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Protein

MORN repeat-containing protein 1

Gene

MORN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 1
Gene namesi
Name:MORN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25852. MORN1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79906.
OpenTargetsiENSG00000116151.
PharmGKBiPA142671342.

Polymorphism and mutation databases

BioMutaiMORN1.
DMDMi110810454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474541 – 497MORN repeat-containing protein 1Add BLAST497

Proteomic databases

EPDiQ5T089.
PaxDbiQ5T089.
PeptideAtlasiQ5T089.
PRIDEiQ5T089.

PTM databases

iPTMnetiQ5T089.
PhosphoSitePlusiQ5T089.

Expressioni

Gene expression databases

BgeeiENSG00000116151.
CleanExiHS_MORN1.
ExpressionAtlasiQ5T089. baseline and differential.
GenevisibleiQ5T089. HS.

Organism-specific databases

HPAiHPA005858.
HPA070703.

Interactioni

Protein-protein interaction databases

IntActiQ5T089. 1 interactor.
STRINGi9606.ENSP00000367792.

Structurei

3D structure databases

ProteinModelPortaliQ5T089.
SMRiQ5T089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 61MORN 1Add BLAST23
Repeati62 – 84MORN 2Add BLAST23
Repeati86 – 108MORN 3Add BLAST23
Repeati109 – 131MORN 4Add BLAST23
Repeati132 – 154MORN 5Add BLAST23
Repeati155 – 177MORN 6Add BLAST23
Repeati178 – 200MORN 7Add BLAST23

Sequence similaritiesi

Contains 7 MORN repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000236340.
HOVERGENiHBG080218.
InParanoidiQ5T089.
OMAiRVEQGCA.
OrthoDBiEOG091G0KGD.
PhylomeDBiQ5T089.
TreeFamiTF329558.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T089-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGEGTPS SRGPRRDPPR RPPRNGYGVY VYPNSFFRYE GEWKAGRKHG
60 70 80 90 100
HGKLLFKDGS YYEGAFVDGE ITGEGRRHWA WSGDTFSGQF VLGEPQGYGV
110 120 130 140 150
MEYKAGGCYE GEVSHGMREG HGFLVDRDGQ VYQGSFHDNK RHGPGQMLFQ
160 170 180 190 200
NGDKYDGDWV RDRRQGHGVL RCADGSTYKG QWHSDVFSGL GSMAHCSGVT
210 220 230 240 250
YYGLWINGHP AEQATRIVIL GPEVMEVAQG SPFSVNVQLL QDHGEIAKSE
260 270 280 290 300
SGRVLQISAG VRYVQLSAYS EVNFFKVDRD NQETLIQTPF GFECIPYPVS
310 320 330 340 350
SPAAGVPGPR AAKGGAEADV PLPRGDLELH LGALHGQEDT PGGLLARGHA
360 370 380 390 400
PHCPGACQRV EQGCAEFTDV LLGPPPPGYH PFLFLDSLHK KAGGRSRGGL
410 420 430 440 450
HPRGTPPTAQ EPPGGSRPEG RATEEQAAAA HLGEYVLMIR DVTTPPFLGR
460 470 480 490
RLPPAFKHLR VVAKRAGQPP HVLEEGPEAS SSWQAAHSCT PEPPAPR
Length:497
Mass (Da):53,850
Last modified:July 25, 2006 - v2
Checksum:i92A70E3880FABF62
GO
Isoform 2 (identifier: Q5T089-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-350: ARGHA → GSSLF
     351-497: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):38,175
Checksum:i94486020C5418BE2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051199124L → V.Corresponds to variant rs12130128dbSNPEnsembl.1
Natural variantiVAR_027105330H → Y.1 PublicationCorresponds to variant rs17851912dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019994346 – 350ARGHA → GSSLF in isoform 2. 1 Publication5
Alternative sequenceiVSP_019995351 – 497Missing in isoform 2. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024003 mRNA. Translation: BAB14768.1.
AL589739, AL513477 Genomic DNA. Translation: CAI22504.1.
AL513477, AL589739 Genomic DNA. Translation: CAI22608.1.
AL513477 Genomic DNA. Translation: CAI22609.1.
BC021704 mRNA. Translation: AAH21704.1.
CCDSiCCDS40.1. [Q5T089-1]
CCDS72688.1. [Q5T089-2]
RefSeqiNP_001287989.1. NM_001301060.1. [Q5T089-2]
NP_079124.1. NM_024848.2. [Q5T089-1]
UniGeneiHs.642701.
Hs.661079.

Genome annotation databases

EnsembliENST00000378529; ENSP00000367790; ENSG00000116151. [Q5T089-2]
ENST00000378531; ENSP00000367792; ENSG00000116151. [Q5T089-1]
GeneIDi79906.
KEGGihsa:79906.
UCSCiuc001ajb.2. human. [Q5T089-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024003 mRNA. Translation: BAB14768.1.
AL589739, AL513477 Genomic DNA. Translation: CAI22504.1.
AL513477, AL589739 Genomic DNA. Translation: CAI22608.1.
AL513477 Genomic DNA. Translation: CAI22609.1.
BC021704 mRNA. Translation: AAH21704.1.
CCDSiCCDS40.1. [Q5T089-1]
CCDS72688.1. [Q5T089-2]
RefSeqiNP_001287989.1. NM_001301060.1. [Q5T089-2]
NP_079124.1. NM_024848.2. [Q5T089-1]
UniGeneiHs.642701.
Hs.661079.

3D structure databases

ProteinModelPortaliQ5T089.
SMRiQ5T089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T089. 1 interactor.
STRINGi9606.ENSP00000367792.

PTM databases

iPTMnetiQ5T089.
PhosphoSitePlusiQ5T089.

Polymorphism and mutation databases

BioMutaiMORN1.
DMDMi110810454.

Proteomic databases

EPDiQ5T089.
PaxDbiQ5T089.
PeptideAtlasiQ5T089.
PRIDEiQ5T089.

Protocols and materials databases

DNASUi79906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378529; ENSP00000367790; ENSG00000116151. [Q5T089-2]
ENST00000378531; ENSP00000367792; ENSG00000116151. [Q5T089-1]
GeneIDi79906.
KEGGihsa:79906.
UCSCiuc001ajb.2. human. [Q5T089-1]

Organism-specific databases

CTDi79906.
DisGeNETi79906.
GeneCardsiMORN1.
HGNCiHGNC:25852. MORN1.
HPAiHPA005858.
HPA070703.
neXtProtiNX_Q5T089.
OpenTargetsiENSG00000116151.
PharmGKBiPA142671342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000236340.
HOVERGENiHBG080218.
InParanoidiQ5T089.
OMAiRVEQGCA.
OrthoDBiEOG091G0KGD.
PhylomeDBiQ5T089.
TreeFamiTF329558.

Miscellaneous databases

ChiTaRSiMORN1. human.
GeneWikiiMorn_repeat_containing_1.
GenomeRNAii79906.
PROiQ5T089.

Gene expression databases

BgeeiENSG00000116151.
CleanExiHS_MORN1.
ExpressionAtlasiQ5T089. baseline and differential.
GenevisibleiQ5T089. HS.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMORN1_HUMAN
AccessioniPrimary (citable) accession number: Q5T089
Secondary accession number(s): A6NKZ6, Q8WW30, Q9H852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.