SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5SZV5

- K0319_MOUSE

UniProt

Q5SZV5 - K0319_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Dyslexia-associated protein KIAA0319 homolog

Gene
Kiaa0319
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites By similarity.

GO - Biological processi

  1. negative regulation of dendrite development Source: UniProtKB
  2. neuron migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Dyslexia-associated protein KIAA0319 homolog
Gene namesi
Name:Kiaa0319
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:3036268. D130043K22Rik.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 964942Extracellular Reviewed predictionAdd
BLAST
Transmembranei965 – 98521Helical; Reviewed predictionAdd
BLAST
Topological domaini986 – 108196Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. early endosome membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Chaini23 – 10811059Dyslexia-associated protein KIAA0319 homologPRO_0000042947Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi196 – 1961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi430 – 4301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi507 – 5071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi545 – 5451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi560 – 5601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi742 – 7421N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.
O-glycosylated By similarity.
Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SZV5.
PRIDEiQ5SZV5.

PTM databases

PhosphoSiteiQ5SZV5.

Expressioni

Developmental stagei

Expressed in the frontal neocortex, glanglionic eminence, mesencephalon and cerebellum at E13.5. More prominently expressed in the developing cerebral neocortex and mesencephalon at E15.5 and in the cortical plate and in the remnant of the ventricular zone at E18.5.1 Publication

Gene expression databases

ArrayExpressiQ5SZV5.
BgeeiQ5SZV5.
CleanExiMM_D130043K22RIK.
GenevestigatoriQ5SZV5.

Interactioni

Subunit structurei

Homodimer. Interacts with AP2M1; required for clathrin-mediated endocytosis By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ5SZV5.
SMRiQ5SZV5. Positions 336-436, 452-532, 540-630, 636-724.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 9977MANSCAdd
BLAST
Domaini345 – 43692PKD 1Add
BLAST
Domaini444 – 53390PKD 2Add
BLAST
Domaini539 – 62991PKD 3Add
BLAST
Domaini630 – 72394PKD 4Add
BLAST
Domaini729 – 82092PKD 5Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1004 – 10074Endocytosis signal

Sequence similaritiesi

Contains 1 MANSC domain.
Contains 5 PKD domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00740000115558.
HOGENOMiHOG000043880.
HOVERGENiHBG057130.
InParanoidiQ14BF3.
OMAiNYEWSLI.
PhylomeDBiQ5SZV5.
TreeFamiTF323356.

Family and domain databases

Gene3Di2.60.40.670. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013980. MANSC.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF02010. REJ. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00089. PKD. 5 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 4 hits.
PROSITEiPS50986. MANSC. 1 hit.
PS50093. PKD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SZV5-1 [UniParc]FASTAAdd to Basket

« Hide

MVSPPGVLSS LLLLAAMAGG SSQQCSEGRT YSDAIISPNP ETIRIMRVSQ     50
TFSVGDCTAA CCDLLTCDLA WWFEGSCYLV KCMRSENCEP RTTGPIRSYL 100
TFVRRPVQRP GQLLDYGDMM LSRGSPSGAW GDSLEDLRKD LPFLGKDGGP 150
EETTEYSDEY KDLERGLLQP SNQQDPRGSA EYPDWSLLPS NEGGFNATAT 200
GDNSAASMEK LQDPTPHPLD QEQLQALNES TWSPTPGHSS ISSVWPSSAS 250
PLPTEEGLEG EETLQLQEQP SNSSGKEVPM PSHNPSPASL ESSPATTEKN 300
SNFTVTPRSR KHSTPTFPTS TVLTGLTPPP WPLSPTASRT VKALAVSAGD 350
NLVLTLPDRE AELKASVEPA PPADTTYSYE WSLMSHPVDF QGKIKQENKP 400
TLHLSQLSVG LYAFRVAVSS ENAFGEGYVN VTVMPAARVN QPPVAVVSPQ 450
TQELSVPLTS ALIDGSQSTD DTEIVSYHWE EVDGPFLGEE FPADTPILRL 500
SNLVPGNYTF RLTITDSDGA TNSTTASLVI RDAVDYPPVA NAGPNQTITL 550
PQNTIILNGN QSSDDHQIVL YEWFAGPGGE SKEMVMQGAQ TPYLHLSELQ 600
EGEYTFQLMV TDSSGQQSTA LVAVTVQAEN NQAPVAVAGP DKELVFPVQS 650
ATLDGSRSSD DHGIVCYHWE HIRGPSAVEM ENVDKAIATV TGLQVGIYHF 700
RLTVRDQQGL SSTSTLTVAV KKENNSPPRA QAGGRHVLIL PNNSITLDGS 750
RSTDDRGIVS YLWIRDGQSP AAGDVIGGSD HRAALQLTNL VEGVYTFHLL 800
VTDSQGASDS DAATVEVLPD PKKDGLVELI LQVGVEQLTE QQKETLVRQL 850
AVLLNVLDSD VKVLKIQAHT DVSTVIVFYV QSGSPFKVLR AAAVARNLHK 900
RLSKEKEAFL LFKVLRVDTA GCLLKCSGHG HCDPITKRCI CSQLWMENLI 950
QRYMWDGESN CEWSVFYVAA LALTLTLLTG AVSWLCICCC RRRKRTKIRK 1000
KTKYTILDSM DEQERMELRP KYGIKHRSTE HNSSLMVSES EFESDQDTLF 1050
SRERMERGVL KGSLNGCARN GVSFGYYSKD R 1081
Length:1,081
Mass (Da):117,988
Last modified:December 21, 2004 - v1
Checksum:iC142C9746D9AF4DA
GO

Sequence cautioni

The sequence BAC65528.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122246 mRNA. Translation: BAC65528.1. Different initiation.
AL589699 Genomic DNA. Translation: CAI26085.1.
BC115723 mRNA. Translation: AAI15724.1.
BC115940 mRNA. Translation: AAI15941.1.
CCDSiCCDS36624.1.
RefSeqiNP_001074520.1. NM_001081051.1.
UniGeneiMm.261514.

Genome annotation databases

EnsembliENSMUST00000006893; ENSMUSP00000006893; ENSMUSG00000006711.
GeneIDi210108.
KEGGimmu:210108.
UCSCiuc007pwn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK122246 mRNA. Translation: BAC65528.1 . Different initiation.
AL589699 Genomic DNA. Translation: CAI26085.1 .
BC115723 mRNA. Translation: AAI15724.1 .
BC115940 mRNA. Translation: AAI15941.1 .
CCDSi CCDS36624.1.
RefSeqi NP_001074520.1. NM_001081051.1.
UniGenei Mm.261514.

3D structure databases

ProteinModelPortali Q5SZV5.
SMRi Q5SZV5. Positions 336-436, 452-532, 540-630, 636-724.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5SZV5.

Proteomic databases

PaxDbi Q5SZV5.
PRIDEi Q5SZV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006893 ; ENSMUSP00000006893 ; ENSMUSG00000006711 .
GeneIDi 210108.
KEGGi mmu:210108.
UCSCi uc007pwn.1. mouse.

Organism-specific databases

MGIi MGI:3036268. D130043K22Rik.
Rougei Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00740000115558.
HOGENOMi HOG000043880.
HOVERGENi HBG057130.
InParanoidi Q14BF3.
OMAi NYEWSLI.
PhylomeDBi Q5SZV5.
TreeFami TF323356.

Miscellaneous databases

NextBioi 372870.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5SZV5.
Bgeei Q5SZV5.
CleanExi MM_D130043K22RIK.
Genevestigatori Q5SZV5.

Family and domain databases

Gene3Di 2.60.40.670. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013980. MANSC.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF02010. REJ. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 4 hits.
SM00089. PKD. 5 hits.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 4 hits.
PROSITEi PS50986. MANSC. 1 hit.
PS50093. PKD. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration."
    Paracchini S., Thomas A., Castro S., Lai C., Paramasivam M., Wang Y., Keating B.J., Taylor J.M., Hacking D.F., Scerri T., Francks C., Richardson A.J., Wade-Martins R., Stein J.F., Knight J.C., Copp A.J., Loturco J., Monaco A.P.
    Hum. Mol. Genet. 15:1659-1666(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiK0319_MOUSE
AccessioniPrimary (citable) accession number: Q5SZV5
Secondary accession number(s): Q14BF3, Q80U39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi