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Q5SZP1 (Q5SZP1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length214 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS001523 RuleBase RU000491.

Sequence similarities

Contains 1 paired domain. RuleBase RU000491

Contains paired domain.

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000398652

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS001523 RuleBase RU000491
   Cellular componentNucleus SAAS SAAS001523 RuleBase RU000491
   DomainPaired box SAAS SAAS001523 RuleBase RU000491
   LigandDNA-binding SAAS SAAS001523 RuleBase RU000491
   Molecular functionDevelopmental protein SAAS SAAS001523 RuleBase RU000491
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from electronic annotation. Source: Ensembl

brain morphogenesis

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell fate determination

Inferred from electronic annotation. Source: Ensembl

cellular response to epidermal growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to retinoic acid

Inferred from electronic annotation. Source: Ensembl

cochlea morphogenesis

Inferred from electronic annotation. Source: Ensembl

glial cell differentiation

Inferred from electronic annotation. Source: Ensembl

mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

mesodermal cell fate specification

Inferred from electronic annotation. Source: Ensembl

mesonephric duct development

Inferred from electronic annotation. Source: Ensembl

mesonephric tubule formation

Inferred from electronic annotation. Source: Ensembl

metanephric collecting duct development

Inferred from electronic annotation. Source: Ensembl

metanephric distal convoluted tubule development

Inferred from electronic annotation. Source: Ensembl

metanephric mesenchymal cell differentiation

Inferred from electronic annotation. Source: Ensembl

metanephric nephron tubule formation

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process involved in metanephric collecting duct development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process involved in metanephric nephron tubule development

Inferred from electronic annotation. Source: Ensembl

negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

nephric duct formation

Inferred from electronic annotation. Source: Ensembl

neural tube closure

Inferred from electronic annotation. Source: Ensembl

optic chiasma development

Inferred from electronic annotation. Source: Ensembl

optic cup morphogenesis involved in camera-type eye development

Inferred from electronic annotation. Source: Ensembl

optic nerve structural organization

Inferred from electronic annotation. Source: Ensembl

pancreas development

Inferred from electronic annotation. Source: Ensembl

paramesonephric duct development

Inferred from electronic annotation. Source: Ensembl

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of metanephric DCT cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of metanephric glomerulus development

Inferred from electronic annotation. Source: Ensembl

positive regulation of optic nerve formation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

pronephric field specification

Inferred from electronic annotation. Source: Ensembl

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of metanephric nephron tubule epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of metanephros size

Inferred from electronic annotation. Source: Ensembl

response to nutrient levels

Inferred from electronic annotation. Source: Ensembl

retinal pigment epithelium development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

ureter maturation

Inferred from electronic annotation. Source: Ensembl

ureter morphogenesis

Inferred from electronic annotation. Source: Ensembl

vestibulocochlear nerve formation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentlysosome

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

protein complex

Inferred from electronic annotation. Source: Ensembl

protein-DNA complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncore promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

superoxide-generating NADPH oxidase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue2141 Ensembl ENSP00000398652

Sequences

Sequence LengthMass (Da)Tools
Q5SZP1 [UniParc].

Last modified December 21, 2004. Version 1.
Checksum: B1D091C8B972B3EA

FASTA21423,046
        10         20         30         40         50         60 
MDMHCKADPF SAMHPGHGGV NQLGGVFVNG RPLPDVVRQR IVELAHQGVR PCDISRQLRV 

        70         80         90        100        110        120 
SHGCVSKILG RYYETGSIKP GVIGGSKPKV ATPKVVDKIA EYKRQNPTMF AWEIRDRLLA 

       130        140        150        160        170        180 
EGICDNDTVP SVSSINRIIR TKVQQPFHPT PDGAGTGVTA PGHTIVPSTA SPPVSSASND 

       190        200        210 
PVGSYSINGI LGIPRSNGEK RKRDEVEVYT DPAH 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL138762 Genomic DNA. No translation available.
AL589862 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalQ5SZP1.
SMRQ5SZP1. Positions 19-142.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000427256; ENSP00000398652; ENSG00000075891.

Organism-specific databases

HGNCHGNC:8616. PAX2.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000230938.
HOVERGENHBG009115.

Gene expression databases

ArrayExpressQ5SZP1.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
InterProIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00292. PAX. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5SZP1_HUMAN
AccessionPrimary (citable) accession number: Q5SZP1
Entry history
Integrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.