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Protein

Low-density lipoprotein receptor class A domain-containing protein 2

Gene

LDLRAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor class A domain-containing protein 2
Gene namesi
Name:LDLRAD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:32071. LDLRAD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 233208ExtracellularSequence analysisAdd
BLAST
Transmembranei234 – 25017HelicalSequence analysisAdd
BLAST
Topological domaini251 – 27222CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671555.

Polymorphism and mutation databases

BioMutaiLDLRAD2.
DMDMi74744157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 272247Low-density lipoprotein receptor class A domain-containing protein 2PRO_0000299377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi173 ↔ 184PROSITE-ProRule annotation
Disulfide bondi179 ↔ 199PROSITE-ProRule annotation
Disulfide bondi191 ↔ 213PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiQ5SZI1.
PRIDEiQ5SZI1.

Expressioni

Gene expression databases

BgeeiQ5SZI1.
CleanExiHS_LDLRAD2.

Organism-specific databases

HPAiHPA030478.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340988.

Structurei

3D structure databases

ProteinModelPortaliQ5SZI1.
SMRiQ5SZI1. Positions 171-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 21443LDL-receptor class APROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGGH. Eukaryota.
ENOG410YXMN. LUCA.
GeneTreeiENSGT00390000004581.
HOGENOMiHOG000113362.
InParanoidiQ5SZI1.
OMAiLCGQTWQ.
OrthoDBiEOG72VH6S.
PhylomeDBiQ5SZI1.
TreeFamiTF333091.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR000859. CUB_dom.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50068. LDLRA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5SZI1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEACCLLQLP QRLLLLGAAA LTATALETAD LAELCGQTWQ GDGLLLRSHA
60 70 80 90 100
ASRRFYFVAP DTDCGLWVQA AAPGDRIRFQ FRFFLVYSLT PAPPALNTSS
110 120 130 140 150
PAPADPCAPG SYLQFYEGPP GAPRPLGSPL CGLNIPVPVA SSGPFLGLRL
160 170 180 190 200
VTRGRQPRVD FVGEVTSFRL GPCGAYFRCQ NGRCIPSSLV CDPWGMDNCG
210 220 230 240 250
DGSDQGSWSP ADCRGPSPVP SQTGSTDAHT SRSLTPSPAL GSAGSLWIAA
260 270
ERSSPAGRDP TRQDAALEGS TE
Length:272
Mass (Da):28,581
Last modified:December 21, 2004 - v1
Checksum:i31F9F3861DDD721B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141Q → R in BAC86913 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti134 – 1341N → T.1 Publication
Corresponds to variant rs10917051 [ dbSNP | Ensembl ].
VAR_034812

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127275 mRNA. Translation: BAC86913.1.
AL590103 Genomic DNA. Translation: CAI12128.1.
CH471134 Genomic DNA. Translation: EAW94993.1.
BC146860 mRNA. Translation: AAI46861.1.
CCDSiCCDS30624.1.
RefSeqiNP_001013715.2. NM_001013693.2.
UniGeneiHs.745158.

Genome annotation databases

EnsembliENST00000344642; ENSP00000340988; ENSG00000187942.
ENST00000543870; ENSP00000444097; ENSG00000187942.
GeneIDi401944.
KEGGihsa:401944.
UCSCiuc001bfg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127275 mRNA. Translation: BAC86913.1.
AL590103 Genomic DNA. Translation: CAI12128.1.
CH471134 Genomic DNA. Translation: EAW94993.1.
BC146860 mRNA. Translation: AAI46861.1.
CCDSiCCDS30624.1.
RefSeqiNP_001013715.2. NM_001013693.2.
UniGeneiHs.745158.

3D structure databases

ProteinModelPortaliQ5SZI1.
SMRiQ5SZI1. Positions 171-208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340988.

Polymorphism and mutation databases

BioMutaiLDLRAD2.
DMDMi74744157.

Proteomic databases

PaxDbiQ5SZI1.
PRIDEiQ5SZI1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344642; ENSP00000340988; ENSG00000187942.
ENST00000543870; ENSP00000444097; ENSG00000187942.
GeneIDi401944.
KEGGihsa:401944.
UCSCiuc001bfg.1. human.

Organism-specific databases

CTDi401944.
GeneCardsiLDLRAD2.
HGNCiHGNC:32071. LDLRAD2.
HPAiHPA030478.
neXtProtiNX_Q5SZI1.
PharmGKBiPA142671555.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGGH. Eukaryota.
ENOG410YXMN. LUCA.
GeneTreeiENSGT00390000004581.
HOGENOMiHOG000113362.
InParanoidiQ5SZI1.
OMAiLCGQTWQ.
OrthoDBiEOG72VH6S.
PhylomeDBiQ5SZI1.
TreeFamiTF333091.

Miscellaneous databases

ChiTaRSiLDLRAD2. human.
GenomeRNAii401944.
NextBioi107209.
PROiQ5SZI1.

Gene expression databases

BgeeiQ5SZI1.
CleanExiHS_LDLRAD2.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR000859. CUB_dom.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00057. Ldl_recept_a. 1 hit.
[Graphical view]
SMARTiSM00192. LDLa. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50068. LDLRA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-134.

Entry informationi

Entry nameiLRAD2_HUMAN
AccessioniPrimary (citable) accession number: Q5SZI1
Secondary accession number(s): B9EJB3, Q6ZSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: November 11, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.