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Q5SZP1

- Q5SZP1_HUMAN

UniProt

Q5SZP1 - Q5SZP1_HUMAN

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Protein
Submitted name: Paired box protein Pax-2
Gene
PAX2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. superoxide-generating NADPH oxidase activity Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. brain morphogenesis Source: Ensembl
  3. branching involved in ureteric bud morphogenesis Source: Ensembl
  4. cell fate determination Source: Ensembl
  5. cellular response to epidermal growth factor stimulus Source: Ensembl
  6. cellular response to glucose stimulus Source: Ensembl
  7. cellular response to hydrogen peroxide Source: Ensembl
  8. cellular response to mechanical stimulus Source: Ensembl
  9. cellular response to retinoic acid Source: Ensembl
  10. cochlea morphogenesis Source: Ensembl
  11. glial cell differentiation Source: Ensembl
  12. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  13. mesodermal cell fate specification Source: Ensembl
  14. mesonephric duct development Source: Ensembl
  15. mesonephric tubule formation Source: Ensembl
  16. metanephric collecting duct development Source: Ensembl
  17. metanephric distal convoluted tubule development Source: Ensembl
  18. metanephric mesenchymal cell differentiation Source: Ensembl
  19. metanephric nephron tubule formation Source: Ensembl
  20. negative regulation of apoptotic process involved in metanephric collecting duct development Source: Ensembl
  21. negative regulation of apoptotic process involved in metanephric nephron tubule development Source: Ensembl
  22. negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: Ensembl
  23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. nephric duct formation Source: Ensembl
  25. neural tube closure Source: Ensembl
  26. optic chiasma development Source: Ensembl
  27. optic cup morphogenesis involved in camera-type eye development Source: Ensembl
  28. optic nerve structural organization Source: Ensembl
  29. pancreas development Source: Ensembl
  30. paramesonephric duct development Source: Ensembl
  31. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
  32. positive regulation of cell proliferation Source: Ensembl
  33. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
  34. positive regulation of metanephric DCT cell differentiation Source: Ensembl
  35. positive regulation of metanephric glomerulus development Source: Ensembl
  36. positive regulation of optic nerve formation Source: Ensembl
  37. positive regulation of transcription, DNA-templated Source: Ensembl
  38. pronephric field specification Source: Ensembl
  39. protein kinase B signaling Source: Ensembl
  40. reactive oxygen species metabolic process Source: Ensembl
  41. regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
  42. regulation of metanephros size Source: Ensembl
  43. response to nutrient levels Source: Ensembl
  44. retinal pigment epithelium development Source: Ensembl
  45. transcription, DNA-templated Source: UniProtKB-KW
  46. ureter maturation Source: Ensembl
  47. ureter morphogenesis Source: Ensembl
  48. vestibulocochlear nerve formation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotations

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-2Imported
Gene namesi
Name:PAX2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:8616. PAX2.

Subcellular locationi

Nucleus By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. lysosome Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
  3. protein complex Source: Ensembl
  4. protein-DNA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ5SZP1.

Structurei

3D structure databases

ProteinModelPortaliQ5SZP1.
SMRiQ5SZP1. Positions 19-142.

Family & Domainsi

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation
Contains paired domain.

Keywords - Domaini

Paired boxUniRule annotationSAAS annotations

Phylogenomic databases

HOGENOMiHOG000230938.
HOVERGENiHBG009115.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SMARTiSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q5SZP1-1 [UniParc]FASTAAdd to Basket

« Hide

MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR    50
PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA 100
EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT 150
PDGAGTGVTA PGHTIVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK 200
RKRDEVEVYT DPAH 214
Length:214
Mass (Da):23,046
Last modified:December 21, 2004 - v1
Checksum:iB1D091C8B972B3EA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei214 – 2141Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138762 Genomic DNA. No translation available.
AL589862 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000427256; ENSP00000398652; ENSG00000075891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138762 Genomic DNA. No translation available.
AL589862 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali Q5SZP1.
SMRi Q5SZP1. Positions 19-142.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000427256 ; ENSP00000398652 ; ENSG00000075891 .

Organism-specific databases

HGNCi HGNC:8616. PAX2.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000230938.
HOVERGENi HBG009115.

Gene expression databases

ArrayExpressi Q5SZP1.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SMARTi SM00351. PAX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ5SZP1_HUMAN
AccessioniPrimary (citable) accession number: Q5SZP1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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