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Protein

Protein SZT2

Gene

SZT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxidative stress. May be involved in superoxide dismutase activity and in neuroprotective effect of peroxisomes, but has no direct dismutase activity when tested in yeast. May enhance epileptogenesis and confer low seizure threshold (By similarity).By similarity

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • corpus callosum morphogenesis Source: UniProtKB
  • pigmentation Source: Ensembl
  • post-embryonic development Source: UniProtKB
  • regulation of superoxide dismutase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SZT2
Alternative name(s):
Seizure threshold 2 protein homolog
Gene namesi
Name:SZT2
Synonyms:C1orf84, KIAA0467
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29040. SZT2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Involvement in diseasei

Epileptic encephalopathy, early infantile, 18 (EIEE18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe autosomal recessive neurologic disorder characterized by lack of psychomotor development apparent from birth, dysmorphic facial features, early onset of refractory seizures, and thick corpus callosum and persistent cavum septum pellucidum on brain imaging.
See also OMIM:615476

Keywords - Diseasei

Epilepsy

Organism-specific databases

MalaCardsiSZT2.
MIMi615476. phenotype.
Orphaneti369894. Early infantile epileptic encephalopathy without suppression burst.
PharmGKBiPA142671628.
PA142672532.

Polymorphism and mutation databases

BioMutaiSZT2.
DMDMi308153547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 34323432Protein SZT2PRO_0000275898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1416 – 14161PhosphoserineCombined sources
Modified residuei1641 – 16411PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T011.
MaxQBiQ5T011.
PaxDbiQ5T011.
PRIDEiQ5T011.

PTM databases

iPTMnetiQ5T011.
PhosphoSiteiQ5T011.

Expressioni

Tissue specificityi

Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.2 Publications

Gene expression databases

BgeeiQ5T011.
CleanExiHS_KIAA0467.
ExpressionAtlasiQ5T011. baseline and differential.
GenevisibleiQ5T011. HS.

Organism-specific databases

HPAiHPA029012.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431863EBI-10245139,EBI-748171
RELQ048643EBI-10245139,EBI-307352
TCF4P158843EBI-10245139,EBI-533224

Protein-protein interaction databases

BioGridi116921. 12 interactions.
IntActiQ5T011. 4 interactions.
MINTiMINT-5003883.
STRINGi9606.ENSP00000457168.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE3I. Eukaryota.
ENOG410XTCX. LUCA.
GeneTreeiENSGT00390000018402.
HOVERGENiHBG080139.
InParanoidiQ5T011.
OMAiDYRAPFL.
OrthoDBiEOG7CNZDW.
PhylomeDBiQ5T011.

Family and domain databases

InterProiIPR033228. SZT2.
[Graphical view]
PANTHERiPTHR14918. PTHR14918. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T011-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASERPEPEV EEAGQVFLLM KKDYRISRNV RLAWFLSHLH QTVQATPQEM
60 70 80 90 100
LLQSEQELEV LSVLPPGWQP DEPVVPRPFL LVPSTRVTFL AWQYRFVIEL
110 120 130 140 150
DLSPSTGIVD DSTGEILFDE VFHALSRCLG GLLRPFRVPG SCIDFQPEIY
160 170 180 190 200
VTIQAYSSII GLQSHQVLVQ GCLLDPSQRE VFLQQIYEQL CLFEDKVATM
210 220 230 240 250
LQQQYDPQSQ AEDQSPDSGD LLGRKVGVSM VTADLGLVSM IRQGILALQL
260 270 280 290 300
LPSNSSAGII VITDGVTSVP DVAVCETLLN QLRSGTVACS FVQVGGVYSY
310 320 330 340 350
DCSFGHVPNV ELMKFIAMAT FGSYLSTCPE PEPGNLGLTV YHRAFLLYSF
360 370 380 390 400
LRSGEALNPE YYCGSQHRLF NEHLVSASSN PALALRRKKH TEKEVPADLV
410 420 430 440 450
STVSVRLREG YSVREVTLAK GGSQLEVKLV LLWKHNMRIE YVAMAPWPLE
460 470 480 490 500
PEGPRVTRVE VTMEGGYDIL HDVSCALRQP IRSLYRTHVI RRFWNTLQSI
510 520 530 540 550
NQTDQMLAHL QSFSSVPEHF TLPDSTKSGV PLFYIPPGST TPVLSLQPSG
560 570 580 590 600
SDSSHAQFAA YWKPVLSMDA NSWQRWLHMH RLVLILEHDT PIPKHLHTPG
610 620 630 640 650
SNGRYSTIQC RISHSSLTSL LRDWSSFVLV EGYSYVKLLS SAPDQPPNSF
660 670 680 690 700
YMVRIISKAP CMVLRLGFPI GTPAPARHKI VSGLREEILR LRFPHRVQSK
710 720 730 740 750
EPTPKVKRKG LGGAGGGSSP SKSPPVLGPQ QALSDRPCLV VLHKPLDKLL
760 770 780 790 800
IRYEKLPLDY RAPFLLTLEP PGPLPLVSGR SASSSLASLS RYLYHQRWLW
810 820 830 840 850
SVPSGLAPAL PLSAIAQLLS ILTEVRLSEG FHFACSGEGI INMVLELPIQ
860 870 880 890 900
NEPPGQAAAE EKHTCVVQYI LFPPHSTSTK DSFSTDDDND VEVEALEGDS
910 920 930 940 950
ELNLVTEVWV EPQYGRVGPG PGIWKHLQDL TYSEIPQALH PRDAACIGSM
960 970 980 990 1000
LSFEYLIQLC QSKEWGPLPP EPRVSDGLDQ GGDTCVHEIP FHFDLMGLLP
1010 1020 1030 1040 1050
QCQQLQMFFL LLAREPEGVP FAEGSCPAND MVLCLLHSCL GQELSDREIP
1060 1070 1080 1090 1100
LTPVDQAAFL SEVLRRTCHV PGAEGPLLGV HGIPKEQAVG STQATGDSAF
1110 1120 1130 1140 1150
TSLSVGLPET LKPLISAQPP QWRCYARLVN PQHVFLTFLP ATFSDVQRLA
1160 1170 1180 1190 1200
ACGLEGPPQE ETKPKFGDWS GAPSLKDLGG TGIKATKSHV PVLSVTLASD
1210 1220 1230 1240 1250
NAQNQGELSP PFRRDLQAYA GRQASQTESA DGPRTRCPVY IYSCSLEALR
1260 1270 1280 1290 1300
EQMVGMQPPQ APRDLIFRTQ FLDHPSPSSA WMEPRYKEAA NHCALLQEHA
1310 1320 1330 1340 1350
QRCYVRGLFR SLQQAQSVTS QDLLTAVDAC EELLQEIDIT PFLLALCGHT
1360 1370 1380 1390 1400
WGLPHAPPSP GPLSPGPFSS SMEEGAEPRE RAILASESSI ETEDLSEPEF
1410 1420 1430 1440 1450
QSTRVPGIPD PGPEISLTDV CQLRGEAHGA LHSVIQEKFL EISRLHFRTV
1460 1470 1480 1490 1500
PSNPHYFFYC PPSSRREDEG PRDTVDRKIS DLEFSEAELM GEEGDTSACC
1510 1520 1530 1540 1550
VVTESDPELE VEYRESRESD LGPAGLDSAS LSDVDTVNPD EDSFSILGGD
1560 1570 1580 1590 1600
SPTGPESFLH DLPPLFLHLT CSVRLRGQHS SVPVCSLPTC LGQVLSSLEG
1610 1620 1630 1640 1650
PPVGGRVPLR DLSVTLDVFM LTLPLEVELP TASDPQHHRS TSESSASFPR
1660 1670 1680 1690 1700
SPGQPSSLRS DDGLGPPLPP PEEERHPGLS NLATPHRLAI ETTMNEIRWL
1710 1720 1730 1740 1750
LEDEMVGALR RGGIPQSPAL HRAAAHIHSS PGRSTCLRQT LPLSFVFGPE
1760 1770 1780 1790 1800
RSLTQFKEEF RRLHLPGHVL LEDPDSGFFF VAAGQQPGGS HGEPSSAAWA
1810 1820 1830 1840 1850
WHSHEDRAEG IEGETLTASP QAPGSPEDSE GVPLISLPRV PQGGSQPGPS
1860 1870 1880 1890 1900
RGLSLMSSQG SVDSDHLGYD GGSSGSDSEG PNDTLGEKAP FTLRTPPGPA
1910 1920 1930 1940 1950
PPQPSLSGLP GPCLPDFWLI VRVLQDRVEV YAHARSLIRE DGGPGTECRH
1960 1970 1980 1990 2000
LQQLLVRRVG EICREVNQRL LLQDLHDSHV CNSLLVAESE EDLWRSETPF
2010 2020 2030 2040 2050
HSRQRAPLPS DDYAADESCA PRGYLAATMQ FVPGHFSCDV VWGTVIRVHS
2060 2070 2080 2090 2100
RLKMGPSMGV SRAIQALRSV LNAFSVVNRK NMFVYQERAT KAVYYLRLLE
2110 2120 2130 2140 2150
TSCSDRPWKG DALPPSLALS RSQEPIYSEE ASGPRSPLDM VSSRSSDAAR
2160 2170 2180 2190 2200
PVGQVDRHIQ LLVHGVGQAG PEITDELVRV LCRRLDEATL DVITVMLVRN
2210 2220 2230 2240 2250
CKLTPADVEF IQPPGSLPSE VLHLALPTSC RPWLPALAWY LRQNLLIFLH
2260 2270 2280 2290 2300
SPKYTDSNSR NHFQHPLPPQ GGLPDLDIYL YNKPGGQGTG GKGVACITLA
2310 2320 2330 2340 2350
FVDEGGAPLS LALWPPSSPG PPDPLREEEF EQLTQVIRCP VVVDSSSAQN
2360 2370 2380 2390 2400
GAPRLRLDVW EKGNISIVQL EEKLRGAARQ ALADAIIELQ LLPASLCTED
2410 2420 2430 2440 2450
TPTGSLRNGS LETKSSAGRA STFPPAPVPG EPVTPPSKAG RRSFWDMLSK
2460 2470 2480 2490 2500
TECGDLGSPK TTDDIVLDRP EDTRGRRRHK TESVRTPGGA ERAPGSDSGA
2510 2520 2530 2540 2550
QRQKRRTTQL EEGEVGTLHP VFARVAQRWM EFMVQIGCAS VSRSSAHMVS
2560 2570 2580 2590 2600
RFLLPSILSE FTALVTSMAG DTSVRIFEQH LGSEPEIFGP CSPGQLGPSP
2610 2620 2630 2640 2650
RPAAERHLLL LGRNFLQWRR PTQQAAKAMQ RFEPGGDGSS GRNAPRQRLL
2660 2670 2680 2690 2700
LLEVVDKKLQ LLTYNWAPDL GAALGRALVR LVQWQNARAH LIFCLLSQKL
2710 2720 2730 2740 2750
GLFHHYGQLD FPVRDEKEPN PFLLPTMEVE TLIRSASPPL SREQGRLSGS
2760 2770 2780 2790 2800
SRGGGPLPLD TFPFDEALRD ITAARPSSVL GPVPRPPDPV TYHGQQFLEI
2810 2820 2830 2840 2850
KMAERRELER QMKMENLFVT WQQRSTPATM PISAGELETL KQSSRLVHYC
2860 2870 2880 2890 2900
ATAMLFDPAA WLHGPPETSG PPDGQRRHRP ESGSGSREAP TSCESLDVSP
2910 2920 2930 2940 2950
PGAREEPWLK ELSLAFLQQY VQYLQSIGFV LVPLRPPSPA RSTSRPRAMA
2960 2970 2980 2990 3000
ILGTEGRGSF SCPKTKTDGS PKSTSSPVTT YHLQRALPGG IILMELAFQG
3010 3020 3030 3040 3050
CYFCVKQFAL ECSRIPMGQA VNSQLSMLFT EECDKVRDLM HVHSFSYDFH
3060 3070 3080 3090 3100
LRLVHQHVLG AHLVLRHGYH LTTFLRHFLA HHPDGPHFGR NHIYQGTLEL
3110 3120 3130 3140 3150
PTPLIAAHQL YNYVADHASS YHMKPLRMAR PGGPEHNEYA LVSAWHSSGS
3160 3170 3180 3190 3200
YLDSEGLRHQ DDFDVSLLVC HCAAPFEEQG EAERHVLRLQ FFVVLTSQRE
3210 3220 3230 3240 3250
LFPRLTADMR RFRKPPRLPP EPEAPGSSAG SPGEASGLIL APGPAPLFPP
3260 3270 3280 3290 3300
LAAEVGMARA RLAQLVRLAG GHCRRDTLWK RLFLLEPPGP DRLRLGGRLA
3310 3320 3330 3340 3350
LAELEELLEA VHAKSIGDID PQLDCFLSMT VSWYQSLIKV LLSRFPQSCR
3360 3370 3380 3390 3400
HFQSPDLGTQ YLVVLNQKFT DCFVLVFLDS HLGKTSLTVV FREPFPVQPQ
3410 3420 3430
DSESPPAQLV STYHHLESVI NTACFTLWTR LL
Note: Gene prediction based on similarity to mouse ortholog. No experimental confirmation available.
Length:3,432
Mass (Da):378,029
Last modified:October 5, 2010 - v3
Checksum:iE65E415FA8C55BC1
GO
Isoform 2 (identifier: Q5T011-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1015-1020: EPEGVP → AAWGRS
     1021-3432: Missing.

Note: No experimental confirmation available.
Show »
Length:1,020
Mass (Da):113,485
Checksum:iD5E0DC50CF82F336
GO
Isoform 3 (identifier: Q5T011-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1015-1071: Missing.

Show »
Length:3,375
Mass (Da):371,855
Checksum:iA0656FB4AD15B05E
GO
Isoform 4 (identifier: Q5T011-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-53: Missing.
     167-180: VLVQGCLLDPSQRE → RQGFTMLARLPSNF
     181-3432: Missing.

Show »
Length:178
Mass (Da):20,286
Checksum:i18612FFDFD9FE130
GO

Sequence cautioni

The sequence AAH52802.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI51233.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15649.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03755.1 differs from that shown.Probable cloning artifact.Curated
The sequence BAC86771.1 differs from that shown.Probable cloning artifact.Curated
The sequence BF926328 differs from that shown.Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BF926328 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BU101724 differs from that shown. Reason: Frameshift at position 287. Curated
The sequence CAI14886.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI23384.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671V → G in BU101724 (PubMed:15028280).Curated
Sequence conflicti309 – 3091N → H in BU101724 (PubMed:15028280).Curated
Sequence conflicti315 – 3151F → L in BU101724 (PubMed:15028280).Curated
Sequence conflicti323 – 3231S → A in BU101724 (PubMed:15028280).Curated
Sequence conflicti446 – 4461P → S in BAC85157 (Ref. 5) Curated
Sequence conflicti3332 – 33321S → P in BAB15649 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 532Missing in isoform 4. 1 PublicationVSP_039913
Alternative sequencei167 – 18014VLVQG…PSQRE → RQGFTMLARLPSNF in isoform 4. 1 PublicationVSP_039914Add
BLAST
Alternative sequencei181 – 34323252Missing in isoform 4. 1 PublicationVSP_039915Add
BLAST
Alternative sequencei1015 – 107157Missing in isoform 3. 2 PublicationsVSP_039916Add
BLAST
Alternative sequencei1015 – 10206EPEGVP → AAWGRS in isoform 2. 1 PublicationVSP_034456
Alternative sequencei1021 – 34322412Missing in isoform 2. 1 PublicationVSP_034457Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139289 Genomic DNA. Translation: CAI23384.1. Sequence problems.
AL139289 Genomic DNA. Translation: CAI23383.1.
AL583862 Genomic DNA. Translation: CAI14886.2. Sequence problems.
BC017576 mRNA. Translation: AAH17576.1.
BC041069 mRNA. Translation: AAH41069.1.
BC052802 mRNA. Translation: AAH52802.1. Different initiation.
BC082968 mRNA. Translation: AAH82968.1.
BC151232 mRNA. Translation: AAI51233.1. Different initiation.
BU101724 mRNA. No translation available.
BF926328 mRNA. No translation available.
AK131107 mRNA. Translation: BAC85157.1.
AB007936 mRNA. Translation: BAA32312.2.
AK027078 mRNA. Translation: BAB15649.1. Different initiation.
AK091821 mRNA. Translation: BAC03755.1. Sequence problems.
AK126972 mRNA. Translation: BAC86771.1. Sequence problems.
AL117402 mRNA. Translation: CAB55903.1.
CCDSiCCDS30694.2. [Q5T011-5]
PIRiT00093.
T17213.
RefSeqiNP_056099.3. NM_015284.3. [Q5T011-5]
XP_006710564.1. XM_006710501.2. [Q5T011-1]
UniGeneiHs.643560.

Genome annotation databases

EnsembliENST00000372450; ENSP00000361528; ENSG00000198198. [Q5T011-7]
ENST00000562955; ENSP00000457168; ENSG00000198198. [Q5T011-5]
ENST00000634258; ENSP00000489255; ENSG00000198198. [Q5T011-1]
GeneIDi23334.
KEGGihsa:23334.
UCSCiuc001cjh.4. human. [Q5T011-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139289 Genomic DNA. Translation: CAI23384.1. Sequence problems.
AL139289 Genomic DNA. Translation: CAI23383.1.
AL583862 Genomic DNA. Translation: CAI14886.2. Sequence problems.
BC017576 mRNA. Translation: AAH17576.1.
BC041069 mRNA. Translation: AAH41069.1.
BC052802 mRNA. Translation: AAH52802.1. Different initiation.
BC082968 mRNA. Translation: AAH82968.1.
BC151232 mRNA. Translation: AAI51233.1. Different initiation.
BU101724 mRNA. No translation available.
BF926328 mRNA. No translation available.
AK131107 mRNA. Translation: BAC85157.1.
AB007936 mRNA. Translation: BAA32312.2.
AK027078 mRNA. Translation: BAB15649.1. Different initiation.
AK091821 mRNA. Translation: BAC03755.1. Sequence problems.
AK126972 mRNA. Translation: BAC86771.1. Sequence problems.
AL117402 mRNA. Translation: CAB55903.1.
CCDSiCCDS30694.2. [Q5T011-5]
PIRiT00093.
T17213.
RefSeqiNP_056099.3. NM_015284.3. [Q5T011-5]
XP_006710564.1. XM_006710501.2. [Q5T011-1]
UniGeneiHs.643560.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116921. 12 interactions.
IntActiQ5T011. 4 interactions.
MINTiMINT-5003883.
STRINGi9606.ENSP00000457168.

PTM databases

iPTMnetiQ5T011.
PhosphoSiteiQ5T011.

Polymorphism and mutation databases

BioMutaiSZT2.
DMDMi308153547.

Proteomic databases

EPDiQ5T011.
MaxQBiQ5T011.
PaxDbiQ5T011.
PRIDEiQ5T011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372450; ENSP00000361528; ENSG00000198198. [Q5T011-7]
ENST00000562955; ENSP00000457168; ENSG00000198198. [Q5T011-5]
ENST00000634258; ENSP00000489255; ENSG00000198198. [Q5T011-1]
GeneIDi23334.
KEGGihsa:23334.
UCSCiuc001cjh.4. human. [Q5T011-1]

Organism-specific databases

CTDi23334.
GeneCardsiSZT2.
H-InvDBHIX0159961.
HGNCiHGNC:29040. SZT2.
HPAiHPA029012.
MalaCardsiSZT2.
MIMi615463. gene.
615476. phenotype.
neXtProtiNX_Q5T011.
Orphaneti369894. Early infantile epileptic encephalopathy without suppression burst.
PharmGKBiPA142671628.
PA142672532.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE3I. Eukaryota.
ENOG410XTCX. LUCA.
GeneTreeiENSGT00390000018402.
HOVERGENiHBG080139.
InParanoidiQ5T011.
OMAiDYRAPFL.
OrthoDBiEOG7CNZDW.
PhylomeDBiQ5T011.

Miscellaneous databases

ChiTaRSiSZT2. human.
GenomeRNAii23334.
NextBioi45273.
PROiQ5T011.
SOURCEiSearch...

Gene expression databases

BgeeiQ5T011.
CleanExiHS_KIAA0467.
ExpressionAtlasiQ5T011. baseline and differential.
GenevisibleiQ5T011. HS.

Family and domain databases

InterProiIPR033228. SZT2.
[Graphical view]
PANTHERiPTHR14918. PTHR14918. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2797-3432 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 689-3432 (ISOFORM 3).
    Tissue: Lung, Spleen and Urinary bladder.
  3. "Bridging expressed sequence alignments through targeted cDNA sequencing."
    Xie H., Diber A., Pollock S., Nemzer S., Safer H., Meloon B., Olson A., Hwang J.J., Endress G.A., Savitsky K., Gill-More R.
    Genomics 83:572-576(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 142-330 (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 256-369 (ISOFORM 1).
  5. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Kikuno R., Nagase T., Ohara O.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 424-3432 (ISOFORM 2).
    Tissue: Spleen.
  6. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 689-3432 (ISOFORM 3).
    Tissue: Brain.
  7. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2849-3432 (ISOFORM 1).
    Tissue: Lung.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3099-3432 (ISOFORM 1).
    Tissue: Testis.
  10. "A novel giant peroxisomal superoxide dismutase motif-containing protein."
    Toutzaris D., Lewerenz J., Albrecht P., Jensen L.T., Letz J., Geerts A., Golz S., Methner A.
    Free Radic. Biol. Med. 48:811-820(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  11. Cited for: INVOLVEMENT IN EIEE18, TISSUE SPECIFICITY.
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1416 AND THR-1641, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSZT2_HUMAN
AccessioniPrimary (citable) accession number: Q5T011
Secondary accession number(s): A0PJK5
, A7E2X4, O75055, Q5JUY7, Q5T012, Q5XKC7, Q6ZNI8, Q6ZT24, Q7Z636, Q8NAY9, Q9H5H7, Q9UFQ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 5, 2010
Last modified: May 11, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.