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Protein
Submitted name:

Dystonin

Gene

DST

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DystoninImported
Gene namesi
Name:DSTImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:1090. DST.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3826HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiQ5T0V7.
PRIDEiQ5T0V7.

Expressioni

Gene expression databases

BgeeiQ5T0V7.
ExpressionAtlasiQ5T0V7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5T0V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini213 – 316104Actin-bindingInterPro annotationAdd
BLAST
Domaini329 – 430102Actin-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119163.
HOGENOMiHOG000049054.
HOVERGENiHBG102439.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR029926. Dystonin.
[Graphical view]
PANTHERiPTHR11915:SF38. PTHR11915:SF38. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5T0V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAAAFLVLL RPYSIQCALF LLLLLLGTIA TIVFFCCWHR KLQKGRHPMK
60 70 80 90 100
SVFSGRSRSR DAVLRSHHFR SEGFRASPRH LRRRVAAAAA ARLEEVKPVV
110 120 130 140 150
EVHHQSEQET SVRKRRIKKS SRVQPEFYHS VQGASIRRPS SGNASYRCSM
160 170 180 190 200
SSSADFSDED DFSQKSGSAS PAPGDTLPWN LPKHERSKRK IQGGSVLDPA
210 220 230 240 250
ERAVLRIADE RDKVQKKTFT KWINQHLMKV RKHVNDLYED LRDGHNLISL
260 270 280 290 300
LEVLSGDTLP REKGRMRFHR LQNVQIALDY LKRRQVKLVN IRNDDITDGN
310 320 330 340 350
PKLTLGLIWT IILHFQISDI HVTGESEDMS AKERLLLWTQ QATEGYAGIR
360 370 380 390 400
CENFTTCWRD GKLFNAIIHK YRPDLIDMNT VAVQSNLANL EHAFYVAEKI
410 420 430 440 450
GVIRLLDPED VDVSSPDEKS VITYVSSLYD AFPKVPEGGE GIGANDVEVK
460 470 480 490 500
WIEYQNMVNY LIQWIRHHVT TMSERTFPNN PVELKALYNQ YLQFKETEIP
510 520 530 540 550
PKETEKSKIK RLYKLLEIWI EFGRIKLLQG YHPNDIEKEW GKLIIAMLER
560 570 580 590 600
EKALRPEVER LEMLQQIANR VQRDSVICED KLILAGNALQ SDSKRLESGV
610 620 630 640 650
QFQNEAEIAG YILECENLLR QHVIDVQILI DGKYYQADQL VQRVAKLRDE
660 670 680
IMALRNECSS VYSKGRILTT EQTKLMISGI TQSLNSGFA
Length:689
Mass (Da):79,168
Last modified:December 21, 2004 - v1
Checksum:iD19F0648CC1BE121
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei689 – 6891Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096710 Genomic DNA. No translation available.
AL137008 Genomic DNA. No translation available.
AL512422 Genomic DNA. No translation available.
AL512448 Genomic DNA. No translation available.
AL590005 Genomic DNA. No translation available.
AL590037 Genomic DNA. No translation available.
KF458172 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000449297; ENSP00000393082; ENSG00000151914.
UCSCiuc063pff.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096710 Genomic DNA. No translation available.
AL137008 Genomic DNA. No translation available.
AL512422 Genomic DNA. No translation available.
AL512448 Genomic DNA. No translation available.
AL590005 Genomic DNA. No translation available.
AL590037 Genomic DNA. No translation available.
KF458172 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ5T0V7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiQ5T0V7.
PRIDEiQ5T0V7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000449297; ENSP00000393082; ENSG00000151914.
UCSCiuc063pff.1. human.

Organism-specific databases

HGNCiHGNC:1090. DST.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119163.
HOGENOMiHOG000049054.
HOVERGENiHBG102439.

Miscellaneous databases

ChiTaRSiDST. human.

Gene expression databases

BgeeiQ5T0V7.
ExpressionAtlasiQ5T0V7. baseline and differential.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR029926. Dystonin.
[Graphical view]
PANTHERiPTHR11915:SF38. PTHR11915:SF38. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ5T0V7_HUMAN
AccessioniPrimary (citable) accession number: Q5T0V7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.