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Protein

Tumor protein p63-regulated gene 1-like protein

Gene

TPRG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p63-regulated gene 1-like protein
Alternative name(s):
Mossy fiber terminal-associated vertebrate-specific presynaptic protein
Protein FAM79A
Gene namesi
Name:TPRG1L
Synonyms:FAM79A, MOVER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27007. TPRG1L.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • synaptic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406855.

Polymorphism and mutation databases

BioMutaiTPRG1L.
DMDMi74744290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Tumor protein p63-regulated gene 1-like proteinPRO_0000269186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei14 – 141PhosphoserineBy similarity
Modified residuei40 – 401PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T0D9.
MaxQBiQ5T0D9.
PaxDbiQ5T0D9.
PeptideAtlasiQ5T0D9.
PRIDEiQ5T0D9.

PTM databases

iPTMnetiQ5T0D9.
PhosphoSiteiQ5T0D9.

Expressioni

Gene expression databases

BgeeiQ5T0D9.
CleanExiHS_TPRG1L.
GenevisibleiQ5T0D9. HS.

Organism-specific databases

HPAiHPA053224.
HPA055404.

Interactioni

Subunit structurei

Interacts with BSN.By similarity

Protein-protein interaction databases

IntActiQ5T0D9. 1 interaction.
STRINGi9606.ENSP00000367595.

Structurei

3D structure databases

ProteinModelPortaliQ5T0D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 238174hSac2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TPRG1 family.Curated
Contains 1 hSac2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEMY. Eukaryota.
ENOG4110AQ3. LUCA.
GeneTreeiENSGT00390000001652.
HOGENOMiHOG000273911.
HOVERGENiHBG056028.
InParanoidiQ5T0D9.
OMAiYTTFIEH.
OrthoDBiEOG7TJ3J8.
PhylomeDBiQ5T0D9.
TreeFamiTF333472.

Family and domain databases

InterProiIPR022158. Inositol_phosphatase.
[Graphical view]
PfamiPF12456. hSac2. 1 hit.
[Graphical view]
PROSITEiPS51791. HSAC2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T0D9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQLRDSVDS AGTSPTAVLA AGEEVGAGGG PGGGRPGAGT PLRQTLWPLS
60 70 80 90 100
IHDPTRRARV KEYFVFRPGS IEQAVEEIRV VVRPVEDGEI QGVWLLTEVD
110 120 130 140 150
HWNNEKERLV LVTEQSLLIC KYDFISLQCQ QVVRIALNAV DTISYGEFQF
160 170 180 190 200
PPKSLNKREG FGIRIQWDKQ SRPSFINRWN PWSTNVPYAT FTEHPMAGAD
210 220 230 240 250
EKTASLCQLE SFKALLIQAV KKAQKESPLP GQANGVLILE RPLLIETYVG
260 270
LMSFINNEAK LGYSMTRGKI GF
Length:272
Mass (Da):30,212
Last modified:December 21, 2004 - v1
Checksum:i3324B992F460E83C
GO
Isoform 2 (identifier: Q5T0D9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-157: Missing.

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):23,347
Checksum:i40E7F8F4606984D2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 15759Missing in isoform 2. 1 PublicationVSP_022019Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289919 mRNA. Translation: BAF82608.1.
AL513320 Genomic DNA. Translation: CAI14338.1.
AL513320 Genomic DNA. Translation: CAI14339.1.
BC019034 mRNA. Translation: AAH19034.1.
CCDSiCCDS47.1. [Q5T0D9-1]
RefSeqiNP_877429.2. NM_182752.3. [Q5T0D9-1]
UniGeneiHs.20529.

Genome annotation databases

EnsembliENST00000344579; ENSP00000339714; ENSG00000158109. [Q5T0D9-2]
ENST00000378344; ENSP00000367595; ENSG00000158109. [Q5T0D9-1]
GeneIDi127262.
KEGGihsa:127262.
UCSCiuc001akm.4. human. [Q5T0D9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289919 mRNA. Translation: BAF82608.1.
AL513320 Genomic DNA. Translation: CAI14338.1.
AL513320 Genomic DNA. Translation: CAI14339.1.
BC019034 mRNA. Translation: AAH19034.1.
CCDSiCCDS47.1. [Q5T0D9-1]
RefSeqiNP_877429.2. NM_182752.3. [Q5T0D9-1]
UniGeneiHs.20529.

3D structure databases

ProteinModelPortaliQ5T0D9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T0D9. 1 interaction.
STRINGi9606.ENSP00000367595.

PTM databases

iPTMnetiQ5T0D9.
PhosphoSiteiQ5T0D9.

Polymorphism and mutation databases

BioMutaiTPRG1L.
DMDMi74744290.

Proteomic databases

EPDiQ5T0D9.
MaxQBiQ5T0D9.
PaxDbiQ5T0D9.
PeptideAtlasiQ5T0D9.
PRIDEiQ5T0D9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344579; ENSP00000339714; ENSG00000158109. [Q5T0D9-2]
ENST00000378344; ENSP00000367595; ENSG00000158109. [Q5T0D9-1]
GeneIDi127262.
KEGGihsa:127262.
UCSCiuc001akm.4. human. [Q5T0D9-1]

Organism-specific databases

CTDi127262.
GeneCardsiTPRG1L.
HGNCiHGNC:27007. TPRG1L.
HPAiHPA053224.
HPA055404.
MIMi611460. gene.
neXtProtiNX_Q5T0D9.
PharmGKBiPA162406855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEMY. Eukaryota.
ENOG4110AQ3. LUCA.
GeneTreeiENSGT00390000001652.
HOGENOMiHOG000273911.
HOVERGENiHBG056028.
InParanoidiQ5T0D9.
OMAiYTTFIEH.
OrthoDBiEOG7TJ3J8.
PhylomeDBiQ5T0D9.
TreeFamiTF333472.

Miscellaneous databases

ChiTaRSiTPRG1L. human.
GenomeRNAii127262.
PROiQ5T0D9.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T0D9.
CleanExiHS_TPRG1L.
GenevisibleiQ5T0D9. HS.

Family and domain databases

InterProiIPR022158. Inositol_phosphatase.
[Graphical view]
PfamiPF12456. hSac2. 1 hit.
[Graphical view]
PROSITEiPS51791. HSAC2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: B-cell.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-40, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTPRGL_HUMAN
AccessioniPrimary (citable) accession number: Q5T0D9
Secondary accession number(s): A8K1K4, Q8WV04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: July 6, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.