Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MORN repeat-containing protein 1

Gene

MORN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MORN repeat-containing protein 1
Gene namesi
Name:MORN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25852. MORN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671342.

Polymorphism and mutation databases

BioMutaiMORN1.
DMDMi110810454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497MORN repeat-containing protein 1PRO_0000247454Add
BLAST

Proteomic databases

EPDiQ5T089.
PaxDbiQ5T089.
PeptideAtlasiQ5T089.
PRIDEiQ5T089.

PTM databases

iPTMnetiQ5T089.

Expressioni

Gene expression databases

BgeeiQ5T089.
CleanExiHS_MORN1.
ExpressionAtlasiQ5T089. baseline and differential.
GenevisibleiQ5T089. HS.

Organism-specific databases

HPAiHPA005858.

Interactioni

Protein-protein interaction databases

IntActiQ5T089. 1 interaction.
STRINGi9606.ENSP00000367792.

Structurei

3D structure databases

ProteinModelPortaliQ5T089.
SMRiQ5T089. Positions 31-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 6123MORN 1Add
BLAST
Repeati62 – 8423MORN 2Add
BLAST
Repeati86 – 10823MORN 3Add
BLAST
Repeati109 – 13123MORN 4Add
BLAST
Repeati132 – 15423MORN 5Add
BLAST
Repeati155 – 17723MORN 6Add
BLAST
Repeati178 – 20023MORN 7Add
BLAST

Sequence similaritiesi

Contains 7 MORN repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000236340.
HOVERGENiHBG080218.
InParanoidiQ5T089.
OMAiRVEQGCA.
OrthoDBiEOG7VDXP7.
PhylomeDBiQ5T089.
TreeFamiTF329558.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T089-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAGEGTPS SRGPRRDPPR RPPRNGYGVY VYPNSFFRYE GEWKAGRKHG
60 70 80 90 100
HGKLLFKDGS YYEGAFVDGE ITGEGRRHWA WSGDTFSGQF VLGEPQGYGV
110 120 130 140 150
MEYKAGGCYE GEVSHGMREG HGFLVDRDGQ VYQGSFHDNK RHGPGQMLFQ
160 170 180 190 200
NGDKYDGDWV RDRRQGHGVL RCADGSTYKG QWHSDVFSGL GSMAHCSGVT
210 220 230 240 250
YYGLWINGHP AEQATRIVIL GPEVMEVAQG SPFSVNVQLL QDHGEIAKSE
260 270 280 290 300
SGRVLQISAG VRYVQLSAYS EVNFFKVDRD NQETLIQTPF GFECIPYPVS
310 320 330 340 350
SPAAGVPGPR AAKGGAEADV PLPRGDLELH LGALHGQEDT PGGLLARGHA
360 370 380 390 400
PHCPGACQRV EQGCAEFTDV LLGPPPPGYH PFLFLDSLHK KAGGRSRGGL
410 420 430 440 450
HPRGTPPTAQ EPPGGSRPEG RATEEQAAAA HLGEYVLMIR DVTTPPFLGR
460 470 480 490
RLPPAFKHLR VVAKRAGQPP HVLEEGPEAS SSWQAAHSCT PEPPAPR
Length:497
Mass (Da):53,850
Last modified:July 25, 2006 - v2
Checksum:i92A70E3880FABF62
GO
Isoform 2 (identifier: Q5T089-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-350: ARGHA → GSSLF
     351-497: Missing.

Note: No experimental confirmation available.
Show »
Length:350
Mass (Da):38,175
Checksum:i94486020C5418BE2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241L → V.
Corresponds to variant rs12130128 [ dbSNP | Ensembl ].
VAR_051199
Natural varianti330 – 3301H → Y.1 Publication
Corresponds to variant rs17851912 [ dbSNP | Ensembl ].
VAR_027105

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei346 – 3505ARGHA → GSSLF in isoform 2. 1 PublicationVSP_019994
Alternative sequencei351 – 497147Missing in isoform 2. 1 PublicationVSP_019995Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024003 mRNA. Translation: BAB14768.1.
AL589739, AL513477 Genomic DNA. Translation: CAI22504.1.
AL513477, AL589739 Genomic DNA. Translation: CAI22608.1.
AL513477 Genomic DNA. Translation: CAI22609.1.
BC021704 mRNA. Translation: AAH21704.1.
CCDSiCCDS40.1. [Q5T089-1]
CCDS72688.1. [Q5T089-2]
RefSeqiNP_001287989.1. NM_001301060.1. [Q5T089-2]
NP_079124.1. NM_024848.2. [Q5T089-1]
UniGeneiHs.642701.
Hs.661079.

Genome annotation databases

EnsembliENST00000378529; ENSP00000367790; ENSG00000116151. [Q5T089-2]
ENST00000378531; ENSP00000367792; ENSG00000116151. [Q5T089-1]
GeneIDi79906.
KEGGihsa:79906.
UCSCiuc001ajb.2. human. [Q5T089-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024003 mRNA. Translation: BAB14768.1.
AL589739, AL513477 Genomic DNA. Translation: CAI22504.1.
AL513477, AL589739 Genomic DNA. Translation: CAI22608.1.
AL513477 Genomic DNA. Translation: CAI22609.1.
BC021704 mRNA. Translation: AAH21704.1.
CCDSiCCDS40.1. [Q5T089-1]
CCDS72688.1. [Q5T089-2]
RefSeqiNP_001287989.1. NM_001301060.1. [Q5T089-2]
NP_079124.1. NM_024848.2. [Q5T089-1]
UniGeneiHs.642701.
Hs.661079.

3D structure databases

ProteinModelPortaliQ5T089.
SMRiQ5T089. Positions 31-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T089. 1 interaction.
STRINGi9606.ENSP00000367792.

PTM databases

iPTMnetiQ5T089.

Polymorphism and mutation databases

BioMutaiMORN1.
DMDMi110810454.

Proteomic databases

EPDiQ5T089.
PaxDbiQ5T089.
PeptideAtlasiQ5T089.
PRIDEiQ5T089.

Protocols and materials databases

DNASUi79906.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378529; ENSP00000367790; ENSG00000116151. [Q5T089-2]
ENST00000378531; ENSP00000367792; ENSG00000116151. [Q5T089-1]
GeneIDi79906.
KEGGihsa:79906.
UCSCiuc001ajb.2. human. [Q5T089-1]

Organism-specific databases

CTDi79906.
GeneCardsiMORN1.
HGNCiHGNC:25852. MORN1.
HPAiHPA005858.
neXtProtiNX_Q5T089.
PharmGKBiPA142671342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0231. Eukaryota.
COG4642. LUCA.
GeneTreeiENSGT00730000110297.
HOGENOMiHOG000236340.
HOVERGENiHBG080218.
InParanoidiQ5T089.
OMAiRVEQGCA.
OrthoDBiEOG7VDXP7.
PhylomeDBiQ5T089.
TreeFamiTF329558.

Miscellaneous databases

ChiTaRSiMORN1. human.
GeneWikiiMorn_repeat_containing_1.
GenomeRNAii79906.
PROiQ5T089.

Gene expression databases

BgeeiQ5T089.
CleanExiHS_MORN1.
ExpressionAtlasiQ5T089. baseline and differential.
GenevisibleiQ5T089. HS.

Family and domain databases

InterProiIPR003409. MORN.
[Graphical view]
PfamiPF02493. MORN. 8 hits.
[Graphical view]
SMARTiSM00698. MORN. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retinoblastoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT TYR-330.
    Tissue: Testis.

Entry informationi

Entry nameiMORN1_HUMAN
AccessioniPrimary (citable) accession number: Q5T089
Secondary accession number(s): A6NKZ6, Q8WW30, Q9H852
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: July 6, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.