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Protein

Spermatogenesis-associated protein 46

Gene

SPATA46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Play a role in spermiogenesis and fertilization.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 461 Publication
Gene namesi
Name:SPATA46Imported
Synonyms:C1orf111
ORF Names:HSD20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27648. SPATA46.

Subcellular locationi

  • Nucleus membrane By similarity

  • Note: Located throughout the subacrosomal area.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171722.
PharmGKBiPA142672495.

Polymorphism and mutation databases

BioMutaiC1orf111.
DMDMi317373467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794581 – 261Spermatogenesis-associated protein 46Add BLAST261

Proteomic databases

PaxDbiQ5T0L3.
PRIDEiQ5T0L3.

PTM databases

PhosphoSitePlusiQ5T0L3.

Expressioni

Tissue specificityi

Testis-specific (PubMed:27488028).1 Publication

Gene expression databases

BgeeiENSG00000171722.
CleanExiHS_C1orf111.
ExpressionAtlasiQ5T0L3. baseline and differential.
GenevisibleiQ5T0L3. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-750105,EBI-740322

Protein-protein interaction databases

BioGridi129933. 11 interactors.
IntActiQ5T0L3. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ5T0L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 144Poly-Ser5

Phylogenomic databases

eggNOGiENOG410IKWE. Eukaryota.
ENOG4111ADC. LUCA.
GeneTreeiENSGT00390000007598.
HOGENOMiHOG000111243.
HOVERGENiHBG080965.
InParanoidiQ5T0L3.
OMAiQNGYKCA.
OrthoDBiEOG091G1ATE.
PhylomeDBiQ5T0L3.
TreeFamiTF337124.

Sequencei

Sequence statusi: Complete.

Q5T0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFSLLSIS GPPISSSALS AFPDIMFSRA TSLPDIAKTA VPTEASSPAQ
60 70 80 90 100
ALPPQYQSII VRQGIQNTAL SPDCSLGDTQ HGEKLRRNCT IYRPWFSPYS
110 120 130 140 150
YFVCADKESQ LEAYDFPEVQ QDEGKWDNCL SEDMAENICS SSSSPENTCP
160 170 180 190 200
REATKKSRHG LDSITSQDIL MASRWHPAQQ NGYKCVACCR MYPTLDFLKS
210 220 230 240 250
HIKRGFREGF SCKVYYRKLK ALWSKEQKAR LGDRLSSGSC QAFNSPAEHL
260
RQIGGEAYLC L
Length:261
Mass (Da):29,150
Last modified:January 11, 2011 - v3
Checksum:iCB3CD34987BD2AD0
GO

Sequence cautioni

The sequence AAP20051 differs from that shown. Reason: Frameshift at position 224.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03090469A → V2 PublicationsCorresponds to variant dbSNP:rs164181Ensembl.1
Natural variantiVAR_030905217R → H1 PublicationCorresponds to variant dbSNP:rs17853130Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA. Translation: CAI15778.1.
BC032957 mRNA. Translation: AAH32957.1.
AY248900 mRNA. Translation: AAP20051.1. Frameshift.
CCDSiCCDS1238.1.
RefSeqiNP_872387.2. NM_182581.3.
UniGeneiHs.97784.

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722.
GeneIDi284680.
KEGGihsa:284680.
UCSCiuc001gbx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA. Translation: CAI15778.1.
BC032957 mRNA. Translation: AAH32957.1.
AY248900 mRNA. Translation: AAP20051.1. Frameshift.
CCDSiCCDS1238.1.
RefSeqiNP_872387.2. NM_182581.3.
UniGeneiHs.97784.

3D structure databases

ProteinModelPortaliQ5T0L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129933. 11 interactors.
IntActiQ5T0L3. 5 interactors.

PTM databases

PhosphoSitePlusiQ5T0L3.

Polymorphism and mutation databases

BioMutaiC1orf111.
DMDMi317373467.

Proteomic databases

PaxDbiQ5T0L3.
PRIDEiQ5T0L3.

Protocols and materials databases

DNASUi284680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722.
GeneIDi284680.
KEGGihsa:284680.
UCSCiuc001gbx.3. human.

Organism-specific databases

CTDi284680.
GeneCardsiC1orf111.
HGNCiHGNC:27648. SPATA46.
MIMi617257. gene.
neXtProtiNX_Q5T0L3.
OpenTargetsiENSG00000171722.
PharmGKBiPA142672495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKWE. Eukaryota.
ENOG4111ADC. LUCA.
GeneTreeiENSGT00390000007598.
HOGENOMiHOG000111243.
HOVERGENiHBG080965.
InParanoidiQ5T0L3.
OMAiQNGYKCA.
OrthoDBiEOG091G1ATE.
PhylomeDBiQ5T0L3.
TreeFamiTF337124.

Miscellaneous databases

ChiTaRSiC1orf111. human.
GenomeRNAii284680.
PROiQ5T0L3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171722.
CleanExiHS_C1orf111.
ExpressionAtlasiQ5T0L3. baseline and differential.
GenevisibleiQ5T0L3. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSPT46_HUMAN
AccessioniPrimary (citable) accession number: Q5T0L3
Secondary accession number(s): Q6X961, Q8NEC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: March 15, 2017
This is version 81 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.