CKS1B

Functionⁱ

Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.UniRule annotation

GO - Molecular functionⁱ

cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro
kinase activity Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

cell division Source: UniProtKB-UniRule
cell proliferation Source: Ensembl
mitotic cell cycle phase transition Source: Ensembl
regulation of transcription, DNA-templated Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	KinaseImported, Transferase
Biological process	Cell cycle, Cell divisionUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinases regulatory subunitUniRule annotation
Gene namesⁱ	Name:CKS1BImported ORF Names:hCG_1739274Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA38791.

PharmGKBⁱ

PA38791.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T178.

MaxQBⁱ

Q5T178.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173207.
ExpressionAtlasⁱ	Q5T178. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q5T178.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CKS family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3484. Eukaryota. ENOG4111UAN. LUCA.
HOVERGENⁱ	HBG003626.
KEGG Orthology (KO) More...KOⁱ	K02219.
OMAⁱ	LMTENEW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18GQ.

Family and domain databases

Gene3Dⁱ	3.30.170.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000789. Cyclin-dep_kinase_reg-sub.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01111. CKS. 1 hit.
PRINTSⁱ	PR00296. CYCLINKINASE.
SMARTⁱ	View protein in SMART SM01084. CKS. 1 hit.
SUPFAMⁱ	SSF55637. SSF55637. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00944. CKS_1. 1 hit. PS00945. CKS_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5T178-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSHKQIYYSD KYDDEEFEYR HVMLPKDIAK LVPKTHLMSE SEWRNLGVQQ 
        60         70 
SQGWVHYMIH EPEPHILLFR RPLPKKPKK

Length:79

Mass (Da):9,660

Last modified:May 10, 2005 - v1

Checksum:ⁱE64207B140FA38D5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311769 mRNA. Translation: BAG34712.1. CH471121 Genomic DNA. Translation: EAW53164.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001817.1. NM_001826.2.
UniGeneⁱ	Hs.374378.

Genome annotation databases

GeneIDⁱ	1163.
KEGGⁱ	hsa:1163.
UCSC genome browser More...UCSCⁱ	uc001fgb.4. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK311769 mRNA. Translation: BAG34712.1. CH471121 Genomic DNA. Translation: EAW53164.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001817.1. NM_001826.2.
UniGeneⁱ	Hs.374378.

3D structure databases

SMRⁱ	Q5T178.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T178.

MaxQBⁱ

Q5T178.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1163.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	1163.
KEGGⁱ	hsa:1163.
UCSC genome browser More...UCSCⁱ	uc001fgb.4. human.

Organism-specific databases

CTDⁱ	1163.
PharmGKBⁱ	PA38791.

Phylogenomic databases

eggNOGⁱ	KOG3484. Eukaryota. ENOG4111UAN. LUCA.
HOVERGENⁱ	HBG003626.
KEGG Orthology (KO) More...KOⁱ	K02219.
OMAⁱ	LMTENEW.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G18GQ.

Miscellaneous databases

GenomeRNAiⁱ	1163.

GenomeRNAiⁱ

1163.

Gene expression databases

Bgeeⁱ	ENSG00000173207.
ExpressionAtlasⁱ	Q5T178. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.30.170.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000789. Cyclin-dep_kinase_reg-sub.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01111. CKS. 1 hit.
PRINTSⁱ	PR00296. CYCLINKINASE.
SMARTⁱ	View protein in SMART SM01084. CKS. 1 hit.
SUPFAMⁱ	SSF55637. SSF55637. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00944. CKS_1. 1 hit. PS00945. CKS_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5T178_HUMAN
Accessionⁱ	Q5T178Primary (citable) accession number: Q5T178
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	July 5, 2017
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q5T178 (Q5T178_HUMAN)

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Cyclin-dependent kinases regulatory subunit

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5T178 (Q5T178_HUMAN)

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Cyclin-dependent kinases regulatory subunit

CKS1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ