Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5T013

- HYI_HUMAN

UniProt

Q5T013 - HYI_HUMAN

Protein

Putative hydroxypyruvate isomerase

Gene

HYI

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).By similarity

    Catalytic activityi

    Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.

    GO - Molecular functioni

    1. hydroxypyruvate isomerase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative hydroxypyruvate isomerase (EC:5.3.1.22)
    Alternative name(s):
    Endothelial cell apoptosis protein E-CE1
    Gene namesi
    Name:HYI
    ORF Names:HT036, SB156
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26948. HYI.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671668.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Putative hydroxypyruvate isomerasePRO_0000289241Add
    BLAST

    Proteomic databases

    MaxQBiQ5T013.
    PaxDbiQ5T013.
    PRIDEiQ5T013.

    PTM databases

    PhosphoSiteiQ5T013.

    Expressioni

    Inductioni

    Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.1 Publication

    Gene expression databases

    ArrayExpressiQ5T013.
    BgeeiQ5T013.
    CleanExiHS_HYI.
    GenevestigatoriQ5T013.

    Organism-specific databases

    HPAiHPA040092.

    Interactioni

    Protein-protein interaction databases

    BioGridi123621. 3 interactions.
    IntActiQ5T013. 1 interaction.
    STRINGi9606.ENSP00000361507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5T013.
    SMRiQ5T013. Positions 5-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hyi family.Curated

    Phylogenomic databases

    eggNOGiCOG3622.
    HOVERGENiHBG056845.
    InParanoidiQ5T013.
    KOiK01816.
    PhylomeDBiQ5T013.
    TreeFamiTF312858.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    InterProiIPR026040. HyI-like.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006241. HyI. 1 hit.
    SUPFAMiSSF51658. SSF51658. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5T013-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPLRFSANL SWLFPELSGL PARVRAAGSS GFEAVEVAWP YAETPEALAR    50
    AAREAGLRLV LINTPPGDQE KGEMGLGAVP GRQAAFREGL EQAVRYAKAL 100
    GCPRIHLMAG RVPQGADRIA VKAEMEAVFL ENLRHAAGVL AQEDLVGLLE 150
    PINTRITDPQ YFLDTPQQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN 200
    IREFLPIVGH VQVAQVPGRG EPSSPGELNF PYLFQLLEDE GYKGFVGCEY 250
    QPRGDTVEGL SWLRSYWDRR GHPEAGQ 277
    Length:277
    Mass (Da):30,406
    Last modified:May 29, 2007 - v2
    Checksum:i79D5072A8717B4F7
    GO
    Isoform 2 (identifier: Q5T013-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.
         248-277: Missing.

    Show »
    Length:174
    Mass (Da):19,084
    Checksum:iD04A820535AB1705
    GO
    Isoform 3 (identifier: Q5T013-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-277: Missing.

    Show »
    Length:247
    Mass (Da):26,874
    Checksum:iDA0485BAB2BB5724
    GO
    Isoform 4 (identifier: Q5T013-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-73: Missing.

    Show »
    Length:204
    Mass (Da):22,616
    Checksum:i80BF040C3520EBD7
    GO

    Sequence cautioni

    The sequence AAH06140.1 differs from that shown. Reason: Frameshift at position 271.
    The sequence AAV84474.1 differs from that shown. Reason: Frameshift at positions 215, 228, 232 and 238.
    The sequence AAH19041.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181S → P in AAV84474. 1 PublicationCurated
    Sequence conflicti18 – 181S → P in AAK67642. 1 PublicationCurated
    Sequence conflicti18 – 181S → P in AAH19041. 1 PublicationCurated
    Sequence conflicti224 – 2241S → KP in AAV84474. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti239 – 2391D → N.1 Publication
    Corresponds to variant rs17850049 [ dbSNP | Ensembl ].
    VAR_032611

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7373Missing in isoform 2 and isoform 4. 1 PublicationVSP_025986Add
    BLAST
    Alternative sequencei248 – 27730Missing in isoform 2 and isoform 3. 4 PublicationsVSP_025987Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY775560 mRNA. Translation: AAV84474.1. Frameshift.
    AF284750 mRNA. Translation: AAG59852.1.
    AF284751 mRNA. Translation: AAG59853.1.
    AY037165 mRNA. Translation: AAK67642.1.
    AL583862 Genomic DNA. Translation: CAI14890.1.
    AL583862 Genomic DNA. Translation: CAI14893.1.
    CH471059 Genomic DNA. Translation: EAX07090.1.
    CH471059 Genomic DNA. Translation: EAX07091.1.
    CH471059 Genomic DNA. Translation: EAX07093.1.
    CH471059 Genomic DNA. Translation: EAX07094.1.
    BC006140 mRNA. Translation: AAH06140.1. Sequence problems.
    BC019041 mRNA. Translation: AAH19041.1. Different initiation.
    CCDSiCCDS488.2. [Q5T013-3]
    CCDS53309.1. [Q5T013-1]
    RefSeqiNP_001177809.1. NM_001190880.2. [Q5T013-1]
    NP_001230455.1. NM_001243526.1.
    NP_112484.3. NM_031207.5. [Q5T013-3]
    UniGeneiHs.709864.

    Genome annotation databases

    EnsembliENST00000372425; ENSP00000361502; ENSG00000178922. [Q5T013-1]
    ENST00000372432; ENSP00000361509; ENSG00000178922. [Q5T013-3]
    ENST00000583037; ENSP00000461969; ENSG00000178922. [Q5T013-4]
    GeneIDi81888.
    KEGGihsa:81888.
    UCSCiuc001cjm.3. human. [Q5T013-1]

    Polymorphism databases

    DMDMi152125829.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY775560 mRNA. Translation: AAV84474.1 . Frameshift.
    AF284750 mRNA. Translation: AAG59852.1 .
    AF284751 mRNA. Translation: AAG59853.1 .
    AY037165 mRNA. Translation: AAK67642.1 .
    AL583862 Genomic DNA. Translation: CAI14890.1 .
    AL583862 Genomic DNA. Translation: CAI14893.1 .
    CH471059 Genomic DNA. Translation: EAX07090.1 .
    CH471059 Genomic DNA. Translation: EAX07091.1 .
    CH471059 Genomic DNA. Translation: EAX07093.1 .
    CH471059 Genomic DNA. Translation: EAX07094.1 .
    BC006140 mRNA. Translation: AAH06140.1 . Sequence problems.
    BC019041 mRNA. Translation: AAH19041.1 . Different initiation.
    CCDSi CCDS488.2. [Q5T013-3 ]
    CCDS53309.1. [Q5T013-1 ]
    RefSeqi NP_001177809.1. NM_001190880.2. [Q5T013-1 ]
    NP_001230455.1. NM_001243526.1.
    NP_112484.3. NM_031207.5. [Q5T013-3 ]
    UniGenei Hs.709864.

    3D structure databases

    ProteinModelPortali Q5T013.
    SMRi Q5T013. Positions 5-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123621. 3 interactions.
    IntActi Q5T013. 1 interaction.
    STRINGi 9606.ENSP00000361507.

    PTM databases

    PhosphoSitei Q5T013.

    Polymorphism databases

    DMDMi 152125829.

    Proteomic databases

    MaxQBi Q5T013.
    PaxDbi Q5T013.
    PRIDEi Q5T013.

    Protocols and materials databases

    DNASUi 81888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372425 ; ENSP00000361502 ; ENSG00000178922 . [Q5T013-1 ]
    ENST00000372432 ; ENSP00000361509 ; ENSG00000178922 . [Q5T013-3 ]
    ENST00000583037 ; ENSP00000461969 ; ENSG00000178922 . [Q5T013-4 ]
    GeneIDi 81888.
    KEGGi hsa:81888.
    UCSCi uc001cjm.3. human. [Q5T013-1 ]

    Organism-specific databases

    CTDi 81888.
    GeneCardsi GC01M043916.
    HGNCi HGNC:26948. HYI.
    HPAi HPA040092.
    neXtProti NX_Q5T013.
    PharmGKBi PA142671668.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3622.
    HOVERGENi HBG056845.
    InParanoidi Q5T013.
    KOi K01816.
    PhylomeDBi Q5T013.
    TreeFami TF312858.

    Miscellaneous databases

    GenomeRNAii 81888.
    NextBioi 72232.
    PROi Q5T013.

    Gene expression databases

    ArrayExpressi Q5T013.
    Bgeei Q5T013.
    CleanExi HS_HYI.
    Genevestigatori Q5T013.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    InterProi IPR026040. HyI-like.
    IPR013022. Xyl_isomerase-like_TIM-brl.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006241. HyI. 1 hit.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Study of a new protein that interacts with endostatin."
      Zhang B.L., Fan B.X., Liu Y.N.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Liver.
    2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
      Tissue: Hypothalamus.
    3. Li N., Zhang M., Wan T., Zhang W., Cao X.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-247 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-247 (ISOFORM 3), VARIANT ASN-239.
      Tissue: Kidney and Ovary.
    7. "Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces alterations of extracellular protein profile of exposed epithelial cells."
      Liu H., Shen J., Feng L., Yu Y.
      Proteomics 9:4259-4264(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, INDUCTION.

    Entry informationi

    Entry nameiHYI_HUMAN
    AccessioniPrimary (citable) accession number: Q5T013
    Secondary accession number(s): D3DPX4
    , D3DPX5, Q5Q9A2, Q7Z778, Q96S83, Q9BZR3, Q9BZR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3