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Q5T1A1 (DCST2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DC-STAMP domain-containing protein 2
Gene names
Name:DCST2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence caution

The sequence BAC05065.1 differs from that shown. Reason: Frameshift at position 736.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5T1A1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5T1A1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     625-639: LYCLTCFRLLDNTCS → FICKWHCSSSLVCTP
     640-773: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 773773DC-STAMP domain-containing protein 2
PRO_0000278826

Regions

Topological domain1 – 2626Cytoplasmic Potential
Transmembrane27 – 4721Helical; Potential
Topological domain48 – 514Extracellular Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 233161Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 32268Extracellular Potential
Transmembrane323 – 34321Helical; Potential
Topological domain344 – 41572Cytoplasmic Potential
Transmembrane416 – 43621Helical; Potential
Topological domain437 – 49963Extracellular Potential
Transmembrane500 – 52021Helical; Potential
Topological domain521 – 773253Cytoplasmic Potential
Compositional bias719 – 77254Pro-rich

Amino acid modifications

Glycosylation2841N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation4801N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence625 – 63915LYCLT…DNTCS → FICKWHCSSSLVCTP in isoform 2.
VSP_023408
Alternative sequence640 – 773134Missing in isoform 2.
VSP_023409

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 20, 2007. Version 2.
Checksum: 5B48863229DFAB36

FASTA77386,230
        10         20         30         40         50         60 
MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH SPWGCLVGTL 

        70         80         90        100        110        120 
TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA FGLVLQGPCA NTLRNFTRAS 

       130        140        150        160        170        180 
EAVACGAELA LNQTAEVLQR AKQPLVSALN KIKAIARKTK EVADRVRKFF RSIMDGVKHI 

       190        200        210        220        230        240 
ARALRNVWQW LLHIGDVCNS ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA 

       250        260        270        280        290        300 
LCGLASLVQV FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS 

       310        320        330        340        350        360 
LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN WDHYDNIYIT 

       370        380        390        400        410        420 
SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW EKFFYILETF NLIRHLLLVL 

       430        440        450        460        470        480 
FLVFLDYAVF WVLDLARHQL QGEIVARSPV LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN 

       490        500        510        520        530        540 
ISILSRRCLL RPSEPDSTGY IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI 

       550        560        570        580        590        600 
SYLYNVLLSR RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL 

       610        620        630        640        650        660 
GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD LDLELDSSDE 

       670        680        690        700        710        720 
EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE SSDLDEEKGP QQRKHGQQPL 

       730        740        750        760        770 
PEAHQPVSIL TSPEPHRPPE TSSATKGAPT PASEPSVPLS PPSLPDPSHP PPK 

« Hide

Isoform 2 [UniParc].

Checksum: E68937CDB0F941D5
Show »

FASTA63971,728

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-773 (ISOFORM 1).
Tissue: Testis and Thymus.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057496 mRNA. Translation: BAB71511.1.
AK097468 mRNA. Translation: BAC05065.1. Sequence problems.
AL451085 Genomic DNA. Translation: CAI13268.2.
BC111794 mRNA. Translation: AAI11795.1.
CCDSCCDS1082.2. [Q5T1A1-1]
RefSeqNP_653223.2. NM_144622.2. [Q5T1A1-1]
UniGeneHs.591491.

3D structure databases

ProteinModelPortalQ5T1A1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126069. 1 interaction.

PTM databases

PhosphoSiteQ5T1A1.

Polymorphism databases

DMDM143975954.

Proteomic databases

PaxDbQ5T1A1.
PRIDEQ5T1A1.

Protocols and materials databases

DNASU127579.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000295536; ENSP00000295536; ENSG00000163354. [Q5T1A1-2]
ENST00000368424; ENSP00000357409; ENSG00000163354. [Q5T1A1-1]
ENST00000485982; ENSP00000436964; ENSG00000163354. [Q5T1A1-2]
GeneID127579.
KEGGhsa:127579.
UCSCuc001fgm.3. human. [Q5T1A1-1]

Organism-specific databases

CTD127579.
GeneCardsGC01M154990.
HGNCHGNC:26562. DCST2.
neXtProtNX_Q5T1A1.
PharmGKBPA142672006.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG277288.
HOGENOMHOG000112181.
InParanoidQ5T1A1.
OMAPWGCLVG.
OrthoDBEOG79GT5Q.
PhylomeDBQ5T1A1.
TreeFamTF318254.

Gene expression databases

ArrayExpressQ5T1A1.
BgeeQ5T1A1.
CleanExHS_DCST2.
GenevestigatorQ5T1A1.

Family and domain databases

InterProIPR012858. DC_STAMP-like.
[Graphical view]
PfamPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi127579.
NextBio82133.
PROQ5T1A1.

Entry information

Entry nameDCST2_HUMAN
AccessionPrimary (citable) accession number: Q5T1A1
Secondary accession number(s): Q2M2R2, Q8N810, Q96M03
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM