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Protein

UBX domain-containing protein 11

Gene

UBXN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 11
Alternative name(s):
Colorectal tumor-associated antigen COA-1
Socius
UBX domain-containing protein 5
Gene namesi
Name:UBXN11
Synonyms:SOC, UBXD5
ORF Names:PP2243
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30600. UBXN11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi91544.
OpenTargetsiENSG00000158062.
PharmGKBiPA162408338.

Polymorphism and mutation databases

BioMutaiUBXN11.
DMDMi146325810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849211 – 520UBX domain-containing protein 11Add BLAST520

Proteomic databases

PaxDbiQ5T124.
PeptideAtlasiQ5T124.
PRIDEiQ5T124.

PTM databases

iPTMnetiQ5T124.
PhosphoSitePlusiQ5T124.

Expressioni

Gene expression databases

BgeeiENSG00000158062.
ExpressionAtlasiQ5T124. baseline and differential.
GenevisibleiQ5T124. HS.

Organism-specific databases

HPAiHPA028600.
HPA031357.

Interactioni

Subunit structurei

Interacts with GNA12, GNA13, RND1, RND2 AND RND3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-746004,EBI-717810
C6orf165Q8IYR04EBI-746004,EBI-749051
EIF4EP067303EBI-746004,EBI-73440
EIF4E2O605733EBI-746004,EBI-398610
ENKD1Q9H0I23EBI-746004,EBI-744099
PRKAA1Q131313EBI-746004,EBI-1181405
PRKAB2O437413EBI-746004,EBI-1053424
PSMA1P257863EBI-746004,EBI-359352
RHOBTB3O949553EBI-746004,EBI-2367123
RNF213Q63HN8-63EBI-746004,EBI-10248548
SCNM1Q9BWG63EBI-746004,EBI-748391
SH2D4AQ9H7883EBI-746004,EBI-747035
TRAF2Q129335EBI-746004,EBI-355744
USHBP1Q8N6Y03EBI-746004,EBI-739895

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124844. 34 interactors.
IntActiQ5T124. 28 interactors.
MINTiMINT-1193561.
STRINGi9606.ENSP00000363338.

Structurei

3D structure databases

ProteinModelPortaliQ5T124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 294SEPPROSITE-ProRule annotationAdd BLAST65
Domaini392 – 469UBXPROSITE-ProRule annotationAdd BLAST78
Repeati487 – 49418
Repeati495 – 50228
Repeati503 – 51038

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni487 – 5103 X 8 AA tandem repeats of P-G-P-G-P-G-P-SAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 149Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 519Pro-richAdd BLAST37

Sequence similaritiesi

Contains 1 SEP domain.PROSITE-ProRule annotation
Contains 1 UBX domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00390000010180.
HOVERGENiHBG105985.
InParanoidiQ5T124.
OMAiFVIRQGE.
OrthoDBiEOG091G02X6.
PhylomeDBiQ5T124.
TreeFamiTF329799.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T124-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSPLASLSK TRKVPLPSEP MNPGRRGIRI YGDEDEVDML SDGCGSEEKI
60 70 80 90 100
SVPSCYGGIG APVSRQVPAS HDSELMAFMT RKLWDLEQQV KAQTDEILSK
110 120 130 140 150
DQKIAALEDL VQTLRPHPAE ATLQRQEELE TMCVQLQRQV REMERFLSDY
160 170 180 190 200
GLQWVGEPMD QEDSESKTVS EHGERDWMTA KKFWKPGDSL APPEVDFDRL
210 220 230 240 250
LASLQDLSEL VVEGDTQVTP VPGGARLRTL EPIPLKLYRN GIMMFDGPFQ
260 270 280 290 300
PFYDPSTQRC LRDILDGFFP SELQRLYPNG VPFKVSDLRN QVYLEDGLDP
310 320 330 340 350
FPGEGRVVGR QLMHKALDRV EEHPGSRMTA EKFLNRLPKF VIRQGEVIDI
360 370 380 390 400
RGPIRDTLQN CCPLPARIQE IVVETPTLAA ERERSQESPN TPAPPLSMLR
410 420 430 440 450
IKSENGEQAF LLMMQPDNTI GDVRALLAQA RVMDASAFEI FSTFPPTLYQ
460 470 480 490 500
DDTLTLQAAG LVPKAALLLR ARRAPKSSLK FSPGPCPGPG PGPSPGPGPG
510 520
PSPGPGPGPS PCPGPSPSPQ
Length:520
Mass (Da):57,373
Last modified:May 1, 2007 - v2
Checksum:i8642DB07C023276E
GO
Isoform 2 (identifier: Q5T124-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.

Show »
Length:487
Mass (Da):53,976
Checksum:i6EC6574FF3D44CE8
GO
Isoform 3 (identifier: Q5T124-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-186: Missing.

Show »
Length:400
Mass (Da):43,272
Checksum:i7E9912421BC64AA9
GO
Isoform 4 (identifier: Q5T124-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):53,192
Checksum:i6D512E3805F8F560
GO
Isoform 5 (identifier: Q5T124-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:208
Mass (Da):22,191
Checksum:i17B2577621F2E843
GO
Isoform 6 (identifier: Q5T124-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:324
Mass (Da):36,302
Checksum:i992910E8E88948D5
GO
Isoform 7 (identifier: Q5T124-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:291
Mass (Da):32,904
Checksum:i23B621EC61D566EA
GO
Isoform 8 (identifier: Q5T124-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:445
Mass (Da):49,445
Checksum:iBBAC87DB55A1A377
GO

Sequence cautioni

The sequence AAM74202 differs from that shown. Reason: Frameshift at position 190.Curated
The sequence AAQ15261 differs from that shown. Reason: Frameshift at position 390.Curated
The sequence CAI15828 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19E → G in CAH56155 (Ref. 2) Curated1
Sequence conflicti103K → M in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti240N → D in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti320V → L in AAQ15261 (PubMed:15498874).Curated1
Sequence conflicti388S → L in AAM74202 (Ref. 2) Curated1
Sequence conflicti418N → D in BAC04307 (PubMed:17974005).Curated1

Polymorphismi

The number of repeats is polymorphic and varies from 1 to 4.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031860165E → G.Corresponds to variant rs6695966dbSNPEnsembl.1
Natural variantiVAR_031861312L → R.2 PublicationsCorresponds to variant rs4332350dbSNPEnsembl.1
Natural variantiVAR_031862474A → V.1 Publication1
Natural variantiVAR_031863486C → CPGPGPGPS.1 Publication1
Natural variantiVAR_031864487 – 494Missing .2 Publications8
Natural variantiVAR_031865488 – 502Missing .Add BLAST15
Natural variantiVAR_052689501P → S.Corresponds to variant rs17838088dbSNPEnsembl.1
Natural variantiVAR_052690509P → S.2 PublicationsCorresponds to variant rs17838088dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0247711 – 312Missing in isoform 5. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_0247721 – 75Missing in isoform 8. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_0247731 – 38Missing in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_02477434 – 66Missing in isoform 2 and isoform 7. 3 PublicationsAdd BLAST33
Alternative sequenceiVSP_02477567 – 186Missing in isoform 3. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_024776286 – 324SDLRN…VEEHP → ISCSSNHTFGDFEGSGDTQP PQTPPILRGSRCTPWGTPV in isoform 6 and isoform 7. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_024777325 – 520Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521017 mRNA. Translation: AAM74201.1.
AF521018 mRNA. Translation: AAM74202.1. Frameshift.
AF520989 mRNA. Translation: AAM76060.1.
CR749413 mRNA. Translation: CAH18255.1.
BX648412 mRNA. Translation: CAH56155.1.
AK093258 mRNA. Translation: BAC04112.1.
AK094198 mRNA. Translation: BAC04307.1.
AK097368 mRNA. Translation: BAC05024.1.
AF370425 mRNA. Translation: AAQ15261.1. Frameshift.
AL451139 Genomic DNA. Translation: CAI15828.1. Sequence problems.
AL451139 Genomic DNA. Translation: CAI15832.1.
AL451139 Genomic DNA. Translation: CAI15833.1.
AL451139 Genomic DNA. Translation: CAI15834.1.
AL451139 Genomic DNA. Translation: CAI15835.1.
AL451139 Genomic DNA. Translation: CAI15836.1.
AL451139 Genomic DNA. Translation: CAI15840.1.
AL451139 Genomic DNA. Translation: CAI15842.1.
CH471059 Genomic DNA. Translation: EAX07823.1.
CH471059 Genomic DNA. Translation: EAX07826.1.
BC038106 mRNA. Translation: AAH38106.1.
CCDSiCCDS41286.1. [Q5T124-2]
CCDS41287.1. [Q5T124-3]
CCDS41288.1. [Q5T124-1]
RefSeqiNP_001070730.1. NM_001077262.1. [Q5T124-3]
NP_663320.2. NM_145345.2. [Q5T124-2]
NP_892120.2. NM_183008.2. [Q5T124-1]
UniGeneiHs.145061.

Genome annotation databases

EnsembliENST00000314675; ENSP00000324721; ENSG00000158062. [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062. [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062. [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062. [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062. [Q5T124-1]
GeneIDi91544.
KEGGihsa:91544.
UCSCiuc001blw.4. human. [Q5T124-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521017 mRNA. Translation: AAM74201.1.
AF521018 mRNA. Translation: AAM74202.1. Frameshift.
AF520989 mRNA. Translation: AAM76060.1.
CR749413 mRNA. Translation: CAH18255.1.
BX648412 mRNA. Translation: CAH56155.1.
AK093258 mRNA. Translation: BAC04112.1.
AK094198 mRNA. Translation: BAC04307.1.
AK097368 mRNA. Translation: BAC05024.1.
AF370425 mRNA. Translation: AAQ15261.1. Frameshift.
AL451139 Genomic DNA. Translation: CAI15828.1. Sequence problems.
AL451139 Genomic DNA. Translation: CAI15832.1.
AL451139 Genomic DNA. Translation: CAI15833.1.
AL451139 Genomic DNA. Translation: CAI15834.1.
AL451139 Genomic DNA. Translation: CAI15835.1.
AL451139 Genomic DNA. Translation: CAI15836.1.
AL451139 Genomic DNA. Translation: CAI15840.1.
AL451139 Genomic DNA. Translation: CAI15842.1.
CH471059 Genomic DNA. Translation: EAX07823.1.
CH471059 Genomic DNA. Translation: EAX07826.1.
BC038106 mRNA. Translation: AAH38106.1.
CCDSiCCDS41286.1. [Q5T124-2]
CCDS41287.1. [Q5T124-3]
CCDS41288.1. [Q5T124-1]
RefSeqiNP_001070730.1. NM_001077262.1. [Q5T124-3]
NP_663320.2. NM_145345.2. [Q5T124-2]
NP_892120.2. NM_183008.2. [Q5T124-1]
UniGeneiHs.145061.

3D structure databases

ProteinModelPortaliQ5T124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124844. 34 interactors.
IntActiQ5T124. 28 interactors.
MINTiMINT-1193561.
STRINGi9606.ENSP00000363338.

PTM databases

iPTMnetiQ5T124.
PhosphoSitePlusiQ5T124.

Polymorphism and mutation databases

BioMutaiUBXN11.
DMDMi146325810.

Proteomic databases

PaxDbiQ5T124.
PeptideAtlasiQ5T124.
PRIDEiQ5T124.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314675; ENSP00000324721; ENSG00000158062. [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062. [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062. [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062. [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062. [Q5T124-1]
GeneIDi91544.
KEGGihsa:91544.
UCSCiuc001blw.4. human. [Q5T124-1]

Organism-specific databases

CTDi91544.
DisGeNETi91544.
GeneCardsiUBXN11.
HGNCiHGNC:30600. UBXN11.
HPAiHPA028600.
HPA031357.
MIMi609151. gene.
neXtProtiNX_Q5T124.
OpenTargetsiENSG00000158062.
PharmGKBiPA162408338.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2086. Eukaryota.
ENOG410YGXU. LUCA.
GeneTreeiENSGT00390000010180.
HOVERGENiHBG105985.
InParanoidiQ5T124.
OMAiFVIRQGE.
OrthoDBiEOG091G02X6.
PhylomeDBiQ5T124.
TreeFamiTF329799.

Miscellaneous databases

ChiTaRSiUBXN11. human.
GeneWikiiUBXD5.
GenomeRNAii91544.
PROiQ5T124.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158062.
ExpressionAtlasiQ5T124. baseline and differential.
GenevisibleiQ5T124. HS.

Family and domain databases

InterProiIPR012989. SEP_domain.
IPR029071. Ubiquitin-rel_dom.
IPR001012. UBX_dom.
[Graphical view]
PfamiPF08059. SEP. 1 hit.
PF00789. UBX. 1 hit.
[Graphical view]
SUPFAMiSSF102848. SSF102848. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS51399. SEP. 1 hit.
PS50033. UBX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBX11_HUMAN
AccessioniPrimary (citable) accession number: Q5T124
Secondary accession number(s): D3DPK6
, Q5T117, Q5T120, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.