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Protein
Submitted name:

Ceramide synthase 2

Gene

CERS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi73 – 129HomeoboxPROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ceramide synthase 2Imported
Gene namesi
Name:CERS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143418.19.
HGNCiHGNC:14076. CERS2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 68HelicalSequence analysisAdd BLAST24
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei180 – 198HelicalSequence analysisAdd BLAST19
Transmembranei210 – 229HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143418.

PTM / Processingi

Proteomic databases

MaxQBiQ5SZE4.
PaxDbiQ5SZE4.
PeptideAtlasiQ5SZE4.
PRIDEiQ5SZE4.

Expressioni

Gene expression databases

BgeeiENSG00000143418.
ExpressionAtlasiQ5SZE4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ5SZE4.
SMRiQ5SZE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 128HomeoboxInterPro annotationAdd BLAST58
Domaini131 – 249TLCInterPro annotationAdd BLAST119

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1607. Eukaryota.
COG5058. LUCA.
GeneTreeiENSGT00550000074401.
HOGENOMiHOG000231977.
HOVERGENiHBG052310.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR001356. Homeobox_dom.
IPR016439. Lag1/Lac1-like.
IPR006634. TLC-dom.
PANTHERiPTHR12560. PTHR12560. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03798. TRAM_LAG1_CLN8. 1 hit.
PIRSFiPIRSF005225. LAG1_LAC1. 1 hit.
SMARTiView protein in SMART
SM00724. TLC. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 1 hit.
PS50922. TLC. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5SZE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTLYDYFW WERLWLPVNL TWADLEDRDG RVYAKASDLY ITLPLALLFL
60 70 80 90 100
IVRYFFELYV ATPLAALLNI KEKTRLRAPP NATLEHFYLT SGKQPKQVEV
110 120 130 140 150
ELLSRQSGLS GRQVERWFRR RRNQDRPSLL KKFREASWRF TFYLIAFIAG
160 170 180 190 200
MAVIVDKPWF YDMKKVWEGY PIQSTIPSQY WYYMIELSFY WSLLFSIASD
210 220 230 240
VKRKDFKEQI IHHVATIILI SFSWFANYIR AGTLIMALHD SSDYLLEVR
Length:249
Mass (Da):29,843
Last modified:December 21, 2004 - v1
Checksum:iA993BDB04F5E45EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei249Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590133 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000361419; ENSP00000355020; ENSG00000143418.
UCSCiuc057krd.1. human.

Similar proteinsi

Entry informationi

Entry nameiQ5SZE4_HUMAN
AccessioniPrimary (citable) accession number: Q5SZE4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 22, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported