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Q5T1A1

- DCST2_HUMAN

UniProt

Q5T1A1 - DCST2_HUMAN

Protein

DC-STAMP domain-containing protein 2

Gene

DCST2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DC-STAMP domain-containing protein 2
    Gene namesi
    Name:DCST2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26562. DCST2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672006.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773DC-STAMP domain-containing protein 2PRO_0000278826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi284 – 2841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5T1A1.
    PRIDEiQ5T1A1.

    PTM databases

    PhosphoSiteiQ5T1A1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5T1A1.
    BgeeiQ5T1A1.
    CleanExiHS_DCST2.
    GenevestigatoriQ5T1A1.

    Interactioni

    Protein-protein interaction databases

    BioGridi126069. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T1A1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini48 – 514ExtracellularSequence Analysis
    Topological domaini73 – 233161CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini255 – 32268ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini344 – 41572CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini437 – 49963ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini521 – 773253CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei500 – 52021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi719 – 77254Pro-richAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG277288.
    HOGENOMiHOG000112181.
    InParanoidiQ5T1A1.
    OMAiPWGCLVG.
    OrthoDBiEOG79GT5Q.
    PhylomeDBiQ5T1A1.
    TreeFamiTF318254.

    Family and domain databases

    InterProiIPR012858. DC_STAMP-like.
    [Graphical view]
    PfamiPF07782. DC_STAMP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T1A1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH    50
    SPWGCLVGTL TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA 100
    FGLVLQGPCA NTLRNFTRAS EAVACGAELA LNQTAEVLQR AKQPLVSALN 150
    KIKAIARKTK EVADRVRKFF RSIMDGVKHI ARALRNVWQW LLHIGDVCNS 200
    ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA LCGLASLVQV 250
    FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS 300
    LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN 350
    WDHYDNIYIT SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW 400
    EKFFYILETF NLIRHLLLVL FLVFLDYAVF WVLDLARHQL QGEIVARSPV 450
    LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN ISILSRRCLL RPSEPDSTGY 500
    IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI SYLYNVLLSR 550
    RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL 600
    GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD 650
    LDLELDSSDE EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE 700
    SSDLDEEKGP QQRKHGQQPL PEAHQPVSIL TSPEPHRPPE TSSATKGAPT 750
    PASEPSVPLS PPSLPDPSHP PPK 773
    Length:773
    Mass (Da):86,230
    Last modified:February 20, 2007 - v2
    Checksum:i5B48863229DFAB36
    GO
    Isoform 2 (identifier: Q5T1A1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         625-639: LYCLTCFRLLDNTCS → FICKWHCSSSLVCTP
         640-773: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:639
    Mass (Da):71,728
    Checksum:iE68937CDB0F941D5
    GO

    Sequence cautioni

    The sequence BAC05065.1 differs from that shown. Reason: Frameshift at position 736.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei625 – 63915LYCLT…DNTCS → FICKWHCSSSLVCTP in isoform 2. 1 PublicationVSP_023408Add
    BLAST
    Alternative sequencei640 – 773134Missing in isoform 2. 1 PublicationVSP_023409Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057496 mRNA. Translation: BAB71511.1.
    AK097468 mRNA. Translation: BAC05065.1. Sequence problems.
    AL451085 Genomic DNA. Translation: CAI13268.2.
    BC111794 mRNA. Translation: AAI11795.1.
    CCDSiCCDS1082.2. [Q5T1A1-1]
    RefSeqiNP_653223.2. NM_144622.2. [Q5T1A1-1]
    UniGeneiHs.591491.

    Genome annotation databases

    EnsembliENST00000368424; ENSP00000357409; ENSG00000163354. [Q5T1A1-1]
    ENST00000485982; ENSP00000436964; ENSG00000163354. [Q5T1A1-2]
    GeneIDi127579.
    KEGGihsa:127579.
    UCSCiuc001fgm.3. human. [Q5T1A1-1]

    Polymorphism databases

    DMDMi143975954.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057496 mRNA. Translation: BAB71511.1 .
    AK097468 mRNA. Translation: BAC05065.1 . Sequence problems.
    AL451085 Genomic DNA. Translation: CAI13268.2 .
    BC111794 mRNA. Translation: AAI11795.1 .
    CCDSi CCDS1082.2. [Q5T1A1-1 ]
    RefSeqi NP_653223.2. NM_144622.2. [Q5T1A1-1 ]
    UniGenei Hs.591491.

    3D structure databases

    ProteinModelPortali Q5T1A1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126069. 1 interaction.

    PTM databases

    PhosphoSitei Q5T1A1.

    Polymorphism databases

    DMDMi 143975954.

    Proteomic databases

    PaxDbi Q5T1A1.
    PRIDEi Q5T1A1.

    Protocols and materials databases

    DNASUi 127579.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368424 ; ENSP00000357409 ; ENSG00000163354 . [Q5T1A1-1 ]
    ENST00000485982 ; ENSP00000436964 ; ENSG00000163354 . [Q5T1A1-2 ]
    GeneIDi 127579.
    KEGGi hsa:127579.
    UCSCi uc001fgm.3. human. [Q5T1A1-1 ]

    Organism-specific databases

    CTDi 127579.
    GeneCardsi GC01M154990.
    HGNCi HGNC:26562. DCST2.
    neXtProti NX_Q5T1A1.
    PharmGKBi PA142672006.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277288.
    HOGENOMi HOG000112181.
    InParanoidi Q5T1A1.
    OMAi PWGCLVG.
    OrthoDBi EOG79GT5Q.
    PhylomeDBi Q5T1A1.
    TreeFami TF318254.

    Miscellaneous databases

    GenomeRNAii 127579.
    NextBioi 82133.
    PROi Q5T1A1.

    Gene expression databases

    ArrayExpressi Q5T1A1.
    Bgeei Q5T1A1.
    CleanExi HS_DCST2.
    Genevestigatori Q5T1A1.

    Family and domain databases

    InterProi IPR012858. DC_STAMP-like.
    [Graphical view ]
    Pfami PF07782. DC_STAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-773 (ISOFORM 1).
      Tissue: Testis and Thymus.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).

    Entry informationi

    Entry nameiDCST2_HUMAN
    AccessioniPrimary (citable) accession number: Q5T1A1
    Secondary accession number(s): Q2M2R2, Q8N810, Q96M03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM

    External Data

    Dasty 3