ID   Q5T1B3_HUMAN            Unreviewed;       138 AA.
AC   Q5T1B3;
DT   21-DEC-2004, integrated into UniProtKB/TrEMBL.
DT   21-DEC-2004, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Inositol polyphosphate-5-phosphatase A {ECO:0000313|Ensembl:ENSP00000390936.1};
DE   Flags: Fragment;
GN   Name=INPP5A {ECO:0000313|Ensembl:ENSP00000390936.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390936.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000390936.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000390936.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL356603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL392043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL451069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5T1B3; -.
DR   MassIVE; Q5T1B3; -.
DR   MaxQB; Q5T1B3; -.
DR   PeptideAtlas; Q5T1B3; -.
DR   ProteomicsDB; 64256; -.
DR   Antibodypedia; 1413; 185 antibodies from 25 providers.
DR   Ensembl; ENST00000423490.5; ENSP00000390936.1; ENSG00000068383.19.
DR   UCSC; uc057wxo.1; human.
DR   HGNC; HGNC:6076; INPP5A.
DR   VEuPathDB; HostDB:ENSG00000068383; -.
DR   GeneTree; ENSGT00390000015226; -.
DR   HOGENOM; CLU_154259_0_0_1; -.
DR   ChiTaRS; INPP5A; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000068383; Expressed in lateral nuclear group of thalamus and 212 other cell types or tissues.
DR   ExpressionAtlas; Q5T1B3; baseline and differential.
DR   GO; GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:InterPro.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR039737; INPP5A.
DR   PANTHER; PTHR12997:SF2; INOSITOL POLYPHOSPHATE-5-PHOSPHATASE A; 1.
DR   PANTHER; PTHR12997; TYPE I INOSITOL-1,4,5-TRISPHOSPHATE 5-PHOSPHATASE; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   1: Evidence at protein level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Proteomics identification {ECO:0007829|EPD:Q5T1B3,
KW   ECO:0007829|MaxQB:Q5T1B3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000390936.1"
FT   NON_TER         138
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000390936.1"
SQ   SEQUENCE   138 AA;  16234 MW;  1BD707921287191F CRC64;
     VTANVGSLFD DPENLQKNWL REFYQALGSF YFLHESLKNI YQFDFKAKKY RKVAGKEIYS
     DTLESTPMLE KEKFPQDYFP ECKWSRKGFI RTRWCIADCA FDLVNIHLFH DASNLVAWET
     SPSVYSGIRH KALGYVLD
//