SHC1

Functionⁱ

GO - Molecular functionⁱ

receptor tyrosine kinase binding Source: InterPro

GO - Biological processⁱ

angiogenesis Source: InterPro
intracellular signal transduction Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: SHC-transforming protein 1Imported
Gene namesⁱ	Name:SHC1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

HGNCⁱ

HGNC:10840. SHC1.

Subcellular locationⁱ

GO - Cellular componentⁱ

intracellular Source: GOC

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000160691.

OpenTargetsⁱ

ENSG00000160691.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	Q5T188.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T188.
PeptideAtlas More...PeptideAtlasⁱ	Q5T188.
PRIDEⁱ	Q5T188.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000160691.
ExpressionAtlasⁱ	Q5T188. baseline and differential.

Interactionⁱ

GO - Molecular functionⁱ

receptor tyrosine kinase binding Source: InterPro

Complete GO annotation...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5T188.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 92	PIDInterPro annotationAdd BLAST		69

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018860.
HOGENOMⁱ	HOG000231974.
HOVERGENⁱ	HBG050121.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR006019. PID_Shc-like. IPR006020. PTB/PI_dom. IPR029586. Shc1/ShcA.
PANTHERⁱ	PTHR10337:SF18. PTHR10337:SF18. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640. PID. 1 hit.
PRINTSⁱ	PR00629. SHCPIDOMAIN.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01179. PID. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q5T188-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPITLTVSTS SLNLMAADCK QDTAEYVAYV AKDPVNQRAC HILECPEGLA 
        60         70         80         90        100
QDVISTIGQA FELRFKQYLR NPPKLVTPHD RMAGFDGSAW DEEEEEPPDH 
       110        120        130        140        150
QYYNDFPGKE PPLGGVVDMR LREGAAPGAA RPTAPNAQTP SHLGATLPVG 
       160        170        180        190        200
QPVGGDPEVR KQMPPPPPCP AGRELFDDPS YVNVQNLDKA RQAVGGAGPP

Length:200

Mass (Da):21,522

Last modified:December 21, 2004 - v1

Checksum:ⁱF756CF32004F8E23

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	200	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL451085 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL451085 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000414115; ENSP00000404908; ENSG00000160691.
UCSC genome browser More...UCSCⁱ	uc057ljo.1. human.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5T188	Q5T182 UPI000387C66B	Homo sapiens (Human)	200	UniRef100_Q5T182	Cluster: SHC-transforming protein 1 (Fragment)	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5T188	Q5R7W7 UPI0005126922 UPI0004F06E03 UPI0004F228F5 UPI0004F1EBAA UPI00045DDCE6 UPI00045DE6EB UPI0008F521AC UPI0008F49C36 UPI0005F43524 +178	Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo) Papio anubis (Olive baboon) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Gorilla gorilla gorilla (Western lowland gorilla) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Homo sapiens (Human) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Colobus angolensis palliatus (Peters' Angolan colobus) And more	583	UniRef90_Q5R7W7	Cluster: SHC-transforming protein 1	189

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q5T188	P98083 D3Z5U6 P98083-3 UPI00001F0461 P98083-2 UPI0003F11E05 UPI000787609F UPI0003344D38 UPI000642957F UPI0006437737 +383	Mus musculus (Mouse) Pteropus alecto (Black flying fox) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Condylura cristata (Star-nosed mole) Rhinolophus sinicus (Chinese rufous horseshoe bat) Odobenus rosmarus divergens (Pacific walrus) Ovis aries (Sheep) Ovis aries musimon (Mouflon) Pteropus vampyrus (Large flying fox) Hipposideros armiger (great roundleaf bat) And more	579	UniRef50_P98083	Cluster: SHC-transforming protein 1	394

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL451085 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL451085 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	Q5T188.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	Q5T188.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T188.
PeptideAtlas More...PeptideAtlasⁱ	Q5T188.
PRIDEⁱ	Q5T188.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000414115; ENSP00000404908; ENSG00000160691.
UCSC genome browser More...UCSCⁱ	uc057ljo.1. human.

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10840. SHC1.
Open Targets More...OpenTargetsⁱ	ENSG00000160691.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018860.
HOGENOMⁱ	HOG000231974.
HOVERGENⁱ	HBG050121.

Miscellaneous databases

ChiTaRSⁱ	SHC1. human.

ChiTaRSⁱ

SHC1. human.

Gene expression databases

Bgeeⁱ	ENSG00000160691.
ExpressionAtlasⁱ	Q5T188. baseline and differential.

Family and domain databases

Gene3Dⁱ	2.30.29.30. 1 hit.
InterProⁱ	View protein in InterPro IPR011993. PH_dom-like. IPR006019. PID_Shc-like. IPR006020. PTB/PI_dom. IPR029586. Shc1/ShcA.
PANTHERⁱ	PTHR10337:SF18. PTHR10337:SF18. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640. PID. 1 hit.
PRINTSⁱ	PR00629. SHCPIDOMAIN.
SUPFAMⁱ	SSF50729. SSF50729. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01179. PID. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5T188_HUMAN
Accessionⁱ	Q5T188Primary (citable) accession number: Q5T188
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	August 30, 2017
	This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5T188 (Q5T188_HUMAN)

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SHC-transforming protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ