 222553.
GeneCardsi GC06P118274.
HGNCi HGNC:21483. SLC35F1.
HPAi HPA019576.
neXtProti NX_Q5T1Q4.
PharmGKBi PA134985447.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00390000015655.
HOGENOMi HOG000241333.
HOVERGENi HBG058983.
InParanoidi Q5T1Q4.
KOi K15287.
OMAi DHITGSN.
OrthoDBi EOG7PCJJB.
PhylomeDBi Q5T1Q4.
TreeFami TF313645.

Miscellaneous databases

GenomeRNAii 222553.
NextBioi 91627.
PROi Q5T1Q4.

Gene expression databases

Bgeei Q5T1Q4.
CleanExi HS_SLC35F1.
ExpressionAtlasi Q5T1Q4. baseline and differential.
Genevestigatori Q5T1Q4.

Family and domain databases

InterProi IPR009262. SLC35_F1/F2/F6.
[Graphical view ]
Pfami PF06027. DUF914. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-408 (ISOFORM 1/2).
    Tissue: Cerebellum.

Entry informationi

Entry nameiS35F1_HUMAN
AccessioniPrimary (citable) accession number: Q5T1Q4
Secondary accession number(s): B4DJ02
, E1P564, Q1RMG1, Q4G0U9, Q4G167, Q6N007
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: January 7, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.