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Protein

Zinc finger protein 362

Gene

ZNF362

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 249C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 362
Gene namesi
Name:ZNF362
ORF Names:PP6997
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18079. ZNF362.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160094.
PharmGKBiPA38290.

Polymorphism and mutation databases

BioMutaiZNF362.
DMDMi74756199.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008121 – 420Zinc finger protein 362Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphothreonineCombined sources1
Cross-linki198Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei404PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T0B9.
MaxQBiQ5T0B9.
PaxDbiQ5T0B9.
PeptideAtlasiQ5T0B9.
PRIDEiQ5T0B9.

PTM databases

iPTMnetiQ5T0B9.
PhosphoSitePlusiQ5T0B9.

Expressioni

Gene expression databases

BgeeiENSG00000160094.
CleanExiHS_ZNF362.
ExpressionAtlasiQ5T0B9. baseline and differential.
GenevisibleiQ5T0B9. HS.

Organism-specific databases

HPAiHPA059239.

Interactioni

Protein-protein interaction databases

BioGridi127190. 2 interactors.
IntActiQ5T0B9. 1 interactor.
STRINGi9606.ENSP00000362527.

Structurei

3D structure databases

ProteinModelPortaliQ5T0B9.
SMRiQ5T0B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri227 – 249C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 335C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri341 – 363C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri371 – 393C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000233753.
HOVERGENiHBG058173.
InParanoidiQ5T0B9.
OMAiQHSPQRT.
OrthoDBiEOG091G09JQ.
PhylomeDBiQ5T0B9.
TreeFamiTF331662.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5T0B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSSPSGKG HSRMAEPRFN NPYFWPPPPT MPSQLDNLVL INKIKEQLMA
60 70 80 90 100
EKIRPPHLPP TSASSQQPLL VPPAPAESSQ AVMSLPKLQQ VPGLHPQAVP
110 120 130 140 150
QPDVALHARP ATSTVTGLGL STRTPSVSTS ESSAGAGTGT GTSTPSTPTT
160 170 180 190 200
TSQSRLIASS PTLISGITSP PLLDSIKTIQ GHGLLGPPKS ERGRKKIKAE
210 220 230 240 250
NPGGPPVLVV PYPILASGET AKEGKTYRCK VCPLTFFTKS EMQIHSKSHT
260 270 280 290 300
EAKPHKCPHC SKSFANASYL AQHLRIHLGV KPYHCSYCDK SFRQLSHLQQ
310 320 330 340 350
HTRIHTGDRP YKCPHPGCEK AFTQLSNLQS HQRQHNKDKP YKCPNCYRAY
360 370 380 390 400
SDSASLQIHL SAHAIKHAKA YCCSMCGRAY TSETYLMKHM SKHTVVEHLV
410 420
SHHSPQRTES PGIPVRISLI
Length:420
Mass (Da):45,814
Last modified:December 21, 2004 - v1
Checksum:iBE15A9B9FD7C9335
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194R → L in AAL55863 (PubMed:15498874).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318356 mRNA. Translation: AAL55863.1.
AL513327 Genomic DNA. Translation: CAI13953.1.
CH471059 Genomic DNA. Translation: EAX07464.1.
BC104779 mRNA. Translation: AAI04780.1.
BC112113 mRNA. Translation: AAI12114.1.
CCDSiCCDS377.1.
RefSeqiNP_689706.2. NM_152493.2.
XP_016855904.1. XM_017000415.1.
UniGeneiHs.743358.

Genome annotation databases

EnsembliENST00000373428; ENSP00000362527; ENSG00000160094.
ENST00000539719; ENSP00000446335; ENSG00000160094.
GeneIDi149076.
KEGGihsa:149076.
UCSCiuc001bxc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318356 mRNA. Translation: AAL55863.1.
AL513327 Genomic DNA. Translation: CAI13953.1.
CH471059 Genomic DNA. Translation: EAX07464.1.
BC104779 mRNA. Translation: AAI04780.1.
BC112113 mRNA. Translation: AAI12114.1.
CCDSiCCDS377.1.
RefSeqiNP_689706.2. NM_152493.2.
XP_016855904.1. XM_017000415.1.
UniGeneiHs.743358.

3D structure databases

ProteinModelPortaliQ5T0B9.
SMRiQ5T0B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127190. 2 interactors.
IntActiQ5T0B9. 1 interactor.
STRINGi9606.ENSP00000362527.

PTM databases

iPTMnetiQ5T0B9.
PhosphoSitePlusiQ5T0B9.

Polymorphism and mutation databases

BioMutaiZNF362.
DMDMi74756199.

Proteomic databases

EPDiQ5T0B9.
MaxQBiQ5T0B9.
PaxDbiQ5T0B9.
PeptideAtlasiQ5T0B9.
PRIDEiQ5T0B9.

Protocols and materials databases

DNASUi149076.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373428; ENSP00000362527; ENSG00000160094.
ENST00000539719; ENSP00000446335; ENSG00000160094.
GeneIDi149076.
KEGGihsa:149076.
UCSCiuc001bxc.1. human.

Organism-specific databases

CTDi149076.
GeneCardsiZNF362.
HGNCiHGNC:18079. ZNF362.
HPAiHPA059239.
neXtProtiNX_Q5T0B9.
OpenTargetsiENSG00000160094.
PharmGKBiPA38290.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000233753.
HOVERGENiHBG058173.
InParanoidiQ5T0B9.
OMAiQHSPQRT.
OrthoDBiEOG091G09JQ.
PhylomeDBiQ5T0B9.
TreeFamiTF331662.

Miscellaneous databases

ChiTaRSiZNF362. human.
GenomeRNAii149076.
PROiQ5T0B9.

Gene expression databases

BgeeiENSG00000160094.
CleanExiHS_ZNF362.
ExpressionAtlasiQ5T0B9. baseline and differential.
GenevisibleiQ5T0B9. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN362_HUMAN
AccessioniPrimary (citable) accession number: Q5T0B9
Secondary accession number(s): Q8WYU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.