Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein FAM83B

Gene

FAM83B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.3 Publications

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • phosphatidylinositol 3-kinase catalytic subunit binding Source: UniProtKB
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • epidermal growth factor receptor signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM83BCurated
Gene namesi
Name:FAM83BImported
Synonyms:C6orf143Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168143.8
HGNCiHGNC:21357 FAM83B
neXtProtiNX_Q5T0W9

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi230K → A: Loss of the ability to interact with and activate EGFR. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi222584
OpenTargetsiENSG00000168143
PharmGKBiPA134987811

Polymorphism and mutation databases

DMDMi74744366

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002975621 – 1011Protein FAM83BAdd BLAST1011

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei334PhosphoserineCombined sources1
Modified residuei422PhosphoserineCombined sources1
Modified residuei424PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1
Modified residuei782PhosphothreonineCombined sources1
Modified residuei802PhosphoserineCombined sources1
Modified residuei852PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei915PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T0W9
MaxQBiQ5T0W9
PaxDbiQ5T0W9
PeptideAtlasiQ5T0W9
PRIDEiQ5T0W9

PTM databases

iPTMnetiQ5T0W9
PhosphoSitePlusiQ5T0W9

Expressioni

Gene expression databases

BgeeiENSG00000168143
CleanExiHS_FAM83B
GenevisibleiQ5T0W9 HS

Organism-specific databases

HPAiHPA031464
HPA031465

Interactioni

Subunit structurei

Interacts with EGFR; the interaction is disrupted by EGF stimulation (PubMed:23912460). Interacts with RAF1; displaces 14-3-3 proteins from RAF1 and activates RAF1 within the RAS/MAPK signaling cascade (PubMed:22886302). Interacts with AKT1, PIK3CA and PIK3R1; activates the PI3K/AKT signaling cascade (PubMed:23676467).3 Publications

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: UniProtKB
  • phosphatidylinositol 3-kinase catalytic subunit binding Source: UniProtKB
  • phosphatidylinositol 3-kinase regulatory subunit binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128805, 28 interactors
IntActiQ5T0W9, 23 interactors
STRINGi9606.ENSP00000304078

Structurei

Secondary structure

11011
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi120 – 127Combined sources8
Beta strandi130 – 133Combined sources4
Helixi135 – 144Combined sources10
Beta strandi147 – 155Combined sources9
Helixi160 – 171Combined sources12
Beta strandi175 – 181Combined sources7
Helixi182 – 184Combined sources3
Helixi185 – 194Combined sources10
Helixi199 – 201Combined sources3
Beta strandi205 – 210Combined sources6
Beta strandi214 – 216Combined sources3
Beta strandi222 – 224Combined sources3
Beta strandi231 – 234Combined sources4
Turni235 – 237Combined sources3
Beta strandi238 – 243Combined sources6
Helixi249 – 252Combined sources4
Beta strandi255 – 263Combined sources9
Helixi265 – 279Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LZKX-ray1.57A/B117-294[»]
ProteinModelPortaliQ5T0W9
SMRiQ5T0W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 284Required for interaction with RAF1 and for the function1 PublicationAdd BLAST284

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi833 – 838Poly-Ser6

Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

eggNOGiENOG410IK0Q Eukaryota
ENOG410ZVMG LUCA
GeneTreeiENSGT00760000119168
HOGENOMiHOG000112484
HOVERGENiHBG095611
InParanoidiQ5T0W9
OMAiRRSFNGT
OrthoDBiEOG091G019W
PhylomeDBiQ5T0W9
TreeFamiTF330777

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83
PANTHERiPTHR16181 PTHR16181, 1 hit
PfamiView protein in Pfam
PF07894 DUF1669, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T0W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METSSMLSSL NDECKSDNYI EPHYKEWYRV AIDILIEHGL EAYQEFLVQE
60 70 80 90 100
RVSDFLAEEE INYILKNVQK VAQSTAHGTD DSCDDTLSSG TYWPVESDVE
110 120 130 140 150
APNLDLGWPY VMPGLLGGTH IDLLFHPPRA HLLTIKETIR KMIKEARKVI
160 170 180 190 200
ALVMDIFTDV DIFKEIVEAS TRGVSVYILL DESNFNHFLN MTEKQGCSVQ
210 220 230 240 250
RLRNIRVRTV KGQDYLSKTG AKFHGKMEQK FLLVDCQKVM YGSYSYMWSF
260 270 280 290 300
EKAHLSMVQI ITGQLVESFD EEFRTLYARS CVPSSFAQEE SARVKHGKAL
310 320 330 340 350
WENGTYQHSV SSLASVSSQR NLFGRQDKIH KLDSSYFKNR GIYTLNEHDK
360 370 380 390 400
YNIRSHGYKP HFVPNFNGPN AIRQFQPNQI NENWKRHSYA GEQPETVPYL
410 420 430 440 450
LLNRALNRTN NPPGNWKKPS DSLSVASSSR EGYVSHHNTP AQSFANRLAQ
460 470 480 490 500
RKTTNLADRN SNVRRSFNGT DNHIRFLQQR MPTLEHTTKS FLRNWRIESY
510 520 530 540 550
LNDHSEATPD SNGSALGDRF EGYDNPENLK ANALYTHSRL RSSLVFKPTL
560 570 580 590 600
PEQKEVNSCT TGSSNSTIIG SQGSETPKEV PDTPTNVQHL TDKPLPESIP
610 620 630 640 650
KLPLQSEAPK MHTLQVPENH SVALNQTTNG HTESNNYIYK TLGVNKQTEN
660 670 680 690 700
LKNQQTENLL KRRSFPLFDN SKANLDPGNS KHYVYSTLTR NRVRQPEKPK
710 720 730 740 750
EDLLKSSKSM HNVTHNLEED EEEVTKRNSP SGTTTKSVSI AALLDVNKEE
760 770 780 790 800
SNKELASKKE VKGSPSFLKK GSQKLRSLLS LTPDKKENLS KNKAPAFYRL
810 820 830 840 850
CSSSDTLVSE GEENQKPKKS DTKVDSSPRR KHSSSSNSQG SIHKSKEDVT
860 870 880 890 900
VSPSQEINAP PDENKRTPSP GPVESKFLER AGDASAPRFN TEQIQYRDSR
910 920 930 940 950
EINAVVTPER RPTSSPRPTS SELLRSHSTD RRVYSRFEPF CKIESSIQPT
960 970 980 990 1000
SNMPNTSINR PEIKSATMGN SYGRSSPLLN YNTGVYRSYQ PNENKFRGFM
1010
QKFGNFIHKN K
Length:1,011
Mass (Da):114,799
Last modified:December 21, 2004 - v1
Checksum:i7EF02DC36F95CFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti349D → G in BAB70873 (PubMed:14702039).Curated1
Sequence conflicti417K → E in BAB70873 (PubMed:14702039).Curated1
Sequence conflicti541R → S in BAB70873 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034638410N → S. Corresponds to variant dbSNP:rs13211183Ensembl.1
Natural variantiVAR_034639435S → R. Corresponds to variant dbSNP:rs9475076Ensembl.1
Natural variantiVAR_034640640K → T1 PublicationCorresponds to variant dbSNP:rs239798Ensembl.1
Natural variantiVAR_034641907T → N1 PublicationCorresponds to variant dbSNP:rs9475077Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512363 Genomic DNA No translation available.
AL049555 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04439.1
BC101628 mRNA Translation: AAI01629.1
BC112275 mRNA Translation: AAI12276.1
AK055204 mRNA Translation: BAB70873.1
CCDSiCCDS34479.1
RefSeqiNP_001010872.1, NM_001010872.2
XP_006715085.1, XM_006715022.3
XP_011512696.1, XM_011514394.2
XP_011512697.1, XM_011514395.2
XP_016865967.1, XM_017010478.1
UniGeneiHs.152423

Genome annotation databases

EnsembliENST00000306858; ENSP00000304078; ENSG00000168143
GeneIDi222584
KEGGihsa:222584
UCSCiuc003pck.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFA83B_HUMAN
AccessioniPrimary (citable) accession number: Q5T0W9
Secondary accession number(s): Q2M1P3, Q96DQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: December 21, 2004
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health