Q5T0U0 (CC122_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 122

Gene names

Name:

CCDC122

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T0U0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q5T0U0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     225-273: VQHKRYDAIL...ELRKCIGMQE → GLAPSPRLEC...IFSRDGVSPC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Coiled-coil domain-containing protein 122		PRO_0000286598
Regions
	Coiled coil	24 – 116	93	Potential
	Coiled coil	179 – 269	91	Potential
Natural variations
	Alternative sequence	225 – 273	49	VQHKR…IGMQE → GLAPSPRLECSSAISAHCKL CLPGSRHSPASASGVAGTTG ACHHTQLIFCIFSRDGVSPC in isoform 2.		VSP_025114
	Natural variant	269	1	I → T. Corresponds to variant rs9567280 [ dbSNP | Ensembl ].		VAR_061579

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: A10760797D60B759	FASTA	273	32,206
	10 20 30 40 50 60 MSDNKERKSQ GFPKEDNQDT SSLADAVEKV AKQQQSQASE IEKNKKVLFN LKNELHELEK 70 80 90 100 110 120 EIAAISAETK ETERQIYQQD SAIENTKLHC DSLETQIKSL HSENVKLKFD IETAQEDFEE 130 140 150 160 170 180 HMIKYNAYYA KIKAHKNSLG EVESKWSFMT ELHEKRDFVK KLKTMKEELM QDLQNPGGNR 190 200 210 220 230 240 ITQVQEDITN LKDKIITVKE SIIEKTCFLE EEKKTHEKLR KEIEVQHKRY DAILKRLHCQ 250 260 270 VNKLQSNRRQ WQWNIQQLEK TAAELRKCIG MQE
	Isoform 2 [UniParc]. Checksum: E84EACB00C3AD584	FASTA	284	32,239
	10 20 30 40 50 60 MSDNKERKSQ GFPKEDNQDT SSLADAVEKV AKQQQSQASE IEKNKKVLFN LKNELHELEK 70 80 90 100 110 120 EIAAISAETK ETERQIYQQD SAIENTKLHC DSLETQIKSL HSENVKLKFD IETAQEDFEE 130 140 150 160 170 180 HMIKYNAYYA KIKAHKNSLG EVESKWSFMT ELHEKRDFVK KLKTMKEELM QDLQNPGGNR 190 200 210 220 230 240 ITQVQEDITN LKDKIITVKE SIIEKTCFLE EEKKTHEKLR KEIEGLAPSP RLECSSAISA 250 260 270 280 HCKLCLPGSR HSPASASGVA GTTGACHHTQ LIFCIFSRDG VSPC

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK056408 mRNA. Translation: BAB71178.1. AL512506 Genomic DNA. Translation: CAI16114.1. BC137289 mRNA. Translation: AAI37290.1. BC137290 mRNA. Translation: AAI37291.1. BC144570 mRNA. Translation: AAI44571.1.
IPI	IPI00043427. IPI00845265.
RefSeq	NP_659411.2. NM_144974.3.
UniGene	Hs.170849.
3D structure databases
ProteinModelPortal	Q5T0U0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5T0U0. 3 interactions.
PTM databases
PhosphoSite	Q5T0U0.
Polymorphism databases
DMDM	74744358.
Proteomic databases
PRIDE	Q5T0U0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281508; ENSP00000281508; ENSG00000151773. ENST00000379193; ENSP00000368491; ENSG00000151773. ENST00000444614; ENSP00000407763; ENSG00000151773.
GeneID	160857.
KEGG	hsa:160857.
UCSC	uc010acf.1. human.
Organism-specific databases
CTD	160857.
GeneCards	GC13M044398.
HGNC	HGNC:26478. CCDC122.
HPA	CAB034233.
MIM	613408. gene.
neXtProt	NX_Q5T0U0.
PharmGKB	PA147358230.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06815.
GeneTree	ENSGT00390000005130.
HOVERGEN	HBG097330.
OMA	ILKRLHC.
OrthoDB	EOG4BZN38.
Gene expression databases
ArrayExpress	Q5T0U0.
Bgee	Q5T0U0.
CleanEx	HS_CCDC122.
Genevestigator	Q5T0U0.
Family and domain databases
ProtoNet	Search...
Other
NextBio	88007.
SOURCE	Search...

Entry information

Entry name

CC122_HUMAN

Accession

Primary (citable) accession number: Q5T0U0
Secondary accession number(s): B2RP70, B7ZMI9, Q96MV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.