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Protein

DC-STAMP domain-containing protein 1

Gene

DCST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri646 – 685RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DC-STAMP domain-containing protein 1
Gene namesi
Name:DCST1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26539. DCST1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 79ExtracellularSequence analysis10
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 115CytoplasmicSequence analysisAdd BLAST15
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 372ExtracellularSequence analysisAdd BLAST236
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 463CytoplasmicSequence analysisAdd BLAST70
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 553ExtracellularSequence analysisAdd BLAST69
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 706CytoplasmicSequence analysisAdd BLAST132

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163357.
PharmGKBiPA142672005.

Polymorphism and mutation databases

BioMutaiDCST1.
DMDMi74756229.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002788241 – 706DC-STAMP domain-containing protein 1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi525N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5T197.
PeptideAtlasiQ5T197.
PRIDEiQ5T197.

PTM databases

iPTMnetiQ5T197.
PhosphoSitePlusiQ5T197.

Expressioni

Gene expression databases

BgeeiENSG00000163357.
CleanExiHS_DCST1.
ExpressionAtlasiQ5T197. baseline and differential.
GenevisibleiQ5T197. HS.

Organism-specific databases

HPAiHPA060314.

Interactioni

Protein-protein interaction databases

BioGridi127192. 2 interactors.
STRINGi9606.ENSP00000295542.

Structurei

3D structure databases

ProteinModelPortaliQ5T197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri646 – 685RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112180.
HOVERGENiHBG081422.
InParanoidiQ5T197.
OMAiLMAKPFT.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ5T197.
TreeFamiTF318254.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T197-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIKHHQNGT RGQRRKQPHT TVQRLLTWGL PVSCSWFLWR QPGEFPVTAL
60 70 80 90 100
LLGAGAGGLL AIGLFQLLVN PMNIYEEQKI MFLYSLVGLG AMGWGTSPHI
110 120 130 140 150
RCASLLLVPK MLGKEGRLFV LGYALAAIYV GPVANLRHNL NNVIASLGCT
160 170 180 190 200
VELQINNTRA AWRISTAPLR AMFKDLLSSK ELLRAETRNI SATFEDLDAQ
210 220 230 240 250
VNSETGYTPE DTMDSGETAQ GREARQAPAS RLHLSTQKMY ELKTKLRCSY
260 270 280 290 300
VVNQAILSCR RWFDRKHEQC MKHIWVPLLT HLLCLPMKFK FFCGIAKVME
310 320 330 340 350
VWCRNRIPVE GNFGQTYDSL NQSIRGLDGE FSANIDFKEE KQAGVLGLNT
360 370 380 390 400
SWERVSTEVR DYVYRQEARL EWALGLLHVL LSCTFLLVLH ASFSYMDSYN
410 420 430 440 450
HDIRFDNIYI STYFCQIDDR RKKLGKRTLL PLRKAEEKTV IFPCKPTIQA
460 470 480 490 500
SEMSNVVREL LETLPILLLL VVLCGLDWAL YSIFDTIRHH SFLQYSFRSS
510 520 530 540 550
HKLEVKVGGD SMLARLLRKT IGALNTSSET VMESNNMPCL PQPVGLDARA
560 570 580 590 600
YWRAAVPIGL LVCLCLLQAF GYRLRRVIAA FYFPKREKKR ILFLYNDLLK
610 620 630 640 650
KRAAFTKLRR AAILRRERQQ KAPRHPLADI LHRGCPLLRR WLCRRCVVCQ
660 670 680 690 700
APETPESYVC RTLDCEAVYC WSCWDDMRQR CPVCTPREEL SSSAFSDSND

DTAYAG
Length:706
Mass (Da):80,712
Last modified:December 21, 2004 - v1
Checksum:iFAE1ADED291F846C
GO
Isoform 2 (identifier: Q5T197-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     624-664: RHPLADILHR...PESYVCRTLD → VFTEPQFLPL...SGVGLRCQRA
     665-706: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):75,737
Checksum:iABE64344EFF240D5
GO
Isoform 3 (identifier: Q5T197-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-87: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,726
Checksum:i1C5D9CE64FE91D70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti467L → P in BAB71440 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056859158T → I.Corresponds to variant rs9427170dbSNPEnsembl.1
Natural variantiVAR_030868512M → L.2 PublicationsCorresponds to variant rs11264300dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04561963 – 87Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_023406624 – 664RHPLA…CRTLD → VFTEPQFLPLKNGKTGEICK ACSLEISLEWWSGVGLRCQR A in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_023407665 – 706Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057347 mRNA. Translation: BAB71440.1.
AK301876 mRNA. Translation: BAG63312.1.
AL451085 Genomic DNA. Translation: CAI13271.1.
AL451085 Genomic DNA. Translation: CAI13272.1.
BC064844 mRNA. Translation: AAH64844.1.
AF314227 Genomic DNA. Translation: AAS46286.1.
CCDSiCCDS1083.1. [Q5T197-1]
CCDS44235.1. [Q5T197-3]
RefSeqiNP_001137159.1. NM_001143687.2. [Q5T197-3]
NP_689707.2. NM_152494.3. [Q5T197-1]
UniGeneiHs.567717.

Genome annotation databases

EnsembliENST00000295542; ENSP00000295542; ENSG00000163357. [Q5T197-1]
ENST00000368419; ENSP00000357404; ENSG00000163357. [Q5T197-2]
ENST00000423025; ENSP00000387369; ENSG00000163357. [Q5T197-3]
GeneIDi149095.
KEGGihsa:149095.
UCSCiuc001fgn.3. human. [Q5T197-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057347 mRNA. Translation: BAB71440.1.
AK301876 mRNA. Translation: BAG63312.1.
AL451085 Genomic DNA. Translation: CAI13271.1.
AL451085 Genomic DNA. Translation: CAI13272.1.
BC064844 mRNA. Translation: AAH64844.1.
AF314227 Genomic DNA. Translation: AAS46286.1.
CCDSiCCDS1083.1. [Q5T197-1]
CCDS44235.1. [Q5T197-3]
RefSeqiNP_001137159.1. NM_001143687.2. [Q5T197-3]
NP_689707.2. NM_152494.3. [Q5T197-1]
UniGeneiHs.567717.

3D structure databases

ProteinModelPortaliQ5T197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127192. 2 interactors.
STRINGi9606.ENSP00000295542.

PTM databases

iPTMnetiQ5T197.
PhosphoSitePlusiQ5T197.

Polymorphism and mutation databases

BioMutaiDCST1.
DMDMi74756229.

Proteomic databases

PaxDbiQ5T197.
PeptideAtlasiQ5T197.
PRIDEiQ5T197.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295542; ENSP00000295542; ENSG00000163357. [Q5T197-1]
ENST00000368419; ENSP00000357404; ENSG00000163357. [Q5T197-2]
ENST00000423025; ENSP00000387369; ENSG00000163357. [Q5T197-3]
GeneIDi149095.
KEGGihsa:149095.
UCSCiuc001fgn.3. human. [Q5T197-1]

Organism-specific databases

CTDi149095.
GeneCardsiDCST1.
HGNCiHGNC:26539. DCST1.
HPAiHPA060314.
neXtProtiNX_Q5T197.
OpenTargetsiENSG00000163357.
PharmGKBiPA142672005.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112180.
HOVERGENiHBG081422.
InParanoidiQ5T197.
OMAiLMAKPFT.
OrthoDBiEOG091G0GX3.
PhylomeDBiQ5T197.
TreeFamiTF318254.

Miscellaneous databases

GenomeRNAii149095.
PROiQ5T197.

Gene expression databases

BgeeiENSG00000163357.
CleanExiHS_DCST1.
ExpressionAtlasiQ5T197. baseline and differential.
GenevisibleiQ5T197. HS.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
IPR001841. Znf_RING.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCST1_HUMAN
AccessioniPrimary (citable) accession number: Q5T197
Secondary accession number(s): B4DXA0
, E9PHV3, Q5T198, Q6P1W6, Q71S70, Q96M70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.