Q5T0J7 (TEX35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-expressed sequence 35 protein

Gene names

Name:	Tex35
Synonyms:	C1orf49

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity

Testis-specific. Ref.5

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	microtubule cytoskeleton Inferred from direct assay. Source: LIFEdb nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T0J7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T0J7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     13-13: L → LVKERHCWT
     196-233: GNIPSEASGLYKGGEEPVTTQPSVGHAVPAPKSQTEGR → GIYAAVGLLDLW

Isoform 3 (identifier: Q5T0J7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     182-233: EKCLLCALKNNYNRGNIPSEASGLYKGGEEPVTTQPSVGHAVPAPKSQTEGR → VSETLPEPSTGARPLAPAPW

Isoform 4 (identifier: Q5T0J7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.
     196-233: GNIPSEASGL...PAPKSQTEGR → AAPLKEARHL...MRDEINSERR

Isoform 5 (identifier: Q5T0J7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     196-233: GNIPSEASGLYKGGEEPVTTQPSVGHAVPAPKSQTEGR → AQLQNLPAVPIHHLQAP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Testis-expressed sequence 35 protein		PRO_0000251187
Regions
	Coiled coil	45 – 111	67	Potential
Natural variations
	Alternative sequence	1 – 76	76	Missing in isoform 4.		VSP_020737
	Alternative sequence	13	1	L → LVKERHCWT in isoform 2.		VSP_020738
	Alternative sequence	182 – 233	52	EKCLL…QTEGR → VSETLPEPSTGARPLAPAPW in isoform 3.		VSP_020739
	Alternative sequence	196 – 233	38	GNIPS…QTEGR → GIYAAVGLLDLW in isoform 2.		VSP_020740
	Alternative sequence	196 – 233	38	GNIPS…QTEGR → AAPLKEARHLLTANSIDPSA ALVLLIEFLLLTLVTGAAAP GLDACGHQRNMRDEINSERR in isoform 4.		VSP_020741
	Alternative sequence	196 – 233	38	GNIPS…QTEGR → AQLQNLPAVPIHHLQAP in isoform 5.		VSP_045739
	Natural variant	55	1	E → G. Corresponds to variant rs16852957 [ dbSNP | Ensembl ].		VAR_027656
	Natural variant	146	1	A → G. Corresponds to variant rs12079481 [ dbSNP | Ensembl ].		VAR_027657
	Natural variant	171	1	L → P. Corresponds to variant rs3813636 [ dbSNP | Ensembl ].		VAR_059592
	Natural variant	171	1	L → R. Ref.2 Corresponds to variant rs3813636 [ dbSNP | Ensembl ].		VAR_027658
Experimental info
	Sequence conflict	14	1	S → C in CAB66629. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 0B8B9168E1809B05	FASTA	233	26,518
	10 20 30 40 50 60 MSAKRAELKK THLSKNYKAV CLELKPEPTK TFDYKAVKQE GRFTKAGVTQ DLKNELREVR 70 80 90 100 110 120 EELKEKMEEI KQIKDLMDKD FDKLHEFVEI MKEMQKDMDE KMDILINTQK NYKLPLRRAP 130 140 150 160 170 180 KEQQELRLMG KTHREPQLRP KKMDGASGVN GAPCALHKKT MAPQKTKQGS LDPLHHCGTC 190 200 210 220 230 CEKCLLCALK NNYNRGNIPS EASGLYKGGE EPVTTQPSVG HAVPAPKSQT EGR
	Isoform 2 [UniParc]. Checksum: B34BB92695CB7868	FASTA	215	25,014
	10 20 30 40 50 60 MSAKRAELKK THLVKERHCW TSKNYKAVCL ELKPEPTKTF DYKAVKQEGR FTKAGVTQDL 70 80 90 100 110 120 KNELREVREE LKEKMEEIKQ IKDLMDKDFD KLHEFVEIMK EMQKDMDEKM DILINTQKNY 130 140 150 160 170 180 KLPLRRAPKE QQELRLMGKT HREPQLRPKK MDGASGVNGA PCALHKKTMA PQKTKQGSLD 190 200 210 PLHHCGTCCE KCLLCALKNN YNRGIYAAVG LLDLW
	Isoform 3 [UniParc]. Checksum: B6B7161A1248EF65	FASTA	201	23,096
	10 20 30 40 50 60 MSAKRAELKK THLSKNYKAV CLELKPEPTK TFDYKAVKQE GRFTKAGVTQ DLKNELREVR 70 80 90 100 110 120 EELKEKMEEI KQIKDLMDKD FDKLHEFVEI MKEMQKDMDE KMDILINTQK NYKLPLRRAP 130 140 150 160 170 180 KEQQELRLMG KTHREPQLRP KKMDGASGVN GAPCALHKKT MAPQKTKQGS LDPLHHCGTC 190 200 CVSETLPEPS TGARPLAPAP W
	Isoform 4 [UniParc]. Checksum: 28CAC48DF030515F	FASTA	179	20,199
	10 20 30 40 50 60 MDKDFDKLHE FVEIMKEMQK DMDEKMDILI NTQKNYKLPL RRAPKEQQEL RLMGKTHREP 70 80 90 100 110 120 QLRPKKMDGA SGVNGAPCAL HKKTMAPQKT KQGSLDPLHH CGTCCEKCLL CALKNNYNRA 130 140 150 160 170 APLKEARHLL TANSIDPSAA LVLLIEFLLL TLVTGAAAPG LDACGHQRNM RDEINSERR
	Isoform 5 [UniParc]. Checksum: A23C8F537A6CD276	FASTA	212	24,531
	10 20 30 40 50 60 MSAKRAELKK THLSKNYKAV CLELKPEPTK TFDYKAVKQE GRFTKAGVTQ DLKNELREVR 70 80 90 100 110 120 EELKEKMEEI KQIKDLMDKD FDKLHEFVEI MKEMQKDMDE KMDILINTQK NYKLPLRRAP 130 140 150 160 170 180 KEQQELRLMG KTHREPQLRP KKMDGASGVN GAPCALHKKT MAPQKTKQGS LDPLHHCGTC 190 200 210 CEKCLLCALK NNYNRAQLQN LPAVPIHHLQ AP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT ARG-171. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[5]	"Identification and characteristics of a novel testis-specific gene, Tsc24, in human and mice." Tang A., Yu Z., Gui Y., Guo X., Long Y., Cai Z. Biol. Pharm. Bull. 29:2187-2191(2006) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136694 mRNA. Translation: CAB66629.1. AK093269 mRNA. Translation: BAC04115.1. AK097518 mRNA. Translation: BAC05085.1. AL513013 Genomic DNA. Translation: CAI23535.1. AL513013 Genomic DNA. Translation: CAI23536.1. AL513013 Genomic DNA. Translation: CAI23537.1. AL513013 Genomic DNA. Translation: CAI23538.1. BC034972 mRNA. Translation: AAH34972.1.
IPI	IPI00030237. IPI00217879. IPI00385721. IPI00514942. IPI00844334.
RefSeq	NP_001164193.1. NM_001170722.1. NP_001164194.1. NM_001170723.1. NP_001164195.1. NM_001170724.1. NP_115502.2. NM_032126.4.
UniGene	Hs.534501.
3D structure databases
ProteinModelPortal	Q5T0J7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000323795.
PTM databases
PhosphoSite	Q5T0J7.
Polymorphism databases
DMDM	74744310.
Proteomic databases
PaxDb	Q5T0J7.
PRIDE	Q5T0J7.
Protocols and materials databases
DNASU	84066.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258298; ENSP00000258298; ENSG00000240021. ENST00000319416; ENSP00000323795; ENSG00000240021. ENST00000367639; ENSP00000356611; ENSG00000240021. ENST00000367641; ENSP00000356613; ENSG00000240021. ENST00000367643; ENSP00000356615; ENSG00000240021.
GeneID	84066.
KEGG	hsa:84066.
UCSC	uc001glt.2. human. uc001glu.1. human. uc001glw.2. human.
Organism-specific databases
CTD	84066.
GeneCards	GC01P178484.
HGNC	HGNC:25366. TEX35.
HPA	HPA039190. HPA041719.
neXtProt	NX_Q5T0J7.
PharmGKB	PA134904440.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39358.
HOGENOM	HOG000111219.
HOVERGEN	HBG058182.
InParanoid	Q5T0J7.
OMA	VLINIQK.
OrthoDB	EOG4TXBSW.
PhylomeDB	Q5T0J7.
Gene expression databases
ArrayExpress	Q5T0J7.
Bgee	Q5T0J7.
CleanEx	HS_C1orf49.
Genevestigator	Q5T0J7.
GermOnline	ENSG00000184909. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	84066.
NextBio	73243.

Entry information

Entry name

TEX35_HUMAN

Accession

Primary (citable) accession number: Q5T0J7
Secondary accession number(s): Q5T0J8 , Q5T0J9, Q8IYU6, Q8N7Z1, Q8NA15, Q9H0Q7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 21, 2004
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.