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Q5T1A1

- DCST2_HUMAN

UniProt

Q5T1A1 - DCST2_HUMAN

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Protein

DC-STAMP domain-containing protein 2

Gene
DCST2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DC-STAMP domain-containing protein 2
Gene namesi
Name:DCST2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26562. DCST2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei27 – 4721Helical; Reviewed predictionAdd
BLAST
Topological domaini48 – 514Extracellular Reviewed prediction
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Topological domaini73 – 233161Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST
Topological domaini255 – 32268Extracellular Reviewed predictionAdd
BLAST
Transmembranei323 – 34321Helical; Reviewed predictionAdd
BLAST
Topological domaini344 – 41572Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei416 – 43621Helical; Reviewed predictionAdd
BLAST
Topological domaini437 – 49963Extracellular Reviewed predictionAdd
BLAST
Transmembranei500 – 52021Helical; Reviewed predictionAdd
BLAST
Topological domaini521 – 773253Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773DC-STAMP domain-containing protein 2PRO_0000278826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi296 – 2961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi480 – 4801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T1A1.
PRIDEiQ5T1A1.

PTM databases

PhosphoSiteiQ5T1A1.

Expressioni

Gene expression databases

ArrayExpressiQ5T1A1.
BgeeiQ5T1A1.
CleanExiHS_DCST2.
GenevestigatoriQ5T1A1.

Interactioni

Protein-protein interaction databases

BioGridi126069. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5T1A1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi719 – 77254Pro-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG277288.
HOGENOMiHOG000112181.
InParanoidiQ5T1A1.
OMAiPWGCLVG.
OrthoDBiEOG79GT5Q.
PhylomeDBiQ5T1A1.
TreeFamiTF318254.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5T1A1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPKVMKDVVH PLGGEEPSMA RAVVRSVGGF TLGLSLATAY GLLELLVEGH    50
SPWGCLVGTL TLAAFLSLGM GFSRQVRATV LLLLPQAFSR QGRTLLLVAA 100
FGLVLQGPCA NTLRNFTRAS EAVACGAELA LNQTAEVLQR AKQPLVSALN 150
KIKAIARKTK EVADRVRKFF RSIMDGVKHI ARALRNVWQW LLHIGDVCNS 200
ELGNPYLKCA RVFDDAKDSC MMVIPQAYHL CYVLMPFKLA LCGLASLVQV 250
FCVIPKYIQP FLRQTIGTPV IQLLNRVRQE FEFNMTATHH FSVDLNASRS 300
LSQVAMDLHE AVSMKLHRVR EALALMGFTT PLLLVLLYLQ ALFYRYCYLN 350
WDHYDNIYIT SRFLRMEAVR STAGLPTVLP LSAHEARRYI PPGSIFLSQW 400
EKFFYILETF NLIRHLLLVL FLVFLDYAVF WVLDLARHQL QGEIVARSPV 450
LVSLTVEGTG YAGNIYRDLV SAFDVLQQGN ISILSRRCLL RPSEPDSTGY 500
IVIGVMYGLC FFITLFGSYV SRLRRVICAS YYPSREQERI SYLYNVLLSR 550
RTNLLAALHR SVRRRAADQG HRSAFLVLAS RCPCLGPFVS HFWLHQAYCL 600
GCGQPQDEGD MENTVSCSTP GCQGLYCLTC FRLLDNTCSV CASPLSYQGD 650
LDLELDSSDE EGPQLWLAAA QRKDPEQAWL LQQQLQEVLG RSLSMESTSE 700
SSDLDEEKGP QQRKHGQQPL PEAHQPVSIL TSPEPHRPPE TSSATKGAPT 750
PASEPSVPLS PPSLPDPSHP PPK 773
Length:773
Mass (Da):86,230
Last modified:February 20, 2007 - v2
Checksum:i5B48863229DFAB36
GO
Isoform 2 (identifier: Q5T1A1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     625-639: LYCLTCFRLLDNTCS → FICKWHCSSSLVCTP
     640-773: Missing.

Note: No experimental confirmation available.

Show »
Length:639
Mass (Da):71,728
Checksum:iE68937CDB0F941D5
GO

Sequence cautioni

The sequence BAC05065.1 differs from that shown. Reason: Frameshift at position 736.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei625 – 63915LYCLT…DNTCS → FICKWHCSSSLVCTP in isoform 2. VSP_023408Add
BLAST
Alternative sequencei640 – 773134Missing in isoform 2. VSP_023409Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057496 mRNA. Translation: BAB71511.1.
AK097468 mRNA. Translation: BAC05065.1. Sequence problems.
AL451085 Genomic DNA. Translation: CAI13268.2.
BC111794 mRNA. Translation: AAI11795.1.
CCDSiCCDS1082.2. [Q5T1A1-1]
RefSeqiNP_653223.2. NM_144622.2. [Q5T1A1-1]
UniGeneiHs.591491.

Genome annotation databases

EnsembliENST00000295536; ENSP00000295536; ENSG00000163354. [Q5T1A1-2]
ENST00000368424; ENSP00000357409; ENSG00000163354. [Q5T1A1-1]
ENST00000485982; ENSP00000436964; ENSG00000163354. [Q5T1A1-2]
GeneIDi127579.
KEGGihsa:127579.
UCSCiuc001fgm.3. human. [Q5T1A1-1]

Polymorphism databases

DMDMi143975954.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057496 mRNA. Translation: BAB71511.1 .
AK097468 mRNA. Translation: BAC05065.1 . Sequence problems.
AL451085 Genomic DNA. Translation: CAI13268.2 .
BC111794 mRNA. Translation: AAI11795.1 .
CCDSi CCDS1082.2. [Q5T1A1-1 ]
RefSeqi NP_653223.2. NM_144622.2. [Q5T1A1-1 ]
UniGenei Hs.591491.

3D structure databases

ProteinModelPortali Q5T1A1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126069. 1 interaction.

PTM databases

PhosphoSitei Q5T1A1.

Polymorphism databases

DMDMi 143975954.

Proteomic databases

PaxDbi Q5T1A1.
PRIDEi Q5T1A1.

Protocols and materials databases

DNASUi 127579.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295536 ; ENSP00000295536 ; ENSG00000163354 . [Q5T1A1-2 ]
ENST00000368424 ; ENSP00000357409 ; ENSG00000163354 . [Q5T1A1-1 ]
ENST00000485982 ; ENSP00000436964 ; ENSG00000163354 . [Q5T1A1-2 ]
GeneIDi 127579.
KEGGi hsa:127579.
UCSCi uc001fgm.3. human. [Q5T1A1-1 ]

Organism-specific databases

CTDi 127579.
GeneCardsi GC01M154990.
HGNCi HGNC:26562. DCST2.
neXtProti NX_Q5T1A1.
PharmGKBi PA142672006.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277288.
HOGENOMi HOG000112181.
InParanoidi Q5T1A1.
OMAi PWGCLVG.
OrthoDBi EOG79GT5Q.
PhylomeDBi Q5T1A1.
TreeFami TF318254.

Miscellaneous databases

GenomeRNAii 127579.
NextBioi 82133.
PROi Q5T1A1.

Gene expression databases

ArrayExpressi Q5T1A1.
Bgeei Q5T1A1.
CleanExi HS_DCST2.
Genevestigatori Q5T1A1.

Family and domain databases

InterProi IPR012858. DC_STAMP-like.
[Graphical view ]
Pfami PF07782. DC_STAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-773 (ISOFORM 1).
    Tissue: Testis and Thymus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).

Entry informationi

Entry nameiDCST2_HUMAN
AccessioniPrimary (citable) accession number: Q5T1A1
Secondary accession number(s): Q2M2R2, Q8N810, Q96M03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: February 20, 2007
Last modified: July 9, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

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