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Q5SZK8

- FREM2_HUMAN

UniProt

Q5SZK8 - FREM2_HUMAN

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Protein

FRAS1-related extracellular matrix protein 2

Gene

FREM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell communication Source: InterPro
  2. homophilic cell adhesion Source: InterPro
  3. inner ear development Source: Ensembl
  4. morphogenesis of an epithelium Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 2
Alternative name(s):
ECM3 homolog
Gene namesi
Name:FREM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:25396. FREM2.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Fraser syndrome (FRASS) [MIM:219000]: Multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1972 – 19721E → K in FRASS; may impair calcium-binding in the 2nd Calx-beta domain. 1 Publication
VAR_023201

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi219000. phenotype.
Orphaneti2052. Fraser syndrome.
93100. Unilateral renal agenesis.
PharmGKBiPA134930862.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4646Sequence AnalysisAdd
BLAST
Chaini47 – 31693123FRAS1-related extracellular matrix protein 2PRO_0000010124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi358 – 3581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1244 – 12441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1369 – 13691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1584 – 15841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1741 – 17411N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ5SZK8.
PaxDbiQ5SZK8.
PRIDEiQ5SZK8.

PTM databases

PhosphoSiteiQ5SZK8.

Expressioni

Gene expression databases

BgeeiQ5SZK8.
CleanExiHS_FREM2.
GenevestigatoriQ5SZK8.

Organism-specific databases

HPAiHPA028831.

Interactioni

Protein-protein interaction databases

BioGridi131147. 13 interactions.
STRINGi9606.ENSP00000280481.

Structurei

3D structure databases

ProteinModelPortaliQ5SZK8.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini47 – 31133067ExtracellularSequence AnalysisAdd
BLAST
Topological domaini3135 – 316935CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3114 – 313421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati298 – 419122CSPG 1Add
BLAST
Repeati420 – 541122CSPG 2Add
BLAST
Repeati542 – 681140CSPG 3Add
BLAST
Repeati682 – 811130CSPG 4Add
BLAST
Repeati812 – 921110CSPG 5Add
BLAST
Repeati922 – 1052131CSPG 6Add
BLAST
Repeati1053 – 1171119CSPG 7Add
BLAST
Repeati1172 – 1284113CSPG 8Add
BLAST
Repeati1285 – 1400116CSPG 9Add
BLAST
Repeati1401 – 1514114CSPG 10Add
BLAST
Repeati1515 – 1633119CSPG 11Add
BLAST
Repeati1634 – 1758125CSPG 12Add
BLAST
Domaini1759 – 1858100Calx-beta 1Add
BLAST
Domaini1871 – 1982112Calx-beta 2Add
BLAST
Domaini1997 – 2103107Calx-beta 3Add
BLAST
Domaini2118 – 2220103Calx-beta 4Add
BLAST
Domaini2238 – 2342105Calx-beta 5Add
BLAST

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated
Contains 5 Calx-beta domains.Curated
Contains 12 CSPG (NG2) repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG081537.
InParanoidiQ5SZK8.
OMAiEDSKFLD.
OrthoDBiEOG751NDJ.
PhylomeDBiQ5SZK8.
TreeFamiTF316876.

Family and domain databases

InterProiIPR002126. Cadherin.
IPR003644. Calx_beta.
[Graphical view]
PfamiPF03160. Calx-beta. 5 hits.
[Graphical view]
SMARTiSM00112. CA. 1 hit.
SM00237. Calx_beta. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5SZK8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHSAGTPGLS SRRTGNSTSF QPGPPPPPRL LLLLLLLLSL VSRVPAQPAA
60 70 80 90 100
FGRALLSPGL AGAAGVPAEE AIVLANRGLR VPFGREVWLD PLHDLVLQVQ
110 120 130 140 150
PGDRCAVSVL DNDALAQRPG RLSPKRFPCD FGPGEVRYSH LGARSPSRDR
160 170 180 190 200
VRLQLRYDAP GGAVVLPLVL EVEVVFTQLE VVTRNLPLVV EELLGTSNAL
210 220 230 240 250
DARSLEFAFQ PETEECRVGI LSGLGALPRY GELLHYPQVP GGAREGGAPE
260 270 280 290 300
TLLMDCKAFQ ELGVRYRHTA ASRSPNRDWI PMVVELRSRG APVGSPALKR
310 320 330 340 350
EHFQVLVRIR GGAENTAPKP SFVAMMMMEV DQFVLTALTP DMLAAEDAES
360 370 380 390 400
PSDLLIFNLT SPFQPGQGYL VSTDDRSLPL SSFTQRDLRL LKIAYQPPSE
410 420 430 440 450
DSDQERLFEL ELEVVDLEGA ASDPFAFMVV VKPMNTMAPV VTRNTGLILY
460 470 480 490 500
EGQSRPLTGP AGSGPQNLVI SDEDDLEAVR LEVVAGLRHG HLVILGASSG
510 520 530 540 550
SSAPKSFTVA ELAAGQVVYQ HDDRDGSLSD NLVLRMVDGG GRHQVQFLFP
560 570 580 590 600
ITLVPVDDQP PVLNANTGLT LAEGETVPIL PLSLSATDMD SDDSLLLFVL
610 620 630 640 650
ESPFLTTGHL LLRQTHPPHE KQELLRGLWR KEGAFYERTV TEWQQQDITE
660 670 680 690 700
GRLFYRHSGP HSPGPVTDQF TFRVQDNHDP PNQSGLQRFV IRIHPVDRLP
710 720 730 740 750
PELGSGCPLR MVVQESQLTP LRKKWLRYTD LDTDDRELRY TVTQSPTDTD
760 770 780 790 800
ENHLPAPLGT LVLTDNPSVV VTHFTQAQIN HHKIAYRPPG QELGVATRVA
810 820 830 840 850
QFQFQVEDRA GNVAPGTFTL YLHPVDNQPP EILNTGFTIQ EKGHHILSET
860 870 880 890 900
ELHVNDVDTD VAHISFTLTQ APKHGHMRVS GQILHVGGLF HLEDIKQGRV
910 920 930 940 950
SYAHNGDKSL TDSCSLEVSD RHHVVPITLR VNVRPVDDEV PILSHPTGTL
960 970 980 990 1000
ESYLDVLENG ATEITANVIK GTNEETDDLM LTFLLEDPPL YGEILVNGIP
1010 1020 1030 1040 1050
AEQFTQRDIL EGSVVYTHTS GEIGLLPKAD SFNLSLSDMS QEWRIGGNTI
1060 1070 1080 1090 1100
QGVTIWVTIL PVDSQAPEIF VGEQLIVMEG DKSVITSVHI SAEDVDSLND
1110 1120 1130 1140 1150
DILCTIVIQP TSGYVENISP APGSEKSRAG IAISAFNLKD LRQGHINYVQ
1160 1170 1180 1190 1200
SVHKGVEPVE DRFVFRCSDG INFSERQFFP IVIIPTNDEQ PEMFMREFMV
1210 1220 1230 1240 1250
MEGMSLVIDT PILNAADADV PLDDLTFTIT QFPTHGHIMN QLINGTVLVE
1260 1270 1280 1290 1300
SFTLDQIIES SSIIYEHDDS ETQEDSFVIK LTDGKHSVEK TVLIIVIPVD
1310 1320 1330 1340 1350
DETPRMTINN GLEIEIGDTK IINNKILMAT DLDSEDKSLV YIIRYGPGHG
1360 1370 1380 1390 1400
LLQRRKPTGA FENITLGMNF TQDEVDRNLI QYVHLGQEGI RDLIKFDVTD
1410 1420 1430 1440 1450
GINPLIDRYF YVSIGSIDIV FPDVISKGVS LKEGGKVTLT TDLLSTSDLN
1460 1470 1480 1490 1500
SPDENLVFTI TRAPMRGHLE CTDQPGVSIT SFTQLQLAGN KIYYIHTADD
1510 1520 1530 1540 1550
EVKMDSFEFQ VTDGRNPVFR TFRISISDVD NKKPVVTIHK LVVSESENKL
1560 1570 1580 1590 1600
ITPFELTVED RDTPDKLLKF TITQVPIHGH LLFNNTRPVM VFTKQDLNEN
1610 1620 1630 1640 1650
LISYKHDGTE SSEDSFSFTV TDGTHTDFYV FPDTVFETRR PQVMKIQVLA
1660 1670 1680 1690 1700
VDNSVPQIAV NKGASTLRTL ATGHLGFMIT SKILKVEDRD SLHISLRFIV
1710 1720 1730 1740 1750
TEAPQHGYLL NLDKGNHSIT QFTQADIDDM KICYVLREGA NATSDMFYFA
1760 1770 1780 1790 1800
VEDGGGNKLT YQNFRLNWAW ISFEKEYYLV NEDSKFLDVV LKRRGYLGET
1810 1820 1830 1840 1850
SFISIGTRDR TAEKDKDFKG KAQKQVQFNP GQTRATWRVR ILSDGEHEQS
1860 1870 1880 1890 1900
ETFQVVLSEP VLAALEFPTV ATVEIVDPGD EPTVFIPQSK YSVEEDVGEL
1910 1920 1930 1940 1950
FIPIRRSGDV SQELMVVCYT QQGTATGTVP TSVLSYSDYI SRPEDHTSVV
1960 1970 1980 1990 2000
RFDKDEREKL CRIVIIDDSL YEEEETFHVL LSMPMGGRIG SEFPGAQVTI
2010 2020 2030 2040 2050
VPDKDDEPIF YFGDVEYSVD ESAGYVEVQV WRTGTDLSKS SSVTVRSRKT
2060 2070 2080 2090 2100
DPPSADAGTD YVGISRNLDF APGVNMQPVR VVILDDLGQP ALEGIEKFEL
2110 2120 2130 2140 2150
VLRMPMNAAL GEPSKATVSI NDSVSDLPKM QFKERIYTGS ESDGQIVTMI
2160 2170 2180 2190 2200
HRTGDVQYRS SVRCYTRQGS AQVMMDFEER PNTDTSIITF LPGETEKPCI
2210 2220 2230 2240 2250
LELMDDVLYE EVEELRLVLG TPQSNSPFGA AVGEQNETLI RIRDDADKTV
2260 2270 2280 2290 2300
IKFGETKFSV TEPKEPGESV VIRIPVIRQG DTSKVSIVRV HTKDGSATSG
2310 2320 2330 2340 2350
EDYHPVSEEI EFKEGETQHV VEIEVTFDGV REMREAFTVH LKPDENMIAE
2360 2370 2380 2390 2400
MQLTKAIVYI EEMSSMADVT FPSVPQIVSL LMYDDTSKAK ESAEPMSGYP
2410 2420 2430 2440 2450
VICITACNPK YSDYDKTGSI CASENINDTL TRYRWLISAP AGPDGVTSPM
2460 2470 2480 2490 2500
REVDFDTFFT SSKMVTLDSI YFQPGSRVQC AARAVNTNGD EGLELMSPIV
2510 2520 2530 2540 2550
TISREEGLCQ PRVPGVVGAE PFSAKLRYTG PEDADYTNLI KLTVTMPHID
2560 2570 2580 2590 2600
GMLPVISTRE LSNFELTLSP DGTRVGNHKC SNLLDYTEVK THYGFLTDAT
2610 2620 2630 2640 2650
KNPEIIGETY PYQYSLSIRG STTLRFYRNL NLEACLWEFV SYYDMSELLA
2660 2670 2680 2690 2700
DCGGTIGTDG QVLNLVQSYV TLRVPLYVSY VFHSPVGVGG WQHFDLKSEL
2710 2720 2730 2740 2750
RLTFVYDTAI LWNDGIGSPP EAELQGSLYP TSMRIGDEGR LAVHFKTEAQ
2760 2770 2780 2790 2800
FHGLFVLSHP ASFTSSVIMS ADHPGLTFSL RLIRSEPTYN QPVQQWSFVS
2810 2820 2830 2840 2850
DFAVRDYSGT YTVKLVPCTA PSHQEYRLPV TCNPREPVTF DLDIRFQQVS
2860 2870 2880 2890 2900
DPVAAEFSLN TQMYLLSKKS LWLSDGSMGF GQESDVAFAE GDIIYGRVMV
2910 2920 2930 2940 2950
DPVQNLGDSF YCSIEKVFLC TGADGYVPKY SPMNAEYGCL ADSPSLLYRF
2960 2970 2980 2990 3000
KIVDKAQPET QATSFGNVLF NAKLAVDDPE AILLVNQPGS DGFKVDSTPL
3010 3020 3030 3040 3050
FQVALGREWY IHTIYTVRSK DNANRGIGKR SVEYHSLVSQ GKPQSTTKSR
3060 3070 3080 3090 3100
KKREIRSTPS LAWEIGAENS RGTNIQHIAL DRTKRQIPHG RAPPDGILPW
3110 3120 3130 3140 3150
ELNSPSSAVS LVTVVGGTTV GLLTICLTVI AVLMCRGKES FRGKDAPKGS
3160
SSSEPMVPPQ SHHNDSSEV
Length:3,169
Mass (Da):351,157
Last modified:August 16, 2005 - v2
Checksum:i4000FC02963417F7
GO
Isoform 2 (identifier: Q5SZK8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2663-2667: LNLVQ → QIYNI
     2668-3169: Missing.

Note: No experimental confirmation available.

Show »
Length:2,667
Mass (Da):295,845
Checksum:i9AD8ABD80F89E9F8
GO

Sequence cautioni

The sequence BAC87040.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2030 – 20301V → A in CAD98088. (PubMed:14702039)Curated
Sequence conflicti2112 – 21121E → K in BAC87040. (PubMed:17974005)Curated
Sequence conflicti2116 – 21161A → T in BAC87040. (PubMed:17974005)Curated
Sequence conflicti2359 – 23591Y → H in CAD98088. (PubMed:14702039)Curated
Sequence conflicti2508 – 25081L → P in BAC87040. (PubMed:17974005)Curated
Sequence conflicti2638 – 26381E → K in BAC87040. (PubMed:17974005)Curated
Sequence conflicti2682 – 26821F → I in CAD98088. (PubMed:14702039)Curated
Sequence conflicti2777 – 27771T → S in CAI46253. (PubMed:14702039)Curated
Sequence conflicti2786 – 27861E → G in CAD98036. (PubMed:14702039)Curated
Sequence conflicti2968 – 29681V → I in CAD98088. (PubMed:14702039)Curated
Sequence conflicti2968 – 29681V → I in CAE45813. (PubMed:14702039)Curated
Sequence conflicti3081 – 30811D → G in CAD98088. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti722 – 7221R → K.
Corresponds to variant rs58363253 [ dbSNP | Ensembl ].
VAR_061174
Natural varianti745 – 7451S → P.
Corresponds to variant rs2496423 [ dbSNP | Ensembl ].
VAR_061175
Natural varianti770 – 7701V → M.
Corresponds to variant rs7327915 [ dbSNP | Ensembl ].
VAR_033933
Natural varianti868 – 8681L → V.
Corresponds to variant rs7329939 [ dbSNP | Ensembl ].
VAR_033934
Natural varianti1039 – 10391M → K.
Corresponds to variant rs2496424 [ dbSNP | Ensembl ].
VAR_033935
Natural varianti1045 – 10451I → S.
Corresponds to variant rs17058433 [ dbSNP | Ensembl ].
VAR_037569
Natural varianti1070 – 10701F → S.
Corresponds to variant rs2496425 [ dbSNP | Ensembl ].
VAR_033936
Natural varianti1668 – 16681R → H.
Corresponds to variant rs1868463 [ dbSNP | Ensembl ].
VAR_037570
Natural varianti1840 – 18401R → W.
Corresponds to variant rs9603422 [ dbSNP | Ensembl ].
VAR_033937
Natural varianti1972 – 19721E → K in FRASS; may impair calcium-binding in the 2nd Calx-beta domain. 1 Publication
VAR_023201
Natural varianti2066 – 20661R → C.1 Publication
Corresponds to variant rs9548505 [ dbSNP | Ensembl ].
VAR_023202
Natural varianti2153 – 21531T → S.1 Publication
Corresponds to variant rs9548506 [ dbSNP | Ensembl ].
VAR_023203
Natural varianti2326 – 23261T → I.2 Publications
Corresponds to variant rs9548509 [ dbSNP | Ensembl ].
VAR_023204
Natural varianti2962 – 29621A → V.
Corresponds to variant rs7996253 [ dbSNP | Ensembl ].
VAR_037571

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2663 – 26675LNLVQ → QIYNI in isoform 2. 1 PublicationVSP_015035
Alternative sequencei2668 – 3169502Missing in isoform 2. 1 PublicationVSP_015036Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354819, AC017111, AL590007 Genomic DNA. Translation: CAI16761.2.
AL590007, AC017111, AL354819 Genomic DNA. Translation: CAI12790.2.
AK127571 mRNA. Translation: BAC87040.1. Different initiation.
BX538150 mRNA. Translation: CAD98036.1.
BX538304 mRNA. Translation: CAD98088.1.
BX640686 mRNA. Translation: CAE45813.1.
CR933724 mRNA. Translation: CAI46253.1.
BN000687 mRNA. Translation: CAH56764.1.
CCDSiCCDS31960.1. [Q5SZK8-1]
RefSeqiNP_997244.4. NM_207361.5.
UniGeneiHs.253994.

Genome annotation databases

EnsembliENST00000280481; ENSP00000280481; ENSG00000150893.
GeneIDi341640.
KEGGihsa:341640.
UCSCiuc001uwv.3. human. [Q5SZK8-1]

Polymorphism databases

DMDMi73620903.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL354819 , AC017111 , AL590007 Genomic DNA. Translation: CAI16761.2 .
AL590007 , AC017111 , AL354819 Genomic DNA. Translation: CAI12790.2 .
AK127571 mRNA. Translation: BAC87040.1 . Different initiation.
BX538150 mRNA. Translation: CAD98036.1 .
BX538304 mRNA. Translation: CAD98088.1 .
BX640686 mRNA. Translation: CAE45813.1 .
CR933724 mRNA. Translation: CAI46253.1 .
BN000687 mRNA. Translation: CAH56764.1 .
CCDSi CCDS31960.1. [Q5SZK8-1 ]
RefSeqi NP_997244.4. NM_207361.5.
UniGenei Hs.253994.

3D structure databases

ProteinModelPortali Q5SZK8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131147. 13 interactions.
STRINGi 9606.ENSP00000280481.

PTM databases

PhosphoSitei Q5SZK8.

Polymorphism databases

DMDMi 73620903.

Proteomic databases

MaxQBi Q5SZK8.
PaxDbi Q5SZK8.
PRIDEi Q5SZK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280481 ; ENSP00000280481 ; ENSG00000150893 .
GeneIDi 341640.
KEGGi hsa:341640.
UCSCi uc001uwv.3. human. [Q5SZK8-1 ]

Organism-specific databases

CTDi 341640.
GeneCardsi GC13P039261.
H-InvDB HIX0026558.
HGNCi HGNC:25396. FREM2.
HPAi HPA028831.
MIMi 219000. phenotype.
608945. gene.
neXtProti NX_Q5SZK8.
Orphaneti 2052. Fraser syndrome.
93100. Unilateral renal agenesis.
PharmGKBi PA134930862.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG081537.
InParanoidi Q5SZK8.
OMAi EDSKFLD.
OrthoDBi EOG751NDJ.
PhylomeDBi Q5SZK8.
TreeFami TF316876.

Miscellaneous databases

ChiTaRSi FREM2. human.
GeneWikii FREM2.
GenomeRNAii 341640.
NextBioi 98177.
PROi Q5SZK8.
SOURCEi Search...

Gene expression databases

Bgeei Q5SZK8.
CleanExi HS_FREM2.
Genevestigatori Q5SZK8.

Family and domain databases

InterProi IPR002126. Cadherin.
IPR003644. Calx_beta.
[Graphical view ]
Pfami PF03160. Calx-beta. 5 hits.
[Graphical view ]
SMARTi SM00112. CA. 1 hit.
SM00237. Calx_beta. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1817-3169 (ISOFORM 2), VARIANT ILE-2326.
    Tissue: Tongue.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1910-3169 (ISOFORM 1), VARIANTS CYS-2066; SER-2153 AND ILE-2326.
    Tissue: Fetal kidney.
  4. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1741.
    Tissue: Plasma.
  5. Cited for: IDENTIFICATION (ISOFORM 1), FUNCTION, VARIANT FRASS LYS-1972.

Entry informationi

Entry nameiFREM2_HUMAN
AccessioniPrimary (citable) accession number: Q5SZK8
Secondary accession number(s): Q4QQG1
, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3