ID   F120S_HUMAN             Reviewed;         256 AA.
AC   Q5T036; A6NN20;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Uncharacterized protein FAM120AOS {ECO:0000305};
DE   AltName: Full=FAM120A opposite strand protein {ECO:0000305};
GN   Name=FAM120AOS; Synonyms=C9orf10OS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-22 AND GLU-241.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- INTERACTION:
CC       Q5T036; Q99750: MDFI; NbExp=3; IntAct=EBI-12420808, EBI-724076;
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DR   EMBL; AK056096; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AL583839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL353629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS6705.1; -.
DR   RefSeq; NP_942138.2; NM_198841.2.
DR   AlphaFoldDB; Q5T036; -.
DR   BioGRID; 127664; 24.
DR   IntAct; Q5T036; 1.
DR   STRING; 9606.ENSP00000364561; -.
DR   GlyGen; Q5T036; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q5T036; -.
DR   PhosphoSitePlus; Q5T036; -.
DR   BioMuta; FAM120AOS; -.
DR   MassIVE; Q5T036; -.
DR   PaxDb; 9606-ENSP00000364561; -.
DR   PeptideAtlas; Q5T036; -.
DR   ProteomicsDB; 64123; -.
DR   Antibodypedia; 54979; 7 antibodies from 7 providers.
DR   DNASU; 158293; -.
DR   Ensembl; ENST00000375412.11; ENSP00000364561.5; ENSG00000188938.17.
DR   GeneID; 158293; -.
DR   KEGG; hsa:158293; -.
DR   MANE-Select; ENST00000375412.11; ENSP00000364561.5; NM_198841.4; NP_942138.2.
DR   UCSC; uc004atu.5; human.
DR   AGR; HGNC:23389; -.
DR   CTD; 158293; -.
DR   DisGeNET; 158293; -.
DR   GeneCards; FAM120AOS; -.
DR   HGNC; HGNC:23389; FAM120AOS.
DR   HPA; ENSG00000188938; Low tissue specificity.
DR   neXtProt; NX_Q5T036; -.
DR   OpenTargets; ENSG00000188938; -.
DR   PharmGKB; PA134893278; -.
DR   VEuPathDB; HostDB:ENSG00000188938; -.
DR   eggNOG; ENOG502TEJ0; Eukaryota.
DR   GeneTree; ENSGT00390000001747; -.
DR   HOGENOM; CLU_1111099_0_0_1; -.
DR   InParanoid; Q5T036; -.
DR   OMA; GTRCPQR; -.
DR   OrthoDB; 4673629at2759; -.
DR   PhylomeDB; Q5T036; -.
DR   TreeFam; TF338583; -.
DR   PathwayCommons; Q5T036; -.
DR   SignaLink; Q5T036; -.
DR   BioGRID-ORCS; 158293; 11 hits in 1152 CRISPR screens.
DR   ChiTaRS; FAM120AOS; human.
DR   GenomeRNAi; 158293; -.
DR   Pharos; Q5T036; Tdark.
DR   PRO; PR:Q5T036; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q5T036; Protein.
DR   Bgee; ENSG00000188938; Expressed in cardiac muscle of right atrium and 191 other cell types or tissues.
DR   ExpressionAtlas; Q5T036; baseline and differential.
DR   Genevisible; Q5T036; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..256
FT                   /note="Uncharacterized protein FAM120AOS"
FT                   /id="PRO_0000337248"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         22
FT                   /note="L -> F (in dbSNP:rs1055710)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_043677"
FT   VARIANT         241
FT                   /note="K -> E (in dbSNP:rs10821128)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_043678"
SQ   SEQUENCE   256 AA;  27929 MW;  1BEA53331BA94241 CRC64;
     MGKTKDIGDD DTVASEFWSG ALSQPSSVPT RPRTPNRDSW RRAWAARGLH PRPSILQPGP
     ARLSRARAGG TRCPQRRHGR ATFCALGRGI GVRRGPGPRP ARIPGLTLTW KRMSARRMQW
     AMQTGGRNQT FGGGVPLFWT WLTICCAVWR SLPCRLTHSC SRAFSSAPLK KTKSSMLPPK
     QALASAARNL CRGAGCNRQA VAGQLLPSTW SLHAHGLAKE APILPVKKIS RSCSVNNKVS
     KKTTKPPTLR SFLSPI
//