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Q5SZP1

- Q5SZP1_HUMAN

UniProt

Q5SZP1 - Q5SZP1_HUMAN

Protein
Submitted name:

Paired box protein Pax-2

Gene

PAX2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: Ensembl
    2. superoxide-generating NADPH oxidase activity Source: Ensembl

    GO - Biological processi

    1. aging Source: Ensembl
    2. brain morphogenesis Source: Ensembl
    3. branching involved in ureteric bud morphogenesis Source: Ensembl
    4. cell fate determination Source: Ensembl
    5. cellular response to epidermal growth factor stimulus Source: Ensembl
    6. cellular response to glucose stimulus Source: Ensembl
    7. cellular response to hydrogen peroxide Source: Ensembl
    8. cellular response to mechanical stimulus Source: Ensembl
    9. cellular response to retinoic acid Source: Ensembl
    10. cochlea morphogenesis Source: Ensembl
    11. glial cell differentiation Source: Ensembl
    12. mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    13. mesodermal cell fate specification Source: Ensembl
    14. mesonephric duct development Source: Ensembl
    15. mesonephric tubule formation Source: Ensembl
    16. metanephric collecting duct development Source: Ensembl
    17. metanephric distal convoluted tubule development Source: Ensembl
    18. metanephric mesenchymal cell differentiation Source: Ensembl
    19. metanephric nephron tubule formation Source: Ensembl
    20. negative regulation of apoptotic process involved in metanephric collecting duct development Source: Ensembl
    21. negative regulation of apoptotic process involved in metanephric nephron tubule development Source: Ensembl
    22. negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: Ensembl
    23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    24. nephric duct formation Source: Ensembl
    25. neural tube closure Source: Ensembl
    26. optic chiasma development Source: Ensembl
    27. optic cup morphogenesis involved in camera-type eye development Source: Ensembl
    28. optic nerve structural organization Source: Ensembl
    29. pancreas development Source: Ensembl
    30. paramesonephric duct development Source: Ensembl
    31. positive regulation of branching involved in ureteric bud morphogenesis Source: Ensembl
    32. positive regulation of cell proliferation Source: Ensembl
    33. positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: Ensembl
    34. positive regulation of metanephric DCT cell differentiation Source: Ensembl
    35. positive regulation of metanephric glomerulus development Source: Ensembl
    36. positive regulation of optic nerve formation Source: Ensembl
    37. positive regulation of transcription, DNA-templated Source: Ensembl
    38. pronephric field specification Source: Ensembl
    39. protein kinase B signaling Source: Ensembl
    40. reactive oxygen species metabolic process Source: Ensembl
    41. regulation of metanephric nephron tubule epithelial cell differentiation Source: Ensembl
    42. regulation of metanephros size Source: Ensembl
    43. response to nutrient levels Source: Ensembl
    44. retinal pigment epithelium development Source: Ensembl
    45. transcription, DNA-templated Source: UniProtKB-KW
    46. ureter maturation Source: Ensembl
    47. ureter morphogenesis Source: Ensembl
    48. vestibulocochlear nerve formation Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Paired box protein Pax-2Imported
    Gene namesi
    Name:PAX2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:8616. PAX2.

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. lysosome Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell
    3. protein complex Source: Ensembl
    4. protein-DNA complex Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ5SZP1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5SZP1.
    SMRiQ5SZP1. Positions 19-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 paired domain.UniRule annotation
    Contains paired domain.SAAS annotation

    Keywords - Domaini

    Paired boxUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000230938.
    HOVERGENiHBG009115.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q5SZP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR    50
    PCDISRQLRV SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA 100
    EYKRQNPTMF AWEIRDRLLA EGICDNDTVP SVSSINRIIR TKVQQPFHPT 150
    PDGAGTGVTA PGHTIVPSTA SPPVSSASND PVGSYSINGI LGIPRSNGEK 200
    RKRDEVEVYT DPAH 214
    Length:214
    Mass (Da):23,046
    Last modified:December 21, 2004 - v1
    Checksum:iB1D091C8B972B3EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei214 – 2141Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138762 Genomic DNA. No translation available.
    AL589862 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000427256; ENSP00000398652; ENSG00000075891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138762 Genomic DNA. No translation available.
    AL589862 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali Q5SZP1.
    SMRi Q5SZP1. Positions 19-142.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000427256 ; ENSP00000398652 ; ENSG00000075891 .

    Organism-specific databases

    HGNCi HGNC:8616. PAX2.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000230938.
    HOVERGENi HBG009115.

    Gene expression databases

    ArrayExpressi Q5SZP1.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiQ5SZP1_HUMAN
    AccessioniPrimary (citable) accession number: Q5SZP1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3