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Protein
Submitted name:

Ceramide synthase 2

Gene

CERS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi73 – 129HomeoboxPROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Ceramide synthase 2Imported
Gene namesi
Name:CERS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143418.19
HGNCiHGNC:14076 CERS2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 68HelicalSequence analysisAdd BLAST24
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei180 – 198HelicalSequence analysisAdd BLAST19
Transmembranei210 – 229HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143418

PTM / Processingi

Proteomic databases

MaxQBiQ5SZE4
PeptideAtlasiQ5SZE4
PRIDEiQ5SZE4

Expressioni

Gene expression databases

BgeeiENSG00000143418
ExpressionAtlasiQ5SZE4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SZE4
SMRiQ5SZE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 128HomeoboxInterPro annotationAdd BLAST58
Domaini131 – 249TLCInterPro annotationAdd BLAST119

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1607 Eukaryota
COG5058 LUCA
GeneTreeiENSGT00550000074401
HOGENOMiHOG000231977
HOVERGENiHBG052310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR016439 Lag1/Lac1-like
IPR006634 TLC-dom
PANTHERiPTHR12560 PTHR12560, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03798 TRAM_LAG1_CLN8, 1 hit
PIRSFiPIRSF005225 LAG1_LAC1, 1 hit
SMARTiView protein in SMART
SM00724 TLC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit
PS50922 TLC, 1 hit

Sequencei

Sequence statusi: Fragment.

Q5SZE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTLYDYFW WERLWLPVNL TWADLEDRDG RVYAKASDLY ITLPLALLFL
60 70 80 90 100
IVRYFFELYV ATPLAALLNI KEKTRLRAPP NATLEHFYLT SGKQPKQVEV
110 120 130 140 150
ELLSRQSGLS GRQVERWFRR RRNQDRPSLL KKFREASWRF TFYLIAFIAG
160 170 180 190 200
MAVIVDKPWF YDMKKVWEGY PIQSTIPSQY WYYMIELSFY WSLLFSIASD
210 220 230 240
VKRKDFKEQI IHHVATIILI SFSWFANYIR AGTLIMALHD SSDYLLEVR
Length:249
Mass (Da):29,843
Last modified:December 21, 2004 - v1
Checksum:iA993BDB04F5E45EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei249Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590133 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000361419; ENSP00000355020; ENSG00000143418
UCSCiuc057krd.1 human

Similar proteinsi

Entry informationi

Entry nameiQ5SZE4_HUMAN
AccessioniPrimary (citable) accession number: Q5SZE4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health