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Protein

FK506-binding protein 15

Gene

FKBP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.By similarity1 Publication

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • negative regulation of phosphatase activity Source: UniProtKB
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Endocytosis, Transport

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 15
Short name:
FKBP-15
Alternative name(s):
133 kDa FK506-binding protein
Short name:
133 kDa FKBP
Short name:
FKBP-133
WASP and FKBP-like
Short name:
WAFL
Gene namesi
Name:FKBP15
Synonyms:KIAA0674
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23397. FKBP15.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: Ensembl
  • axon Source: UniProtKB-SubCell
  • early endosome Source: UniProtKB-SubCell
  • growth cone Source: Ensembl
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi23307.
OpenTargetsiENSG00000119321.
PharmGKBiPA162388608.

Polymorphism and mutation databases

BioMutaiFKBP15.
DMDMi158563913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995561 – 1219FK506-binding protein 15Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei92N6-acetyllysineCombined sources1
Modified residuei307PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei619PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1056PhosphoserineBy similarity1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1065PhosphoserineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1099PhosphothreonineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1203PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5T1M5.
MaxQBiQ5T1M5.
PaxDbiQ5T1M5.
PeptideAtlasiQ5T1M5.
PRIDEiQ5T1M5.

PTM databases

iPTMnetiQ5T1M5.
PhosphoSitePlusiQ5T1M5.

Expressioni

Gene expression databases

BgeeiENSG00000119321.
CleanExiHS_FKBP15.
ExpressionAtlasiQ5T1M5. baseline and differential.
GenevisibleiQ5T1M5. HS.

Organism-specific databases

HPAiHPA007979.

Interactioni

Subunit structurei

Interacts with WIP and actin.1 Publication

Protein-protein interaction databases

BioGridi116899. 34 interactors.
IntActiQ5T1M5. 11 interactors.
STRINGi9606.ENSP00000238256.

Structurei

3D structure databases

ProteinModelPortaliQ5T1M5.
SMRiQ5T1M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 290PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni72 – 169Important for function in growth cone organizationBy similarityAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili522 – 789Sequence analysisAdd BLAST268
Coiled coili818 – 878Sequence analysisAdd BLAST61
Coiled coili925 – 951Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1208 – 1216Poly-Asp9

Domaini

The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.By similarity
The central coiled-coil region is responsible for association with early endosomes.

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410INYI. Eukaryota.
ENOG4112APP. LUCA.
GeneTreeiENSGT00530000064286.
HOGENOMiHOG000112601.
HOVERGENiHBG067251.
InParanoidiQ5T1M5.
KOiK17478.
PhylomeDBiQ5T1M5.
TreeFamiTF328592.

Family and domain databases

InterProiIPR001179. PPIase_FKBP_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T1M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG
60 70 80 90 100
QGTAATGNQA TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV
110 120 130 140 150
LGNHTAREYR ILLYISQQQP VTVARIHVNF ELMVRPNNYS TFYDDQRQNW
160 170 180 190 200
SIMFESEKAA VEFNKQVCIA KCNSTSSLDA VLSQDLIVAD GPAVEVGDSL
210 220 230 240 250
EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG WEDGMLGMKK
260 270 280 290 300
GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH
310 320 330 340 350
SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ
360 370 380 390 400
LAINTSPDAV KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG
410 420 430 440 450
QPVVTPSVQP SLHPAHPALP QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH
460 470 480 490 500
SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ LQPVRPLYPA PLSQPPHFQG
510 520 530 540 550
SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL QKHSAGNSML
560 570 580 590 600
IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE
610 620 630 640 650
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA
660 670 680 690 700
QVSHLQLKMT AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET
710 720 730 740 750
SEQAQSKFKS EKQNRKQLEL KVTSLEEELT DLRVEKESLE KNLSERKKKS
760 770 780 790 800
AQERSQAEEE IDEIRKSYQE ELDKLRQLLK KTRVSTDQAA AEQLSLVQAE
810 820 830 840 850
LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ LQEKCLALQA
860 870 880 890 900
QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR
910 920 930 940 950
EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE
960 970 980 990 1000
RPRRPSQEQS ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT
1010 1020 1030 1040 1050
TSQDGHRRKG DSEAEALSEI KDGSLPPELS CIPSHRVLGP PTSIPPEPLG
1060 1070 1080 1090 1100
PVSMDSECEE SLAASPMAAK PDNPSGKVCV REVAPDGPLQ ESSTRLSLTS
1110 1120 1130 1140 1150
DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS TEAGSTVAGA
1160 1170 1180 1190 1200
ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP
1210
PPTPLFGDDD DDDDIDWLG
Length:1,219
Mass (Da):133,630
Last modified:September 11, 2007 - v2
Checksum:i86563D82B540B51D
GO
Isoform 2 (identifier: Q5T1M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-638: Missing.

Note: No experimental confirmation available.
Show »
Length:1,209
Mass (Da):132,467
Checksum:iAD3F9C4AA1FD65A6
GO
Isoform 3 (identifier: Q5T1M5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-472: PYAGMQAYAYP → VTFYNRINYIL
     473-1219: Missing.

Show »
Length:472
Mass (Da):50,330
Checksum:i2112364B487D6E69
GO

Sequence cautioni

The sequence AAH09609 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA31649 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI10963 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI10964 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034851106A → T.Corresponds to variant rs1133618dbSNPEnsembl.1
Natural variantiVAR_034852413H → Q.2 PublicationsCorresponds to variant rs10435864dbSNPEnsembl.1
Natural variantiVAR_034853434L → F.Corresponds to variant rs10465129dbSNPEnsembl.1
Natural variantiVAR_061543847A → S.Corresponds to variant rs1128116dbSNPEnsembl.1
Natural variantiVAR_061544993P → T.Corresponds to variant rs57348436dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027756462 – 472PYAGMQAYAYP → VTFYNRINYIL in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027757473 – 1219Missing in isoform 3. 1 PublicationAdd BLAST747
Alternative sequenceiVSP_027758629 – 638Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014574 mRNA. Translation: BAA31649.1. Different initiation.
AL449305 Genomic DNA. Translation: CAI10963.1. Different initiation.
AL449305, AL449105 Genomic DNA. Translation: CAI10964.1. Different initiation.
AL449105, AL449305 Genomic DNA. Translation: CAI95402.1.
BC009609 mRNA. Translation: AAH09609.1. Different initiation.
BC077732 mRNA. Translation: AAH77732.1.
CCDSiCCDS48007.1. [Q5T1M5-1]
PIRiT00363.
RefSeqiNP_056073.1. NM_015258.1. [Q5T1M5-1]
XP_006717081.1. XM_006717018.2. [Q5T1M5-2]
UniGeneiHs.522351.

Genome annotation databases

EnsembliENST00000238256; ENSP00000238256; ENSG00000119321. [Q5T1M5-1]
GeneIDi23307.
KEGGihsa:23307.
UCSCiuc004bgs.3. human. [Q5T1M5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014574 mRNA. Translation: BAA31649.1. Different initiation.
AL449305 Genomic DNA. Translation: CAI10963.1. Different initiation.
AL449305, AL449105 Genomic DNA. Translation: CAI10964.1. Different initiation.
AL449105, AL449305 Genomic DNA. Translation: CAI95402.1.
BC009609 mRNA. Translation: AAH09609.1. Different initiation.
BC077732 mRNA. Translation: AAH77732.1.
CCDSiCCDS48007.1. [Q5T1M5-1]
PIRiT00363.
RefSeqiNP_056073.1. NM_015258.1. [Q5T1M5-1]
XP_006717081.1. XM_006717018.2. [Q5T1M5-2]
UniGeneiHs.522351.

3D structure databases

ProteinModelPortaliQ5T1M5.
SMRiQ5T1M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116899. 34 interactors.
IntActiQ5T1M5. 11 interactors.
STRINGi9606.ENSP00000238256.

PTM databases

iPTMnetiQ5T1M5.
PhosphoSitePlusiQ5T1M5.

Polymorphism and mutation databases

BioMutaiFKBP15.
DMDMi158563913.

Proteomic databases

EPDiQ5T1M5.
MaxQBiQ5T1M5.
PaxDbiQ5T1M5.
PeptideAtlasiQ5T1M5.
PRIDEiQ5T1M5.

Protocols and materials databases

DNASUi23307.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238256; ENSP00000238256; ENSG00000119321. [Q5T1M5-1]
GeneIDi23307.
KEGGihsa:23307.
UCSCiuc004bgs.3. human. [Q5T1M5-1]

Organism-specific databases

CTDi23307.
DisGeNETi23307.
GeneCardsiFKBP15.
H-InvDBHIX0008300.
HIX0153287.
HGNCiHGNC:23397. FKBP15.
HPAiHPA007979.
neXtProtiNX_Q5T1M5.
OpenTargetsiENSG00000119321.
PharmGKBiPA162388608.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INYI. Eukaryota.
ENOG4112APP. LUCA.
GeneTreeiENSGT00530000064286.
HOGENOMiHOG000112601.
HOVERGENiHBG067251.
InParanoidiQ5T1M5.
KOiK17478.
PhylomeDBiQ5T1M5.
TreeFamiTF328592.

Miscellaneous databases

ChiTaRSiFKBP15. human.
GenomeRNAii23307.
PROiQ5T1M5.

Gene expression databases

BgeeiENSG00000119321.
CleanExiHS_FKBP15.
ExpressionAtlasiQ5T1M5. baseline and differential.
GenevisibleiQ5T1M5. HS.

Family and domain databases

InterProiIPR001179. PPIase_FKBP_dom.
[Graphical view]
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKB15_HUMAN
AccessioniPrimary (citable) accession number: Q5T1M5
Secondary accession number(s): Q05DK8
, Q5T1M2, Q6DD85, Q9Y4D0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.