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Protein

Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)

Gene

DHDDS

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55).UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)UniRule annotation (EC:2.5.1.87UniRule annotation)
Gene namesi
Name:DHDDSImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117682.16
HGNCiHGNC:20603 DHDDS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117682

PTM / Processingi

Proteomic databases

MaxQBiQ5T0A2
PeptideAtlasiQ5T0A2

Expressioni

Gene expression databases

BgeeiENSG00000117682
ExpressionAtlasiQ5T0A2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T0A2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili94 – 114Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1602 Eukaryota
COG0020 LUCA
GeneTreeiENSGT00390000007879
HOGENOMiHOG000006053
HOVERGENiHBG051350

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit

Sequencei

Sequence statusi: Fragment.

Q5T0A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWIKEGELS LWERFCANII KAGPMPKHIA FIMDGNRRYA KKCQVERQEG
60 70 80 90 100
HSQGFNKLAE TLRWCLNLGI LEVTVYAFSI ENFKRSKSEV DGLMDLARQK
110 120 130 140 150
FSRLMEEKEK LQKHGVCIRV LGDLHLLPLD LQELIAQAVQ ATKNYNKCFL
160 170
NVCFAYTSRH EISNAVREMA WGV
Length:173
Mass (Da):20,008
Last modified:June 26, 2013 - v2
Checksum:i3EEFBA64ECE10429
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei173Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513365 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000436153; ENSP00000405604; ENSG00000117682
UCSCiuc057drq.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5T0A2_HUMAN
AccessioniPrimary (citable) accession number: Q5T0A2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health