Reviewed, UniProtKB/Swiss-Prot Q5T0D9 (TPRGL_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor protein p63-regulated gene 1-like protein
Alternative name(s):
    Mossy fiber terminal-associated vertebrate-specific presynaptic protein
    Protein FAM79A

Gene names

Name:	TPRG1L
Synonyms:	FAM79A, MOVER

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with BSN By similarity.
Subcellular location	Cytoplasmic vesicle › secretory vesicle › synaptic vesicleBy similarity. Note= Localized to presynaptic nerve terminals By similarity.
Sequence similarities	Belongs to the TPRG1 family.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasmic vesicle Synapse
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synapse Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5T0D9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5T0D9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     99-157: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Tumor protein p63-regulated gene 1-like protein		PRO_0000269186
Amino acid modifications
	Modified residue	13	1	Phosphothreonine By similarity
	Modified residue	14	1	Phosphoserine
	Modified residue	40	1	Phosphothreonine
Natural variations
	Alternative sequence	99 – 157	59	Missing in isoform 2.		VSP_022019

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 3324B992F460E83C	FASTA	272	30,212
	10 20 30 40 50 60 MLQLRDSVDS AGTSPTAVLA AGEEVGAGGG PGGGRPGAGT PLRQTLWPLS IHDPTRRARV 70 80 90 100 110 120 KEYFVFRPGS IEQAVEEIRV VVRPVEDGEI QGVWLLTEVD HWNNEKERLV LVTEQSLLIC 130 140 150 160 170 180 KYDFISLQCQ QVVRIALNAV DTISYGEFQF PPKSLNKREG FGIRIQWDKQ SRPSFINRWN 190 200 210 220 230 240 PWSTNVPYAT FTEHPMAGAD EKTASLCQLE SFKALLIQAV KKAQKESPLP GQANGVLILE 250 260 270 RPLLIETYVG LMSFINNEAK LGYSMTRGKI GF
	Isoform 2 [UniParc]. Checksum: 40E7F8F4606984D2		213	23,347
	10 20 30 40 50 60 MLQLRDSVDS AGTSPTAVLA AGEEVGAGGG PGGGRPGAGT PLRQTLWPLS IHDPTRRARV 70 80 90 100 110 120 KEYFVFRPGS IEQAVEEIRV VVRPVEDGEI QGVWLLTERE GFGIRIQWDK QSRPSFINRW 130 140 150 160 170 180 NPWSTNVPYA TFTEHPMAGA DEKTASLCQL ESFKALLIQA VKKAQKESPL PGQANGVLIL 190 200 210 ERPLLIETYV GLMSFINNEA KLGYSMTRGK IGF

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: B-cell.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND THR-40, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK289919 mRNA. Translation: BAF82608.1. AL513320 Genomic DNA. Translation: CAI14338.1. AL513320 Genomic DNA. Translation: CAI14339.1. BC019034 mRNA. Translation: AAH19034.1.
RefSeq	NP_877429.2.
UniGene	Hs.20529
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5T0D9.
Genome annotation databases
Ensembl	ENSG00000158109. Homo sapiens. [Contig view]
GeneID	127262.
KEGG	hsa:127262.
Organism-specific databases
HGNC	HGNC:27007. TPRG1L.
MIM	611460. gene.
PharmGKB	PA142671842.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q5T0D9.
Gene expression databases
ArrayExpress	Q5T0D9.
CleanEx	HS_TPRG1L.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	82051.
SOURCE	Search...

Entry information

Entry name

TPRGL_HUMAN

Accession

Primary (citable) accession number: Q5T0D9
Secondary accession number(s): A8K1K4, Q8WV04

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 21, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)