Q5T0I2 (Q5T0I2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Gelsolin (Amyloidosis, Finnish type) EMBL CAI14413.1

Submitted name:
Gelsolin (Amyloidosis, Finnish type), isoform CRA_c EMBL EAW87491.1
Submitted name:
cDNA, FLJ96557, Homo sapiens gelsolin (amyloidosis, Finnish type) (GSN), mRNA EMBL BAG37878.1

Gene names

Name:	GSN EMBL CAI14413.1
ORF Names:	hCG_27454 EMBL EAW87491.1, RP11-477J21.1-001 EMBL CAI14413.1

Organism

Homo sapiens (Human) EMBL CAI14413.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	actin filament polymerization Inferred from sequence or structural similarity. Source: UniProtKB actin filament severing Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5T0I2 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 8CEBC52257A160F7	FASTA	782	85,698
	10 20 30 40 50 60 MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN SMVVEHPEFL 70 80 90 100 110 120 KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT VQLRNGNLQY DLHYWLGNEC 130 140 150 160 170 180 SQDESGAAAI FTVQLDDYLN GRAVQHREVQ GFESATFLGY FKSGLKYKKG GVASGFKHVV 190 200 210 220 230 240 PNEVVVQRLF QVKGRRVVRA TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA 250 260 270 280 290 300 TQVSKGIRDN ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL 310 320 330 340 350 360 YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA NTEERKAALK 370 380 390 400 410 420 TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD QTDGLGLSYL SSHIANVERV 430 440 450 460 470 480 PFDAATLHTS TAMAAQHGMD DDGTGQKQIW RIEGSNKVPV DPATYGQFYG GDSYIILYNY 490 500 510 520 530 540 RHGGRQGQII YNWQGAQSTQ DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG 550 560 570 580 590 600 GKPMIIYKGG TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS 610 620 630 640 650 660 AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA YRTSPRLKDK 670 680 690 700 710 720 KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML LDTWDQVFVW VGKDSQEEEK 730 740 750 760 770 780 TEALTSAKRY IETDPANRDR RTPITVVKQG FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL AA

References

[1]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Tongue EMBL BAG37878.1.
[2]	Laird G. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK315494 mRNA. Translation: BAG37878.1. AL513122 Genomic DNA. Translation: CAI14413.1. CH471090 Genomic DNA. Translation: EAW87491.1.
IPI	IPI00026314.
RefSeq	NP_000168.1. NM_000177.4.
UniGene	Hs.522373.
3D structure databases
ProteinModelPortal	Q5T0I2.
SMR	Q5T0I2. Positions 50-782.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5T0I2.
Proteomic databases
PRIDE	Q5T0I2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2934.
KEGG	hsa:2934.
Organism-specific databases
CTD	2934.
Phylogenomic databases
HOVERGEN	HBG004183.
OMA	KGKQANM.
PhylomeDB	Q5T0I2.
Gene expression databases
ArrayExpress	Q5T0I2.
Bgee	Q5T0I2.
Family and domain databases
InterPro	IPR007122. Gelsolin. IPR007123. Gelsolin_dom. [Graphical view]
KO	K05768.
PANTHER	PTHR11977. Gelsolin. 1 hit.
Pfam	PF00626. Gelsolin. 6 hits. [Graphical view]
PRINTS	PR00597. GELSOLIN.
SMART	SM00262. GEL. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	11625.

Entry information

Entry name

Q5T0I2_HUMAN

Accession

Primary (citable) accession number: Q5T0I2

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.