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Protein

DC-STAMP domain-containing protein 2

Gene

DCST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DC-STAMP domain-containing protein 2
Gene namesi
Name:DCST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26562. DCST2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 51ExtracellularSequence analysis4
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 233CytoplasmicSequence analysisAdd BLAST161
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 322ExtracellularSequence analysisAdd BLAST68
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 415CytoplasmicSequence analysisAdd BLAST72
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 499ExtracellularSequence analysisAdd BLAST63
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 773CytoplasmicSequence analysisAdd BLAST253

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127579.
OpenTargetsiENSG00000163354.
PharmGKBiPA142672006.

Polymorphism and mutation databases

BioMutaiDCST2.
DMDMi143975954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002788261 – 773DC-STAMP domain-containing protein 2Add BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi480N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T1A1.
PeptideAtlasiQ5T1A1.
PRIDEiQ5T1A1.

PTM databases

iPTMnetiQ5T1A1.
PhosphoSitePlusiQ5T1A1.

Expressioni

Gene expression databases

BgeeiENSG00000163354.
CleanExiHS_DCST2.
ExpressionAtlasiQ5T1A1. baseline and differential.
GenevisibleiQ5T1A1. HS.

Structurei

3D structure databases

ProteinModelPortaliQ5T1A1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi719 – 772Pro-richAdd BLAST54

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112181.
InParanoidiQ5T1A1.
OMAiWGCLVGT.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ5T1A1.
TreeFamiTF318254.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T1A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH
60 70 80 90 100
SPWGCLVGTL TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA
110 120 130 140 150
FGLVLQGPCA NTLRNFTRAS EAVACGAELA LNQTAEVLQR AKQPLVSALN
160 170 180 190 200
KIKAIARKTK EVADRVRKFF RSIMDGVKHI ARALRNVWQW LLHIGDVCNS
210 220 230 240 250
ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA LCGLASLVQV
260 270 280 290 300
FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS
310 320 330 340 350
LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN
360 370 380 390 400
WDHYDNIYIT SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW
410 420 430 440 450
EKFFYILETF NLIRHLLLVL FLVFLDYAVF WVLDLARHQL QGEIVARSPV
460 470 480 490 500
LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN ISILSRRCLL RPSEPDSTGY
510 520 530 540 550
IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI SYLYNVLLSR
560 570 580 590 600
RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL
610 620 630 640 650
GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD
660 670 680 690 700
LDLELDSSDE EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE
710 720 730 740 750
SSDLDEEKGP QQRKHGQQPL PEAHQPVSIL TSPEPHRPPE TSSATKGAPT
760 770
PASEPSVPLS PPSLPDPSHP PPK
Length:773
Mass (Da):86,230
Last modified:February 20, 2007 - v2
Checksum:i5B48863229DFAB36
GO
Isoform 2 (identifier: Q5T1A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-639: LYCLTCFRLLDNTCS → FICKWHCSSSLVCTP
     640-773: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):71,728
Checksum:iE68937CDB0F941D5
GO

Sequence cautioni

The sequence BAC05065 differs from that shown. Reason: Frameshift at position 736.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023408625 – 639LYCLT…DNTCS → FICKWHCSSSLVCTP in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_023409640 – 773Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057496 mRNA. Translation: BAB71511.1.
AK097468 mRNA. Translation: BAC05065.1. Sequence problems.
AL451085 Genomic DNA. Translation: CAI13268.2.
BC111794 mRNA. Translation: AAI11795.1.
CCDSiCCDS1082.2. [Q5T1A1-1]
RefSeqiNP_653223.2. NM_144622.2. [Q5T1A1-1]
UniGeneiHs.591491.

Genome annotation databases

EnsembliENST00000368424; ENSP00000357409; ENSG00000163354. [Q5T1A1-1]
ENST00000485982; ENSP00000436964; ENSG00000163354. [Q5T1A1-2]
GeneIDi127579.
KEGGihsa:127579.
UCSCiuc001fgm.4. human. [Q5T1A1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057496 mRNA. Translation: BAB71511.1.
AK097468 mRNA. Translation: BAC05065.1. Sequence problems.
AL451085 Genomic DNA. Translation: CAI13268.2.
BC111794 mRNA. Translation: AAI11795.1.
CCDSiCCDS1082.2. [Q5T1A1-1]
RefSeqiNP_653223.2. NM_144622.2. [Q5T1A1-1]
UniGeneiHs.591491.

3D structure databases

ProteinModelPortaliQ5T1A1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ5T1A1.
PhosphoSitePlusiQ5T1A1.

Polymorphism and mutation databases

BioMutaiDCST2.
DMDMi143975954.

Proteomic databases

PaxDbiQ5T1A1.
PeptideAtlasiQ5T1A1.
PRIDEiQ5T1A1.

Protocols and materials databases

DNASUi127579.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368424; ENSP00000357409; ENSG00000163354. [Q5T1A1-1]
ENST00000485982; ENSP00000436964; ENSG00000163354. [Q5T1A1-2]
GeneIDi127579.
KEGGihsa:127579.
UCSCiuc001fgm.4. human. [Q5T1A1-1]

Organism-specific databases

CTDi127579.
DisGeNETi127579.
GeneCardsiDCST2.
HGNCiHGNC:26562. DCST2.
neXtProtiNX_Q5T1A1.
OpenTargetsiENSG00000163354.
PharmGKBiPA142672006.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112181.
InParanoidiQ5T1A1.
OMAiWGCLVGT.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ5T1A1.
TreeFamiTF318254.

Miscellaneous databases

GenomeRNAii127579.
PROiQ5T1A1.

Gene expression databases

BgeeiENSG00000163354.
CleanExiHS_DCST2.
ExpressionAtlasiQ5T1A1. baseline and differential.
GenevisibleiQ5T1A1. HS.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCST2_HUMAN
AccessioniPrimary (citable) accession number: Q5T1A1
Secondary accession number(s): Q2M2R2, Q8N810, Q96M03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.