Q5SZI1 (LRAD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low-density lipoprotein receptor class A domain-containing protein 2

Gene names

Name:

LDLRAD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the LDLR family. Contains 1 LDL-receptor class A domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 272	247	Low-density lipoprotein receptor class A domain-containing protein 2		PRO_0000299377
Regions
	Topological domain	26 – 233	208	Extracellular Potential
	Transmembrane	234 – 250	17	Helical; Potential
	Topological domain	251 – 272	22	Cytoplasmic Potential
	Domain	172 – 214	43	LDL-receptor class A
Amino acid modifications
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Disulfide bond	173 ↔ 184		By similarity
	Disulfide bond	179 ↔ 199		By similarity
	Disulfide bond	191 ↔ 213		By similarity
Natural variations
	Natural variant	134	1	N → T. Ref.4 Corresponds to variant rs10917051 [ dbSNP | Ensembl ].		VAR_034812
Experimental info
	Sequence conflict	114	1	Q → R in BAC86913. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q5SZI1 [UniParc]. Last modified December 21, 2004. Version 1. Checksum: 31F9F3861DDD721B	FASTA	272	28,581
	10 20 30 40 50 60 MEACCLLQLP QRLLLLGAAA LTATALETAD LAELCGQTWQ GDGLLLRSHA ASRRFYFVAP 70 80 90 100 110 120 DTDCGLWVQA AAPGDRIRFQ FRFFLVYSLT PAPPALNTSS PAPADPCAPG SYLQFYEGPP 130 140 150 160 170 180 GAPRPLGSPL CGLNIPVPVA SSGPFLGLRL VTRGRQPRVD FVGEVTSFRL GPCGAYFRCQ 190 200 210 220 230 240 NGRCIPSSLV CDPWGMDNCG DGSDQGSWSP ADCRGPSPVP SQTGSTDAHT SRSLTPSPAL 250 260 270 GSAGSLWIAA ERSSPAGRDP TRQDAALEGS TE

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK127275 mRNA. Translation: BAC86913.1. AL590103 Genomic DNA. Translation: CAI12128.1. CH471134 Genomic DNA. Translation: EAW94993.1. BC146860 mRNA. Translation: AAI46861.1.
IPI	IPI00418890.
RefSeq	NP_001013715.2. NM_001013693.2.
UniGene	Hs.710255.
3D structure databases
HSSP	HSSP built from PDB template 1J8E based on UniProtKB Q07954.
ProteinModelPortal	Q5SZI1.
ModBase	Search...
Polymorphism databases
DMDM	74744157.
Proteomic databases
PaxDb	Q5SZI1.
PRIDE	Q5SZI1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000344642; ENSP00000340988; ENSG00000187942. ENST00000543870; ENSP00000444097; ENSG00000187942.
GeneID	401944.
KEGG	hsa:401944.
UCSC	uc001bfg.1. human.
Organism-specific databases
CTD	401944.
GeneCards	GC01P022138.
HGNC	HGNC:32071. LDLRAD2.
HPA	HPA030478.
neXtProt	NX_Q5SZI1.
PharmGKB	PA142671555.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73820.
HOGENOM	HOG000113362.
InParanoid	Q5SZI1.
OMA	CGAYFRC.
OrthoDB	EOG4CJVJK.
Gene expression databases
Bgee	Q5SZI1.
CleanEx	HS_LDLRAD2.
Genevestigator	Q5SZI1.
Family and domain databases
Gene3D	2.60.120.290. 1 hit. 4.10.400.10. 1 hit.
InterPro	IPR000859. CUB_dom. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 1 hit. [Graphical view]
SMART	SM00192. LDLa. 1 hit. [Graphical view]
SUPFAM	SSF49854. CUB. 1 hit. SSF57424. LDL_rcpt_classA_cys-rich. 1 hit.
PROSITE	PS50068. LDLRA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	401944.
NextBio	107209.

Entry information

Entry name

LRAD2_HUMAN

Accession

Primary (citable) accession number: Q5SZI1
Secondary accession number(s): B9EJB3, Q6ZSN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 21, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.