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Protein

Uncharacterized protein C1orf111

Gene

C1orf111

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf111
Gene namesi
ORF Names:HSD20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27648. C1orf111.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672495.

Polymorphism and mutation databases

BioMutaiC1orf111.
DMDMi317373467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Uncharacterized protein C1orf111PRO_0000279458Add
BLAST

Proteomic databases

PaxDbiQ5T0L3.
PRIDEiQ5T0L3.

PTM databases

PhosphoSiteiQ5T0L3.

Expressioni

Gene expression databases

BgeeiQ5T0L3.
CleanExiHS_C1orf111.
ExpressionAtlasiQ5T0L3. baseline and differential.
GenevisibleiQ5T0L3. HS.

Organism-specific databases

HPAiHPA034567.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-750105,EBI-740322

Protein-protein interaction databases

BioGridi129933. 11 interactions.
IntActiQ5T0L3. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5T0L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 1445Poly-Ser

Phylogenomic databases

eggNOGiENOG410IKWE. Eukaryota.
ENOG4111ADC. LUCA.
GeneTreeiENSGT00390000007598.
HOGENOMiHOG000111243.
HOVERGENiHBG080965.
InParanoidiQ5T0L3.
OMAiQNGYKCA.
OrthoDBiEOG7327PH.
PhylomeDBiQ5T0L3.
TreeFamiTF337124.

Sequencei

Sequence statusi: Complete.

Q5T0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFSLLSIS GPPISSSALS AFPDIMFSRA TSLPDIAKTA VPTEASSPAQ
60 70 80 90 100
ALPPQYQSII VRQGIQNTAL SPDCSLGDTQ HGEKLRRNCT IYRPWFSPYS
110 120 130 140 150
YFVCADKESQ LEAYDFPEVQ QDEGKWDNCL SEDMAENICS SSSSPENTCP
160 170 180 190 200
REATKKSRHG LDSITSQDIL MASRWHPAQQ NGYKCVACCR MYPTLDFLKS
210 220 230 240 250
HIKRGFREGF SCKVYYRKLK ALWSKEQKAR LGDRLSSGSC QAFNSPAEHL
260
RQIGGEAYLC L
Length:261
Mass (Da):29,150
Last modified:January 11, 2011 - v3
Checksum:iCB3CD34987BD2AD0
GO

Sequence cautioni

The sequence AAP20051.1 differs from that shown. Reason: Frameshift at position 224. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691A → V.2 Publications
Corresponds to variant rs164181 [ dbSNP | Ensembl ].
VAR_030904
Natural varianti217 – 2171R → H.1 Publication
Corresponds to variant rs17853130 [ dbSNP | Ensembl ].
VAR_030905

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA. Translation: CAI15778.1.
BC032957 mRNA. Translation: AAH32957.1.
AY248900 mRNA. Translation: AAP20051.1. Frameshift.
CCDSiCCDS1238.1.
RefSeqiNP_872387.2. NM_182581.3.
UniGeneiHs.97784.

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722.
GeneIDi284680.
KEGGihsa:284680.
UCSCiuc001gbx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA. Translation: CAI15778.1.
BC032957 mRNA. Translation: AAH32957.1.
AY248900 mRNA. Translation: AAP20051.1. Frameshift.
CCDSiCCDS1238.1.
RefSeqiNP_872387.2. NM_182581.3.
UniGeneiHs.97784.

3D structure databases

ProteinModelPortaliQ5T0L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129933. 11 interactions.
IntActiQ5T0L3. 2 interactions.

PTM databases

PhosphoSiteiQ5T0L3.

Polymorphism and mutation databases

BioMutaiC1orf111.
DMDMi317373467.

Proteomic databases

PaxDbiQ5T0L3.
PRIDEiQ5T0L3.

Protocols and materials databases

DNASUi284680.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722.
GeneIDi284680.
KEGGihsa:284680.
UCSCiuc001gbx.3. human.

Organism-specific databases

CTDi284680.
GeneCardsiC1orf111.
HGNCiHGNC:27648. C1orf111.
HPAiHPA034567.
neXtProtiNX_Q5T0L3.
PharmGKBiPA142672495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKWE. Eukaryota.
ENOG4111ADC. LUCA.
GeneTreeiENSGT00390000007598.
HOGENOMiHOG000111243.
HOVERGENiHBG080965.
InParanoidiQ5T0L3.
OMAiQNGYKCA.
OrthoDBiEOG7327PH.
PhylomeDBiQ5T0L3.
TreeFamiTF337124.

Miscellaneous databases

ChiTaRSiC1orf111. human.
GenomeRNAii284680.
NextBioi95049.
PROiQ5T0L3.

Gene expression databases

BgeeiQ5T0L3.
CleanExiHS_C1orf111.
ExpressionAtlasiQ5T0L3. baseline and differential.
GenevisibleiQ5T0L3. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-69 AND HIS-217.
    Tissue: Testis.
  3. "A new spermatogenesis-related gene."
    Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-253, VARIANT VAL-69.
    Tissue: Testis.

Entry informationi

Entry nameiCA111_HUMAN
AccessioniPrimary (citable) accession number: Q5T0L3
Secondary accession number(s): Q6X961, Q8NEC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: March 16, 2016
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.