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Protein

Zinc finger protein 362

Gene

ZNF362

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 249C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 362
Gene namesi
Name:ZNF362
ORF Names:PP6997
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000160094.14
HGNCiHGNC:18079 ZNF362
neXtProtiNX_Q5T0B9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160094
PharmGKBiPA38290

Polymorphism and mutation databases

BioMutaiZNF362
DMDMi74756199

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008121 – 420Zinc finger protein 362Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphothreonineCombined sources1
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei404PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T0B9
MaxQBiQ5T0B9
PaxDbiQ5T0B9
PeptideAtlasiQ5T0B9
PRIDEiQ5T0B9

PTM databases

iPTMnetiQ5T0B9
PhosphoSitePlusiQ5T0B9

Expressioni

Gene expression databases

BgeeiENSG00000160094
CleanExiHS_ZNF362
ExpressionAtlasiQ5T0B9 baseline and differential
GenevisibleiQ5T0B9 HS

Organism-specific databases

HPAiHPA059239

Interactioni

Protein-protein interaction databases

BioGridi127190, 3 interactors
IntActiQ5T0B9, 1 interactor
STRINGi9606.ENSP00000362527

Structurei

3D structure databases

ProteinModelPortaliQ5T0B9
SMRiQ5T0B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 249C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140926
HOGENOMiHOG000233753
HOVERGENiHBG058173
InParanoidiQ5T0B9
OMAiPPLRDNK
OrthoDBiEOG091G09JQ
PhylomeDBiQ5T0B9
TreeFamiTF331662

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q5T0B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSSPSGKG HSRMAEPRFN NPYFWPPPPT MPSQLDNLVL INKIKEQLMA
60 70 80 90 100
EKIRPPHLPP TSASSQQPLL VPPAPAESSQ AVMSLPKLQQ VPGLHPQAVP
110 120 130 140 150
QPDVALHARP ATSTVTGLGL STRTPSVSTS ESSAGAGTGT GTSTPSTPTT
160 170 180 190 200
TSQSRLIASS PTLISGITSP PLLDSIKTIQ GHGLLGPPKS ERGRKKIKAE
210 220 230 240 250
NPGGPPVLVV PYPILASGET AKEGKTYRCK VCPLTFFTKS EMQIHSKSHT
260 270 280 290 300
EAKPHKCPHC SKSFANASYL AQHLRIHLGV KPYHCSYCDK SFRQLSHLQQ
310 320 330 340 350
HTRIHTGDRP YKCPHPGCEK AFTQLSNLQS HQRQHNKDKP YKCPNCYRAY
360 370 380 390 400
SDSASLQIHL SAHAIKHAKA YCCSMCGRAY TSETYLMKHM SKHTVVEHLV
410 420
SHHSPQRTES PGIPVRISLI
Length:420
Mass (Da):45,814
Last modified:December 21, 2004 - v1
Checksum:iBE15A9B9FD7C9335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194R → L in AAL55863 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318356 mRNA Translation: AAL55863.1
AL513327 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07464.1
BC104779 mRNA Translation: AAI04780.1
BC112113 mRNA Translation: AAI12114.1
CCDSiCCDS377.1
RefSeqiNP_689706.2, NM_152493.2
XP_016855904.1, XM_017000415.1
UniGeneiHs.743358

Genome annotation databases

EnsembliENST00000373428; ENSP00000362527; ENSG00000160094
ENST00000539719; ENSP00000446335; ENSG00000160094
GeneIDi149076
KEGGihsa:149076
UCSCiuc001bxc.1 human

Similar proteinsi

Entry informationi

Entry nameiZN362_HUMAN
AccessioniPrimary (citable) accession number: Q5T0B9
Secondary accession number(s): Q8WYU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health