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Protein
Submitted name:

60 kDa U4/U6 snRNP-specific spliceosomal protein

Gene

PRPF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
60 kDa U4/U6 snRNP-specific spliceosomal proteinImported
Submitted name:
PRP4 pre-mRNA processing factor 4 homolog (Yeast), isoform CRA_bImported
Gene namesi
Name:PRPF4Imported
ORF Names:hCG_29193Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000136875.12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000136875

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 521WD_REPEATS_REGIONInterPro annotationAdd BLAST296
Repeati268 – 317WDPROSITE-ProRule annotationAdd BLAST50
Repeati318 – 359WDPROSITE-ProRule annotationAdd BLAST42
Repeati360 – 401WDPROSITE-ProRule annotationAdd BLAST42
Repeati402 – 443WDPROSITE-ProRule annotationAdd BLAST42
Repeati444 – 476WDPROSITE-ProRule annotationAdd BLAST33
Repeati487 – 521WDPROSITE-ProRule annotationAdd BLAST35

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.720.150, 1 hit
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR027106 Prp4
IPR014906 PRP4-like
IPR036285 PRP4-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19846 PTHR19846, 1 hit
PfamiView protein in Pfam
PF08799 PRP4, 1 hit
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00500 SFM, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF158230 SSF158230, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T1M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRASSTA TKTKAPDDLV APVVKKPHIY YGSLEEKERE RLAKGESGIL
60 70 80 90 100
GKDGLKAGIE AGNINITSGE VFEIEEHISE RQAEVLAEFE RRKRARQINV
110 120 130 140 150
STDDSEVKAC LRALGEPITL FGEGPAERRE RLRNILSVVG TDALKKTKKD
160 170 180 190 200
DEKSKKSKEE YQQTWYHEGP NSLKVARLWI ANYSLPRAMK RLEEARLHKE
210 220 230 240 250
IPETTRTSQM QELHKSLRSL NNFCSQIGDD RPISYCHFSP NSKMLATACW
260 270 280 290 300
SGLCKLWSVP DCNLLHTLRG HNTNVGAIVF HPKSTVSLDP KDVNLASCAA
310 320 330 340 350
DGSVKLWSLD SDEPVADIEG HTVRVARVMW HPSGRFLGTT CYDRSWRLWD
360 370 380 390 400
LEAQEEILHQ EGHSMGVYDI AFHQDGSLAG TGGLDAFGRV WDLRTGRCIM
410 420 430 440 450
FLEGHLKEIY GINFSPNGYH IATGSGDNTC KVWDLRQRRC VYTIPAHQNL
460 470 480 490 500
VTGVKFEPIH GNFLLTGAYD NTAKIWTHPG WSPLKTLAGH EGKVMGLDIS
510 520
SDGQLIATCS YDRTFKLWMA E
Length:521
Mass (Da):58,321
Last modified:May 10, 2005 - v1
Checksum:iB4EF92D9E12C9188
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY572489 mRNA Translation: AAS78572.1
CH471090 Genomic DNA Translation: EAW87363.1
RefSeqiNP_001231855.1, NM_001244926.1
UniGeneiHs.744014

Genome annotation databases

GeneIDi9128
UCSCiuc004bgy.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5T1M7_HUMAN
AccessioniPrimary (citable) accession number: Q5T1M7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health